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1350514-68-9,MFCD25976700
Catalog No.:AA009CAJ

1350514-68-9 | MK-5172

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Purity
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Price(USD)
Quantity
  
5mg
≥98%
in stock  
$76.00   $53.00
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10mg
≥98%
in stock  
$132.00   $92.00
- +
25mg
≥98%
in stock  
$216.00   $151.00
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50mg
≥98%
in stock  
$395.00   $276.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009CAJ
Chemical Name:
MK-5172
CAS Number:
1350514-68-9
Molecular Formula:
C38H50N6O9S
Molecular Weight:
766.9034
MDL Number:
MFCD25976700
SMILES:
C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H]2CN1C(=O)[C@@H](NC(=O)O[C@@H]1C[C@H]1CCCCCc1c(O2)nc2cc(OC)ccc2n1)C(C)(C)C)C(=O)NS(=O)(=O)C1CC1
Properties
Computed Properties
 
Complexity:
1580  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
54  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
4.7  

Literature

Title: Resistance Mechanisms in Hepatitis C Virus: implications for Direct-Acting Antiviral Use.

Journal: Drugs 20170701

Title: An update on the management of chronic hepatitis C: 2015 Consensus guidelines from the Canadian Association for the Study of the Liver.

Journal: Canadian journal of gastroenterology & hepatology 20150101

Title: MK-5172 : a second-generation protease inhibitor for the treatment of hepatitis C virus infection.

Journal: Expert opinion on investigational drugs 20140501

Title: MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants.

Journal: Antimicrobial agents and chemotherapy 20120801

Title: Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor.

Journal: ACS medicinal chemistry letters 20120412

Title: Summa V, et al. MK-5172, a selective inhibitor of hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants. Antimicrob Agents Chemother. 2012 Aug;56(8):4161-7.

Title: Harper S, et al. Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor. ACS Med Chem Lett. 2012 Mar 2;3(4):332-6.

Title: Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6(1):212.

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