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132203-70-4,MFCD00865853
Catalog No.:AA0010AZ

132203-70-4 | Cilnidipine

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10mg
98%
in stock  
$7.00   $5.00
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50mg
98%
in stock  
$9.00   $7.00
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100mg
98%
in stock  
$12.00   $8.00
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250mg
98%
in stock  
$16.00   $11.00
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1g
98%
in stock  
$33.00   $23.00
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5g
98%(HPLC)
in stock  
$86.00   $60.00
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25g
98%(HPLC)
in stock  
$193.00   $135.00
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100g
98%(HPLC)
in stock  
$469.00   $328.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0010AZ
Chemical Name:
Cilnidipine
CAS Number:
132203-70-4
Molecular Formula:
C27H28N2O7
Molecular Weight:
492.5204
MDL Number:
MFCD00865853
SMILES:
COCCOC(=O)C1=C(C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)OC/C=C/c1ccccc1)C
Properties
Computed Properties
 
Complexity:
896  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.4  

Literature

Title: Differential modulation of FXR activity by chlorophacinone and ivermectin analogs.

Journal: Toxicology and applied pharmacology 20161215

Title: Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.

Journal: Scientific reports 20140101

Title: Investigation of inclusion complex of cilnidipine with hydroxypropyl-β-cyclodextrin.

Journal: Carbohydrate polymers 20121106

Title: Renoprotective and antioxidant effects of cilnidipine in hypertensive patients.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20121101

Title: The efficacy and safety of cilnidipine on mild to moderate essential hypertension: a systematic review and meta-analysis of randomized controlled trials in Chinese patients.

Journal: Cardiovascular & hematological disorders drug targets 20120901

Title: Comparison of the effects of cilnidipine and amlodipine on cardiac remodeling and diastolic dysfunction in Dahl salt-sensitive rats.

Journal: Journal of hypertension 20120901

Title: N-type calcium channel inhibition with cilnidipine elicits glomerular podocyte protection independent of sympathetic nerve inhibition.

Journal: Journal of pharmacological sciences 20120818

Title: L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action.

Journal: Heart and vessels 20120701

Title: Antialbuminuric advantage of cilnidipine compared with L-type calcium channel blockers in type 2 diabetic patients with normoalbuminuria and microalbuminuria.

Journal: Diabetes research and clinical practice 20120701

Title: Cilnidipine, an L/N-type calcium channel blocker prevents acquisition and expression of ethanol-induced locomotor sensitization in mice.

Journal: Neuroscience letters 20120411

Title: Anti-stress effects of cilnidipine and nimodipine in immobilization subjected mice.

Journal: Physiology & behavior 20120320

Title: Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120101

Title: Switching to an L/N-type calcium channel blocker shows renoprotective effects in patients with chronic kidney disease: the Kyoto Cilnidipine Study.

Journal: The Journal of international medical research 20120101

Title: Asymmetric synthesis and biological evaluations of (+)- and (-)-6-dimethoxymethyl-1,4-dihydropyridine-3-carboxylic acid derivatives blocking N-type calcium channels.

Journal: Bioorganic & medicinal chemistry letters 20110601

Title: Dual actions of cilnidipine in human internal thoracic artery: inhibition of calcium channels and enhancement of endothelial nitric oxide synthase.

Journal: The Journal of thoracic and cardiovascular surgery 20110401

Title: L/N-type calcium channel blocker cilnidipine ameliorates proteinuria and inhibits the renal renin-angiotensin-aldosterone system in deoxycorticosterone acetate-salt hypertensive rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110401

Title: Beneficial effects of L- and N-type calcium channel blocker on glucose and lipid metabolism and renal function in patients with hypertension and type II diabetes mellitus.

Journal: Cardiovascular therapeutics 20110201

Title: Effects of an N-type calcium antagonist on angiotensin II-renin feedback.

Journal: American journal of nephrology 20110101

Title: Effects of the L/N-type calcium channel antagonist cilnidipine on morning blood pressure control and peripheral edema formation.

