Catalog No.:AA009CAP

1228960-69-7 | Mln0905

Name: Name:Mln0905
Brand: AABLOCKS
SKU: AA009CAP
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Rating: 90 (10 reviews)

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1mg

≥98%

in stock

$72.00 $50.00

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5mg

≥98%

in stock

$246.00 $172.00

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10mg

≥98%

in stock

$383.00 $268.00

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50mg

97%

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$1,772.00 $1,240.00

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100mg

97%

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$3,145.00 $2,202.00

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250mg

97%

in stock

$7,002.00 $4,902.00

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Technical Information
Properties
Downstream Synthesis Route
Literature
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Technical Information
Properties
Downstream Synthesis Route
Literature

Technical Information

Catalog Number:

AA009CAP

Chemical Name:

Mln0905

CAS Number:

1228960-69-7

Molecular Formula:

C24H25F3N6S

Molecular Weight:

486.5557

MDL Number:

MFCD22683863

SMILES:

CN(CCCc1cnc(c(c1)Nc1ncc2c(n1)c1ccc(cc1NC(=S)C2)C(F)(F)F)C)C

Properties

Computed Properties

Complexity:

692

Covalently-Bonded Unit Count:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

XLogP3:

4.1

Downstream Synthesis Route

61500-87-6

1228960-69-7

[1]JournalofMedicinalChemistry,2012,vol.55,p.197-208

Literature

Title: Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905).

Journal: Journal of medicinal chemistry 20120112

Title: Duffey MO, et al. Discovery of a potent and orally bioavailable benzolactam-derived inhibitor of Polo-like kinase 1 (MLN0905). J Med Chem. 2012 Jan 12;55(1):197-208.

Title: Shi JQ, et al. MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma. Mol Cancer Ther. 2012 Sep;11(9):2045-53.

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SDS