Home Amines 122647-32-9
122647-32-9,MFCD01715410
Catalog No.:AA0017IA

122647-32-9 | Methanesulfonamide, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-, (2E)-2-butenedioate (2:1)

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1mg
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10mg
98%
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$46.00   $32.00
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25mg
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50mg
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0017IA
Chemical Name:
Methanesulfonamide, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-, (2E)-2-butenedioate (2:1)
CAS Number:
122647-32-9
Molecular Formula:
C44H76N4O10S2
Molecular Weight:
885.2250
MDL Number:
MFCD01715410
SMILES:
OC(=O)/C=C/C(=O)O.CCCCCCCN(CCCC(c1ccc(cc1)NS(=O)(=O)C)O)CC.CCCCCCCN(CCCC(c1ccc(cc1)NS(=O)(=O)C)O)CC
Properties
Computed Properties
 
Complexity:
561  
Covalently-Bonded Unit Count:
3  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
60  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
30  
Undefined Atom Stereocenter Count:
2  

Literature

Title: Effect of ibutilide on the canine cardiac conduction system.

Journal: Cell biochemistry and biophysics 20121101

Title: Enhanced sensitivity to drug-induced QT interval lengthening in patients with heart failure due to left ventricular systolic dysfunction.

Journal: Journal of clinical pharmacology 20120901

Title: Ibutilide decreases defibrillation threshold by the reduction of activation pattern complexity during ventricular fibrillation in canine hearts.

Journal: Chinese medical journal 20120801

Title: The Modified Ablation Guided by Ibutilide Use in Chronic Atrial Fibrillation (MAGIC-AF) Study: clinical background and study design.

Journal: Journal of cardiovascular electrophysiology 20120401

Title: Brugada syndrome masked by ibutilide treatment in a patient with atrial flutter.

Journal: Cardiology 20120101

Title: [Efficacy of ibutilide for cardioversion of persistent atrial fibrillation during radiofrequency ablation].

Journal: Zhonghua xin xue guan bing za zhi 20111101

Title: Factors affecting the degree of QT prolongation with drug challenge in a large cohort of normal volunteers.

Journal: Heart rhythm 20111001

Title: Predicting the degree of drug-induced QT prolongation and the risk for torsades de pointes.

Journal: Heart rhythm 20111001

Title: Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.

Journal: Circulation. Arrhythmia and electrophysiology 20110801

Title: A 2-year survey of treatment of acute atrial fibrillation in an ED.

Journal: The American journal of emergency medicine 20110601

Title: Effects of ibutilide on inhibiting heart rate and rapidly terminating atrial flutter in canine.

Journal: Cell biochemistry and biophysics 20110401

Title: Atrial fibrillation: AVRO--were the results a surprise?

Journal: Nature reviews. Cardiology 20110401

Title: Single dose of ibutilide for conversion of persistent atrial fibrillation after radiofrequency ablation.

Journal: Chinese medical journal 20110301

Title: Safety and efficacy of ibutilide in cardioversion of atrial flutter and fibrillation.

Journal: Journal of the American Board of Family Medicine : JABFM 20110101

Title: Effect of high doses of magnesium on converting ibutilide to a safe and more effective agent.

Journal: The American journal of cardiology 20100901

Title: Pre-injection of magnesium sulfate enhances the efficacy of ibutilide for the conversion of typical but not of atypical persistent atrial flutter.

Journal: International journal of cardiology 20100611

Title: Intraprocedural use of ibutilide to organize and guide ablation of complex fractionated atrial electrograms: preliminary assessment of a modified step-wise approach to ablation of persistent atrial fibrillation.

Journal: Journal of cardiovascular electrophysiology 20100601

Title: 2:1 left to right interatrial block and other effects of ibutilide during non-isthmus-dependent atrial flutter.

Journal: Pacing and clinical electrophysiology : PACE 20091001

Title: [The study of inhibiting heart rate and rapidly terminating atrial flutter of ibutilide on canine].

Journal: Zhonghua xin xue guan bing za zhi 20091001

Title: Ibutilide-induced changes in the temporal lability of ventricular repolarization in patients with and without structural heart disease.

Journal: Journal of cardiovascular electrophysiology 20090801

Title: The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel.

Journal: Journal of cardiovascular pharmacology 20090701

Title: Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and ibutilide-induced block of HERG.

Journal: The pharmacogenomics journal 20090601

Title: Safety and efficacy of ibutilide in heart transplant recipients.

Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20090501

Title: Acute beta-adrenoceptor blockade improves efficacy of ibutilide in conversion of atrial fibrillation with a rapid ventricular rate.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090101

Title: Ibutilide revisited: stronger and safer than ever.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20090101

Title: Pharmacokinetics of ibutilide in patients with heart failure due to left ventricular systolic dysfunction.

Journal: Pharmacotherapy 20081201

Title: Extracellular acidification and hyperkalemia induce changes in HERG inhibition by ibutilide.

Journal: Cardiology 20080101

Title: Rapid ventricular response.

Journal: American journal of critical care : an official publication, American Association of Critical-Care Nurses 20080101

Title: Ibutilide therapy for atrial fibrillation: 5-year experience in a community hospital.

Journal: The Journal of cardiovascular nursing 20080101

Title: Intravenous magnesium sulfate enhances the ability of intravenous ibutilide to successfully convert atrial fibrillation or flutter.

Journal: Pacing and clinical electrophysiology : PACE 20071101

Title: Autonomic tone attenuates drug-induced QT prolongation.

Journal: Journal of cardiovascular electrophysiology 20070901

Title: Monotherapy versus combination therapy with class III antiarrhythmic agents to attenuate transmural dispersion of repolarization: a potential risk factor for torsade de pointes.

Journal: Pharmacotherapy 20070901

Title: Pharmacokinetic and pharmacodynamic properties of a single intravenous dose of ibutilide fumarate: a phase I, randomized, open-label, increasing-dose study in healthy Chinese men.

Journal: Clinical therapeutics 20070901

Title: The safety and efficacy of ibutilide in children and in patients with congenital heart disease.

Journal: Pacing and clinical electrophysiology : PACE 20070801

Title: Enhancement of bupivacaine local anesthesia with the potassium channel blocker ibutilide.

Journal: European journal of pain (London, England) 20070701

Title: Cardioversion of persistent atrial fibrillation by a combination of atrial specific and non-specific class III drugs in the goat.

Journal: Cardiovascular research 20070701

Title: Conversion efficacy of intravenous ibutilide compared with intravenous amiodarone in patients with recent-onset atrial fibrillation and atrial flutter.

Journal: International journal of cardiology 20070612

Title: Ibutilide and sinus arrest.

Journal: Herz 20070601

Title: Ibutilide-induced cardioversion of atrial fibrillation during pregnancy.

Journal: Journal of cardiovascular electrophysiology 20070501

Title: Successful termination of atrial flutter by ibutilide during pregnancy.

Journal: Pacing and clinical electrophysiology : PACE 20070201

Title: The role of amiodarone in recent-onset atrial fibrillation after ibutilide has failed to restore sinus rhythm.

Journal: Cardiology 20070101

Title: The mechanisms of atrial fibrillation.

Journal: Journal of cardiovascular electrophysiology 20061201

Title: Bazett and Fridericia QT correction formulas interfere with measurement of drug-induced changes in QT interval.

Journal: Heart rhythm 20060901

Title: Ibutilide to expedite ED therapy for recent-onset atrial fibrillation flutter.

Journal: The American journal of emergency medicine 20060701

Title: Propafenone added to ibutilide increases conversion rates of persistent atrial fibrillation.

Journal: Heart (British Cardiac Society) 20060501

Title: Efficacy and safety of ibutilide for the conversion of monomorphic atrial tachycardia.

Journal: Pacing and clinical electrophysiology : PACE 20060401

Title: Drug binding interactions in the inner cavity of HERG channels: molecular insights from structure-activity relationships of clofilium and ibutilide analogs.

Journal: Molecular pharmacology 20060201

Title: Ibutilide for treatment of atrial fibrillation in the emergency department.

Journal: Emergency medicine journal : EMJ 20060201

Title: Is pretreatment with ibutilide useful for atrial fibrillation cardioversion when combined with biphasic shock?

Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20060201

Title: High-density mapping of pulmonary veins and left atrium during ibutilide administration in a canine model of sustained atrial fibrillation.

Journal: American journal of physiology. Heart and circulatory physiology 20051201

Title: In vivo antiarrhythmic and cardiac electrophysiologic effects of a novel diphenylphosphine oxide IKur blocker (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide.

Journal: The Journal of pharmacology and experimental therapeutics 20051201

Title: Comparison of intravenous ibutilide vs. propafenone for rapid termination of recent onset atrial fibrillation.

Journal: International journal of clinical practice 20051201

Title: [Inhibition of the muscarinic potassium current by KB130015, a new antiarrhythmic agent to treat atrial fibrillation].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20051115

Title: [Atrial flutter and fibrillation].

Journal: Praxis 20051109

Title: Synthesis of biologically active amines via rhodium-bisphosphite-catalyzed hydroaminomethylation.

