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216699-07-9
Catalog No.:AA01EP13

216699-07-9 | 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-(1S,4R)-2-cyclopentene-1-methanolsulfate

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5mg
≥98%
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$63.00   $44.00
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10mg
≥98%
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$120.00   $84.00
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25mg
≥98%
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50mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01EP13
Chemical Name:
4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-(1S,4R)-2-cyclopentene-1-methanolsulfate
CAS Number:
216699-07-9
Molecular Formula:
C14H20N6O5S
Molecular Weight:
384.4108
SMILES:
OS(=O)(=O)O.OC[C@@H]1C=C[C@@H](C1)n1cnc2c1nc(N)nc2NC1CC1
Properties
Computed Properties
 
Complexity:
496  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
4  

Literature

Title: T-cells from HLA-B*57:01+ human subjects are activated with abacavir through two independent pathways and induce cell death by multiple mechanisms.

Journal: Chemical research in toxicology 20130520

Title: N-terminal valine adduct from the anti-HIV drug abacavir in rat haemoglobin as evidence for abacavir metabolism to a reactive aldehyde in vivo.

Journal: British journal of pharmacology 20121101

Title: A case of adverse drug reaction induced by dispensing error.

Journal: Journal of forensic and legal medicine 20121101

Title: Renal toxicity of long-term therapy with tenofovir in HIV-infected patients.

Journal: Journal of pharmacy practice 20121001

Title: Trade deal to curb generic-drug use.

Journal: Nature 20120906

Title: Copy number variation and incomplete linkage disequilibrium interfere with the HCP5 genotyping assay for abacavir hypersensitivity.

Journal: Genetic testing and molecular biomarkers 20120901

Title: Adaptive trials in paediatric development: dealing with heterogeneity and uncertainty in pharmacokinetic differences in children.

Journal: British journal of clinical pharmacology 20120801

Title: Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity.

Journal: AIDS (London, England) 20120717

Title: Avidity determines T-cell reactivity in abacavir hypersensitivity.

Journal: European journal of immunology 20120701

Title: Exposure to abacavir and biomarkers of cardiovascular disease in HIV-1-infected patients on suppressive antiretroviral therapy: a longitudinal study.

Journal: Journal of acquired immune deficiency syndromes (1999) 20120701

Title: Immune self-reactivity triggered by drug-modified HLA-peptide repertoire.

Journal: Nature 20120628

Title: Pharmacology: A false sense of non-self.

Journal: Nature 20120627

Title: Detection of abacavir hypersensitivity by ELISpot method.

Journal: Inflammation & allergy drug targets 20120601

Title: Tools for eradicating HIV in the brain: prodrug dimeric inhibitors of P-gp.

Journal: Therapeutic delivery 20120601

Title: Management of patients coinfected with HCV and HIV: a close look at the role for direct-acting antivirals.

Journal: Gastroenterology 20120501

Title: Population pharmacokinetics and maximum a posteriori probability Bayesian estimator of abacavir: application of individualized therapy in HIV-infected infants and toddlers.

Journal: British journal of clinical pharmacology 20120401

Title: [Leucoencephalopathy in a patient with type I human immunodeficiency virus (HIV-1) infection and symptoms of a hypertensive emergency].

Journal: Enfermedades infecciosas y microbiologia clinica 20120401

Title: HLA alleles and drug hypersensitivity reactions.

Journal: International journal of immunogenetics 20120401

Title: Dynamics of cognitive change in HIV-infected individuals commencing three different initial antiretroviral regimens: a randomized, controlled study.

Journal: HIV medicine 20120401

Title: Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing.

Journal: Clinical pharmacology and therapeutics 20120401

Title: Enantioselective synthesis of the carbocyclic nucleoside (-)-abacavir.

Journal: Organic & biomolecular chemistry 20120307

Title: Early changes in parathyroid hormone concentrations in HIV-infected patients initiating antiretroviral therapy with tenofovir.

Journal: AIDS research and human retroviruses 20120301

Title: Toward eradicating HIV reservoirs in the brain: inhibiting P-glycoprotein at the blood-brain barrier with prodrug abacavir dimers.

Journal: Journal of the American Chemical Society 20120215

Title: Pharmacokinetics of antiretroviral drug varies with formulation in the target population of children with HIV-1.

Journal: Clinical pharmacology and therapeutics 20120201

Title: Human leukocyte antigen (HLA) and pharmacogenetics: screening for HLA-B*57:01 among human immunodeficiency virus-positive patients from southern Alberta.

Journal: Human immunology 20120201

Title: [Coinfection with HIV and HCV: abacavir and ribavirine, why not?].

Journal: Revista clinica espanola 20120101

Title: Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex.

Journal: Annual review of pharmacology and toxicology 20120101

Title: Early markers of tubular dysfunction in antiretroviral-experienced HIV-infected patients treated with tenofovir versus abacavir.

Journal: AIDS patient care and STDs 20120101

Title: Renal function declines more in tenofovir- than abacavir-based antiretroviral therapy in low-body weight treatment-naïve patients with HIV infection.

Journal: PloS one 20120101

Title: Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects.

Journal: Antiviral therapy 20120101

Title: Effect of abacavir on acute changes in biomarkers associated with cardiovascular dysfunction.

Journal: Antiviral therapy 20120101

Title: Genetics and the potential for predictive tests in adverse drug reactions.

Journal: Chemical immunology and allergy 20120101

Title: Abacavir alters the transcription of inflammatory cytokines in virologically suppressed, HIV-infected women.

Journal: Journal of the International AIDS Society 20120101

Title: The role of raltegravir in the treatment of HIV-2 infections: evidence from a case series.

Journal: Antiviral therapy 20120101

Title: Reactive aldehyde metabolites from the anti-HIV drug abacavir: amino acid adducts as possible factors in abacavir toxicity.

Journal: Chemical research in toxicology 20111219

Title: Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension.

Journal: The Journal of infectious diseases 20111215

Title: Abacavir increases platelet reactivity via competitive inhibition of soluble guanylyl cyclase.

Journal: AIDS (London, England) 20111128

Title: Abacavir use and cardiovascular disease events: a meta-analysis of published and unpublished data.

Journal: AIDS (London, England) 20111023

Title: Abacavir and myocardial infarctions: the benefit of doubt?

Journal: AIDS (London, England) 20111023

Title: Optimizing initial therapy for HIV infection.

Journal: The Journal of infectious diseases 20111015

Title: Abacavir/lamivudine versus tenofovir DF/emtricitabine as part of combination regimens for initial treatment of HIV: final results.

Journal: The Journal of infectious diseases 20111015

Title: Increased platelet reactivity in HIV-1-infected patients receiving abacavir-containing antiretroviral therapy.

Journal: The Journal of infectious diseases 20111015

Title: A new approach to safely type for HLA the HIV infected people eligible to abacavir therapy: saliva or buccal swab as reliable DNA sources.

Journal: Clinica chimica acta; international journal of clinical chemistry 20111009

Title: Efficacy and safety of a switch to unboosted atazanavir in combination with nucleoside analogues in HIV-1-infected patients with virological suppression under antiretroviral therapy.

