Home Amines 642-72-8
642-72-8,MFCD00864286
Catalog No.:AA00E8O9

642-72-8 | Benzydamine

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1mg
≥95%
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5mg
≥95%
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10mg
≥95%
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00E8O9
Chemical Name:
Benzydamine
CAS Number:
642-72-8
Molecular Formula:
C19H23N3O
Molecular Weight:
309.4054
MDL Number:
MFCD00864286
SMILES:
CN(CCCOc1nn(c2c1cccc2)Cc1ccccc1)C
Properties
Computed Properties
 
Complexity:
344  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
7  
XLogP3:
3.9  

Downstream Synthesis Route

[1]Pharmazie,1980,vol.35,p.232-233

Literature

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Title: Efficacy of topical benzydamine hydrochloride gel on oral mucosal ulcers: an in vivo animal study.

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Journal: The Journal of laryngology and otology 20110601

Title: New solid mucoadhesive systems for benzydamine vaginal administration.

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Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101

Title: Efficacy of benzydamine hydrochloride, chlorhexidine, and povidone iodine in the treatment of oral mucositis among patients undergoing radiotherapy in head and neck malignancies: A drug trail.

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Title: Simultaneous determination of benzydamine hydrochloride and five impurities in an oral collutory as a pharmaceutical formulation by high-performance liquid chromatography.

Journal: Journal of chromatographic science 20101101

Title: Effects of chlorhexidine/benzydamine mouth spray on pain and quality of life in acute viral pharyngitis: a prospective, randomized, double-blind, placebo-controlled, multicenter study.

Journal: Ear, nose, & throat journal 20101101

Title: Effect on postoperative sore throat of spraying the endotracheal tube cuff with benzydamine hydrochloride, 10% lidocaine, and 2% lidocaine.

Journal: Anesthesia and analgesia 20101001

Title: The effectiveness of benzydamine hydrochloride spraying on the endotracheal tube cuff or oral mucosa for postoperative sore throat.

Journal: Anesthesia and analgesia 20101001

Title: Genotoxicity of two mouthwash products in the Drosophila Wing-Spot Test.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101001

Title: Electro-catalysis by immobilised human flavin-containing monooxygenase isoform 3 (hFMO3).

Journal: Analytical and bioanalytical chemistry 20101001

Title: The development and in vitro evaluation of sustained release tablet formulations of benzydamine hydrochloride and its determination.

Journal: Combinatorial chemistry & high throughput screening 20100901

Title: Interventions for treating oral mucositis for patients with cancer receiving treatment.

Journal: The Cochrane database of systematic reviews 20100804

Title: Photoallergic contact dermatitis from benzydamine presenting mainly as lip dermatitis.

Journal: Contact dermatitis 20100801

Title: Benzydamine as a useful substrate of hepatic flavin-containing monooxygenase activity in veterinary species.

Journal: Journal of veterinary pharmacology and therapeutics 20100801

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Journal: Journal of psychiatry & neuroscience : JPN 20100301

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Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20100201

Title: Lymphomatoid photocontact dermatitis to benzydamine hydrochloride.

Journal: Contact dermatitis 20100201

Title: Direct electrochemistry of drug metabolizing human flavin-containing monooxygenase: electrochemical turnover of benzydamine and tamoxifen.

Journal: Journal of the American Chemical Society 20100120

Title: Oral rinses, mouthwashes and sprays for improving recovery following tonsillectomy.

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Title: Mutual prodrug of cephazolin and benzydamin: 3-[(1-benzyl-1H-indazol-3-yl)-oxy]-N,N-dimethyl-propan-1-aminium 3-{[(5-methyl-1,3,4-thia-diazol-2-yl)sulfan-yl]meth-yl}-8-oxo-7-[(1H-tetra-zol-1-yl)acetamido]-5-thia-1-aza-bicyclo-[4.2.0]octane-2-carboxyl-ate (benzydaminium cephazolinate).

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Title: Photopatch testing with an extended series of photoallergens: a 5-year study.

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Title: Benzydamine for prophylaxis of radiation-induced oral mucositis in head and neck cancers: a double-blind placebo-controlled randomized clinical trial.

Journal: European journal of cancer care 20090301

Title: Ingestions of benzydamine-containing vaginal preparations.

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Title: Relief of radiation-induced oral mucositis in head and neck cancer.

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Title: Evaluation of sutures after immersion in nonalcoholic benzydamine hydrochloride mouthrinse by scanning electron microscopy.

Journal: Clinical oral investigations 20080901

Title: Antifungal effect of mouth rinses on oral Candida counts and salivary flow in treatment-naïve HIV-infected patients.

Journal: AIDS patient care and STDs 20080801

Title: Spectrophotometric determination of benzydamine HCl, levamisole HCl and mebeverine HCl through ion-pair complex formation with methyl orange.

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Title: Effect of leukocyte inhibitors benzydamine and cyclophosphamide, on lung injury caused by Tityus discrepans scorpion venom.

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Journal: Yonsei medical journal 20070831

Title: Reduction of mouth malodour and volatile sulphur compounds in intensive care patients using an essential oil mouthwash.