Journal: Journal of the American Society of Hypertension : JASH 20110101

Title: Design and rationale of the study of assessment for kidney function by urinary microalbumin in randomized (SAKURA) trial.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20110101

Title: Anti-leishmanial and anti-trypanosomal activities of 1,4-dihydropyridines: In vitro evaluation and structure-activity relationship study.

Journal: Bioorganic & medicinal chemistry 20101115

Title: The N-type and L-type calcium channel blocker cilnidipine suppresses renal injury in Dahl rats fed a high-salt diet.

Journal: Heart and vessels 20101101

Title: A new-generation N/L-type calcium channel blocker leads to less activation of the renin-angiotensin system compared with conventional L type calcium channel blocker.

Journal: Journal of hypertension 20101001

Title: Comparison between the antiproteinuric effects of the calcium channel blockers benidipine and cilnidipine in combination with angiotensin receptor blockers in hypertensive patients with chronic kidney disease.

Journal: Expert opinion on investigational drugs 20100901

Title: Cilnidipine suppresses podocyte injury and proteinuria in metabolic syndrome rats: possible involvement of N-type calcium channel in podocyte.

Journal: Journal of hypertension 20100501

Title: Effect of cilnidipine vs losartan on cerebral blood flow in hypertensive patients with a history of ischemic stroke: a randomized controlled trial.

Journal: Acta neurologica Scandinavica 20100101

Title: [Calcium antagonists: current and future applications based on new evidence. Calcium channel blockers and autonomic nervous system].

Journal: Clinical calcium 20100101

Title: [Calcium antagonists: current and future applications based on new evidence. Neuroprotective effect of calcium antagonists].

Journal: Clinical calcium 20100101

Title: The L/N-type calcium channel blocker, Cilnidipine, reduces heart rate and albuminuria in patients with type 2 diabetes.

Journal: The Journal of international medical research 20100101

Title: Effect of cilnidipine on normal to marginally elevated urine albumin-creatinine ratio in asymptomatic non-diabetic hypertensive patients: an exponential decay curve analysis.

Journal: Clinical drug investigation 20100101

Title: Antiproteinuric effect of cilnidipine in hypertensive Japanese treated with renin-angiotensin-system inhibitors - a multicenter, open, randomized trial using 24-hour urine collection.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20100101

Title: Oral administration of cilnidipine to patients with hypertensive intracerebral hemorrhage in the acute stage: significance and role of an N-type calcium channel blocker.

Journal: Irish journal of medical science 20091201

Title: Long-term blockade of L/N-type Ca(2+) channels by cilnidipine ameliorates repolarization abnormality of the canine hypertrophied heart.

Journal: British journal of pharmacology 20091101

Title: Cilnidipine mediates a neuroprotective effect by scavenging free radicals and activating the phosphatidylinositol 3-kinase pathway.

Journal: Journal of neurochemistry 20091001

Title: Cardioprotective effect of an L/N-type calcium channel blocker in patients with hypertensive heart disease.

Journal: Journal of cardiology 20091001

Title: Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.

Journal: Biological & pharmaceutical bulletin 20091001

Title: Effects of a dual L/N-type calcium channel blocker cilnidipine on blood pressure, pulse rate, and autonomic functions in patients with mild to moderate hypertension.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20091001

Title: Efficacy of an L- and N-type calcium channel blocker in hypertensive patients with neurovascular compression of the rostral ventrolateral medulla.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20090801

Title: Comparison of antioxidant activity of cilnidipine and amlodipine.

Journal: Kidney international 20090701

Title: Histological protection by cilnidipine, a dual L/N-type Ca(2+) channel blocker, against neurotoxicity induced by ischemia-reperfusion in rat retina.

Journal: Experimental eye research 20090501

Title: Cilnidipine inhibits the sympathetic nerve activity and improves baroreflex sensitivity in patients with hypertension.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20090501

Title: The calcium channel blocker cilnidipine selectively suppresses hypoxia-inducible factor 1 activity in vascular cells.

