+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Other Building Blocks 1337531-89-1
1337531-89-1,MFCD28138541
Catalog No.:AA009EQC

1337531-89-1 | GSK PERK Inhibitor

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$125.00   $88.00
- +
10mg
98%
1 week  
$126.00   $89.00
- +
25mg
98%
1 week  
$251.00   $176.00
- +
50mg
98%
1 week  
$426.00   $298.00
- +
100mg
98%
1 week  
$722.00   $505.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009EQC
Chemical Name:
GSK PERK Inhibitor
CAS Number:
1337531-89-1
Molecular Formula:
C24H19F4N5O
Molecular Weight:
469.4342
MDL Number:
MFCD28138541
SMILES:
Fc1cc(CC(=O)N2CCc3c2ccc(c3)c2cn(c3c2c(N)ncn3)C)cc(c1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
753  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.9  

Downstream Synthesis Route
195447-79-1   
5-(2,3-dihydro-1H-indol-5-yl)-7-methyl-7H-pyrrolo2,3-dpyrimidin-4-aminedihydrochloride 
  1337531-89-1 

[1]JournalofMedicinalChemistry,2012,vol.55,p.7193-7207

[1]JournalofMedicinalChemistry,2012,vol.55,p.7193-7207

[1]JournalofMedicinalChemistry,2012,vol.55,p.7193-7207

[1]JournalofMedicinalChemistry,2012,vol.55,p.7193-7207

[1]JournalofMedicinalChemistry,2012,vol.55,p.7193-7207

Literature

Title: The unfolded protein response: mechanisms and therapy of neurodegeneration.

Journal: Brain : a journal of neurology 20160801

Title: Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development.

Journal: ACS medicinal chemistry letters 20131010

Title: Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice.

Journal: Science translational medicine 20131009

Title: Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).

Journal: Journal of medicinal chemistry 20120823

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1337531-89-1
1337531-36-8

1337531-36-8
Building Blocks
More >
Tags:1337531-89-1 Molecular Formula|1337531-89-1 MDL|1337531-89-1 SMILES|1337531-89-1 GSK PERK Inhibitor