Journal: Phytotherapy research : PTR 20070701

Title: Combined photocontact dermatitis to benzydamine hydrochloride and the emulsifiers, Span 60 and Tween 60 contained in Tantum cream.

Journal: Contact dermatitis 20070701

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Title: Dexpanthenol pastille and benzydamine hydrochloride spray for the prevention of post-operative sore throat.

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Journal: Clinical toxicology (Philadelphia, Pa.) 20070101

Title: Cancer treatment-induced oral mucositis.

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Title: [Clinical experience with tantum rosa (benzydamine hydrochloride) in prophylaxis and treatment of vaginitis and proctitis, following radiotherapy of patients with cancer of the vagina and uterus].

Journal: Akusherstvo i ginekologiia 20070101

Title: An evaluation of the efficacy of aspirin and benzydamine hydrochloride gargle for attenuating postoperative sore throat: a prospective, randomized, single-blind study.

Journal: Anesthesia and analgesia 20061001

Title: Cancer treatment-induced mucositis pain: strategies for assessment and management.

Journal: Therapeutics and clinical risk management 20060901

Title: Anti-inflammatory agents in the management of alimentary mucositis.

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Title: Oral mucositis.

Journal: Oral diseases 20060501

Title: Interventions for preventing oral mucositis for patients with cancer receiving treatment.

Journal: The Cochrane database of systematic reviews 20060419

Title: Local irritant effects of topical oral sprays on oral mucosa in mice.

Journal: Advances in therapy 20060101

Title: Benzydamine N-oxygenation as a measure of flavin-containing monooxygenase activity.

Journal: Methods in molecular biology (Clifton, N.J.) 20060101

Title: A pilot study of chlorhexidine and benzydamine oral rinses for the prevention and treatment of irradiation mucositis in patients with head and neck cancer.

Journal: Cancer nursing 20060101

Title: Several therapies may prevent or reduce the severity of oral mucositis associated with cancer treatment.

Journal: Evidence-based dentistry 20060101

Title: A new method of oral drug provocation testing for determining safe alternatives for patients with non-steroidal anti-inflammatory drug intolerance: the triple test.

Journal: International archives of allergy and immunology 20051201

Title: The molecular immunology of mucositis: implications for evidence-based research in alternative and complementary palliative treatments.

Journal: Evidence-based complementary and alternative medicine : eCAM 20051201

Title: The effects of three oral sprays on plaque and gingival inflammation.

Journal: Journal of periodontology 20051001

Title: Effect of lipophilic counter-ions on membrane diffusion of benzydamine.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050901

Title: Are adjuvant therapies for tonsillectomy evidence based?

Journal: The Journal of laryngology and otology 20050801

Title: Analgesic therapy in postherpetic neuralgia: a quantitative systematic review.

Journal: PLoS medicine 20050701

Title: Solvation in electrospray mass spectrometry: effects on the reaction kinetics of fragmentation mediated by ion-neutral complexes.

Journal: The Journal of organic chemistry 20050624

Title: Efficacy of a 0.15% benzydamine hydrochloride and 0.05% cetylpyridinium chloride mouth rinse on 4-day de novo plaque formation.

Journal: Journal of clinical periodontology 20050601

Title: Pressure ulcers: diagnostics and interventions aimed at wound-related complaints: a review of the literature.

Journal: Journal of clinical nursing 20050401

Title: Chemotherapy-induced oral mucositis: new approaches to prevention and management.

Journal: Expert opinion on drug safety 20050301

Title: [The effectiveness of a benzydamine rinse in the management of stomato-glossopyrosis].

Journal: Fogorvosi szemle 20050201

Title: Children's acceptance and tolerance of chlorhexidine and benzydamine oral rinses in the treatment of chemotherapy-induced oropharyngeal mucositis.

Journal: European journal of oncology nursing : the official journal of European Oncology Nursing Society 20041201

Title: Microfabricated fractal branching networks.

Journal: Journal of biomedical materials research. Part A 20041101

Title: Benzydamine metabolism in vivo is impaired in patients with deficiency of flavin-containing monooxygenase 3.

Journal: Pharmacogenetics 20041101

Title: Does benzydamine hydrochloride applied preemptively reduce sore throat due to laryngeal mask airway?

Journal: Anesthesia and analgesia 20040901

Title: Topical benzydamine cream and the relief of pressure pain.

Journal: Palliative medicine 20040901

Title: Prevention of oral mucositis in paediatric patients treated with chemotherapy; a randomised crossover trial comparing two protocols of oral care.

Journal: European journal of cancer (Oxford, England : 1990) 20040501

Title: Photoallergic hand eczema due to benzydamine.

Journal: European journal of dermatology : EJD 20040101

Title: Interventions for treating oral mucositis for patients with cancer receiving treatment.

Journal: The Cochrane database of systematic reviews 20040101

Title: Topical NSAIDs for acute pain: a meta-analysis.

Journal: BMC family practice 20040101

Title: Unique monooxygenation pattern indicates novel flavin-containing monooxygenase in liver of rainbow trout.

Journal: Marine environmental research 20040101

Title: Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis.