Journal: European journal of pharmacology 20090315

Title: Different effects of L/N-type and L-type calcium channel blockers on the renin-angiotensin-aldosterone system in SHR/Izm.

Journal: American journal of nephrology 20090101

Title: Renoprotective effect of the L/N-type calcium channel antagonist cilnidipine on puromycin aminonucleoside-induced nephrosis in rats.

Journal: Arzneimittel-Forschung 20090101

Title: Cilnidipine: a new generation Ca channel blocker with inhibitory action on sympathetic neurotransmitter release.

Journal: Cardiovascular therapeutics 20090101

Title: Comparison of the anti-hypertensive effects of the L/N-type calcium channel antagonist cilnidipine, and the L-type calcium channel antagonist amlodipine in hypertensive patients with cerebrovascular disease.

Journal: Internal medicine (Tokyo, Japan) 20090101

Title: Stress-induced blood pressure elevation in subjects with mild cognitive impairment: effects of the dual-type calcium channel blocker, cilnidipine.

Journal: Geriatrics & gerontology international 20081201

Title: Vasodilatory effect of cilnidipine, an L-type and N-type calcium channel blocker, on rat kidney glomerular arterioles.

Journal: International heart journal 20081101

Title: The structure-activity relationship study on 2-, 5-, and 6-position of the water soluble 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Journal: Bioorganic & medicinal chemistry letters 20080901

Title: Antiproteinuric effects of cilnidipine.

Journal: Kidney international 20080501

Title: Development of a liquid chromatography/negative-ion electrospray tandem mass spectrometry assay for the determination of cilnidipine in human plasma and its application to a bioequivalence study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201

Title: Antiproteinuric effect of the calcium channel blocker cilnidipine added to renin-angiotensin inhibition in hypertensive patients with chronic renal disease.

Journal: Kidney international 20071201

Title: Influence of cilnidipine or nisoldipine on sympathetic activity in healthy male subjects.

Journal: Heart and vessels 20071101

Title: Renal and vascular protective effects of cilnidipine in patients with essential hypertension.

Journal: Journal of hypertension 20071001

Title: Determination of cilnidipine, a new calcium antagonist, in human plasma using high performance liquid chromatography with tandem mass spectrometric detection.

Journal: Analytica chimica acta 20070926

Title: Bedtime administration of cilnidipine controls morning hypertension.

Journal: International heart journal 20070901

Title: The effect of combination therapy with an L/N-Type Ca(2+) channel blocker, cilnidipine, and an angiotensin II receptor blocker on the blood pressure and heart rate in Japanese hypertensive patients: an observational study conducted in Japan.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20070901

Title: Assessment of the effects of L- and N-type Ca2+ channel blocking drugs using canine blood-perfused papillary muscle preparations.

Journal: The Tohoku journal of experimental medicine 20070801

Title: Cardiac effects of L/N-type Ca2+ channel blocker cilnidipine in anesthetized dogs.

Journal: European journal of pharmacology 20070622

Title: Cilnidipine improves left-ventricular midwall function independently of blood pressure changes in Chinese patients with hypertension.

Journal: Journal of cardiovascular pharmacology 20070101

Title: Renoprotective effect of N-type Ca channel blockade in diabetic nephropathy.

Journal: Journal of diabetes and its complications 20070101

Title: Effect of benidipine hydrochloride, a long-acting T-type calcium channel blocker, on blood pressure and renal function in hypertensive patients with diabetes mellitus. Analysis after switching from cilnidipine to benidipine.

Journal: Arzneimittel-Forschung 20070101

Title: Effect of cilnidipine on left ventricular function in hypertensive patients as assessed by tissue Doppler Tei index.

Journal: Journal of human hypertension 20060801

Title: Comparison between valsartan and valsartan plus cilnidipine in type II diabetics with normo- and microalbuminuria.

