Home Thiazoles 367514-88-3
367514-88-3,MFCD18917095
Catalog No.:AA00C6DF

367514-88-3 | (1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione hydrochloride

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250mg
98%
in stock  
$128.00   $90.00
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1g
98%
in stock  
$328.00   $230.00
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5g
98%
in stock  
$942.00   $660.00
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10g
98%
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$1,391.00   $974.00
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25g
98%
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$2,804.00   $1,963.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00C6DF
Chemical Name:
(1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione hydrochloride
CAS Number:
367514-88-3
Molecular Formula:
C28H37ClN4O2S
Molecular Weight:
529.1370
MDL Number:
MFCD18917095
SMILES:
O=C1N(C[C@@H]2CCCC[C@H]2CN2CCN(CC2)c2nsc3c2cccc3)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1.Cl
Properties
Computed Properties
 
Complexity:
804  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  

Literature

Title: Newer antipsychotics and upcoming molecules for schizophrenia.

Journal: European journal of clinical pharmacology 20130801

Title: Evaluation of dopamine D₂/D₃ and serotonin 5-HT₂A receptor occupancy for a novel antipsychotic, lurasidone, in conscious common marmosets using small-animal positron emission tomography.

Journal: Psychopharmacology 20130101

Title: Asenapine, iloperidone and lurasidone: critical appraisal of the most recently approved pharmacotherapies for schizophrenia in adults.

Journal: Expert review of clinical pharmacology 20130101

Title: Lurasidone in schizophrenia: new information about dosage and place in therapy.

Journal: Advances in therapy 20121001

Title: Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120901

Title: Iloperidone, asenapine and lurasidone: a primer on their current status.

Journal: Expert opinion on pharmacotherapy 20120901

Title: Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.

Journal: CNS drugs 20120901

Title: A review of published evidence reporting on the efficacy and pharmacology of lurasidone.

Journal: Expert opinion on pharmacotherapy 20120801

Title: Lurasidone for the acute treatment of adults with schizophrenia: what is the number needed to treat, number needed to harm, and likelihood to be helped or harmed?

Journal: Clinical schizophrenia & related psychoses 20120701

Title: 5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux.

Journal: Neuroreport 20120509

Title: The role of 5-HT1A receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats.

Journal: Psychopharmacology 20120501

Title: Long-term safety and tolerability of lurasidone in schizophrenia: a 12-month, double-blind, active-controlled study.

Journal: International clinical psychopharmacology 20120501

Title: Lurasidone (latuda®): an atypical antipsychotic.

Journal: Issues in mental health nursing 20120501

Title: Modulation of BDNF expression by repeated treatment with the novel antipsychotic lurasidone under basal condition and in response to acute stress.

Journal: The international journal of neuropsychopharmacology 20120301

Title: New drugs 2012 part I.

Journal: Nursing 20120301

Title: Lurasidone for schizophrenia: what's different?

Journal: Expert review of neurotherapeutics 20120301

Title: The novel antipsychotic drug lurasidone enhances N-methyl-D-aspartate receptor-mediated synaptic responses.

Journal: Molecular pharmacology 20120201

Title: Update on the development of lurasidone as a treatment for patients with acute schizophrenia.

Journal: Drug design, development and therapy 20120101

Title: Lurasidone: an atypical antipsychotic for schizophrenia.

Journal: The Annals of pharmacotherapy 20120101

Title: Quantification of lurasidone, an atypical antipsychotic drug, in rat plasma with high-performance liquid chromatography with tandem mass spectrometry.

Journal: Biomedical chromatography : BMC 20111201

Title: Pharmacokinetics of lurasidone, a novel atypical anti-psychotic drug, in rats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20111201

Title: Double-blind comparison of the safety and efficacy of lurasidone and ziprasidone in clinically stable outpatients with schizophrenia or schizoaffective disorder.

Journal: Schizophrenia research 20111101

Title: Lurasidone: a new treatment option for schizophrenia.

