Home Amines 132-69-4
132-69-4,MFCD00078957
Catalog No.:AA003O0G

132-69-4 | {3-[(1-benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine hydrochloride

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25mg
98%
in stock  
$6.00   $4.00
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100mg
98%
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$12.00   $8.00
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5g
98%
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$23.00   $16.00
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25g
97%
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$95.00   $67.00
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100g
98%
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$181.00   $127.00
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500g
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA003O0G
Chemical Name:
{3-[(1-benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine hydrochloride
CAS Number:
132-69-4
Molecular Formula:
C19H24ClN3O
Molecular Weight:
345.8664
MDL Number:
MFCD00078957
SMILES:
CN(CCCOc1nn(c2c1cccc2)Cc1ccccc1)C.Cl
NSC Number:
759276
Properties
Properties
 
BP:
474.4°C at 760 mmHg  
Form:
Solid  
MP:
147-153 °C  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
344  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  

Upstream Synthesis Route

[1]Patent:US4749794,1988,A,

Downstream Synthesis Route

[1]Pharmazie,1980,vol.35,p.232-233

[1]Xenobiotica,2002,vol.32,p.73-86

chlorobase 
  7440-44-0    13185-09-6    109-54-6    132-69-4 

[1]Patent:US4749794,1988,A

2-(2-dimethylamino-ethoxy)-N,N-dimethylamino-methylenebenzamide 
  132-69-4   
2-{2-2-(N,N-Dimethylamino)ethyloxy-phenyl}-4-phenyl-1,3,5-triazine 

[1]Patent:US6235738,2001,B1

Literature

Title: Entrapment of human flavin-containing monooxygenase 3 in the presence of gold nanoparticles: TEM, FTIR and electrocatalysis.

Journal: Biochimica et biophysica acta 20121201

Title: In vitro drug metabolism by C-terminally truncated human flavin-containing monooxygenase 3.

Journal: Biochemical pharmacology 20120215

Title: Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study.

Journal: International journal of oral and maxillofacial surgery 20110901

Title: Fluorescence quenching of biologically active carboxamide by aniline and carbon tetrachloride in different solvents using Stern-Volmer plots.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901

Title: Effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray on clinical signs and quality of life of patients with streptococcal tonsillopharyngitis: multicentre, prospective, randomised, double-blinded, placebo-controlled study.

Journal: The Journal of laryngology and otology 20110601

Title: New solid mucoadhesive systems for benzydamine vaginal administration.

Journal: Colloids and surfaces. B, Biointerfaces 20110601

Title: An anti-inflammatory as a recreational drug in Brazil.

Journal: Addiction (Abingdon, England) 20110101

Title: The effect of polyvinylpyrrolidone-sodium hyaluronate gel (Gelclair) on oral microbial colonization and pain control compared with other rinsing solutions in patients with oral mucositis after allogeneic stem cells transplantation.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Simultaneous determination of benzydamine hydrochloride and five impurities in an oral collutory as a pharmaceutical formulation by high-performance liquid chromatography.

Journal: Journal of chromatographic science 20101101

Title: Effects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: a prospective, randomized, double-blind, placebo-controlled, multicenter study.

Journal: Ear, nose, & throat journal 20101101

Title: Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine.

Journal: Anesthesia and analgesia 20101001

Title: The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat.

Journal: Anesthesia and analgesia 20101001

Title: Genotoxicity of two mouthwash products in the Drosophila Wing-Spot Test.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101001

Title: The development and in vitro evaluation of sustained release tablet formulations of benzydamine hydrochloride and its determination.

Journal: Combinatorial chemistry & high throughput screening 20100901

Title: Photoallergic contact dermatitis from benzydamine presenting mainly as lip dermatitis.

Journal: Contact dermatitis 20100801

Title: Benzydamine as a useful substrate of hepatic flavin-containing monooxygenase activity in veterinary species.

Journal: Journal of veterinary pharmacology and therapeutics 20100801

Title: Management of aphthous ulceration with topical quercetin: a randomized clinical trial.

Journal: The journal of contemporary dental practice 20100701

Title: [Use abusive of benzydamine in Brazil: an overview in pharmacovigilance].

Journal: Ciencia & saude coletiva 20100501

Title: Hippocampal and caudate volume reductions in antipsychotic-naive first-episode schizophrenia.

Journal: Journal of psychiatry & neuroscience : JPN 20100301

Title: Respiratory symptoms and inflammatory responses to Difflam throat-spray intervention in half-marathon runners: a randomised controlled trial.

