Home Amines 136470-79-6
136470-79-6,MFCD28138132
Catalog No.:AA0011TJ

136470-79-6 | 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R,4S)-

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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0011TJ
Chemical Name:
2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R,4S)-
CAS Number:
136470-79-6
Molecular Formula:
C14H18N6O
Molecular Weight:
286.3323
MDL Number:
MFCD28138132
SMILES:
OC[C@H]1C=C[C@H](C1)n1cnc2c1nc(N)nc2NC1CC1
Properties
Computed Properties
 
Complexity:
414  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  
XLogP3:
0.9  

Literature

Title: Do companion diagnostics make economic sense for drug developers?

Journal: New biotechnology 20120915

Title: Spillover adherence effects of fixed-dose combination HIV therapy.

Journal: Patient preference and adherence 20120101

Title: HLA-B*5701 testing to predict abacavir hypersensitivity.

Journal: PLoS currents 20101207

Title: Patent Pooling for Promoting Access to Antiretroviral Drugs (ARVs) - A Strategic Option for India.

Journal: The open AIDS journal 20100101

Title: Abacavir/lamivudine combination in the treatment of HIV: a review.

Journal: Therapeutics and clinical risk management 20100101

Title: The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines.

Journal: PloS one 20100101

Title: Patent protection strategies.

Journal: Journal of pharmacy & bioallied sciences 20100101

Title: Efavirenz: a decade of clinical experience in the treatment of HIV.

Journal: The Journal of antimicrobial chemotherapy 20091101

Title: Survey of physician knowledge regarding antiretroviral medications in hospitalized HIV-infected patients.

Journal: Journal of the International AIDS Society 20090101

Title: FDA reviewing safety of Ziagen and Videx.

Journal: The AIDS reader 20080501

Title: XVII International AIDS Conference--Mexico City, August 3-8, 2008. Can Ziagen hurt your heart? Research presented at the International AIDS Conference weighs in on the controversy.

Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20080101

Title: Factors in AIDS dementia complex trial design: results and lessons from the abacavir trial.

Journal: PLoS clinical trials 20070301

Title: Advisory issued for Epzicom.

Journal: AIDS patient care and STDs 20061201

Title: Bioequivalence of abacavir generic and innovator formulations under fasting and fed conditions.

Journal: International journal of clinical pharmacology and therapeutics 20060601

Title: Response to: Are all non-thymidine analogue backbones appropriate for treating antiretroviral-naïve patients?

Journal: International journal of clinical practice 20060501

Title: Abacavir and lamivudine fixed-dose combination tablet once daily compared with abacavir and lamivudine twice daily in HIV-infected patients over 48 weeks (ESS30008, SEAL).

Journal: Journal of acquired immune deficiency syndromes (1999) 20051201

Title: Abacavir once or twice daily combined with once-daily lamivudine and efavirenz for the treatment of antiretroviral-naive HIV-infected adults: results of the Ziagen Once Daily in Antiretroviral Combination Study.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050401

Title: Two-once-daily fixed-dose NRTI combinations for HIV.

Journal: The Medical letter on drugs and therapeutics 20050227

Title: Once-daily abacavir in place of twice-daily administration.

Journal: The Annals of pharmacotherapy 20050101

Title: Membrane permeation characteristics of abacavir in human erythrocytes and human T-lymphoblastoid CD4+ CEM cells: comparison with (-)-carbovir.

Journal: Biochemical pharmacology 20041101

Title: FDA approves two combination pills, Epzicom and Truvada; comment on commercial race to once-a-day nucleosides.

Journal: AIDS treatment news 20040723

Title: Abacavir hypersensitivity reaction predicted by genetic test.

Journal: AIDS treatment news 20040326

Title: New once-a-day drugs: Truvada and Epzicom.

Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20040101

Title: Capillary electrophoresis-ion trap mass spectrometry analysis of Ziagen and its phosphorylated metabolites.

Journal: Electrophoresis 20030901

Title: Viread, Epivir and Ziagen combination: failure in naïve patients with a once-daily regimen.

Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20030101

Title: The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes.

Journal: Chemico-biological interactions 20021110

Title: FDA notifications. Product tampering labels Ziagen as Combivir.

Journal: AIDS alert 20020801

Title: Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate.

Journal: Biochemistry 20020423

Title: Simultaneous determination of Ziagen and its phosphorylated metabolites by ion-pairing high-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010425

Title: Determination of serum levels of thirteen human immunodeficiency virus-suppressing drugs by high-performance liquid chromatography.

Journal: Journal of chromatography. A 20010413

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Tags:136470-79-6 Molecular Formula|136470-79-6 MDL|136470-79-6 SMILES|136470-79-6 2-Cyclopentene-1-methanol, 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-, (1R,4S)-