Home Other Building Blocks 1252003-15-8
1252003-15-8,MFCD18071463
Catalog No.:AA009BML

1252003-15-8 | Tubastatin a

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1mg
98%
in stock  
$17.00   $12.00
- +
5mg
98%
in stock  
$44.00   $31.00
- +
10mg
98%
in stock  
$54.00   $38.00
- +
50mg
98%
in stock  
$144.00   $101.00
- +
250mg
98%
in stock  
$613.00   $429.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009BML
Chemical Name:
Tubastatin a
CAS Number:
1252003-15-8
Molecular Formula:
C20H21N3O2
Molecular Weight:
335.3996
MDL Number:
MFCD18071463
SMILES:
ONC(=O)c1ccc(cc1)Cn1c2ccccc2c2c1CCN(C2)C
Properties
Computed Properties
 
Complexity:
478  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
2.3  

Upstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,2010,vol.132,#31,p.10842-10846

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,2010,vol.132,p.10842-10846

[1]JournaloftheAmericanChemicalSociety,2010,vol.132,p.10842-10846

32315-10-9    1252003-15-8   
methyl4-((3,5-dichloro-2-hydroxybenzyl)amino)-2-hydroxybenzoate 
 
C36H32Cl2N4O7 

[1]Patent:CN107722002,2018,A.Locationinpatent:Paragraph0023-0025

1252003-15-8    120221-14-9   
C26H31N3O7 

[1]ChemBioChem,2020,vol.21,p.952-957

Literature

Title: Histone deacetylase 6 inhibition reduces cysts by decreasing cAMP and Ca(2+) in knock-out mouse models of polycystic kidney disease.

Journal: The Journal of biological chemistry 20171027

Title: Development and therapeutic implications of selective histone deacetylase 6 inhibitors.

Journal: Journal of medicinal chemistry 20130822

Title: Tubastatin, a selective histone deacetylase 6 inhibitor shows anti-inflammatory and anti-rheumatic effects.

Journal: International immunopharmacology 20130501

Title: Selective histone deacetylase 6 inhibitors bearing substituted urea linkers inhibit melanoma cell growth.

Journal: Journal of medicinal chemistry 20121126

Title: Histone deacetylase 6 associates with ribosomes and regulates de novo protein translation during arsenite stress.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120501

Title: Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.

Journal: Journal of the American Chemical Society 20100811

Title: Kyle V. Butler et al. Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A J. Am. Chem. Soc., 2010, 132 (31), pp 10842-10846

Title: Kozyreva VK, et al. NEDD9 regulates actin dynamics through cortactin deacetylation in an AURKA/HDAC6-dependent manner. Mol Cancer Res. 2014 May;12(5):681-93.

Title: de Zoeten EF, et al. Histone deacetylase 6 and heat shock protein 90 control the functions of Foxp3(+) T-regulatory cells. Mol Cell Biol. 2011 May;31(10):2066-78.

Title: Brijmohan, Angela, et al. Role of HDAC6 in Transcription Factor EB Mediated Clearance of Misfolded Proteins in Chronic Kidney Disease. University of Toronto.Nov-2017.

Title: Di Fulvio S, et al. Dysferlin interacts with histone deacetylase 6 and increases alpha-tubulin acetylation. PLoS One. 2011;6(12):e28563

Title: Ketene AN, et al. Actin filaments play a primary role for structural integrity and viscoelastic response in cells. Integr Biol (Camb). 2012 May;4(5):540-9.

Title: Lechner S, Malgapo MIP, Grätz C, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target [published online ahead of print, 2022 Apr 28 Nat Chem Biol. 2022;10.1038/s41589-022-01015-5.

Title: Géraldy M, Morgen M, Sehr P, et al. Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated. J Med Chem. 2019;62(9):4426-4443.

Title: [9 Severin Lechner, et al. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nat Chem Biol. 2022 Apr 28.

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