Journal: The Journal of antimicrobial chemotherapy 20111001

Title: Impact of tenofovir versus abacavir on HIV-related endothelial dysfunction.

Journal: AIDS patient care and STDs 20111001

Title: [Raltegravir in a special case: patient with HIV and Burkitt's lymphoma].

Journal: Deutsche medizinische Wochenschrift (1946) 20111001

Title: A randomized trial of punctuated antiretroviral therapy in Ugandan HIV-seropositive adults with pulmonary tuberculosis and CD4⁺ T-cell counts of ≥ 350 cells/μL.

Journal: The Journal of infectious diseases 20110915

Title: Paediatric drug development: are population models predictive of pharmacokinetics across paediatric populations?

Journal: British journal of clinical pharmacology 20110901

Title: Abacavir and lamivudine for the treatment of human immunodeficiency virus.

Journal: Expert opinion on pharmacotherapy 20110901

Title: [Immune reconstitution syndrome related to a Mycobacterium avium complex infection, revealed by a mono-adenitis].

Journal: Medecine et maladies infectieuses 20110901

Title: Prevalence of human leukocyte antigen HLA-B*57:01 in HIV-infected subjects in the Czech Republic.

Journal: Central European journal of public health 20110901

Title: Medication-based urolithiasis and atazanavir.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20110809

Title: Comparative effectiveness of continuing a virologically effective first-line boosted protease inhibitor combination or of switching to a three-drug regimen containing either efavirenz, nevirapine or abacavir.

Journal: The Journal of antimicrobial chemotherapy 20110801

Title: Treatment of Asian flush with abacavir.

Journal: Medical hypotheses 20110801

Title: Optimizing antiretroviral product selection: a sample approach to improving patient outcomes, saving money, and scaling-up health services in developing countries.

Journal: Journal of acquired immune deficiency syndromes (1999) 20110801

Title: Frequency of HLA B*5701 allele carriers in abacavir treated-HIV infected patients and controls from northeastern Brazil.

Journal: Clinics (Sao Paulo, Brazil) 20110801

Title: Rapid HCP5 single-nucleotide polymorphism genotyping: a simple allele-specific PCR method for prediction of hypersensitivity reaction to Abacavir.

Journal: Clinica chimica acta; international journal of clinical chemistry 20110715

Title: Abacavir use and risk of acute myocardial infarction and cerebrovascular events in the highly active antiretroviral therapy era.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110701

Title: HIV and Cardiovascular Disease.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110701

Title: Cardiovascular risks associated with abacavir and tenofovir exposure in HIV-infected persons.

Journal: AIDS (London, England) 20110619

Title: Acetoxy Meldrum's acid: a versatile acyl anion equivalent in the Pd-catalyzed asymmetric allylic alkylation.

Journal: Organic letters 20110617

Title: Low incidence of abacavir hypersensitivity reaction among African children initiating antiretroviral therapy.

Journal: The Pediatric infectious disease journal 20110601

Title: Can fomepizole be substituted by abacavir in the treatment of methanol poisoning?

Journal: Journal of medical toxicology : official journal of the American College of Medical Toxicology 20110601

Title: Association of the genetic marker for abacavir hypersensitivity HLA-B*5701 with HCP5 rs2395029 in Mexican Mestizos.

Journal: Pharmacogenomics 20110601

Title: Change in high-sensitivity c-reactive protein levels following initiation of efavirenz-based antiretroviral regimens in HIV-infected individuals.

Journal: AIDS research and human retroviruses 20110501

Title: Molecular recognition of the antiretroviral drug abacavir: towards the development of a novel carbazole-based fluorosensor.

Journal: Journal of fluorescence 20110501

Title: From old to new nucleoside reverse transcriptase inhibitors: changes in body fat composition, metabolic parameters and mitochondrial toxicity after the switch from thymidine analogs to tenofovir or abacavir.

Journal: Expert opinion on drug safety 20110501

Title: Hypersensitivity reactions to HIV therapy.

Journal: British journal of clinical pharmacology 20110501

Title: FDA notifications. Abacavir sulfate tablets tentatively approved.

Journal: AIDS alert 20110501

Title: FDA notifications. Ongoing safety review of abacavir, possible MI risk.

Journal: AIDS alert 20110501

Title: No risk of myocardial infarction associated with initial antiretroviral treatment containing abacavir: short and long-term results from ACTG A5001/ALLRT.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110401

Title: Novel sensitive, specific and rapid pharmacogenomic test for the prediction of abacavir hypersensitivity reaction: HLA-B*57:01 detection by real-time PCR.

Journal: Pharmacogenomics 20110401

Title: Tenofovir (TDF)-selected or abacavir (ABC)-selected low-frequency HIV type 1 subpopulations during failure with persistent viremia as detected by ultradeep pyrosequencing.

Journal: AIDS research and human retroviruses 20110201

Title: Distribution of HLA-B alleles in a Ugandan HIV-infected adult population: NORA pharmacogenetic substudy of DART.

Journal: Tropical medicine & international health : TM & IH 20110201

Title: Recent FDA approvals and changes.

Journal: AIDS patient care and STDs 20110201

Title: Separation and characterization of forced degradation products of abacavir sulphate by LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20110125

Title: The toxicogenetics of antiretroviral therapy: the evil inside.

Journal: Current medicinal chemistry 20110101

Title: Estimation strategies for reacting to the identification of an association between the genome and adverse drug reactions.

Journal: Journal of biopharmaceutical statistics 20110101

Title: Early changes in inflammatory and pro-thrombotic biomarkers in patients initiating antiretroviral therapy with abacavir or tenofovir.

Journal: BMC infectious diseases 20110101

Title: Open-label randomized multicenter selection study of once daily antiretroviral treatment regimen comparing ritonavir-boosted atazanavir to efavirenz with fixed-dose abacavir and lamivudine.

Journal: Internal medicine (Tokyo, Japan) 20110101

Title: [Efficacy and safety of the substitution of zidovudine by nevirapine in treatments based on three nucleoside analogue reverse transcriptase inhibitors in HIV-1 infected patients].

Journal: Enfermedades infecciosas y microbiologia clinica 20110101

Title: Decreased heart rate variability in HIV positive patients receiving antiretroviral therapy: importance of blood glucose and cholesterol.

Journal: PloS one 20110101

Title: Low-density lipoprotein size and lipoprotein-associated phospholipase A2 in HIV-infected patients switching to abacavir or tenofovir.

Journal: Antiviral therapy 20110101

Title: Cost-effectiveness of nucleoside reverse transcriptase inhibitor pairs in efavirenz-based regimens for treatment-naïve adults with HIV infection in the United States.

Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20110101

Title: Abacavir coadministration does not interfere with the suppressive activity of ribavirin in an HCV replicon system.

Journal: Antiviral therapy 20110101

Title: Increased prevalence of albuminuria in HIV-infected adults with diabetes.

Journal: PloS one 20110101

Title: Noninvasive coronary imaging for atherosclerosis in human immunodeficiency virus infection.

Journal: Current problems in diagnostic radiology 20110101

Title: Evaluation of cardiovascular biomarkers in HIV-infected patients switching to abacavir or tenofovir based therapy.

