Home Indole and Oxindoles 129273-38-7
129273-38-7,MFCD00890882
Catalog No.:AA000YXX

129273-38-7 | 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, hydrochloride (1:1), (3aR,7aS)-rel-

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25mg
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250mg
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1g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000YXX
Chemical Name:
1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, hydrochloride (1:1), (3aR,7aS)-rel-
CAS Number:
129273-38-7
Molecular Formula:
C23H31ClN4O2S
Molecular Weight:
463.0358
MDL Number:
MFCD00890882
SMILES:
O=C1N(CCCCN2CCN(CC2)c2nsc3c2cccc3)C(=O)C2C1CCCC2.Cl
Properties
Computed Properties
 
Complexity:
615  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  

Literature

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Title: State and trait markers of emotionally charged visual event-related potentials (P300) in drug-naïve schizophrenia.

Journal: Psychiatry and clinical neurosciences 20120601

Title: Improvement in QTc prolongation induced by zotepine following a switch to perospirone.

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Journal: Journal of medicinal chemistry 20110714

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Journal: Expert opinion on drug metabolism & toxicology 20110701

Title: Mirtazapine in combination with perospirone synergistically enhances dopamine release in the rat prefrontal cortex via 5-HT1A receptor activation.

Journal: Psychiatry and clinical neurosciences 20110401

Title: A case of schizophrenia with Meige syndrome induced by long-term aripiprazole successfully treated with perospirone.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110115

Title: An unblinded comparison of the clinical and cognitive effects of switching from first-generation antipsychotics to aripiprazole, perospirone or olanzapine in patients with chronic schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20110115

Title: The wide variability of perospirone metabolism and the effect of perospirone on prolactin in psychiatric patients.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20100816

Title: Dopamine D2 receptor occupancy by perospirone: a positron emission tomography study in patients with schizophrenia and healthy subjects.

Journal: Psychopharmacology 20100501

Title: Prolactin fluctuation over the course of a day during treatments with three atypical antipsychotics in schizophrenic patients.

Journal: Human psychopharmacology 20100401

Title: Effect of perospirone on P300 electrophysiological activity and social cognition in schizophrenia: a three-dimensional analysis with sloreta.

Journal: Psychiatry research 20090630

Title: Randomized clinical comparison of perospirone and risperidone in patients with schizophrenia: Kansai Psychiatric Multicenter Study.

Journal: Psychiatry and clinical neurosciences 20090601

Title: Augmentation of antidepressants with perospirone for treatment-resistant major depressive disorder.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20090430

Title: Determination of azelnidipine by LC-ESI-MS and its application to a pharmacokinetic study in healthy Chinese volunteers.

Journal: Die Pharmazie 20080801

Title: Effect of the novel antipsychotic drug perospirone on P-glycoprotein function and expression in Caco-2 cells.

Journal: European journal of clinical pharmacology 20080701

Title: Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors.

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Title: The effect of atypical antipsychotics, perospirone, ziprasidone and quetiapine on microglial activation induced by interferon-gamma.

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Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

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Journal: Psychopharmacology 20070501

Title: Perospirone augmentation of paroxetine in treatment of refractory obsessive-compulsive disorder with depression.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070330

Title: Determination of perospirone by liquid chromatography/electrospray mass spectrometry: application to a pharmacokinetic study in healthy Chinese volunteers.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

Title: Alteration in serum neural cell adhesion molecule in patients of schizophrenia.

Journal: Human psychopharmacology 20070301

Title: Perospirone in the treatment of patients with delirium.

Journal: Psychiatry and clinical neurosciences 20070201

Title: Perospirone in treatment of Huntington's disease: a first case report.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070130

Title: New-onset diabetic ketoacidosis induced by the addition of perospirone hydrochloride in a patient treated with risperidone.

Journal: Internal medicine (Tokyo, Japan) 20070101

Title: [Pharmacokinetics of perospirone hydrochloride at an excessive dose and changes in the serum prolactin level].

Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20070101

Title: 5-HT1A receptor agonist properties of antipsychotics determined by [35S]GTPgammaS binding in rat hippocampal membranes.

Journal: Clinical and experimental pharmacology & physiology 20070101

Title: Neuroleptic malignant syndrome induced by perospirone.

Journal: The international journal of neuropsychopharmacology 20061001

Title: Perospirone is a new generation antipsychotic: evidence from a positron emission tomography study of serotonin 2 and D2 receptor occupancy in the living human brain.

Journal: Journal of clinical psychopharmacology 20061001

Title: Effect of carbamazepine on the single oral dose pharmacokinetics of perospirone and its active metabolite.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060930

Title: The effect of perospirone on auditory P300 in schizophrenia: a preliminary study.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060830

Title: Efficacy of perospirone in the management of aggressive behavior associated with dementia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Effective treatment of coprophagia in a patient with schizophrenia with the novel atypical antipsychotic drug perospirone.

Journal: Pharmacopsychiatry 20060501

Title: Perospirone in the treatment of schizophrenia: effect on verbal memory organization.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20060301

Title: Neuroleptic malignant syndrome related to a switch to perospirone and anticholinergic withdrawal.

Journal: The American journal of psychiatry 20060301

Title: Effects of itraconazole and tandospirone on the pharmacokinetics of perospirone.

Journal: Therapeutic drug monitoring 20060201

Title: Beneficial effects of perospirone on aggressive behavior associated with dementia.

Journal: Psychiatry and clinical neurosciences 20060201

Title: Perospirone for treatment of dissociative identity disorder.

Journal: Psychiatry and clinical neurosciences 20051001

Title: Perospirone, a novel antipsychotic drug, inhibits marble-burying behavior via 5-HT1A receptor in mice: implications for obsessive-compulsive disorder.

Journal: Journal of pharmacological sciences 20051001

Title: Perospirone improves food refusal in elderly patients with mental disorders.

Journal: Journal of clinical psychopharmacology 20050601

Title: Influence of aging on the improvement of subjective sleep quality by atypical antipsychotic drugs in patients with schizophrenia: comparison of middle-aged and older adults.

Journal: The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20050501

Title: Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone.

Journal: Biopharmaceutics & drug disposition 20050301

Title: Efficacy of carbamazepine against neuroleptic-induced akathisia in treatment with perospirone: case series.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20050201

Title: Correlation between plasma homovanillic acid levels and the response to atypical antipsychotics in male patients with schizophrenia.

Journal: Clinical neuropharmacology 20050101

Title: A novel antipsychotic, perospirone, has antiserotonergic and antidopaminergic effects in human brain: findings from neuroendocrine challenge tests.

Journal: Psychopharmacology 20041101

Title: Effects of changing from typical to atypical antipsychotic drugs on subjective sleep quality in patients with schizophrenia in a Japanese population.

Journal: The Journal of clinical psychiatry 20041101

Title: Effects of serotonin-dopamine antagonists on prepulse inhibition and neurotransmitter contents in the rat cortex.

Journal: Neuroscience letters 20040812

Title: Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response.

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Title: Perospirone, a novel atypical antipsychotic drug, potentiates fluoxetine-induced increases in dopamine levels via multireceptor actions in the rat medial prefrontal cortex.

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Title: Two cases of perospirone-induced mania in schizophrenia.

Journal: The Journal of clinical psychiatry 20040101

Title: Use of perospirone for obesity and diabetes mellitus in patients with schizophrenia: three case reports.

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Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

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Tags:129273-38-7 Molecular Formula|129273-38-7 MDL|129273-38-7 SMILES|129273-38-7 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, hydrochloride (1:1), (3aR,7aS)-rel-