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1310693-92-5,MFCD20488052
Catalog No.:AA000VEB

1310693-92-5 | Tubastatin a hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$9.00   $7.00
- +
5mg
98%
in stock  
$23.00   $16.00
- +
10mg
98%
in stock  
$32.00   $22.00
- +
50mg
98%
in stock  
$73.00   $51.00
- +
250mg
98%
in stock  
$165.00   $116.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA000VEB
Chemical Name:
Tubastatin a hydrochloride
CAS Number:
1310693-92-5
Molecular Formula:
C20H22ClN3O2
Molecular Weight:
371.8606
MDL Number:
MFCD20488052
SMILES:
ONC(=O)c1ccc(cc1)Cn1c2ccccc2c2c1CCN(C2)C.Cl
Properties
Computed Properties
 
Complexity:
478  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
3  

Literature

Title: Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846

Title: de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78.

Title: Di Fulvio S, et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563

Title: Ketene AN, et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9.

Title: Brijmohan AS, et al. HDAC6 Inhibition Promotes Transcription Factor EB Activation and Is Protective in Experimental Kidney Disease. Front Pharmacol. 2018 Feb 1;9:34.

Title: Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.

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SDS
Tags:1310693-92-5 Molecular Formula|1310693-92-5 MDL|1310693-92-5 SMILES|1310693-92-5 Tubastatin a hydrochloride