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1246525-60-9,MFCD18782737
Catalog No.:AA009BMK

1246525-60-9 | SR-1078

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$9.00   $7.00
- +
5mg
98+%
in stock  
$14.00   $10.00
- +
10mg
98+%
in stock  
$18.00   $13.00
- +
100mg
98+%
in stock  
$89.00   $62.00
- +
250mg
98+%
in stock  
$170.00   $119.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009BMK
Chemical Name:
SR-1078
CAS Number:
1246525-60-9
Molecular Formula:
C17H10F9NO2
Molecular Weight:
431.2524
MDL Number:
MFCD18782737
SMILES:
O=C(c1ccc(cc1)C(F)(F)F)Nc1ccc(cc1)C(C(F)(F)F)(C(F)(F)F)O
Properties
Computed Properties
 
Complexity:
555  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
4.8  

Literature

Title: Retinoic acid receptor-related orphan receptor α stimulates adipose tissue inflammation by modulating endoplasmic reticulum stress.

Journal: The Journal of biological chemistry 20170825

Title: Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.

Journal: Pharmacological research 20150901

Title: Regulation of p53 stability and apoptosis by a ROR agonist.

Journal: PloS one 20120101

Title: Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.

Journal: ACS chemical biology 20101119

Title: Wang Y, et al. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. ACS Chem Biol. 2010 Nov 19;5(11):1029-34.

Title: Wang Y, Billon C, Walker JK, Burris TP. Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism. ACS Chem Neurosci. 2016;7(2):143-148.

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SDS
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