Name: Name:N-{[4-(4-phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide
Brand: AABLOCKS
SKU: AA009CCC
Rating: 90 (10 reviews)

Catalog No.: AA009CCC

1314890-29-3 | N-{[4-(4-phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide

Pack Size： 1mg

Purity： ≥95%

in stock

$53.00 $37.00

Pack Size： 5mg

Purity： 98%

in stock

$100.00 $70.00

Pack Size： 50mg

Purity： 95%

in stock

$255.00 $179.00

Pack Size： 100mg

Purity： 95%

in stock

$390.00 $273.00

Pack Size： 250mg

Purity： 95%

in stock

$601.00 $421.00

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Technical Information

Catalog Number: AA009CCC

Chemical Name: N-{[4-(4-phenyl-1,3-thiazol-2-yl)oxan-4-yl]methyl}-3-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide

CAS Number: 1314890-29-3

Molecular Formula: C25H21F3N4O3S

Molecular Weight: 514.5194

MDL Number: MFCD26522023

SMILES: O=C(c1cccc(c1)c1noc(n1)C(F)(F)F)NCC1(CCOCC1)c1scc(n1)c1ccccc1

Properties

Complexity: 749

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 36

Hydrogen Bond Acceptor Count: 10

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.8

Downstream Synthesis Route

1314886-95-7

1314890-29-3

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-EP2533783,2015,B1

1092400-82-2

1314886-98-0

N-((4-(4-phenylthiazol-2-yl)tetrahydro-2H-pyran-4-yl)methyl)-3-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)benzamide

[1]Patent:EP2533783,2015,B1.Locationinpatent:Paragraph0138-0139

1877-72-1

1314890-29-3

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-EP2533783,2015,B1

Literature fold

Title: Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group.

Journal: Nature chemical biology20130501

Title: Lobera M, et al. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol. 2013 May;9(5):319-25.

Title: Sinnett-Smith J, et al. Protein kinase D1 mediates class IIa histone deacetylase phosphorylation and nuclear extrusion in intestinal epithelial cells: role in mitogenic signaling. Am J Physiol Cell Physiol. 2014 May 15;306(10):C961-71.

Title: Kikuchi S, et al. Class IIa HDAC inhibition enhances ER stress-mediated cell death in multiple myeloma. Leukemia. 2015 Sep;29(9):1918-1927.

Title: EricSalgado, et al. Volume 503 HDAC9 overexpression confers invasive and angiogenic potential to triple negative breast cancer cells via modulating microRNA-206. Biochemical and Biophysical Research Communications.

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