Journal: Kidney international 20060701

Title: Effects of L/N-type calcium channel antagonist, cilnidipine on progressive renal injuries in Dahl salt-sensitive rats.

Journal: Biological & pharmaceutical bulletin 20060501

Title: Beneficial effect of cilnidipine on morning hypertension and white-coat effect in patients with essential hypertension.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20060501

Title: Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.

Journal: Bioorganic & medicinal chemistry letters 20060215

Title: Cilnidipine, a slow-acting Ca2+ channel blocker, induces relaxation in porcine coronary artery: role of endothelial nitric oxide and [Ca2+]i.

Journal: British journal of pharmacology 20060101

Title: Comparison of the effects of cilnidipine and amlodipine on ambulatory blood pressure.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20051201

Title: Anti-proteinuric effect of an N-type calcium channel blocker, cilnidipine.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20051101

Title: Comparison of the direct negative dromotropic effect of a new calcium channel blocker, cilnidipine, with that of nicardipine.

Journal: Heart and vessels 20050501

Title: Cilnidipine, an N+L-type dihydropyridine Ca channel blocker, suppresses the occurrence of ischemia/reperfusion arrhythmia in a rabbit model of myocardial infarction.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20050401

Title: The N- and L-type calcium channel blocker cilnidipine suppresses renal injury in dahl rats fed a high-sucrose diet, an experimental model of metabolic syndrome.

Journal: Nephron. Physiology 20050101

Title: Prophylactic effects of an N- and L-type Ca2+ antagonist, cilnidipine, against cardiac hypertrophy and dysfunction in stroke-prone, spontaneously hypertensive rats.

Journal: Canadian journal of physiology and pharmacology 20050101

Title: Different effects of L-type and L+N-type calcium channel blockers on hamster cheek pouch venules.

Journal: Journal of cardiovascular pharmacology 20041201

Title: Cardiovascular effects of an L/N-type Ca2+ channel blocker cilnidipine assessed in the chronic atrioventricular conduction block dogs.

Journal: Journal of pharmacological sciences 20041001

Title: Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.

Journal: Biological & pharmaceutical bulletin 20040901

Title: Inhibitory effect of pranidipine on N-type voltage-dependent Ca2+ channels in mice.

Journal: Neuroscience letters 20040826

Title: Effect of cilnidipine on L- and T-type calcium currents in guinea pig ventricle and action potential in rabbit sinoatrial node.

Journal: Journal of pharmacological sciences 20040701

Title: Effects of the long-acting calcium channel blockers, amlodipine, manidipine and cilnidipine on steroid hormones and insulin resistance in hypertensive obese patients.

Journal: Internal medicine (Tokyo, Japan) 20040701

Title: [Development of desulfated chondroitin sulfate C as a novel chiral selector in capillary electrophoresis and enantioseparation of cilnidipine].

Journal: Se pu = Chinese journal of chromatography 20040701

Title: The evaluation of the N-type channel blocking properties of cilnidipine and other voltage-dependent calcium antagonists.

Journal: Fundamental & clinical pharmacology 20040601

Title: Comparison between cilnidipine and amlodipine besilate with respect to proteinuria in hypertensive patients with renal diseases.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20040601

Title: [Diagnosis of and therapy for renal hypertension].

Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20040310

Title: Effect of morning and bedtime dosing with cilnidipine on blood pressure, heart rate, and sympathetic nervous activity in essential hypertensive patients.

Journal: Journal of cardiovascular pharmacology 20040101

Title: Effects of calcium channel antagonists on left ventricular hypertrophy and diastolic function in patients with essential hypertension.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20031101

Title: [Clinical usefulness of a dual L/N-type Ca2+ channel blocker, cilnidipine, in patients with chronic heart failure: assessment with 123I-MIBG myocardial scintigraphy].

