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134448-10-5,MFCD00797531
Catalog No.:AA009AQO

134448-10-5 | CA-074

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1mg
≥95%
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$252.00   $176.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA009AQO
Chemical Name:
CA-074
CAS Number:
134448-10-5
Molecular Formula:
C18H29N3O6
Molecular Weight:
383.4394
MDL Number:
MFCD00797531
SMILES:
CCCNC(=O)[C@H]1O[C@@H]1C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)[C@H](CC)C
Properties
Computed Properties
 
Complexity:
596  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
0.9  

Downstream Synthesis Route
N-(L-3-trans-n-propylcarbamoyloxirane-2-carbonyl)-L-isoleucyl-L-prolinebenzylester 
  134448-10-5 

[1]CurrentPatentAssignee:TAISHOPHARMACEUTICALHOLDINGSCO.,LTD.-US5281717,1994,A

3282-30-2    134448-10-5   
C23H37N3O7 

[1]CurrentPatentAssignee:AMERICANLIFESCIENCEPHARMACEUTICALS-WO2007/38772,2007,A1Locationinpatent:Example3

18997-19-8    134448-10-5   
C24H39N3O8 

[1]CurrentPatentAssignee:AMERICANLIFESCIENCEPHARMACEUTICALS-WO2007/38772,2007,A1Locationinpatent:Example3

50893-36-2    134448-10-5   
C23H37N3O9 

[1]Patent:WO2007/38772,2007,A1.Locationinpatent:Example3

C11H10ClNO 
  134448-10-5   
C29H38N4O7 

[1]CurrentPatentAssignee:AMERICANLIFESCIENCEPHARMACEUTICALS-WO2007/38772,2007,A1Locationinpatent:Example3

Literature

Title: Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20141201

Title: Cathepsin B inhibition limits bone metastasis in breast cancer.

Journal: Cancer research 20120301

Title: An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001

Title: Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm.

Journal: The Journal of biological chemistry 20100115

Title: [Structure-based drug development and medical/biological application of cathepsin specific inhibitors].

Journal: Seikagaku. The Journal of Japanese Biochemical Society 20091101

Title: Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model.

Journal: Journal of neurochemistry 20090901

Title: Identification of 3-acetyl-2-aminoquinolin-4-one as a novel, nonpeptidic scaffold for specific calpain inhibitory activity.

Journal: Journal of medicinal chemistry 20090514

Title: Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells.

Journal: The Journal of biological chemistry 20090327

Title: [The experimental study of specific inhibitor-CA-074Me of Cathepsin B suppressing retinal neovascularization].

Journal: [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20080301

Title: Cathepsins B, L and D in inflammatory bowel disease macrophages and potential therapeutic effects of cathepsin inhibition in vivo.

Journal: Clinical and experimental immunology 20061001

Title: Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells.

Journal: Analytical biochemistry 20060601

Title: High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.

Journal: Analytical chemistry 20051215

Title: Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.

Journal: FEBS letters 20050815

Title: The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20050726

Title: Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis.

Journal: International journal of oncology 20050101

Title: Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.

Journal: The Biochemical journal 20040715

Title: Cathepsin L is crucial for a Th1-type immune response during Leishmania major infection.

Journal: Microbes and infection 20040401

Title: Significant accumulations of cathepsin B and prolylendopeptidase in inflammatory focus of delayed-type hypersensitivity induced by Mycobacterium tuberculosis in mice.

Journal: Biochemical and biophysical research communications 20040326

Title: Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.

Journal: Eukaryotic cell 20031201

Title: Cathepsin B in osteoblasts.

Journal: Biochimica et biophysica acta 20030502

Title: Primate neurons show different vulnerability to transient ischemia and response to cathepsin inhibition.

Journal: Acta neuropathologica 20020901

Title: Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex.

Journal: Biochimica et biophysica acta 20020603

Title: CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.

Journal: Biological chemistry 20020101

Title: Cathepsin B knockout mice are resistant to tumor necrosis factor-alpha-mediated hepatocyte apoptosis and liver injury: implications for therapeutic applications.

Journal: The American journal of pathology 20011201

Title: Towatari T, et al. Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo. FEBS Lett. 1991 Mar 25;280(2):311-5.

Title: Montaser M, et al. CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells. Biol Chem. 2002 Jul-Aug;383(7-8):1305-8.

Title: Yamashima T, et al. Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. Eur J Neurosci. 1998 May;10(5):1723-33.

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