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1223405-08-0,MFCD29472286
Catalog No.:AA00171N

1223405-08-0 | LOXO-101 sulfate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98% by HPLC
in stock  
$122.00   $85.00
- +
10mg
98% by HPLC
in stock  
$161.00   $113.00
- +
25mg
98% by HPLC
in stock  
$269.00   $188.00
- +
50mg
98% by HPLC
in stock  
$413.00   $289.00
- +
100mg
98% by HPLC
in stock  
$667.00   $467.00
- +
500mg
98% by HPLC
in stock  
$2,011.00   $1,408.00
- +
1000mg
98% by HPLC
in stock  
$3,180.00   $2,226.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00171N
Chemical Name:
LOXO-101 sulfate
CAS Number:
1223405-08-0
Molecular Formula:
C21H24F2N6O6S
Molecular Weight:
526.5137
MDL Number:
MFCD29472286
SMILES:
OS(=O)(=O)O.O[C@H]1CCN(C1)C(=O)Nc1cnn2c1nc(cc2)N1CCC[C@@H]1c1cc(F)ccc1F
Properties
Computed Properties
 
Complexity:
741  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
3  

Literature

Title: Karyn Bouhana, et al. LOXO-101, a pan TRK inhibitor, For The Treatment Of TRK-driven Cancers.

Title: Nagasubramanian R, et al. Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101. Pediatr Blood Cancer. 2016 Aug;63(8):1468-70.

Title: Kathryn G, et al. Genetic Modeling and Therapeutic Targeting of ETV6-NTRK3 with Loxo-101in Acute Lymphoblastic Leukemia. Blood 2016 128:278.

Title: Doebele RC, et al. An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101. Cancer Discov. 2015 Oct;5(10):1049-57.

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SDS
Tags:1223405-08-0 Molecular Formula|1223405-08-0 MDL|1223405-08-0 SMILES|1223405-08-0 LOXO-101 sulfate