Journal: Drugs of today (Barcelona, Spain : 1998) 20111101

Title: Biological perspectives: update on newer antipsychotic drugs: are they evidence based?

Journal: Perspectives in psychiatric care 20111001

Title: Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats.

Journal: Psychopharmacology 20110901

Title: Lurasidone in the treatment of schizophrenia: a randomized, double-blind, placebo- and olanzapine-controlled study.

Journal: The American journal of psychiatry 20110901

Title: Comment on the potential utility of the new atypical antipsychotic lurasidone in the geriatric population.

Journal: The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20110801

Title: Pharmacokinetics and metabolism update for some recent antipsychotics.

Journal: Expert opinion on drug metabolism & toxicology 20110701

Title: The effects of selective antagonists of serotonin 5-HT7 and 5-HT1A receptors on MK-801-induced impairment of learning and memory in the passive avoidance and Morris water maze tests in rats: mechanistic implications for the beneficial effects of the novel atypical antipsychotic lurasidone.

Journal: Behavioural brain research 20110620

Title: Performance and interview-based assessments of cognitive change in a randomized, double-blind comparison of lurasidone vs. ziprasidone.

Journal: Schizophrenia research 20110401

Title: Update on newer antipsychotic drugs.

Journal: Journal of psychosocial nursing and mental health services 20110401

Title: Iloperidone, asenapine, and lurasidone: a brief overview of 3 new second-generation antipsychotics.

Journal: Postgraduate medicine 20110301

Title: Lurasidone (Latuda) for schizophrenia.

Journal: The Medical letter on drugs and therapeutics 20110221

Title: Characteristics of the MATRICS Consensus Cognitive Battery in a 29-site antipsychotic schizophrenia clinical trial.

Journal: Schizophrenia research 20110201

Title: Lurasidone for schizophrenia: a review of the efficacy and safety profile for this newly approved second-generation antipsychotic.

Journal: International journal of clinical practice 20110201

Title: Lurasidone for schizophrenia: a brief review of a new second-generation antipsychotic.

Journal: Clinical schizophrenia & related psychoses 20110101

Title: New drugs. Azilsartan medoxomil, belimumab, and lurasidone hydrochloride.

Journal: Journal of the American Pharmacists Association : JAPhA 20110101

Title: Lurasidone: a clinical overview.

Journal: The Journal of clinical psychiatry 20110101

Title: Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity.

Journal: The Journal of pharmacology and experimental therapeutics 20100701

Title: Lurasidone: a new drug in development for schizophrenia.

Journal: Expert opinion on investigational drugs 20091101

Title: Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial.

Journal: The Journal of clinical psychiatry 20090601

Title: Lurasidone reverses MK-801-induced impairment of learning and memory in the Morris water maze and radial-arm maze tests in rats.

Journal: Behavioural brain research 20080125

Title: Lurasidone (SM-13496), a novel atypical antipsychotic drug, reverses MK-801-induced impairment of learning and memory in the rat passive-avoidance test.

Journal: European journal of pharmacology 20071031

Title: Ishibashi T, et al. Pharmacological profile of lurasidone, a novel antipsychotic agent with potent 5-hydroxytryptamine 7 (5-HT7) and 5-HT1A receptor activity. J Pharmacol Exp Ther. 2010 Jul;334(1):171-81.

Title: Sakine Atila Karaca, et al. Development of a validated high-performance liquid chromatographic method for the determination of Lurasidone in pharmaceuticals. Marmara Pharm J. 2017;21 (4): 931-937.

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Tags:367514-88-3 Molecular Formula|367514-88-3 MDL|367514-88-3 SMILES|367514-88-3 (1R,2S,6R,7S)-4-{[(1R,2R)-2-{[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]methyl}cyclohexyl]methyl}-4-azatricyclo[5.2.1.0^{2,6}]decane-3,5-dione hydrochloride