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13602-53-4,MFCD00167500
Catalog No.:AA009BAQ

13602-53-4 | Angiotensin III, 4-L-isoleucine-

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5mg
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$46.00   $32.00
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10mg
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25mg
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  • Technical Information
  • Properties
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009BAQ
Chemical Name:
Angiotensin III, 4-L-isoleucine-
CAS Number:
13602-53-4
Molecular Formula:
C46H66N12O9
Molecular Weight:
931.0912
MDL Number:
MFCD00167500
SMILES:
CCC(C(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)O)Cc1ccccc1)Cc1[nH]cnc1)NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)N)Cc1ccc(cc1)O)C
Properties
Computed Properties
 
Complexity:
1680  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
67  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
11  
Rotatable Bond Count:
25  
XLogP3:
-0.5  

Literature

Title: Similarities and differences between effects of angiotensin III and angiotensin II on human prostate cancer cell migration and proliferation.

Journal: Peptides 20121001

Title: Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors.

Journal: Hypertension (Dallas, Tex. : 1979) 20120801

Title: Angiotensin III induces c-Jun N-terminal kinase leading to proliferation of rat astrocytes.

Journal: Neurochemical research 20120701

Title: Mass spectrometry for the molecular imaging of angiotensin metabolism in kidney.

Journal: American journal of physiology. Endocrinology and metabolism 20120415

Title: The role of the brain renin-angiotensin system in hypertension: implications for new treatment.

Journal: Progress in neurobiology 20111001

Title: Angiotensin III stimulates ERK1/2 mitogen-activated protein kinases and astrocyte growth in cultured rat astrocytes.

Journal: Neuropeptides 20111001

Title: Angiotensin III stimulates aldosterone secretion from adrenal gland partially via angiotensin II type 2 receptor but not angiotensin II type 1 receptor.

Journal: Endocrinology 20110401

Title: Mammary renin-angiotensin system-regulating aminopeptidase activities are modified in rats with breast cancer.

Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20101201

Title: Effects of angiotensin III on protein, DNA, and collagen synthesis of neonatal cardiomyocytes and cardiac fibroblasts in vitro.

Journal: Journal of cardiovascular pharmacology and therapeutics 20101201

Title: Effects of angiotensin metabolites in the coronary vascular bed of the spontaneously hypertensive rat: loss of angiotensin II type 2 receptor-mediated vasodilation.

Journal: Hypertension (Dallas, Tex. : 1979) 20100201

Title: Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter.

Journal: Neuroscience 20091215

Title: Brain AT1 angiotensin receptor subtype binding: importance of peptidase inhibition for identification of angiotensin II as its endogenous ligand.

Journal: The Journal of pharmacology and experimental therapeutics 20091001

Title: Deletion of LOX-1 attenuates renal injury following angiotensin II infusion.

Journal: Kidney international 20090901

Title: Identification of threonine 348 as a residue involved in aminopeptidase A substrate specificity.

Journal: The Journal of biological chemistry 20090417

Title: Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20090201

Title: Stress influences brain enkephalinase, oxytocinase and angiotensinase activities: a new hypothesis.

Journal: Neuropsychobiology 20090101

Title: The influence of peptides from the angiotensin family on tyrosine kinase activity and cell viability in a human hormone-dependent prostate cancer line.

Journal: Endokrynologia Polska 20090101

Title: Peptide-phospholipid complex formation at liquid-liquid interfaces.

Journal: Analytical chemistry 20081215

Title: Evaluation of role of angiotensin III and aminopeptidases in prostate cancer cells.

Journal: The Prostate 20081101

Title: [Angiotensin III participation in mechanisms of development of an alcoholism and other kinds of behavioural activity].

Journal: Georgian medical news 20081101

Title: Aminopeptidase A inhibitors as centrally acting antihypertensive agents.

Journal: Heart failure reviews 20080901

Title: The renin-angiotensin system and diabetes: an update.

Journal: Vascular health and risk management 20080801

Title: Angiotensin II relaxations of bovine adrenal cortical arteries: role of angiotensin II metabolites and endothelial nitric oxide.

Journal: Hypertension (Dallas, Tex. : 1979) 20080701

Title: Aminopeptidase A: could it be a novel target for neurogenic hypertension?

Journal: Hypertension (Dallas, Tex. : 1979) 20080501

Title: Hydrolysis of various bioactive peptides by goat brain dipeptidylpeptidase-III homologue.

Journal: Cell biochemistry and function 20080401

Title: Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20080201

Title: Doxazosin blockade of alpha 1-adrenergic receptors increases rat serum progesterone levels: a putative role of ovarian angiotensin III in steroidogenesis.