Journal: BMC infectious diseases 20110101

Title: Glomerular dysfunction and associated risk factors over 4-5 years following antiretroviral therapy initiation in Africa.

Journal: Antiviral therapy 20110101

Title: The impact of pharmacogenetics in the treatment of allergic disease and asthma.

Journal: Missouri medicine 20110101

Title: Abacavir, didanosine and tenofovir do not induce inflammatory, apoptotic or oxidative stress genes in coronary endothelial cells.

Journal: Antiviral therapy 20110101

Title: Use of patch testing for the diagnosis of abacavir-related hypersensitivity reaction in HIV patients.

Journal: Dermatologic therapy 20110101

Title: [HLA-B*5701 and abacavir hypersensitivity reaction].

Journal: Pathologie-biologie 20101201

Title: HLA-B*5701 genetic screening prior to abacavir prescription in Georgia.

Journal: Georgian medical news 20101201

Title: Abacavir does not affect circulating levels of inflammatory or coagulopathic biomarkers in suppressed HIV: a randomized clinical trial.

Journal: AIDS (London, England) 20101113

Title: Cost-effectiveness analysis of HLA-B*5701 typing in the prevention of hypersensitivity to abacavir in HIV+ patients in Spain.

Journal: Enfermedades infecciosas y microbiologia clinica 20101101

Title: Impact of hepatitis C and liver fibrosis on antiretroviral plasma drug concentrations in HIV-HCV co-infected patients: the HEPADOSE study.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: FDA notifications. FDA approves generic abacavir.

Journal: AIDS alert 20101101

Title: Efavirenz versus boosted atazanavir or zidovudine and abacavir in antiretroviral treatment-naive, HIV-infected subjects: week 48 data from the Altair study.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101001

Title: The impact of gender and anchor drugs on TDF renal toxicity.

Journal: Journal of acquired immune deficiency syndromes (1999) 20101001

Title: Association between abacavir exposure and increased risk for cardiovascular disease in patients with human immunodeficiency virus.

Journal: Pharmacotherapy 20101001

Title: A fluorescence-based sequence-specific primer PCR for the screening of HLA-B(*)57:01.

Journal: Electrophoresis 20101001

Title: Lower arterial stiffness and Framingham score after switching abacavir to tenofovir in men at high cardiovascular risk.

Journal: AIDS (London, England) 20100924

Title: Use of abacavir in 30 HIV-infected children from Durban, South Africa: report from a pilot study.

Journal: The Pediatric infectious disease journal 20100901

Title: Development and validation of a selective and rapid LC-MS-MS method for the quantification of abacavir in human plasma.

Journal: Journal of chromatographic science 20100901

Title: Similar efficacy and tolerability of atazanavir compared with atazanavir/ritonavir, each with abacavir/lamivudine after initial suppression with abacavir/lamivudine plus ritonavir-boosted atazanavir in HIV-infected patients.

Journal: AIDS (London, England) 20100824

Title: First report of abacavir associated with hypoglycemia.

Journal: AIDS (London, England) 20100824

Title: Abacavir and cardiovascular risk: reviewing the evidence.

Journal: Current HIV/AIDS reports 20100801

Title: Use of the HCP5 single nucleotide polymorphism to predict hypersensitivity reactions to abacavir: correlation with HLA-B*5701.

Journal: The Journal of antimicrobial chemotherapy 20100801

Title: [Pharmacogenetics].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20100801

Title: Impact of individual antiretroviral drugs on the risk of myocardial infarction in human immunodeficiency virus-infected patients: a case-control study nested within the French Hospital Database on HIV ANRS cohort CO4.

Journal: Archives of internal medicine 20100726

Title: Inflammatory biomarkers and abacavir use in the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study.

Journal: AIDS (London, England) 20100717

Title: Pharmacogenetics of drug hypersensitivity.

Journal: Pharmacogenomics 20100701

Title: Absence of mitochondrial toxicity in hearts of transgenic mice treated with abacavir.

Journal: Cardiovascular toxicology 20100601

Title: Abacavir and didanosine induce the interaction between human leukocytes and endothelial cells through Mac-1 upregulation.

Journal: AIDS (London, England) 20100601

Title: Abacavir/lamivudine/zidovudine maintenance after standard induction in antiretroviral therapy-naïve patients: FREE randomized trial interim results.

Journal: AIDS patient care and STDs 20100601

Title: Recent FDA approvals and changes.

Journal: AIDS patient care and STDs 20100601

Title: Abacavir-induced agranulocytosis in two Taiwanese patients tested HLA-B*5701-negative.

Journal: AIDS (London, England) 20100515

Title: Voriconazole use and pharmacokinetics in combination with interferon-gamma for refractory cryptococcal meningitis in a patient receiving low-dose ritonavir.

Journal: Medical mycology 20100501

Title: Introduction of pharmacogenetic screening for the human leucocyte antigen (HLA) B*5701 variant in Polish HIV-infected patients.

Journal: HIV medicine 20100501

Title: Nevirapine/zidovudine/lamivudine has superior immunological and virological responses not reflected in clinical outcomes in a 48-week randomized comparison with abacavir/zidovudine/lamivudine in HIV-infected Ugandan adults with low CD4 cell counts.

Journal: HIV medicine 20100501

Title: [Protease inhibitor or non-nucleoside reverse transcriptase inhibitor. ACTG study 5202 in focus].

Journal: MMW Fortschritte der Medizin 20100429

Title: Drug-induced hypersensitivity reactions and pharmacogenomics: past, present and future.

Journal: Pharmacogenomics 20100401

Title: Myocardial infarction risk in HIV-infected patients: epidemiology, pathogenesis, and clinical management.

Journal: AIDS (London, England) 20100327

Title: Abacavir and tenofovir disoproxil fumarate co-administration results in a nonadditive antiviral effect in HIV-1-infected patients.

Journal: AIDS (London, England) 20100313

Title: Prospective epidemiological study of the prevalence of human leukocyte antigen (HLA)-B*5701 in HIV-1-infected UK subjects.

Journal: HIV medicine 20100301

Title: Implementing the number needed to harm in clinical practice: risk of myocardial infarction in HIV-1-infected patients treated with abacavir.

Journal: HIV medicine 20100301

Title: A model-based approach to dose selection in early pediatric development.

Journal: Clinical pharmacology and therapeutics 20100301

Title: [Durability and tolerability of long-term nevirapine-based HAART].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20100301

Title: Abacavir and risk of myocardial infarction in HIV-infected patients on highly active antiretroviral therapy: a population-based nationwide cohort study.

Journal: HIV medicine 20100201

Title: Abacavir and cardiovascular risk.

Journal: Current opinion in infectious diseases 20100201

Title: HIV treatment information.

Journal: Project Inform perspective 20100201

Title: Abacavir-based therapy does not affect biological mechanisms associated with cardiovascular dysfunction.

Journal: AIDS (London, England) 20100128

Title: Treatment modification in human immunodeficiency virus-infected individuals starting combination antiretroviral therapy between 2005 and 2008.

Journal: Archives of internal medicine 20100111

Title: Routine versus clinically driven laboratory monitoring of HIV antiretroviral therapy in Africa (DART): a randomised non-inferiority trial.