Journal: Organic letters 20051027

Title: Efficacy and safety of ibutilide for cardioversion of atrial flutter and fibrillation in patients receiving amiodarone or propafenone.

Journal: Pacing and clinical electrophysiology : PACE 20050901

Title: Rapid cardioversion of new onset atrial fibrillation with ibutilide in the emergency department.

Journal: Irish medical journal 20050901

Title: The combined use of ibutilide as an active control with intensive electrocardiographic sampling and signal averaging as a sensitive method to assess the effects of tadalafil on the human QT interval.

Journal: Journal of the American College of Cardiology 20050816

Title: Making a silk purse out of a sow's ear.

Journal: Journal of the American College of Cardiology 20050816

Title: Consequences of atrial electrical remodeling for the anti-arrhythmic action of class IC and class III drugs.

Journal: Cardiovascular research 20050701

Title: Conversion of recent-onset atrial fibrillation or flutter with amiodarone after ibutilide has failed: a rapid, efficient, and safe algorithm.

Journal: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20050701

Title: Ibutilide--recent molecular insights and accumulating evidence for use in atrial flutter and fibrillation.

Journal: Expert opinion on investigational drugs 20050501

Title: [Immediate cardioversion of atrial fibrillation and atrial flutter lasting less than 90 days by ibutilide versus propafenone: a multicenter study].

Journal: Zhonghua yi xue za zhi 20050330

Title: Ibutilide in persistent atrial fibrillation refractory to conventional cardioversion methods.

Journal: International journal of cardiology 20050318

Title: Sensitive method for the determination of ibutilide in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225

Title: Ibutilide for rapid conversion of atrial fibrillation or flutter in a mixed critically ill patient population.

Journal: Wiener klinische Wochenschrift 20050201

Title: Comparative efficacy of monophasic and biphasic waveforms for transthoracic cardioversion of atrial fibrillation and atrial flutter.

Journal: American heart journal 20050201

Title: Clinical comparison of ibutilide and propafenone for converting atrial flutter.

Journal: Cardiovascular drugs and therapy 20050101

Title: A benefit-risk assessment of class III antiarrhythmic agents.

Journal: Expert opinion on drug safety 20041101

Title: Ibutilide (Corvert): suspected association with torsades de pointes.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20041012

Title: Electrophysiological and proarrhythmic parameters in transmural canine left-ventricular needle biopsies.

Journal: Pflugers Archiv : European journal of physiology 20041001

Title: 'Early' class III drugs for the treatment of atrial fibrillation: efficacy and atrial selectivity of AVE0118 in remodeled atria of the goat.

Journal: Circulation 20040928

Title: Ibutilide added to propafenone for the conversion of atrial fibrillation and atrial flutter.

Journal: Journal of the American College of Cardiology 20040818

Title: Use of ibutilide in cardioversion of patients with atrial fibrillation or atrial flutter treated with class IC agents.

Journal: Journal of the American College of Cardiology 20040818

Title: Structural determinants of HERG channel block by clofilium and ibutilide.

Journal: Molecular pharmacology 20040801

Title: Pharmacological cardioversion of recent onset atrial fibrillation.

Journal: European heart journal 20040801

Title: Flecainide versus ibutilide for immediate cardioversion of atrial fibrillation of recent onset.

Journal: European heart journal 20040801

Title: [Perspectives and limitations in the treatment of vagus-induced atrial fibrillation. Insights from cellular pharmacology].

Journal: Medizinische Klinik (Munich, Germany : 1983) 20040715

Title: Efficacy and safety of ibutilide vs. transoesophageal atrial pacing for the termination of type I atrial flutter.

Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20040701

Title: Atrial-selective antiarrhythmic actions of novel Ikur vs. Ikr, Iks, and IKAch class Ic drugs and beta blockers in pigs.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20040701

Title: Intrapericardial ibutilide administration fails to terminate pacing-induced sustained atrial fibrillation in dogs.

Journal: Cardiovascular drugs and therapy 20040701

Title: Facilitating internal cardioversion of chronic atrial fibrillation with ibutilide--predictors of atrial defibrillation-threshold decrease.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20040601

Title: Female preponderance in ibutilide-induced torsade de pointes.

Journal: International journal of cardiology 20040601

Title: Ibutilide-induced alterations in electrocardiographic and spatial vectorcardiographic descriptors of ventricular repolarization.

Journal: Clinical cardiology 20040601

Title: Comparing methods of measurement for detecting drug-induced changes in the QT interval: implications for thoroughly conducted ECG studies.

