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Home Other Building Blocks 1254053-43-4
1254053-43-4,MFCD28144685
Catalog No.:AA000NJX

1254053-43-4 | Gilteritinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$15.00   $11.00
- +
2mg
97%
in stock  
$25.00   $18.00
- +
10mg
98%
in stock  
$97.00   $68.00
- +
50mg
97%
in stock  
$146.00   $103.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA000NJX
Chemical Name:
Gilteritinib
CAS Number:
1254053-43-4
Molecular Formula:
C29H44N8O3
Molecular Weight:
552.7115
MDL Number:
MFCD28144685
SMILES:
COc1cc(ccc1N1CCC(CC1)N1CCN(CC1)C)Nc1nc(NC2CCOCC2)c(nc1C(=O)N)CC
Properties
Computed Properties
 
Complexity:
785  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
3.5  

Downstream Synthesis Route
C12H15BrN4O 
  1254053-43-4 

[1]CurrentPatentAssignee:MEDCHEMEXPRESSCHINA-CN106083821,2016,A

6-ethyl-3-((3-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-5-((tetrahydro-2H-pyran-4-yl)amino)pyrazine-2-carbonitrile 
  1254053-43-4 

[1]CurrentPatentAssignee:MEDCHEMEXPRESSCHINA-CN106083821,2016,ALocationinpatent:Paragraph0049;0050;0051;0052

[2]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED-WO2022/9235,2022,A1Locationinpatent:Page/Pagecolumn9

3-bromo-5-chloro-6-ethylpyrazine-2-carbonitrile 
  1254053-43-4 

[1]CurrentPatentAssignee:MEDCHEMEXPRESSCHINA-CN106083821,2016,A

[1]Patent:CN106083821,2016,A

1254053-43-4    110-17-8   
2-pyrazinecarboxamide,6-ethyl-3-3-methoxy-4-4-(4-methyl-1-piperazinyl)-1-piperidinylphenylamino-5-(tetrahydro-2H-pyran-4-yl)amino-,(2E)-2-butenedioate 

[1]CurrentPatentAssignee:MSNLABORATORIESPRIVATELIMITED-WO2022/9235,2022,A1Locationinpatent:Page/Pagecolumn9-10

Literature

Title: [Thefts without motive of gain as a psychopathologic syndrome (author's transl)].

Journal: Fortschritte der Neurologie, Psychiatrie, und ihrer Grenzgebiete 19750501

Title: ASP2215, a novel FLT3/AXL inhibitor: Preclinical evaluation in acute myeloid leukemia (AML). 2014 ASCO Annual Meeting.

Title: Mori M, et al. Gilteritinib, a FLT3/AXL inhibitor, shows antileukemic activity in mouse models of FLT3 mutated acute myeloid leukemia. Invest New Drugs. 2017 Oct;35(5):556-565.

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SDS
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Tags:1254053-43-4 Molecular Formula|1254053-43-4 MDL|1254053-43-4 SMILES|1254053-43-4 Gilteritinib