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Title: The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.
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Title: Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3.
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Title: Dual carbamoylations on the polyketide and glycosyl moiety by asm21 result in extended ansamitocin biosynthesis.
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Title: Enhanced production of ansamitocin P-3 by addition of Mg2+ in fermentation of Actinosynnema pretiosum.
Journal: Bioresource technology 20111101
Title: N-methylation of the amide bond by methyltransferase asm10 in ansamitocin biosynthesis.
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Title: Mutational biosynthesis of ansamitocin antibiotics: a diversity-oriented approach to exploit biosynthetic flexibility.
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Title: Enhanced production of ansamitocin P-3 by addition of isobutanol in fermentation of Actinosynnema pretiosum.
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Title: Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.
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Title: A new antitumour ansamitocin from Actinosynnema pretiosum.
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Title: Preparative isolation and purification of anti-tumor agent ansamitocin P-3 from fermentation broth of Actinosynnema pretiosum using high-performance counter-current chromatography.
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Title: Constitutive overexpression of asm2 and asm39 increases AP-3 production in the actinomycete Actinosynnema pretiosum.
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Title: Timing of the Delta(10,12)-Delta(11,13) double bond migration during ansamitocin biosynthesis in Actinosynnema pretiosum.
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Title: Amide N-glycosylation by Asm25, an N-glycosyltransferase of ansamitocins.
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Title: Highly active ansamitocin derivatives: mutasynthesis using an AHBA-blocked mutant.
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Title: The ansacarbamitocins: polar ansamitocin derivatives.
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Title: New amide N-glycosides of ansamitocins identified from Actinosynnema pretiosum.
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Title: An integrative expression vector for Actinosynnema pretiosum.
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Title: On the biosynthetic origin of methoxymalonyl-acyl carrier protein, the substrate for incorporation of 'glycolate' units into ansamitocin and soraphen A.
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Title: Determination of the cryptic stereochemistry of the first PKS chain-extension step in ansamitocin biosynthesis by Actinosynnema pretiosum.
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Title: Metabolism studies of the anti-tumor agent maytansine and its analog ansamitocin P-3 using liquid chromatography/tandem mass spectrometry.
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Title: An API LC/MS/MS quantitation method for ansamitocin P-3 (AP3) and its preclinical pharmacokinetics.
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Title: A novel amide N-glycoside of ansamitocins from Actinosynnema pretiosum.
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Title: The post-polyketide synthase modification steps in the biosynthesis of the antitumor agent ansamitocin by Actinosynnema pretiosum.
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Title: Identification of asm19 as an acyltransferase attaching the biologically essential ester side chain of ansamitocins using N-desmethyl-4,5-desepoxymaytansinol, not maytansinol, as its substrate.
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Title: Identification of a set of genes involved in the formation of the substrate for the incorporation of the unusual 'glycolate' chain extension unit in ansamitocin biosynthesis.
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