Journal: Lancet (London, England) 20100109

Title: Pharmacogenetics of antiretrovirals.

Journal: Antiviral research 20100101

Title: Successful implementation of a national HLA-B*5701 genetic testing service in Canada.

Journal: Tissue antigens 20100101

Title: Viral rebound and emergence of drug resistance in the absence of viral load testing: a randomized comparison between zidovudine-lamivudine plus Nevirapine and zidovudine-lamivudine plus Abacavir.

Journal: The Journal of infectious diseases 20100101

Title: Mitochondrial changes during D-drug-containing once-daily therapy in HIV-positive treatment-naive patients.

Journal: Antiviral therapy 20100101

Title: The influence of abacavir and other antiretroviral agents on virological response to HCV therapy among antiretroviral-treated HIV-infected patients.

Journal: Antiviral therapy 20100101

Title: Pharmacokinetic study of once-daily versus twice-daily abacavir and lamivudine in HIV type-1-infected children aged 3-<36 months.

Journal: Antiviral therapy 20100101

Title: Safety and efficacy of a 36-week induction regimen of abacavir/lamivudine and ritonavir-boosted atazanavir in HIV-infected patients.

Journal: HIV clinical trials 20100101

Title: Cost impact of prospective HLA-B*5701-screening prior to abacavir/lamivudine fixed dose combination use in Germany.

Journal: European journal of medical research 20100101

Title: Economic efficiency of genetic screening to inform the use of abacavir sulfate in the treatment of HIV.

Journal: PharmacoEconomics 20100101

Title: Abacavir and CVD--more data but no consensus. Studies this year were evenly split, leaving patients and clinicians with few answers.

Journal: Journal watch. AIDS clinical care 20100101

Title: Simplified maintenance therapy with abacavir/lamivudine and atazanavir after discontinuation of ritonavir.

Journal: HIV clinical trials 20100101

Title: Anti-retroviral therapy-induced status epilepticus in 'pseudo-HIV serodeconversion'.

Journal: General hospital psychiatry 20100101

Title: Pharmacokinetics and acceptability of once- versus twice-daily lamivudine and abacavir in HIV type-1-infected Ugandan children in the ARROW Trial.

Journal: Antiviral therapy 20100101

Title: The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines.

Journal: PloS one 20100101

Title: HLA-B*5701 frequency in Chilean HIV-infected patients and in general population.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20100101

Title: A randomized, placebo-controlled trial of abacavir intensification in HIV-1-infected adults with virologic suppression on a protease inhibitor-containing regimen.

Journal: HIV clinical trials 20100101

Title: Two-dimensional LC-MS/MS determination of antiretroviral drugs in rat serum and urine.

Journal: Journal of pharmaceutical and biomedical analysis 20091205

Title: Antiretroviral-induced toxic epidermal necrolysis in a patient positive for human immunodeficiency virus.

Journal: Clinical and experimental dermatology 20091201

Title: Abacavir and lamivudine combination.

Journal: Expert opinion on drug metabolism & toxicology 20091201

Title: Early versus delayed fixed dose combination abacavir/lamivudine/zidovudine in patients with HIV and tuberculosis in Tanzania.

Journal: AIDS research and human retroviruses 20091201

Title: Investigation of the micellar effect of pluronic P85 on P-glycoprotein inhibition: cell accumulation and equilibrium dialysis studies.

Journal: Journal of pharmaceutical sciences 20091101

Title: A study of HIV provider attitudes toward HLA-B 5701 testing in the United States.

Journal: AIDS patient care and STDs 20091101

Title: Changes in biomarkers of cardiovascular risk after a switch to abacavir in HIV-1-infected individuals receiving combination antiretroviral therapy.

Journal: HIV medicine 20091101

Title: Effectiveness of antiretroviral regimens containing abacavir with tenofovir in treatment-experienced patients: predictors of virological response and drug resistance evolution in a multi-cohort study.

Journal: Infection 20091001

Title: Report from the 5th IAS Conference on HIV Pathogenesis Treatment and Prevention. Abacavir and CVD--again.

Journal: Journal watch. AIDS clinical care 20091001

Title: Association of abacavir and impaired endothelial function in treated and suppressed HIV-infected patients.

Journal: AIDS (London, England) 20090924

Title: B-mode ultrasound study of carotid plaques in HIV-positive patients to detect the presence of inflammatory endothelial lesions.

Journal: Current HIV research 20090901

Title: Anti-human immunodeficiency virus activity, cross-resistance, cytotoxicity, and intracellular pharmacology of the 3'-azido-2',3'-dideoxypurine nucleosides.

Journal: Antimicrobial agents and chemotherapy 20090901

Title: Virological response to initial antiretroviral regimens containing abacavir or tenofovir.

Journal: The Journal of infectious diseases 20090901

Title: Nevirapine increases high-density lipoprotein cholesterol concentration by stimulation of apolipoprotein A-I production.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20090901

Title: [Efficacy and safety of TAM-sparing antiretroviral regimens in naïve HIV-positive patients].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20090901

Title: FDA notifications. Tentative approval given for combination of abacavir, lamivudine & zidovudine tablets.

Journal: AIDS alert 20090901

Title: Randomized, double-blind, placebo-matched, multicenter trial of abacavir/lamivudine or tenofovir/emtricitabine with lopinavir/ritonavir for initial HIV treatment.

Journal: AIDS (London, England) 20090731

Title: The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cells.

Journal: International journal of cancer 20090701

Title: A simplification trial switching from nucleoside reverse transcriptase inhibitors to once-daily fixed-dose abacavir/lamivudine or tenofovir/emtricitabine in HIV-1-infected patients with virological suppression.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090701

Title: Improvements in cheek volume in lipoatrophic individuals switching away from thymidine nucleoside reverse transcriptase inhibitors.

Journal: HIV medicine 20090701

Title: The convenience of flow cytometry for HLA-B*5701 screening to prevent abacavir hypersensitivity reactions.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090701

Title: Modulation of K65R selection by zidovudine inclusion: analysis of HIV resistance selection in subjects with virologic failure receiving once-daily abacavir/lamivudine/zidovudine and tenofovir DF (study COL40263).

Journal: AIDS research and human retroviruses 20090701

Title: Weight evolution in HIV-1 infected women in Rwanda after stavudine substitution due to lipoatrophy: comparison of zidovudine with tenofovir/abacavir.

Journal: Transactions of the Royal Society of Tropical Medicine and Hygiene 20090601

Title: HLA and drug-induced toxicity.

Journal: Current opinion in molecular therapeutics 20090601

Title: Risk of myocardial infarction and abacavir therapy: no increased risk across 52 GlaxoSmithKline-sponsored clinical trials in adult subjects.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090501

Title: Abacavir and metabolite pharmacokinetics in HIV-1-infected children and adolescents.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090501

Title: Peripheral and visceral fat changes following a treatment switch to a non-thymidine analogue or a nucleoside-sparing regimen in HIV-infected subjects with peripheral lipoatrophy: results of ACTG A5110.