Journal: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc 20040401

Title: Model of effect of magnesium prophylaxis on frequency of torsades de pointes in ibutilide-treated patients.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040401

Title: Ibutilide for cardioversion of atrial flutter: efficacy of a single dose in recent-onset arrhythmias.

Journal: Minerva cardioangiologica 20040201

Title: Oral class III antiarrhythmics: what is new?

Journal: Current opinion in cardiology 20040101

Title: Use of ibutilide for cardioversion of recent-onset atrial fibrillation and flutter in elderly.

Journal: American journal of therapeutics 20040101

Title: Genetic basis of drug-induced arrhythmias.

Journal: Annals of medicine 20040101

Title: Recent developments in cardiovascular drug therapy: treatment of atrial arrhythmias with new class III drugs and beyond.

Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20040101

Title: Cost effectiveness of ibutilide with prophylactic magnesium in the treatment of atrial fibrillation.

Journal: PharmacoEconomics 20040101

Title: Adjunctive intravenous magnesium to reduce toxicity and enhance efficacy of class III antiarrhythmic agents.

Journal: Connecticut medicine 20040101

Title: Impact of prophylactic i.v. magnesium on the efficacy of ibutilide for conversion of atrial fibrillation or flutter.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20031115

Title: [Progress in the clinical use of anti-arrhythmic drugs (I)].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20031001

Title: An update on electrical cardioversion of atrial fibrillation.

Journal: Cardiac electrophysiology review 20030901

Title: Effectiveness of ibutilide in cardioversion of persistent atrial fibrillation in patients with dual chamber stimulation.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20030801

Title: Ibutilide versus amiodarone in atrial fibrillation: a double-blinded, randomized study.

Journal: Critical care medicine 20030401

Title: Pharmacologic and nonpharmacologic options to maintain sinus rhythm: guideline-based and new approaches.

Journal: The American journal of cardiology 20030320

Title: Effects of intravenous magnesium sulfate on the QT interval in patients receiving ibutilide.

Journal: Pharmacotherapy 20030301

Title: Propafenone versus ibutilide for post operative atrial fibrillation following cardiac surgery: neither strategy improves outcomes compared to rate control alone (the PIPAF study).

Journal: Medical science monitor : international medical journal of experimental and clinical research 20030301

Title: Atrial fibrillation in the elderly.

Journal: The American journal of geriatric cardiology 20030101

Title: Potentially significant drug interactions of class III antiarrhythmic drugs.

Journal: Drug safety 20030101

Title: Ibutilide for pharmacological cardioversion of atrial fibrillation and flutter: impact of race on efficacy and safety.

Journal: American journal of therapeutics 20030101

Title: [Development of original Russian antiarrhythmic drugs of the 3rd class].

Journal: Vestnik Rossiiskoi akademii meditsinskikh nauk 20030101

Title: Electrophysiological and antiarrhythmic effects of the novel I(Kur) channel blockers, S9947 and S20951, on left vs. right pig atrium in vivo in comparison with the I(Kr) blockers dofetilide, azimilide, d,l-sotalol and ibutilide.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20021101

Title: Hybrid therapy of atrial fibrillation.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20021001

Title: Comparison of amiodarone versus ibutilide for the prevention of immediate recurrences of atrial fibrillation during pulmonary vein isolation.

Journal: The American journal of cardiology 20020901

Title: Cardioversion of atrial fibrillation with ibutilide: when is it most effective?

Journal: Clinical cardiology 20020901

Title: Electrophysiological response of the right atrium to ibutilide during typical atrial flutter.

Journal: Circulation 20020813

Title: Conversion of recent-onset atrial fibrillation or flutter with ibutilide after amiodarone has failed.

Journal: Intensive care medicine 20020701

Title: [Current strategies of pharmacological and non-pharmacological treatment in atrial fibrillation and atrial flutter].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020701

Title: [Ventricular fibrillation/tachycardia].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20020701

Title: Comparison of verapamil and ibutilide for the suppression of immediate recurrences of atrial fibrillation after transthoracic cardioversion.

Journal: Journal of cardiovascular pharmacology and therapeutics 20020701

Title: The JT-area indicates dispersion of repolarization in dogs with atrioventricular block.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20020601

Title: Effects of verapamil and ibutilide on atrial fibrillation and postfibrillation atrial refractoriness.

Journal: Journal of cardiovascular electrophysiology 20020201

Title: New antiarrhythmic drugs for the treatment of atrial fibrillation.

Journal: Pacing and clinical electrophysiology : PACE 20020201

Title: Clinical and electrophysiologic effects of calcium channel blockers in patients receiving ibutilide.

