Title: Interplay between lysosomal, mitochondrial and death receptor pathways during manganese-induced apoptosis in glial cells.
Journal: Archives of toxicology 20170901
Title: Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation.
Journal: Oncotarget 20161108
Title: GDC-0941 enhances the lysosomal compartment via TFEB and primes glioblastoma cells to lysosomal membrane permeabilization and cell death.
Journal: Cancer letters 20130201
Title: Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120815
Title: Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process.
Journal: Cell death and differentiation 20120801
Title: Autophagic-lysosomal dysregulation downstream of cathepsin B inactivation in human skin fibroblasts exposed to UVA.
Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20120101
Title: Pepstatin A alters host cell autophagic machinery and leads to a decrease in influenza A virus production.
Journal: Journal of cellular physiology 20111201
Title: An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20111001
Title: Caspase-1 protein induces apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC)-mediated necrosis independently of its catalytic activity.
Journal: The Journal of biological chemistry 20110930
Title: Hypersensitivity of mtDNA-depleted cells to staurosporine-induced apoptosis: roles of Bcl-2 downregulation and cathepsin B.
Journal: American journal of physiology. Cell physiology 20110501
Title: Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion.
Journal: Breast cancer research : BCR 20110101
Title: Doxorubicin-induced cell death requires cathepsin B in HeLa cells.
Journal: Biochemical pharmacology 20101115
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis.
Journal: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20100601
Title: Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
Journal: PLoS neglected tropical diseases 20100601
Title: Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.
Journal: International journal of cancer 20100515
Title: Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells.
Journal: Biological chemistry 20100501
Title: Zaire Ebola virus entry into human dendritic cells is insensitive to cathepsin L inhibition.
Journal: Cellular microbiology 20100201
Title: Endostatin expression in neurons during the early stage of cerebral ischemia is associated with neuronal apoptotic cell death in adult hypertensive rat model of stroke.
Journal: Brain research 20100122
Title: Proteomic identification of cathepsin B and nucleophosmin as novel UVA-targets in human skin fibroblasts.
Journal: Photochemistry and photobiology 20100101
Title: Cathepsin L is required for ecotropic murine leukemia virus infection in NIH3T3 cells.
Journal: Virology 20091125
Title: Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice.
Journal: Chinese medical journal 20091020
Title: Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells.
Journal: Immunology letters 20090427
Title: Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice.
Journal: World journal of gastroenterology 20090314
Title: Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75.
Journal: Molecular cancer 20090101
Title: IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts.
Journal: Journal of cellular physiology 20081101
Title: Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat.
Journal: Neuroscience letters 20080919
Title: Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Journal: Nature immunology 20080801
Title: Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20080701
Title: Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein.
Journal: The Journal of biological chemistry 20080321
Title: Fluid shear-induced activation and cleavage of CD18 during pseudopod retraction by human neutrophils.
Journal: Journal of cellular physiology 20080201
Title: Calcium signaling leads to mitochondrial depolarization in impact-induced chondrocyte death in equine articular cartilage explants.
Journal: Arthritis and rheumatism 20070701
Title: Cause-effect relationships between zymogen activation and other early events in secretagogue-induced acute pancreatitis.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20070601
Title: Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells.
Journal: Blood 20070401
Title: Cysteine protease inhibitors effectively reduce in vivo levels of brain beta-amyloid related to Alzheimer's disease.
Journal: Biological chemistry 20070201
Title: Endogenous expression and endocytosis of tartrate-resistant acid phosphatase (TRACP) by osteoblast-like cells.
Journal: Bone 20050601
Title: Cathepsin B-independent abrogation of cell death by CA-074-OMe upstream of lysosomal breakdown.
Journal: Cell death and differentiation 20041201
Title: Inhibitors of cysteine cathepsin and calpain do not prevent ultraviolet-B-induced apoptosis in human keratinocytes and HeLa cells.
Journal: Archives of dermatological research 20040701
Title: Cysteine proteases and cell differentiation: excystment of the ciliated protist Sterkiella histriomuscorum.
Journal: Eukaryotic cell 20031201
Title: Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin.
Journal: Cell death and differentiation 20030901
Title: Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis.
Journal: The Journal of biological chemistry 20030606
Title: Cathepsin B in osteoblasts.
Journal: Biochimica et biophysica acta 20030502
Title: Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20020901
Title: Cathepsin L and cathepsin B mediate reovirus disassembly in murine fibroblast cells.
Journal: The Journal of biological chemistry 20020705
Title: Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas.
Journal: International journal of cancer 20020220
Title: CA-074, but not its methyl ester CA-074Me, is a selective inhibitor of cathepsin B within living cells.
Journal: Biological chemistry 20020101
Title: Treatment with cathepsin L inhibitor potentiates Th2-type immune response in Leishmania major-infected BALB/c mice.
Journal: International immunology 20010801
Title: Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.
Journal: The Journal of biological chemistry 20010427
Title: Xu Y, et al. Protective mechanisms of CA074-me (other than cathepsin-B inhibition) against programmed necrosis induced by global cerebral ischemia/reperfusion injury in rats. Brain Res Bull. 2016 Jan;120:97-105
Title: Patel N, et al. CA-074Me compound inhibits osteoclastogenesis via suppression of the NFATc1 and c-FOS signaling pathways. J Orthop Res. 2015 Oct;33(10):1474-86
Title: Zhang L, et al. Treatment with CA-074Me, a Cathepsin B inhibitor, reduces lung interstitial inflammation and fibrosis in a rat model of polymyositis. Lab Invest. 2015 Jan;95(1):65-77
