129-20-4,MFCD00057278
Catalog No.:AA007NNF

129-20-4 | Oxyphenbutazone

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1mg
≥98%
in stock  
$46.00   $32.00
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5mg
≥98%
in stock  
$123.00   $86.00
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10mg
≥98%
in stock  
$199.00   $139.00
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25mg
≥98%
in stock  
$382.00   $267.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007NNF
Chemical Name:
Oxyphenbutazone
CAS Number:
129-20-4
Molecular Formula:
C19H20N2O3
Molecular Weight:
324.3737
MDL Number:
MFCD00057278
SMILES:
CCCCC1C(=O)N(N(C1=O)c1ccc(cc1)O)c1ccccc1
Properties
Computed Properties
 
Complexity:
454  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.7  

Downstream Synthesis Route

[1]Pfister;Haeflinger[HelveticaChimicaActa,1957,vol.40,p.395,399]

[1]Pfister;Haeflinger[HelveticaChimicaActa,1957,vol.40,p.395,399]

[1]Pfister;Haeflinger[HelveticaChimicaActa,1957,vol.40,p.395,399]

[1]JournalofPharmaceuticalSciences,1981,vol.70,p.460-461

[1]Rahtz;Bottcher[EuropeanJournalofMedicinalChemistry,1982,vol.17,#5,p.429-432]

[2]CurrentPatentAssignee:BAYERAG-US3968219,1976,A

Literature

Title: FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.

Journal: Chemico-biological interactions 20130905

Title: Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20121002

Title: Infrared and Raman spectroscopic analyses and theoretical computation of 4-butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120801

Title: Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.

Journal: European journal of medicinal chemistry 20120701

Title: Systemic treatment of sarcoidosis.

Journal: Ocular immunology and inflammation 20110401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Determination of non-steroidal anti-inflammatory drugs residues in animal muscles by liquid chromatography-tandem mass spectrometry.

Journal: Analytica chimica acta 20100705

Title: Chemopreventive activities of etodolac and oxyphenbutazone against mouse skin carcinogenesis.

Journal: Bioorganic & medicinal chemistry letters 20100415

Title: Screening, quantification, and confirmation of phenylbutazone and oxyphenbutazone in equine plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of analytical toxicology 20090101

Title: Structural and ligand-binding properties of serum albumin species interacting with a biomembrane interface.

Journal: Journal of pharmaceutical sciences 20071101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production.

Journal: European cytokine network 20050601

Title: Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6 A resolution.

Journal: Biochemistry 20041123

Title: Antirheumatic effect of pirfenidone in a double blind clinical pilot trial in humans.

Journal: Research communications in molecular pathology and pharmacology 20040101

Title: Analysis of adulterants in a traditional herbal medicinal product using liquid chromatography-mass spectrometry-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20030226

Title: Interactions of oxyphenbutazone with different cyclodextrins in aqueous medium and in the solid state.

Journal: Journal of pharmaceutical and biomedical analysis 20020601

Title: Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys.

Journal: American journal of veterinary research 20010501

Title: Drug-associated acute pancreatitis: twenty-one years of spontaneous reporting in The Netherlands.

Journal: The American journal of gastroenterology 19990901

Title: Effects of commonly used non steroidal anti-inflammatory drugs on gastric mucosa. A clinical, endoscopic and histopathological study.

Journal: The Journal of the Association of Physicians of India 19900901

Title: Risks of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics. The International Agranulocytosis and Aplastic Anemia Study.

Journal: JAMA 19861003

Title: Oxyphenbutazone-induced sialadenitis, intrahepatic cholestasis and pancreatitis.

Journal: Acta gastro-enterologica Belgica 19850101

Title: [Intrahepatic cholestasis following ketazone successfully treated using the enzyme inductor phenobarbital].

Journal: Vnitrni lekarstvi 19780401

Title: Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.

Journal: The American journal of digestive diseases 19770701

Title: Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone.

Journal: British medical journal 19770611

Title: [Current aspects of iatrogenic lesions of the bone marrow].

Journal: Minerva medica 19761114

Title: Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.

Journal: Pathology 19760701

Title: Further studies of the acute effects of phenylbutazone, oxyphenbutazone and indomethacin on the rat kidney.

Journal: Pathology 19760401

Title: [Acute myelogenous leukemia. Associated with oxyphenbutazone induced aplastic anemia].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 19740810

Title: Drug-induced blood dyscrasias in Sweden.

Journal: British medical journal 19730811

Title: Oxyphenbutazone and aplastic anemia.

Journal: The American journal of medicine 19721101

Title: [Inhibitory effect of oxyphenbutazone against Mycobacterium tuberculosis in vitro].

Journal: Arzneimittel-Forschung 19690201

Title: [Vasculitis allergica cutis caused by phenylbutazone].