Journal: American heart journal 20020101

Title: Ibutilide in rapid conversion of atrial flutter in octogenarians.

Journal: Drugs & aging 20020101

Title: Ibutilide-induced long QT syndrome and torsade de pointes.

Journal: American journal of therapeutics 20020101

Title: Electrophysiological effects of ibutilide in patients with accessory pathways.

Journal: Circulation 20011016

Title: [Severe ibutilide-induced arrhythmia in patients with heart failure].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20011010

Title: Cardiovascular effects of the R- and S-enantiomers of ibutilide in conscious beagle dogs.

Journal: Methods and findings in experimental and clinical pharmacology 20011001

Title: Ibutilide induced intraatrial Wenckebach periodicity in the neonatal canine heart.

Journal: Pacing and clinical electrophysiology : PACE 20010901

Title: Ibutilide: efficacy and safety in atrial fibrillation and atrial flutter in a general cardiology practice.

Journal: Clinical cardiology 20010701

Title: Female gender does not influence the magnitude of ibutilide-induced repolarization delay and incidence of torsades de pointes in an in vivo rabbit model of the acquired long QT syndrome.

Journal: Journal of cardiovascular pharmacology and therapeutics 20010701

Title: Comparison of the rate dependent effects of dofetilide and ibutilide in the newborn heart.

Journal: Pacing and clinical electrophysiology : PACE 20010501

Title: Safety and effectiveness of ibutilide in a community hospital.

Journal: Pharmacotherapy 20010401

Title: Progress toward the development of a safe and effective agent for treating reentrant cardiac arrhythmias: synthesis and evaluation of ibutilide analogues with enhanced metabolic stability and diminished proarrhythmic potential.

Journal: Journal of medicinal chemistry 20010329

Title: Usefulness of handgrip to improve ibutilide efficacy in organizing atrial electrical activity during atrial fibrillation.

Journal: The American journal of cardiology 20010315

Title: Drug-induced QT prolongation in women during the menstrual cycle.

Journal: JAMA 20010314

Title: Frequency-dependent electrophysiological effect of ibutilide on human atrium and ventricle.

Journal: Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing 20010301

Title: Comparison of the effects on drug concentrations, electrophysiologic parameters, and termination of atrial fibrillation in dogs when procainamide and ibutilide are delivered into the right atrium versus intravenously.

Journal: Journal of cardiovascular electrophysiology 20010301

Title: Myocardial repolarization and drugs. Impossibility to predict the dominance of anti-arrhythmic over pro-arrhythmic effects of drugs due to differential and ventricular electrical remodeling.

Journal: Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology 20010301

Title: Potassium and calcium current blocking properties of the novel antiarrhythmic agent H 345/52: implications for proarrhythmic potential.

Journal: Cardiovascular research 20010201

Title: Chemical cardioversion of atrial fibrillation or flutter with ibutilide in patients receiving amiodarone therapy.

Journal: Circulation 20010116

Title: Altered response to ibutilide in a heart failure model.

Journal: Cardiovascular research 20010101

Title: Ibutilide: a class III rapidly acting antidysrhythmic for atrial fibrillation or atrial flutter.

Journal: The Journal of emergency medicine 20010101

Title: Multifocal atrial tachycardia and Ibutilide.

Journal: The American journal of geriatric cardiology 20010101

Title: Newer antiarrhythmic drugs.

Journal: Indian heart journal 20010101

Title: New antiarrhythmic agents for atrial fibrillation.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010101

Title: Pharmacologic conversion of atrial fibrillation: a systematic review of available evidence.

Journal: Progress in cardiovascular diseases 20010101

Title: Termination of recent-onset atrial fibrillation/flutter in the emergency department: a sequential approach with intravenous ibutilide and external electrical cardioversion.

Journal: Resuscitation 20000801

Title: Usefulness of ibutilide in facilitating successful external cardioversion of refractory atrial fibrillation.

Journal: The American journal of cardiology 19991101

Title: Acute renal failure after ibutilide.

Journal: Lancet (London, England) 19990206

Title: Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995 Mar 15;91(6):1799-806.

Title: B F McBride, et al. Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and Ibutilide-induced block of HERG. Pharmacogenomics J. 2009 Jun;9(3):194-201.

Title: S S Chugh, et al. Altered response to Ibutilide in a heart failure model. Cardiovasc Res. 2001 Jan;49(1):94-102.

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Tags:122647-32-9 Molecular Formula|122647-32-9 MDL|122647-32-9 SMILES|122647-32-9 Methanesulfonamide, N-[4-[4-(ethylheptylamino)-1-hydroxybutyl]phenyl]-, (2E)-2-butenedioate (2:1)