Journal: British journal of sports medicine 20100201

Title: Thermally sensitive gels based on chitosan derivatives for the treatment of oral mucositis.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100201

Title: Lymphomatoid photocontact dermatitis to benzydamine hydrochloride.

Journal: Contact dermatitis 20100201

Title: Direct electrochemistry of drug metabolizing human flavin-containing monooxygenase: electrochemical turnover of benzydamine and tamoxifen.

Journal: Journal of the American Chemical Society 20100120

Title: [Ten-year experience with use of Tantum Rosa drug for prevention and therapy of radiation-related rectitis and vaginitis in uterine and vaginal cancer].

Journal: Voprosy onkologii 20100101

Title: Recreational use of benzydamine as a hallucinogen among street youth in Brazil.

Journal: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20090901

Title: Formulation studies of benzydamine mucoadhesive formulations for vaginal administration.

Journal: Drug development and industrial pharmacy 20090701

Title: Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo-controlled randomized clinical trial.

Journal: European journal of cancer care 20090301

Title: Ingestions of benzydamine-containing vaginal preparations.

Journal: Clinical toxicology (Philadelphia, Pa.) 20090201

Title: Relief of radiation-induced oral mucositis in head and neck cancer.

Journal: Cancer nursing 20090101

Title: Inter-individual variation in flavin-containing monooxygenase 3 in livers from Japanese: correlation with hepatic transcription factors.

Journal: Drug metabolism and pharmacokinetics 20090101

Title: [Misuse of substances theoretically without abuse potential--case series].

Journal: Przeglad lekarski 20090101

Title: Benzydamine hydrochloride buccal bioadhesive gels designed for oral ulcers: preparation, rheological, textural, mucoadhesive and release properties.

Journal: Pharmaceutical development and technology 20090101

Title: Evaluation of sutures after immersion in nonalcoholic benzydamine hydrochloride mouthrinse by scanning electron microscopy.

Journal: Clinical oral investigations 20080901

Title: Antifungal effect of mouth rinses on oral Candida counts and salivary flow in treatment-naïve HIV-infected patients.

Journal: AIDS patient care and STDs 20080801

Title: Spectrophotometric determination of benzydamine HCl, levamisole HCl and mebeverine HCl through ion-pair complex formation with methyl orange.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080301

Title: Effect of different mouth rinses on third molar surgery-related oral malodor.

Journal: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20080301

Title: [Medicine consumption and the internet: critical evaluation of a virtual community].

Journal: Revista da Associacao Medica Brasileira (1992) 20080101

Title: Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venom.

Journal: Toxicon : official journal of the International Society on Toxinology 20071215

Title: Reduction of mouth malodour and volatile sulphur compounds in intensive care patients using an essential oil mouthwash.

Journal: Phytotherapy research : PTR 20070701

Title: Combined photocontact dermatitis to benzydamine hydrochloride and the emulsifiers, Span 60 and Tween 60 contained in Tantum cream.

Journal: Contact dermatitis 20070701

Title: Novel hydrogels via click chemistry: synthesis and potential biomedical applications.

Journal: Biomacromolecules 20070601

Title: Digital analysis of mouthrinses' staining characteristics on provisional acrylic resins.

Journal: Journal of oral rehabilitation 20070401

Title: Effect of genetic variants of the human flavin-containing monooxygenase 3 on N- and S-oxygenation activities.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070301

Title: Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat.

Journal: Acta anaesthesiologica Scandinavica 20070201

Title: Recreational abuse with benzydamine hydrochloride (tantum rosa).

Journal: Clinical toxicology (Philadelphia, Pa.) 20070101

Title: [Clinical experience with tantum rosa (benzydamine hydrochloride) in prophylaxis and treatment of vaginitis and proctitis, following radiotherapy of patients with cancer of the vagina and uterus].

Journal: Akusherstvo i ginekologiia 20070101

Title: An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study.

Journal: Anesthesia and analgesia 20061001

Title: Anti-inflammatory agents in the management of alimentary mucositis.

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20060601

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Oral mucositis.

Journal: Oral diseases 20060501

Title: Benzydamine N-oxygenation as a measure of flavin-containing monooxygenase activity.

Journal: Methods in molecular biology (Clifton, N.J.) 20060101

Title: A pilot study of chlorhexidine and benzydamine oral rinses for the prevention and treatment of irradiation mucositis in patients with head and neck cancer.

Journal: Cancer nursing 20060101

Title: The effects of three oral sprays on plaque and gingival inflammation.

Journal: Journal of periodontology 20051001

Title: Effect of lipophilic counter-ions on membrane diffusion of benzydamine.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901

Title: Efficacy of a 0.15% benzydamine hydrochloride and 0.05% cetylpyridinium chloride mouth rinse on 4-day de novo plaque formation.

