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Home Other Building Blocks 1341200-45-0
1341200-45-0,MFCD28502172
Catalog No.:AA009CHP

1341200-45-0 | TP0903

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$36.00   $25.00
- +
2mg
98%
in stock  
$53.00   $37.00
- +
10mg
95%
in stock  
$208.00   $145.00
- +
25mg
98%
in stock  
$493.00   $345.00
- +
50mg
95%
in stock  
$522.00   $365.00
- +
100mg
95%
in stock  
$760.00   $532.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009CHP
Chemical Name:
TP0903
CAS Number:
1341200-45-0
Molecular Formula:
C24H30ClN7O2S
Molecular Weight:
516.0587
MDL Number:
MFCD28502172
SMILES:
CN1CCN(CC1)Cc1ccc(cc1)Nc1ncc(c(n1)Nc1ccccc1S(=O)(=O)N(C)C)Cl
Properties
Computed Properties
 
Complexity:
752  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
3.9  

Upstream Synthesis Route

[1]ACSMedicinalChemistryLetters,2011,vol.2,#12,p.907-912

Downstream Synthesis Route

[1]ACSMedicinalChemistryLetters,2011,vol.2,p.907-912

109-01-3   
2-((5-chloro-2-((4-(chloromethyl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide 
  1341200-45-0 

[1]Patent:WO2019/195753,2019,A1.Locationinpatent:Page/Pagecolumn162;164

147-71-7    1341200-45-0   
C24H30ClN7O2S*2C4H6O6 

[1]Patent:WO2019/195753,2019,A1.Locationinpatent:Page/Pagecolumn193-194

[1]CurrentPatentAssignee:SumitomoChemical(w/oDongwooFine-Chem);SumitomoPharma(in:SumitomoChemical);SUMITOMOCHEMICALCOMPANYLIMITED-WO2021/67772,2021,A1

Literature

Title: Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20150501

Title: Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.

Journal: ACS medicinal chemistry letters 20111208

Title: Chemistry of tobacco constituents. Oxidation of alpha-ionone and the acid-catalyzed rearrangement of 5-keto-alpha-ionone.

Journal: Journal of agricultural and food chemistry 19760101

Title: Mollard A, et al. Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors. ACS Med Chem Lett. 2011 Dec 8;2(12):907-912.

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SDS
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