Journal: Fertility and sterility 20071001

Title: Intrarenal aminopeptidase N inhibition augments natriuretic responses to angiotensin III in angiotensin type 1 receptor-blocked rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20070301

Title: Effector peptides of the renin-angiotensin system in the central mechanisms of acquired and innate behavior in thirst in rats.

Journal: Neuroscience and behavioral physiology 20070301

Title: The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors.

Journal: European journal of pharmacology 20061203

Title: Systemic effects of angiotensin III in conscious dogs during acute double blockade of the renin-angiotensin-aldosterone-system.

Journal: Acta physiologica (Oxford, England) 20061001

Title: Ang II and Ang III modulate PTZ seizure threshold in non-stressed and stressed mice: possible involvement of noradrenergic mechanism.

Journal: Neuropeptides 20061001

Title: Lack of angiotensin II conversion to angiotensin III increases water but not alcohol consumption in aminopeptidase A-deficient mice.

Journal: Regulatory peptides 20060911

Title: Formation of anionic peptide radicals in vacuo.

Journal: Journal of the American Society for Mass Spectrometry 20060901

Title: Pressor responses to alligator Angiotensin I and some analogs in the spectacled caiman (Caiman crocodilus).

Journal: General and comparative endocrinology 20060601

Title: Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat.

Journal: Hypertension (Dallas, Tex. : 1979) 20060301

Title: Tyrosine kinase and mitogen-activated protein kinase/extracellularly regulated kinase differentially regulate intracellular calcium concentration responses to angiotensin II/III and bradykinin in rat cortical thick ascending limb.

Journal: Endocrinology 20060101

Title: Influence of thyroid disorders on kidney angiotensinase activity.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20060101

Title: [Effector peptides of the brain renin-angiotensin system in central mechanisms of learned and natural forms of drinking behavior in rats].

Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20060101

Title: Angiotensin II and III upregulate body fluid volume of the clam worm Perinereis sp. via angiotensin II receptors in different manners.

Journal: Peptides 20051201

Title: Roles of brain angiotensins II and III in thirst and sodium appetite.

Journal: Brain research 20051026

Title: ANG III induces expression of inducible transcription factors of AP-1 and Krox families in rat brain.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050901

Title: The effect of angiotensin III on protein tyrosine kinase activity in rat pituitary.

Journal: Regulatory peptides 20050815

Title: Angiotensin II enhances thrombosis development in renovascular hypertensive rats.

Journal: Thrombosis and haemostasis 20050601

Title: Role of angiotensin III in hypertension.

Journal: Current hypertension reports 20050401

Title: Chemiluminescence detection of arginine-containing peptides separated with monolithic high-performance liquid chromatography.

Journal: Analytical biochemistry 20050101

Title: Isotope ratio monitoring of small molecules and macromolecules by liquid chromatography coupled to isotope ratio mass spectrometry.

Journal: Rapid communications in mass spectrometry : RCM 20050101

Title: Effect of bestatin on angiotensin I-, II- and III-induced collagen gel contraction in cardiac fibroblasts.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20041201

Title: Angiotensin II and its fragments (angiotensins III and IV) decrease the growth of DU-145 prostate cancer in vitro.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20041101

Title: A pharmacological differentiation between postjunctional (AT1A) and prejunctional (AT1B) angiotensin II receptors in the rabbit aorta.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20041001

Title: A mechanistic investigation of the enhanced cleavage at histidine in the gas-phase dissociation of protonated peptides.

Journal: Analytical chemistry 20040401

Title: Effects of angiotensin II and AIII microinjections into the zona incerta after intra- and extracellular fluid loss.

Journal: Brain research 20040326

Title: Integrated protein microchip assay with dual fluorescent- and MALDI read-out.

Journal: Journal of proteome research 20040101

Title: Effects of different angiotensins during acute, double blockade of the renin system in conscious dogs.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20031101

Title: Effects of truncated angiotensins in humans after double blockade of the renin system.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20031101

Title: Angiotensin II and III microinjections into the zona incerta influence drinking behavior.

Journal: Brain research 20030711

Title: Effects of angiotensin-(1-7) and other bioactive components of the renin-angiotensin system on vascular resistance and noradrenaline release in rat kidney.

Journal: Journal of hypertension 20030701

Title: Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030301

Title: Angiotensin II induces prostaglandin E(2) release in human gingival fibroblasts.

Journal: Life sciences 20030103

Title: Aminopeptidase A, generating one of the main effector peptides of the brain renin-angiotensin system, angiotensin III, plays a key role in central control of blood pressure.

Journal: Proceedings of the Western Pharmacology Society 20030101

Title: Stimulation of collagen gel contraction by angiotensin II and III in cardiac fibroblasts.

Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20020901

Title: Potentiation of [Ca2+]i response to angiotensin III by cAMP in cortical thick ascending limb.

Journal: Kidney international 20020601

Title: Interleukin-1 inhibits angiotensin II-stimulated protein kinase B pathway in renal mesangial cells via the inducible nitric oxide synthase.

Journal: European journal of pharmacology 20020510

Title: Interaction of angiotensin II and III with adenosine A(1) receptor-related drugs in passive avoidance conditioning in rats.

Journal: Behavioural brain research 20020201

Title: Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor.

Journal: Regulatory peptides 20020115

Title: Radioligand binding reveals chymase as the predominant enzyme for mediating tissue conversion of angiotensin I in the normal human heart.

Journal: Clinical science (London, England : 1979) 20020101

Title: Rat tripeptidyl peptidase I: molecular cloning, functional expression, tissue localization and enzymatic characterization.

Journal: Biological chemistry 20011201

Title: Effects of angiotensin III and angiotensin IV on pentylenetetrazol seizure susceptibility (threshold and kindling): interaction with adenosine A(1) receptors.

Journal: Brain research bulletin 20010915

Title: Angiotensin II and its metabolites stimulate PAI-1 protein release from human adipocytes in primary culture.

Journal: Hypertension (Dallas, Tex. : 1979) 20010501

Title: Tonic suppression of spontaneous baroreceptor reflex by endogenous angiotensins via AT(2) subtype receptors at nucleus reticularis ventrolateralis in the rat.

Journal: Synapse (New York, N.Y.) 20010401

Title: Different types of antagonism by losartan and irbesartan on the effects of angiotensin II and its degradation products in rabbit arteries.

Journal: Fundamental & clinical pharmacology 20010401

Title: Angiotensin III: a central regulator of vasopressin release and blood pressure.

Journal: Trends in endocrinology and metabolism: TEM 20010101

Title: Differential effects of dietary cholesterol on aminopeptidase A, B and M in the frontal cortex of male and female mice.

Journal: Nutritional neuroscience 20010101

Title: Participation of AT1 and AT2 receptor subtypes in the tonic inhibitory modulation of baroreceptor reflex response by endogenous angiotensins at the nucleus tractus solitarii in the rat.

Journal: Brain research 19980126

Title: Intramolecular assistance of cis/trans isomerization of the histidine-proline moiety.

Journal: Biochemistry 19971111

Title: Involvement of AT2 receptors at NRVL in tonic baroreflex suppression by endogenous angiotensins.

Journal: The American journal of physiology 19970501

Title: Blockage of 5HT2C serotonin receptors by fluoxetine (Prozac).

Journal: Proceedings of the National Academy of Sciences of the United States of America 19970304

Title: Identification of metabolic pathways of brain angiotensin II and III using specific aminopeptidase inhibitors: predominant role of angiotensin III in the control of vasopressin release.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19961015

Title: Comparison of the antihypertensive effects of the new angiotensin II (AT1) receptor antagonist candesartan cilexetil (TCV-116) and the angiotensin converting enzyme inhibitor enalapril in rats.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 19960601

Title: Antihypertensive effects of angiotensin fragments in SHR.

Journal: Bioscience, biotechnology, and biochemistry 19950801

Title: Human angiotensin receptor subtypes.

Journal: Current opinion in nephrology and hypertension 19940101

Title: Angiotensin II--derived peptides devoid of phenylalanine in position 8 have full psychotropic activity of the parent hormone.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 19920601

Title: Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands.

Journal: Molecular pharmacology 19900301

Title: Angiotensin 'antipeptides': (-)messenger RNA complementary to human angiotensin II (+)messenger RNA encodes an angiotensin receptor antagonist.

Journal: Biochemical and biophysical research communications 19890515

Title: Antihypertensive and renal effects of cilazapril and their reversal by angiotensin in renovascular hypertensive rats.

Journal: Clinical science (London, England : 1979) 19880401

Title: Angiotensins II and III prevent captopril-induced renin release in the rat.

Journal: Clinical and experimental pharmacology & physiology 19880201

Title: Bosnyak S, et al. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors. Clin Sci (Lond). 2011 Oct;121(7):297-303.

Title: Kemp BA, et al. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors. Hypertension. 2012 Aug;60(2):387-95.

Title: Gao J, et al. A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors. Clin Sci (Lond). 2014 Aug;127(3):135-48.

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Tags:13602-53-4 Molecular Formula|13602-53-4 MDL|13602-53-4 SMILES|13602-53-4 Angiotensin III, 4-L-isoleucine-