Journal: Journal of clinical periodontology 20050601

Title: Chemotherapy-induced oral mucositis: new approaches to prevention and management.

Journal: Expert opinion on drug safety 20050301

Title: [The effectiveness of a benzydamine rinse in the management of stomato-glossopyrosis].

Journal: Fogorvosi szemle 20050201

Title: Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis.

Journal: European journal of oncology nursing : the official journal of European Oncology Nursing Society 20041201

Title: Microfabricated fractal branching networks.

Journal: Journal of biomedical materials research. Part A 20041101

Title: Benzydamine metabolism in vivo is impaired in patients with deficiency of flavin-containing monooxygenase 3.

Journal: Pharmacogenetics 20041101

Title: Does benzydamine hydrochloride applied preemptively reduce sore throat due to laryngeal mask airway?

Journal: Anesthesia and analgesia 20040901

Title: Topical benzydamine cream and the relief of pressure pain.

Journal: Palliative medicine 20040901

Title: Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care.

Journal: European journal of cancer (Oxford, England : 1990) 20040501

Title: Photoallergic hand eczema due to benzydamine.

Journal: European journal of dermatology : EJD 20040101

Title: Unique monooxygenation pattern indicates novel flavin-containing monooxygenase in liver of rainbow trout.

Journal: Marine environmental research 20040101

Title: Necrotizing sialometaplasia: a case report.

Journal: Acta dermato-venereologica 20040101

Title: [Role of Tantum Verde in prevention and treatment of oral cavity mucosal damages after cytostatic and radiotherapy in cancer patients].

Journal: Voprosy onkologii 20040101

Title: Amperometric biosensor based on monoamine oxidase (MAO) immobilized in sol-gel film for benzydamine determination in pharmaceuticals.

Journal: Journal of pharmaceutical and biomedical analysis 20031204

Title: Palliation of oral mucositis symptoms in pediatric patients treated with cancer chemotherapy.

Journal: Cancer nursing 20031201

Title: Current developments in treating chemotherapy-related oral mucositis.

Journal: Clinical advances in hematology & oncology : H&O 20031201

Title: Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists.

Journal: British journal of pharmacology 20030901

Title: Interventions for the treatment of burning mouth syndrome: a systematic review.

Journal: Journal of orofacial pain 20030101

Title: Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021001

Title: Photocontact dermatitis after gargling with a solution containing benzydamine.

Journal: Contact dermatitis 20020701

Title: Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria.

Journal: Allergy 20020501

Title: Biotransformation of benzydamine by microsomes and precision-cut slices prepared from cattle liver.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020101

Title: Clinical trial comparing the activity and efficacy of ibuprofen isobutanolammonium vs Benzydamine hydrochloride, applied as vaginal irrigations, in patients with vaginitis.

Journal: Clinical and experimental obstetrics & gynecology 20020101

Title: In vitro cytotoxicity of chlorhexidine gluconate, benzydamine-HCl and povidone iodine mouthrinses on human gingival fibroblasts.

Journal: SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging 20011001

Title: Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study.

Journal: Clinical therapeutics 20010901

Title: Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial.

Journal: Cancer 20010815

Title: [The use of benzydamine Hcl -- Tantum Verde -- in otolaryngology].

Journal: Otolaryngologia polska = The Polish otolaryngology 20010101

Title: Renal disease and use of topical non-steroidal anti-inflammatory drugs.

Journal: BMJ (Clinical research ed.) 19940108

Title: Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects.

Journal: Biopharmaceutics & drug disposition 19911001

Title: Anand JS, et al. Recreational abuse with benzydamine hydrochloride (tantum rosa). Clin Toxicol (Phila). 2007;45(2):198-9.

Title: Opaleye ES, et al. Recreational use of benzydamine as a hallucinogen among street youth in Brazil. Rev Bras Psiquiatr. 2009 Sep;31(3):208-13.

Title: Mota DM, et al. Use abusive of benzydamine in Brazil: an overview in pharmacovigilance. Cien Saude Colet. 2010 May;15(3):717-24.

Title: Fanaki NH, et al. Antimicrobial activity of benzydamine, a non-steroid anti-inflammatory agent. J Chemother. 1992 Dec;4(6):347-52.

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SDS
Tags:132-69-4 Molecular Formula|132-69-4 MDL|132-69-4 SMILES|132-69-4 {3-[(1-benzyl-1H-indazol-3-yl)oxy]propyl}dimethylamine hydrochloride |Heterocyclic_Building_Blocks