Journal: The Journal of antimicrobial chemotherapy 20090501

Title: Quadruple nucleos(t)ide reverse transcriptase inhibitors-only regimen of tenofovir plus zidovudine/lamivudine/abacavir in heavily pre-treated HIV-1 infected patients: salvage therapy or backbone only?

Journal: Current HIV research 20090501

Title: [Current data on antiretroviral therapy. CROI 2009: tenofovir DR convinces by high effectiveness and tolerance].

Journal: MMW Fortschritte der Medizin 20090430

Title: Proinflammatory cytokine changes in clinically stable, virologically suppressed, HIV-infected patients switching from protease inhibitors to abacavir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20090415

Title: Improvement of sensitivity and selectivity of high-performance liquid chromatography for anti-retroviral drugs (non-reverse transcriptase inhibitors) by diamond-electrode electrochemical and fluorescence detection.

Journal: Journal of chromatography. A 20090410

Title: Abacavir pharmacokinetics during chronic therapy in HIV-1-infected adolescents and young adults.

Journal: Clinical pharmacology and therapeutics 20090401

Title: Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3.

Journal: The Journal of pharmacology and experimental therapeutics 20090401

Title: Abacavir-induced reaction with fever and severe skin rash in a patient tested human leukocyte antigen-B*5701 negative.

Journal: International journal of STD & AIDS 20090401

Title: Comparison of once-daily fosamprenavir boosted with either 100 or 200 mg of ritonavir, in combination with abacavir/lamivudine: 96-week results from COL100758.

Journal: AIDS research and human retroviruses 20090401

Title: CROI 2009: a few key presentations on antiretroviral therapy.

Journal: The AIDS reader 20090401

Title: Select updates from the 16th CROI: treatment-related cardiovascular risk, pharmacokinetic issues, and interleukin-2 use.

Journal: The AIDS reader 20090401

Title: Report from the 16th Conference on Retroviruses and Opportunistic Infections. Continued concern about abacavir and cardiovascular risk.

Journal: Journal watch. AIDS clinical care 20090401

Title: Aid agencies condemn drug confiscation.

Journal: BMJ (Clinical research ed.) 20090311

Title: Highly active antiretroviral therapy-associated ptosis in patients with human immunodeficiency virus.

Journal: Archives of ophthalmology (Chicago, Ill. : 1960) 20090301

Title: Genome-wide approaches to identify pharmacogenetic contributions to adverse drug reactions.

Journal: The pharmacogenomics journal 20090201

Title: Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090201

Title: Genetic association studies to detect adverse drug reactions: abacavir hypersensitivity as an example.

Journal: Pharmacogenomics 20090201

Title: FDA notifications. Tentative approval for fixed-dose combo abacavir/lamivudine.

Journal: AIDS alert 20090201

Title: FDA notifications. Abacavir approved for pediatric patients.

Journal: AIDS alert 20090201

Title: [Atazanavir-induced nephrolithiasis].

Journal: Enfermedades infecciosas y microbiologia clinica 20090201

Title: The medical and economic roles of pipeline pharmacogenetics: Alzheimer's disease as a model of efficacy and HLA-B(*)5701 as a model of safety.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

Title: Sensitivity of phenotypic susceptibility analyses for nonthymidine nucleoside analogues conferred by K65R or M184V in mixtures with wild-type HIV-1.

Journal: The Journal of infectious diseases 20090101

Title: Top stories of 2008. Abacavir turmoil.

Journal: AIDS clinical care 20090101

Title: Top stories of 2008. Beyond abacavir/3TC: good news on first-line regimens.

Journal: AIDS clinical care 20090101

Title: Are mutations in HIV type-1 reverse transcriptase 245 codon predictive of abacavir hypersensitivity reaction?

Journal: Antiviral therapy 20090101

Title: Successful translation of pharmacogenetics into the clinic: the abacavir example.

Journal: Molecular diagnosis & therapy 20090101

Title: Prevalence of HLA-B*5701 in HIV-infected patients in Spain (results of the EPI Study).

Journal: HIV clinical trials 20090101

Title: Changes in hematological parameters after switching treatment of HIV-infected patients from zidovudine to abacavir or tenofovir DF.

Journal: HIV clinical trials 20090101

Title: HLA-B*5701 screening prior to abacavir prescription: clinical and laboratory aspects.

Journal: Critical reviews in clinical laboratory sciences 20090101

Title: [Correlation, in previously treated HIV-1 positive patients, between hypersensitivity reaction to abacavir and the presence of the HLA-B*5701 allele].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20090101

Title: Primary HIV-1 drug resistance and polymorphic patterns among injecting drug users (IDUs) in Chennai, Southern India.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20090101

Title: Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility.

Journal: The pharmacogenomics journal 20081201

Title: Efficacy of pegylated interferon plus ribavirin treatment in HIV/hepatitis C virus co-infected patients receiving abacavir plus lamivudine or tenofovir plus either lamivudine or emtricitabine as nucleoside analogue backbone.

Journal: The Journal of antimicrobial chemotherapy 20081201

Title: Abacavir and cardiovascular risk in HIV-infected patients: does T lymphocyte hyperactivation exert a pathogenic role?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20081201

Title: Abacavir hypersensitivity: a model system for pharmacogenetic test adoption.

Journal: Genetics in medicine : official journal of the American College of Medical Genetics 20081201

Title: Report from the 2008 joint ICAAC/IDSA meeting. More data on abacavir/3TC.

Journal: AIDS clinical care 20081201

Title: Longitudinal evaluation of cardiovascular disease-associated biomarkers in relation to abacavir therapy.

Journal: AIDS (London, England) 20081130

Title: Abacavir-induced hepatotoxicity: a report of two cases.

Journal: AIDS (London, England) 20081130

Title: Generic lamivudine and abacavir approved.

Journal: AIDS patient care and STDs 20081101

Title: FDA notifications. Abacavir tablet approved for pediatric patients.

Journal: AIDS alert 20081101

Title: Abacavir-induced febrile agranulocytosis and anaemia.

Journal: AIDS (London, England) 20081018

Title: Switching from twice-daily abacavir and lamivudine to the once-daily fixed-dose combination tablet of abacavir and lamivudine improves patient adherence and satisfaction with therapy.

Journal: HIV medicine 20081001

Title: Hypersensitivity reactions in patients treated with abacavir: strategies to avoid such reactions.

Journal: AIDS patient care and STDs 20081001

Title: Comment: Abacavir hypersensitivity reaction: an update.

Journal: The Annals of pharmacotherapy 20081001

Title: The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV.

Journal: AIDS (London, England) 20081001

Title: Current trends in screening across ethnicities for hypersensitivity to abacavir.

Journal: Pharmacogenomics 20081001

Title: FDA notifications. Generic abacavir and lamivudine combo approved.

Journal: AIDS alert 20081001

Title: The HCP5 single-nucleotide polymorphism: a simple screening tool for prediction of hypersensitivity reaction to abacavir.

Journal: The Journal of infectious diseases 20080915

Title: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients.

Journal: AIDS (London, England) 20080912

Title: The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research.

Journal: American journal of human genetics 20080912

Title: Abacavir and increased risk of myocardial infarction.

