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1334298-90-6,MFCD28579595
Catalog No.:AA00399W

1334298-90-6 | Itacitinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$44.00   $31.00
- +
10mg
98+%
in stock  
$160.00   $112.00
- +
50mg
98+%
in stock  
$433.00   $303.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00399W
Chemical Name:
Itacitinib
CAS Number:
1334298-90-6
Molecular Formula:
C26H23F4N9O
Molecular Weight:
553.5141
MDL Number:
MFCD28579595
SMILES:
N#CCC1(CN(C1)C1CCN(CC1)C(=O)c1ccnc(c1F)C(F)(F)F)n1ncc(c1)c1ncnc2c1cc[nH]2
Properties
Computed Properties
 
Complexity:
977  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
40  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
1.6  

Upstream Synthesis Route

[1]Patent:WO2013/36611,2013,A1,.Locationinpatent:Page/Pagecolumn36;37

[2]Patent:US2011/224190,2011,A1,.Locationinpatent:Page/Pagecolumn40

[3]Patent:US2015/246046,2015,A1,.Locationinpatent:Paragraph0139

[1]Patent:US2014/256941,2014,A1,.Locationinpatent:Paragraph0148

[1]Patent:US2014/256941,2014,A1,.Locationinpatent:Paragraph0142

[1]Patent:WO2013/36611,2013,A1,

[2]Patent:US2014/256941,2014,A1,

[3]Patent:US2015/246046,2015,A1,

[1]Patent:WO2013/36611,2013,A1,

[2]Patent:US2014/256941,2014,A1,

[3]Patent:US2015/246046,2015,A1,

Downstream Synthesis Route

[1]CurrentPatentAssignee:INCYTECORP-US2011/224190,2011,A1

[2]CurrentPatentAssignee:INCYTECORP-US2019/233392,2019,A1

[3]CurrentPatentAssignee:INCYTECORP-US2019/233392,2019,A1

[4]CurrentPatentAssignee:INCYTECORP-US2019/233392,2019,A1

[5]CurrentPatentAssignee:INCYTECORP-US2019/233392,2019,A1

[1]CurrentPatentAssignee:INCYTECORP-WO2013/36611,2013,A1Locationinpatent:Page/Pagecolumn36;37

[2]CurrentPatentAssignee:INCYTECORP-US2011/224190,2011,A1Locationinpatent:Page/Pagecolumn40

[3]CurrentPatentAssignee:INCYTECORP-US2015/246046,2015,A1Locationinpatent:Paragraph0139

[1]CurrentPatentAssignee:INCYTECORP-WO2013/36611,2013,A1

[1]Patent:WO2013/36611,2013,A1

[2]Patent:US2015/246046,2015,A1

[1]CurrentPatentAssignee:INCYTECORP-WO2013/36611,2013,A1

[2]CurrentPatentAssignee:INCYTECORP-US2014/256941,2014,A1

[3]CurrentPatentAssignee:INCYTECORP-US2015/246046,2015,A1

[4]CurrentPatentAssignee:INCYTECORP-US2019/233392,2019,A1

[5]CurrentPatentAssignee:INCYTECORP-US2019/233392,2019,A1

[6]CurrentPatentAssignee:INCYTECORP-US2022/56034,2022,A1

[7]CurrentPatentAssignee:INCYTECORP-US2022/56034,2022,A1

[8]CurrentPatentAssignee:INCYTECORP-US2022/56034,2022,A1

[9]CurrentPatentAssignee:INCYTECORP-US2022/56034,2022,A1

[10]CurrentPatentAssignee:INCYTECORP-US2022/56034,2022,A1

Literature

Title: Molecular size of nerve growth factor in dilute solution.

Journal: The Journal of biological chemistry 19760125

Title: Mascarenhas JO, et al. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica. 2017 Feb;102(2):327-335.

Title: Alain Lescoat, et al. Combined Anti-Fibrotic and Anti-Inflammatory Properties of JAK-inhibitors on Macrophages in Vitro and in Vivo: Perspectives for Scleroderma-Associated Interstitial Lung Disease. Biochem Pharmacol. 2020 Jun 17;114103.

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SDS
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