Journal: Dermatologica 19660101

Quotation Request
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Additional Info:
SDS
Tags:129-20-4 Molecular Formula|129-20-4 MDL|129-20-4 SMILES|129-20-4 Oxyphenbutazone
Catalog No.: AA007NNF
129-20-4,MFCD00057278
129-20-4 | Oxyphenbutazone
Pack Size: 1mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 5mg
Purity: ≥98%
in stock
$123.00 $86.00
Pack Size: 10mg
Purity: ≥98%
in stock
$199.00 $139.00
Pack Size: 25mg
Purity: ≥98%
in stock
$382.00 $267.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA007NNF
Chemical Name: Oxyphenbutazone
CAS Number: 129-20-4
Molecular Formula: C19H20N2O3
Molecular Weight: 324.3737
MDL Number: MFCD00057278
SMILES: CCCCC1C(=O)N(N(C1=O)c1ccc(cc1)O)c1ccccc1
Properties
Complexity: 454  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 5  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.7  
Downstream Synthesis Route
27455-08-9    129-20-4 

[1]Pfister;Haeflinger[HelveticaChimicaActa,1957,vol.40,p.395,399]

31603-00-6    129-20-4 

[1]Pfister;Haeflinger[HelveticaChimicaActa,1957,vol.40,p.395,399]

31603-00-6    129-20-4    101708-50-3 

[1]Pfister;Haeflinger[HelveticaChimicaActa,1957,vol.40,p.395,399]

50-33-9    129-20-4    3583-64-0    16860-42-7    1227476-15-4 

[1]JournalofPharmaceuticalSciences,1981,vol.70,p.460-461

123-99-9    129-20-4    59555-07-6 

[1]Rahtz;Bottcher[EuropeanJournalofMedicinalChemistry,1982,vol.17,#5,p.429-432]

[2]CurrentPatentAssignee:BAYERAG-US3968219,1976,A

Literature fold

Title: FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.

Journal: Chemico-biological interactions20130905

Title: Nonsteroidal anti-inflammatory drug sensitizes Mycobacterium tuberculosis to endogenous and exogenous antimicrobials.

Journal: Proceedings of the National Academy of Sciences of the United States of America20121002

Title: Infrared and Raman spectroscopic analyses and theoretical computation of 4-butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20120801

Title: Self-organizing molecular field analysis of NSAIDs: assessment of pharmacokinetic and physicochemical properties using 3D-QSPkR approach.

Journal: European journal of medicinal chemistry20120701

Title: Systemic treatment of sarcoidosis.

Journal: Ocular immunology and inflammation20110401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Determination of non-steroidal anti-inflammatory drugs residues in animal muscles by liquid chromatography-tandem mass spectrometry.

Journal: Analytica chimica acta20100705

Title: Chemopreventive activities of etodolac and oxyphenbutazone against mouse skin carcinogenesis.

Journal: Bioorganic & medicinal chemistry letters20100415

Title: Screening, quantification, and confirmation of phenylbutazone and oxyphenbutazone in equine plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of analytical toxicology20090101

Title: Structural and ligand-binding properties of serum albumin species interacting with a biomembrane interface.

Journal: Journal of pharmaceutical sciences20071101

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: 4-Hydroxy-oxyphenbutazone is a potent inhibitor of cytokine production.

Journal: European cytokine network20050601

Title: Phospholipase A2 as a target protein for nonsteroidal anti-inflammatory drugs (NSAIDS): crystal structure of the complex formed between phospholipase A2 and oxyphenbutazone at 1.6 A resolution.

Journal: Biochemistry20041123

Title: Antirheumatic effect of pirfenidone in a double blind clinical pilot trial in humans.

Journal: Research communications in molecular pathology and pharmacology20040101

Title: Analysis of adulterants in a traditional herbal medicinal product using liquid chromatography-mass spectrometry-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis20030226

Title: Interactions of oxyphenbutazone with different cyclodextrins in aqueous medium and in the solid state.

Journal: Journal of pharmaceutical and biomedical analysis20020601

Title: Pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in miniature donkeys.

Journal: American journal of veterinary research20010501

Title: Drug-associated acute pancreatitis: twenty-one years of spontaneous reporting in The Netherlands.

Journal: The American journal of gastroenterology19990901

Title: Effects of commonly used non steroidal anti-inflammatory drugs on gastric mucosa. A clinical, endoscopic and histopathological study.

Journal: The Journal of the Association of Physicians of India19900901

Title: Risks of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics. The International Agranulocytosis and Aplastic Anemia Study.

Journal: JAMA19861003

Title: Oxyphenbutazone-induced sialadenitis, intrahepatic cholestasis and pancreatitis.

Journal: Acta gastro-enterologica Belgica19850101

Title: [Intrahepatic cholestasis following ketazone successfully treated using the enzyme inductor phenobarbital].

Journal: Vnitrni lekarstvi19780401

Title: Granulomas and cholestatic--hepatocellular injury associated with phenylbutazone. Report of two cases.

Journal: The American journal of digestive diseases19770701

Title: Study of fatal bone marrow depression with special reference to phenylbutazone and oxyphenbutazone.

Journal: British medical journal19770611

Title: [Current aspects of iatrogenic lesions of the bone marrow].

Journal: Minerva medica19761114

Title: Studies on the modification of renal lesions due to aspirin and oxyphenbutazone in the rat and the effects on the kidney of 2:4 dinitrophenol.

Journal: Pathology19760701

Title: Further studies of the acute effects of phenylbutazone, oxyphenbutazone and indomethacin on the rat kidney.

Journal: Pathology19760401

Title: [Acute myelogenous leukemia. Associated with oxyphenbutazone induced aplastic anemia].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke19740810

Title: Drug-induced blood dyscrasias in Sweden.

Journal: British medical journal19730811

Title: Oxyphenbutazone and aplastic anemia.

Journal: The American journal of medicine19721101

Title: [Inhibitory effect of oxyphenbutazone against Mycobacterium tuberculosis in vitro].

Journal: Arzneimittel-Forschung19690201

Title: [Vasculitis allergica cutis caused by phenylbutazone].

Journal: Dermatologica19660101

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