Journal: Kaku igaku. The Japanese journal of nuclear medicine 20031101

Title: Neuronal Ca2+ channel blocking action of an antihypertensive drug, cilnidipine, in IMR-32 human neuroblastoma cells.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030901

Title: Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030801

Title: Cilnidipine as an agent to lower blood pressure without sympathetic nervous activation as demonstrated by iodine-123 metaiodobenzylguanidine imaging in rat hearts.

Journal: Annals of nuclear medicine 20030601

Title: Effect of cilnidipine on insulin sensitivity in patients with essential hypertension.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20030501

Title: Characterization of Ca2+ current inhibition by cilnidipine using a beta-subunit antisense oligonucleotide.

Journal: European journal of pharmacology 20030411

Title: Metabolism and metabolic inhibition of cilnidipine in human liver microsomes.

Journal: Acta pharmacologica Sinica 20030301

Title: Comparative effect of clinidipine and quinapril on left ventricular mass in mild essential hypertension.

Journal: Drugs under experimental and clinical research 20030101

Title: Inhibitory effects of cilnidipine on peripheral and brain N-type Ca2+ channels expressed in BHK cells.

Journal: Neuropharmacology 20020601

Title: Cilnidipine is a novel slow-acting blocker of vascular L-type calcium channels that does not target protein kinase C.

Journal: Journal of hypertension 20020501

Title: N- and L-type calcium channel antagonist improves glomerular dynamics, reverses severe nephrosclerosis, and inhibits apoptosis and proliferation in an l-NAME/SHR model.

Journal: Journal of hypertension 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Cilnidipine improves spontaneously hypertensive rat coronary hemodynamics without altering cardiovascular mass and collagen.

Journal: Journal of hypertension 20020201

Title: Antisympathetic and hemodynamic property of a dual L/N-type Ca(2+) channel blocker cilnidipine in rats.

Journal: European journal of pharmacology 20020102

Title: In vivo measurement of 1,4-dihydropyridine receptors in mesenteric arteries of spontaneously hypertensive rats and effect of nifedipine and cilnidipine.

Journal: Biological & pharmaceutical bulletin 20020101

Title: Cilnidipine more highly attenuates cold pressor stress-induced platelet activation in hypertension than does amlodipine.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20011101

Title: Reduction of white coat effect by cilnidipine in essential hypertension.

Journal: American journal of hypertension 20011001

Title: Effects of the L- and N-type calcium channel blocker cilnidipine on growth of vascular smooth muscle cells from spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20010901

Title: Effects of cilnidipine on muscle fiber composition, capillary density and muscle blood flow in fructose-fed rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010901

Title: Cilnidipine is as effective as benazepril for control of blood pressure and proteinuria in hypertensive patients with benign nephrosclerosis.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20010701

Title: Effects of cilnidipine on nitric oxide and endothelin-1 expression and extracellular signal-regulated kinase in hypertensive rats.

Journal: European journal of pharmacology 20010622

Title: Effect of cilnidipine on left ventricular diastolic function in hypertensive patients as assessed by pulsed Doppler echocardiography and pulsed tissue Doppler imaging.

Journal: Japanese circulation journal 20010401

Title: State-dependent inhibition of L-type Ca2+ channels in A7r5 cells by cilnidipine and its derivatives.

Journal: Japanese journal of pharmacology 20010301

Title: Effects of a dual L/N-type Ca(2+) channel blocker cilnidipine on neurally mediated chronotropic response in anesthetized dogs.

Journal: European journal of pharmacology 20010209

Title: [Effects of benidipine hydrochloride (Coniel) on blood pressure, heart rate and plasma norepinephrine concentration in spontaneously hypertensive rats].

Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19990501

Title: Comparison of 24-hour blood pressure, heart rate, and autonomic nerve activity in hypertensive patients treated with cilnidipine or nifedipine retard.

Journal: Journal of cardiovascular pharmacology 19980801

Title: Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons.

Journal: The Journal of pharmacology and experimental therapeutics 19970301

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Tags:132203-70-4 Molecular Formula|132203-70-4 MDL|132203-70-4 SMILES|132203-70-4 Cilnidipine