Journal: Lancet (London, England) 20080906

Title: Abacavir and increased risk of myocardial infarction.

Journal: Lancet (London, England) 20080906

Title: Abacavir and increased risk of myocardial infarction.

Journal: Lancet (London, England) 20080906

Title: Cariogenic and erosive potential of the medication used by HIV-infected children: pH and sugar concentration.

Journal: Community dental health 20080901

Title: FDA notifications. Abacavir package insert changes approved. Hypersensitivity, other issues addressed.

Journal: AIDS alert 20080901

Title: Abacavir controversy continues to brew.

Journal: Project Inform perspective 20080901

Title: First large, multicenter, open-label study utilizing HLA-B*5701 screening for abacavir hypersensitivity in North America.

Journal: AIDS (London, England) 20080820

Title: Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20080801

Title: Targeting only reverse transcriptase with zidovudine/lamivudine/abacavir plus tenofovir in HIV-1-infected patients with multidrug-resistant virus: a multicentre pilot study.

Journal: HIV medicine 20080801

Title: The A62V and S68G mutations in HIV-1 reverse transcriptase partially restore the replication defect associated with the K65R mutation.

Journal: Journal of acquired immune deficiency syndromes (1999) 20080801

Title: Labeling changes for abacavir.

Journal: AIDS patient care and STDs 20080801

Title: CD4 count improvement following tenofovir to abacavir switch in a patient with persistent lymphopenia despite an undetectable viral load.

Journal: The AIDS reader 20080801

Title: An unusual abacavir reaction.

Journal: AIDS (London, England) 20080731

Title: Severe abacavir hypersensitivity reaction in a patient tested HLA-B*5701 negative.

Journal: AIDS (London, England) 20080731

Title: Parsonage-Turner syndrome: a rare case of abacavir hypersensitivity reaction in HIV-infected patients.

Journal: The Journal of infection 20080701

Title: Zidovudine/lamivudine/abacavir plus tenofovir in HIV-infected naive patients: a 96-week prospective one-arm pilot study.

Journal: AIDS research and human retroviruses 20080701

Title: Abacavir hypersensitivity.

Journal: The New England journal of medicine 20080605

Title: Abacavir hypersensitivity.

Journal: The New England journal of medicine 20080605

Title: Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity.

Journal: Immunity 20080601

Title: Pharmacogenomics of antiretrovirals.

Journal: Recent patents on anti-infective drug discovery 20080601

Title: A review of drug patch testing and implications for HIV clinicians.

Journal: AIDS (London, England) 20080531

Title: Abacavir and warfarin modulate allosterically kinetics of NO dissociation from ferrous nitrosylated human serum heme-albumin.

Journal: Biochemical and biophysical research communications 20080502

Title: Cardiac tamponade: an unusual complication of simultaneous treatment of tuberculosis and HIV.

Journal: Southern medical journal 20080501

Title: Long-term subcutaneous tissue changes among antiretroviral-naive persons initiating stavudine, zidovudine, or abacavir with lamivudine.

Journal: Journal of acquired immune deficiency syndromes (1999) 20080501

Title: FDA reviewing safety of Ziagen and Videx.

Journal: The AIDS reader 20080501

Title: [Pharmacogenetic contribution to individualized treatment. Severe adverse effects can be avoided].

Journal: Lakartidningen 20080501

Title: FDA notifications. Large study suggests heart attack risk from use of abacavir or didanosine.

Journal: AIDS alert 20080501

Title: [HLA-B*5701 and hypersensitivity reactions to abacavir. Study methods and clinical relevance].

Journal: Enfermedades infecciosas y microbiologia clinica 20080501

Title: [Prospective validation of a pharmacogenetic test: the PREDICT-1 study].

Journal: Enfermedades infecciosas y microbiologia clinica 20080501

Title: Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients enrolled in the D:A:D study: a multi-cohort collaboration.

Journal: Lancet (London, England) 20080426

Title: Abacavir and the potential risk of myocardial infarction.

Journal: Lancet (London, England) 20080426

Title: Recent availability of two novel, fixed formulations of antiretroviral nucleoside analogues: a 12-month prospective, open-label survey of their practical use and therapeutic perspectives in antiretroviral-naive and -experienced patients.

Journal: AIDS patient care and STDs 20080401

Title: Heart attack risk with abacavir and didanosine.

Journal: AIDS patient care and STDs 20080401

Title: High sensitivity of human leukocyte antigen-b*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080401

Title: Report from the 15th Retrovirus Conference. Is abacavir therapy associated with MI risk?

Journal: AIDS clinical care 20080401

Title: Abacavir/3TC vs. tenofovir/FTC: interim results from ACTG 5202.

Journal: AIDS clinical care 20080401

Title: Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080301

Title: Abacavir hypersensitivity reaction: an update.

Journal: The Annals of pharmacotherapy 20080301

Title: Abacavir and didanosine increase the risk of heart attack.

Journal: AIDS patient care and STDs 20080301

Title: Anti-HIV agents. Controversial findings on abacavir and heart attacks.

Journal: TreatmentUpdate 20080301

Title: HLA-B*5701 screening for hypersensitivity to abacavir.

Journal: The New England journal of medicine 20080207

Title: Pharmacogenomic biomarkers for prediction of severe adverse drug reactions.

Journal: The New England journal of medicine 20080207

Title: Evolution of bone mineral density in AIDS patients on treatment with zidovudine/lamivudine plus abacavir or lopinavir/ritonavir.

Journal: HIV medicine 20080201

Title: Pharmacogenetic information derived from analysis of HLA alleles.

Journal: Pharmacogenomics 20080201

Title: PREDICT-1 (CNA106030): the first powered, prospective trial of pharmacogenetic screening to reduce drug adverse events.

Journal: Pharmaceutical statistics 20080101

Title: Electrochemical determination of HIV drug Abacavir based on its reduction.

Journal: Analytical chemistry 20080101

Title: Treatment options for lipodystrophy in HIV-positive patients.

Journal: Expert opinion on pharmacotherapy 20080101

Title: Initiatives for developing and comparing genotype interpretation systems: external validation of existing rule-based interpretation systems for abacavir against virological response.

Journal: HIV medicine 20080101

Title: Association of efavirenz hypersusceptibility with virologic response in ACTG 368, a randomized trial of abacavir (ABC) in combination with efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior nucleoside analog experience.

Journal: HIV clinical trials 20080101

Title: Twenty-four-week safety and tolerability of nevirapine vs. abacavir in combination with zidovudine/lamivudine as first-line antiretroviral therapy: a randomized double-blind trial (NORA).

Journal: Tropical medicine & international health : TM & IH 20080101

Title: New formulations approved for children.

Journal: AIDS patient care and STDs 20080101

Title: A review of the pharmacokinetics of abacavir.

Journal: Clinical pharmacokinetics 20080101

Title: Cytokine profiling in abacavir hypersensitivity patients.

Journal: Antiviral therapy 20080101

Title: Once-daily abacavir/lamivudine and ritonavir-boosted atazanavir for the treatment of HIV-1 infection in antiretroviral-naïve patients: a 48-week pilot study.