Journal: BMC musculoskeletal disorders 20040101

Title: Necrotizing sialometaplasia: a case report.

Journal: Acta dermato-venereologica 20040101

Title: [Role of Tantum Verde in prevention and treatment of oral cavity mucosal damages after cytostatic and radiotherapy in cancer patients].

Journal: Voprosy onkologii 20040101

Title: Amperometric biosensor based on monoamine oxidase (MAO) immobilized in sol-gel film for benzydamine determination in pharmaceuticals.

Journal: Journal of pharmaceutical and biomedical analysis 20031204

Title: Oral mucositis: a challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: part 1, pathogenesis and prophylaxis of mucositis.

Journal: Head & neck 20031201

Title: Oropharyngeal mucositis in cancer therapy. Review of pathogenesis, diagnosis, and management.

Journal: Oncology (Williston Park, N.Y.) 20031201

Title: Palliation of oral mucositis symptoms in pediatric patients treated with cancer chemotherapy.

Journal: Cancer nursing 20031201

Title: Current developments in treating chemotherapy-related oral mucositis.

Journal: Clinical advances in hematology & oncology : H&O 20031201

Title: Benzydamine inhibits monocyte migration and MAPK activation induced by chemotactic agonists.

Journal: British journal of pharmacology 20030901

Title: A parallel synthesis demonstration library of tri-substituted indazoles containing new antimutagenic/antioxidant hits related to benzydamine.

Journal: Combinatorial chemistry & high throughput screening 20030801

Title: Persistent painful ulcer of the posterior lingual mandibular mucosa.

Journal: The journal of contemporary dental practice 20030215

Title: Interventions for the physical aspects of sexual dysfunction in women following pelvic radiotherapy.

Journal: The Cochrane database of systematic reviews 20030101

Title: Interventions for preventing oral mucositis for patients with cancer receiving treatment.

Journal: The Cochrane database of systematic reviews 20030101

Title: Interventions for the treatment of burning mouth syndrome: a systematic review.

Journal: Journal of orofacial pain 20030101

Title: Flavin-containing monooxygenase activity in hepatocytes and microsomes: in vitro characterization and in vivo scaling of benzydamine clearance.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20021001

Title: Antimicrobial action of Nitens mouthwash (cetyltrimethylammonium naproxenate) on multiple isolates of pharyngeal microbes: a controlled study against chlorhexidine, benzydamine, hexetidine, amoxicillin, amoxicillin-clavulanate, clarithromycin, and cefaclor.

Journal: Chemotherapy 20020901

Title: Photocontact dermatitis after gargling with a solution containing benzydamine.

Journal: Contact dermatitis 20020701

Title: Benzydamine: an alternative nonsteroidal anti-inflammatory drug in patients with nimesulide-induced urticaria.

Journal: Allergy 20020501

Title: Prevention of radiation-induced oral mucositis with benzydamine.

Journal: Current oncology reports 20020101

Title: Biotransformation of benzydamine by microsomes and precision-cut slices prepared from cattle liver.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20020101

Title: Interventions for treating oral mucositis for patients with cancer receiving treatment.

Journal: The Cochrane database of systematic reviews 20020101

Title: Clinical trial comparing the activity and efficacy of ibuprofen isobutanolammonium vs Benzydamine hydrochloride, applied as vaginal irrigations, in patients with vaginitis.

Journal: Clinical and experimental obstetrics & gynecology 20020101

Title: Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients.

Journal: Immunopharmacology and immunotoxicology 20011101

Title: [Management of mucositis following radiotherapy for head and neck cancers].

Journal: Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique 20011101

Title: In vitro cytotoxicity of chlorhexidine gluconate, benzydamine-HCl and povidone iodine mouthrinses on human gingival fibroblasts.

Journal: SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging 20011001

Title: Efficacy and safety of ketoprofen lysine salt mouthwash versus benzydamine hydrochloride mouthwash in acute pharyngeal inflammation: a randomized, single-blind study.

Journal: Clinical therapeutics 20010901

Title: Benzydamine HCl for prophylaxis of radiation-induced oral mucositis: results from a multicenter, randomized, double-blind, placebo-controlled clinical trial.

Journal: Cancer 20010815

Title: Solution-Phase parallel synthesis of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles as activators of soluble guanylate cyclase with improved oral bioavailability.

Journal: Bioorganic & medicinal chemistry letters 20010423

Title: Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.

Journal: Journal of medicinal chemistry 20010104

Title: [The use of benzydamine Hcl -- Tantum Verde -- in otolaryngology].

Journal: Otolaryngologia polska = The Polish otolaryngology 20010101

Title: Renal disease and use of topical non-steroidal anti-inflammatory drugs.

Journal: BMJ (Clinical research ed.) 19940108

Title: Pharmacokinetics of benzydamine after intravenous, oral, and topical doses to human subjects.

Journal: Biopharmaceutics & drug disposition 19911001

Title: Toxicology of benzydamine.

Journal: Toxicology and applied pharmacology 19670101

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SDS
Tags:642-72-8 Molecular Formula|642-72-8 MDL|642-72-8 SMILES|642-72-8 Benzydamine