Home Amines 126784-99-4
126784-99-4,MFCD00899035
Catalog No.:AA003A9F

126784-99-4 | (11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione

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5mg
98%(HPLC)
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10mg
98%(HPLC)
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25mg
98%(HPLC)
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100mg
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250mg
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA003A9F
Chemical Name:
(11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione
CAS Number:
126784-99-4
Molecular Formula:
C30H37NO4
Molecular Weight:
475.6191
MDL Number:
MFCD00899035
SMILES:
CC(=O)O[C@@]1(CC[C@@H]2[C@]1(C)C[C@H](c1ccc(cc1)N(C)C)C1=C3CCC(=O)C=C3CC[C@@H]21)C(=O)C
Properties
Computed Properties
 
Complexity:
984  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
5  
Rotatable Bond Count:
5  
XLogP3:
3.5  

Literature

Title: Ulipristal acetate - safety and pharmacokinetics following multiple doses of 10-50 mg per day.

Journal: Journal of clinical pharmacy and therapeutics 20130801

Title: Emergency contraception.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20130301

Title: Results from pooled Phase III studies of ulipristal acetate for emergency contraception.

Journal: Contraception 20121201

Title: Endometrial morphology after treatment of uterine fibroids with the selective progesterone receptor modulator, ulipristal acetate.

Journal: International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 20121101

Title: Emergency contraception: separating fact from fiction.

Journal: Cleveland Clinic journal of medicine 20121101

Title: Ulipristal acetate does not impact human normal breast tissue.

Journal: Human reproduction (Oxford, England) 20120901

Title: Ulipristal acetate as an emergency contraceptive agent.

Journal: Expert opinion on pharmacotherapy 20120901

Title: Ulipristal acetate and its role in emergency contraception: a comment.

Journal: Expert opinion on pharmacotherapy 20120901

Title: Interventions for emergency contraception.

Journal: The Cochrane database of systematic reviews 20120815

Title: Ulipristal acetate: a novel option for the medical management of symptomatic uterine fibroids.

Journal: Advances in therapy 20120801

Title: Pharmacokinetic evaluation of ulipristal acetate for uterine leiomyoma treatment.

Journal: Expert opinion on drug metabolism & toxicology 20120701

Title: Emergency contraception: an underutilized resource.

Journal: The Journal of family practice 20120701

Title: Ulipristal acetate: in uterine fibroids.

Journal: Drugs 20120528

Title: Effects of a novel estrogen-free, progesterone receptor modulator contraceptive vaginal ring on inhibition of ovulation, bleeding patterns and endometrium in normal women.

Journal: Contraception 20120501

Title: Ulipristal acetate versus placebo for fibroid treatment before surgery.

Journal: The New England journal of medicine 20120202

Title: Ulipristal acetate versus leuprolide acetate for uterine fibroids.

Journal: The New England journal of medicine 20120202

Title: Uterine fibroids and evidence-based medicine--not an oxymoron.

Journal: The New England journal of medicine 20120202

Title: Ulipristal acetate: review of the efficacy and safety of a newly approved agent for emergency contraception.

Journal: Clinical therapeutics 20120101

Title: Ulipristal acetate: the newest emergency contraceptive.

Journal: Nursing for women's health 20120101

Title: Current and future medical treatments for menometrorrhagia during the premenopause.

Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20111201

Title: [Forgetting hormonal contraceptive methods: expert opinion about their daily management in clinical routine practice].

Journal: Gynecologie, obstetrique & fertilite 20111101

Title: Adolescents and emergency contraception: update 2011.

Journal: Current opinion in obstetrics & gynecology 20111001

Title: Can we identify women at risk of pregnancy despite using emergency contraception? Data from randomized trials of ulipristal acetate and levonorgestrel.

Journal: Contraception 20111001

Title: Unintended pregnancy in Australia: what more can we do?

Journal: The Medical journal of Australia 20110815

Title: Ulipristal acetate: a new emergency contraceptive.

Journal: Expert review of clinical pharmacology 20110701

Title: New drugs 2011 part 2.

Journal: Nursing 20110601

Title: Ulipristal acetate: contraceptive or contragestive?

Journal: The Annals of pharmacotherapy 20110601

Title: Ulipristal acetate for emergency contraception.

Journal: The Annals of pharmacotherapy 20110601

Title: Ulipristal acetate: a review of its use in emergency contraception.

Journal: Drugs 20110507

Title: LNG may still be the most cost-effective oral emergency contraception method.

Journal: The journal of family planning and reproductive health care 20110401

Title: Ella: a new emergency contraceptive.

Journal: The Medical letter on drugs and therapeutics 20110110

Title: Ulipristal acetate: a new emergency contraceptive that is safe and more effective than levonorgestrel.

Journal: Women's health (London, England) 20110101

Title: New drugs: dabigatran etexilate mesylate, fingolimod hydrochloride, and ulipristal acetate.

Journal: Journal of the American Pharmacists Association : JAPhA 20110101

Title: The state-of-the-art of emergency contraception with the cutting edge drug.

Journal: German medical science : GMS e-journal 20110101

Title: [Ulipristal acetate: an emergency contraception extended to 5 days using a progesterone receptor modulator (Ellaone)].

Journal: Revue medicale de Liege 20101201

Title: Mechanism of action of emergency contraception.

Journal: Contraception 20101101

Title: Ulipristal acetate taken 48-120 hours after intercourse for emergency contraception.

Journal: Obstetrics and gynecology 20100201

Title: 11-(pyridinylphenyl)steroids--a new class of mixed-profile progesterone agonists/antagonists.

Journal: Bioorganic & medicinal chemistry 20080315

Title: In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone.

Journal: The Journal of steroid biochemistry and molecular biology 20040301

Title: Jadav SP, et al. Ulipristal acetate, a progesterone receptor modulator for emergency contraception. J Pharmacol Pharmacother. 2012 Apr;3(2):109-11.

Title: Del Bello B, et al. Autophagy up-regulation by ulipristal acetate as a novel target mechanism in the treatment of uterine leiomyoma: an in vitro study. Fertil Steril. 2019 Dec;112(6):1150-1159.

Title: Hild SA, et al. CDB-2914: anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits. Hum Reprod. 2000 Apr;15(4):822-9.

Title: Ciarmela P, et al. Ulipristal acetate modulates the expression and functions of activin a in leiomyoma cells. Reprod Sci. 2014 Sep;21(9):1120-5.

Title: Attardi BJ, et al. In vitro antiprogestational/antiglucocorticoid activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, CDB-4124, and mifepristone. J Steroid Biochem Mol Biol.

Title: Pohl O, et al. Carcinogenicity and chronic rodent toxicity of the selective progesterone receptor modulator ulipristal acetate. Curr Drug Saf. 2013 Apr;8(2):77-97.

Title: Pohl O, et al. A 39-week oral toxicity study of ulipristal acetate in cynomolgus monkeys. Regul Toxicol Pharmacol. 2013 Jun;66(1):6-12.

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Tags:126784-99-4 Molecular Formula|126784-99-4 MDL|126784-99-4 SMILES|126784-99-4 (11β)-17-(Acetyloxy)-11-[4-(dimethylamino)phenyl]-19-norpregna-4,9-diene-3,20-dione