Journal: HIV clinical trials 20080101

Title: Low response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C treated with abacavir.

Journal: Antiviral therapy 20080101

Title: Incidence of abacavir hypersensitivity reactions in euroSIDA.

Journal: Antiviral therapy 20080101

Title: Abacavir does not influence the rate of virological response in HIV-HCV-coinfected patients treated with pegylated interferon and weight-adjusted ribavirin.

Journal: Antiviral therapy 20080101

Title: XVII International AIDS Conference--Mexico City, August 3-8, 2008. Can Ziagen hurt your heart? Research presented at the International AIDS Conference weighs in on the controversy.

Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20080101

Title: Refining abacavir hypersensitivity diagnoses using a structured clinical assessment and genetic testing in the Swiss HIV Cohort Study.

Journal: Antiviral therapy 20080101

Title: Dosage adjustments in hepatic dysfunction.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20071215

Title: Screening for abacavir hypersensitivity.

Journal: AIDS alert 20071201

Title: Prospective HLA-B*5701 screening and abacavir hypersensitivity: a single centre experience.

Journal: AIDS (London, England) 20071130

Title: P-glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20071101

Title: Polymorphisms at position 245 of HIV reverse transcriptase do not accurately predict the presence of human leukocyte antigen B*5701.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071101

Title: Value of the HLA-B*5701 allele to predict abacavir hypersensitivity in Spaniards.

Journal: AIDS research and human retroviruses 20071101

Title: Predictors of optimal viral suppression in patients switched to abacavir, lamivudine, and zidovudine: the Swiss HIV Cohort Study.

Journal: AIDS (London, England) 20071018

Title: Large lymphadenopathies complicating the abacavir hypersensitivity reaction.

Journal: AIDS (London, England) 20071018

Title: [Incidence and reasons of premature discontinuation of abacavir: results of a hospital investigation among 628 patients].

Journal: Medecine et maladies infectieuses 20071001

Title: Low-level K65R mutation in HIV-1 reverse transcriptase of treatment-experienced patients exposed to abacavir or didanosine.

Journal: Journal of acquired immune deficiency syndromes (1999) 20071001

Title: Pharmacokinetics of coadministered ritonavir-boosted elvitegravir and zidovudine, didanosine, stavudine, or abacavir.

Journal: Journal of acquired immune deficiency syndromes (1999) 20071001

Title: Acute fibrinous and organizing pneumonia as a rare presentation of abacavir hypersensitivity reaction.

Journal: AIDS (London, England) 20071001

Title: HLA-B*5701 clinical testing: early experience in the United States.

Journal: Pharmacogenetics and genomics 20071001

Title: Genotypic resistance in HIV-infected naive patients receiving abacavir plus lamivudine and efavirenz.

Journal: Journal of acquired immune deficiency syndromes (1999) 20071001

Title: Advances in HIV therapeutics: news from the 4th International AIDS Society Conference.

Journal: The AIDS reader 20071001

Title: Report from the 4th IAS Conference on HIV Pathogenesis, Treatment and Prevention. HLA B-5701 and abacavir hypersensitivity.

Journal: AIDS clinical care 20071001

Title: Early virological response of zidovudine/lamivudine/abacavir for patients co-infected with HIV and tuberculosis in Uganda.

Journal: AIDS (London, England) 20070912

Title: A comparison of three initial antiretroviral AIDS regimens.

Journal: The New England journal of medicine 20070906

Title: Molecular basis of antagonism between K70E and K65R tenofovir-associated mutations in HIV-1 reverse transcriptase.

Journal: Antiviral research 20070901

Title: Incidence of abacavir hypersensitivity and its relationship with HLA-B*5701 in HIV-infected patients in Taiwan.

Journal: The Journal of antimicrobial chemotherapy 20070901

Title: Are disulfiram-like reactions associated with abacavir-containing antiretroviral regimens in clinical practice?

Journal: AIDS (London, England) 20070820

Title: Virologic characterization of HIV type 1 with a codon 70 deletion in reverse transcriptase.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070815

Title: Human leukocyte antigens and drug hypersensitivity.

Journal: Current opinion in allergy and clinical immunology 20070801

Title: Drug hypersensitivity in HIV.

Journal: Current opinion in allergy and clinical immunology 20070801

Title: Hair loss induced by lopinavir-ritonavir.

Journal: Pharmacotherapy 20070801

Title: Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20070701

Title: HLA-B*5701 typing: evaluation of an allele-specific polymerase chain reaction melting assay.

Journal: Tissue antigens 20070701

Title: Immune responses to abacavir in antigen-presenting cells from hypersensitive patients.

Journal: AIDS (London, England) 20070619

Title: Uncertainties of routine HLA B*5701 testing in black African HIV cohorts in the UK.

Journal: Sexually transmitted infections 20070601

Title: A simple screening approach to reduce B*5701-associated abacavir hypersensitivity on the basis of sequence variation in HIV reverse transcriptase.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070601

Title: 'Personalized medicine: elusive dream or imminent reality?': A commentary.

Journal: Clinical pharmacology and therapeutics 20070601

Title: Abacavir sulfate and mania in HIV.

Journal: The American journal of psychiatry 20070601

Title: HPV oral infection. Case report of an HIV-positive Nigerian sex worker.

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20070601

Title: FDA notifications. FDA grants approval for generic didanosine for oral solution.

Journal: AIDS alert 20070601

Title: Testing antiretroviral drug efficacy in conventional mice infected with chimeric HIV-1.

Journal: AIDS (London, England) 20070511

Title: Lamivudine/abacavir maintains virological superiority over zidovudine/lamivudine and zidovudine/abacavir beyond 5 years in children.

Journal: AIDS (London, England) 20070511

Title: Simultaneous determination of abacavir and zidovudine from rat tissues using HPLC with ultraviolet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Title: Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC-MS/MS.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070501

Title: Prospective screening for human leukocyte antigen-B*5701 avoids abacavir hypersensitivity reaction in the ethnically mixed French HIV population.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070501

Title: Association of serum lipid levels with HIV serostatus, specific antiretroviral agents, and treatment regimens.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070501

Title: Early virologic failure in HIV-coinfected hepatitis C patients treated with the peginterferon-ribavirin combination: does abacavir play a role?

Journal: Journal of acquired immune deficiency syndromes (1999) 20070501

Title: Advances in HIV therapeutics: the 14th CROI.

Journal: The AIDS reader 20070501

Title: Metabolic effects of protease inhibitor-sparing antiretroviral regimens given as initial treatment of HIV-1 Infection (AIDS Clinical Trials Group Study A5095).

Journal: Journal of acquired immune deficiency syndromes (1999) 20070415

Title: Plasma HIV-1 RNA dynamics in antiretroviral-naive subjects receiving either triple-nucleoside or efavirenz-containing regimens: ACTG A5166s.

Journal: The Journal of infectious diseases 20070415

Title: HLA-B*5701 screening for susceptibility to abacavir hypersensitivity.

Journal: The Journal of antimicrobial chemotherapy 20070401

Title: Tenofovir and abacavir combination therapy: lessons learned from an urban clinic population.

Journal: AIDS patient care and STDs 20070401

Title: Identification of abacavir hypersensitivity reaction in health care claims data.

Journal: Pharmacoepidemiology and drug safety 20070301

Title: Once-daily highly active antiretroviral therapy for HIV-infected children: safety and efficacy of an efavirenz-containing regimen.

Journal: Pediatrics 20070301

Title: Abacavir sulfate/lamivudine/zidovudine fixed combination in the treatment of HIV infection.

Journal: Expert opinion on pharmacotherapy 20070301

Title: Abacavir modulates peroxynitrite-mediated oxidation of ferrous nitrosylated human serum heme-albumin.

Journal: Biochemical and biophysical research communications 20070209

Title: Less lipoatrophy and better lipid profile with abacavir as compared to stavudine: 96-week results of a randomized study.

Journal: Journal of acquired immune deficiency syndromes (1999) 20070201

Title: Three-year follow-up of protease inhibitor-based regimen simplification in HIV-infected patients.

Journal: AIDS (London, England) 20070130

Title: Comparative biological and clinical outcomes after a switch from a virologically unsuccessful first protease inhibitor-containing antiretroviral combination to a 3-drug regimen containing efavirenz, nevirapine, or abacavir.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070101

Title: Abacavir hypersensitivity reaction after switching from the twice-daily to the once-daily formulation.

Journal: AIDS patient care and STDs 20070101

Title: Development and validation of a reverse-phase liquid chromatographic method for assay and related substances of abacavir sulfate.

Journal: Journal of separation science 20070101

Title: Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations.

Journal: Environmental and molecular mutagenesis 20070101

Title: The NEFA study: results at three years.

Journal: AIDS reviews 20070101

Title: Simplified maintenance therapy with abacavir/lamivudine/zidovudine plus tenofovir after sustained HIV load suppression: four years of follow-up.

Journal: HIV clinical trials 20070101

Title: Quadruple nucleoside therapy with zidovudine, lamivudine, abacavir and tenofovir in the treatment of HIV.

Journal: Antiviral therapy 20070101

Title: Abacavir plasma pharmacokinetics in the absence and presence of atazanavir/ritonavir or lopinavir/ritonavir and vice versa in HIV-infected patients.

Journal: Antiviral therapy 20070101

Title: Complications and side effects. Abacavir hypersensitivity testing results--Montreal.

Journal: TreatmentUpdate 20070101

Title: External quality assessment of HLA-B*5701 reporting: an international multicentre survey.

Journal: Antiviral therapy 20070101

Title: Mitochondrial toxicity of tenofovir, emtricitabine and abacavir alone and in combination with additional nucleoside reverse transcriptase inhibitors.

Journal: Antiviral therapy 20070101

Title: A new and short convergent synthetic strategy to carbocyclic nucleosides.

Journal: Nucleosides, nucleotides & nucleic acids 20070101

Title: [Pilot study of antiretroviral therapy in Djibouti].

Journal: Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit 20070101

Title: In vitro human immunodeficiency virus type 1 resistance selections with combinations of tenofovir and emtricitabine or abacavir and lamivudine.

Journal: Antimicrobial agents and chemotherapy 20061201

Title: Salvage therapy with abacavir and other reverse transcriptase inhibitors for human immunodeficiency-associated encephalopathy.

Journal: The Pediatric infectious disease journal 20061201

Title: Switch to abacavir-based triple nucleoside regimens in HIV-1 infected patients never treated with suboptimal antiretroviral therapy: a review.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20061201

Title: Abacavir/lamividune combination in the treatment of HIV-1 infection: a review.

Journal: Expert opinion on pharmacotherapy 20061201

Title: FDA approves generic abacavir sulfate tablets.

Journal: AIDS alert 20061201

Title: Report from the XVI International AIDS Conference. Efavirenz for high viral load and low CD4--a secondary analysis of ACTG 5095.

Journal: AIDS clinical care 20061101

Title: A randomized comparative trial of tenofovir DF or abacavir as replacement for a thymidine analogue in persons with lipoatrophy.

Journal: AIDS (London, England) 20061024

Title: Switch from a first virologically effective protease inhibitor-containing regimen to a regimen containing efavirenz, nevirapine or abacavir.

Journal: AIDS (London, England) 20061024

Title: The effects of prolonged treatment with zidovudine, lamivudine, and abacavir on a T-lymphoblastoid cell line.

Journal: AIDS research and human retroviruses 20061001

Title: Discontinuation of highly active antiretroviral therapy leads to cryptococcal meningitis/choroiditis in an AIDS patient.

Journal: Optometry (St. Louis, Mo.) 20060901

Title: Long-term follow-up of patients with initial early virologic failure after being treated with once-daily tenofovir/abacavir/lamivudine.

Journal: AIDS patient care and STDs 20060901

Title: Three- vs four-drug antiretroviral regimens for the initial treatment of HIV-1 infection: a randomized controlled trial.

Journal: JAMA 20060816

Title: The KLEAN study of fosamprenavir-ritonavir versus lopinavir-ritonavir, each in combination with abacavir-lamivudine, for initial treatment of HIV infection over 48 weeks: a randomised non-inferiority trial.

Journal: Lancet (London, England) 20060805

Title: Human genetic variability and HIV treatment response.

Journal: Current HIV/AIDS reports 20060701

Title: A comparison between abacavir and efavirenz as the third drug used in combination with a background therapy regimen of 2 nucleoside reverse-transcriptase inhibitors in patients with initially suppressed viral loads.

Journal: The Journal of infectious diseases 20060701

Title: Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060701

Title: Genetic screening to prevent abacavir hypersensitivity reaction: are we there yet?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060701

Title: Synthesis of carbovir and abacavir from a carbocyclic precursor.

Journal: Current protocols in nucleic acid chemistry 20060701

Title: Investigating new antiretroviral combinations.

Journal: The Journal of infectious diseases 20060615

Title: Abacavir hypersensitivity reaction in primary HIV infection.

Journal: AIDS (London, England) 20060612

Title: Virological response to HIV-1 nucleoside/nucleotide reverse transcriptase inhibitors-based, tenofovir DF-including regimens in the ANRS Aquitaine Cohort.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20060601

Title: Adherence and acceptability of once daily Lamivudine and abacavir in human immunodeficiency virus type-1 infected children.

Journal: The Pediatric infectious disease journal 20060601

Title: The clinical implications of antiretroviral pharmacogenomics.

Journal: Pharmacogenomics 20060601

Title: Bioequivalence of abacavir generic and innovator formulations under fasting and fed conditions.

Journal: International journal of clinical pharmacology and therapeutics 20060601

Title: [Antiretroviral treatment associated life-threatening adverse events].

Journal: Medicina clinica 20060520

Title: A sensitive and rapid alternative to HLA typing as a genetic screening test for abacavir hypersensitivity syndrome.

Journal: Pharmacogenetics and genomics 20060501

Title: Response to: Are all non-thymidine analogue backbones appropriate for treating antiretroviral-naïve patients?

Journal: International journal of clinical practice 20060501

Title: Abacavir prodrugs: microwave-assisted synthesis and their evaluation of anti-HIV activities.

Journal: Bioorganic & medicinal chemistry letters 20060415

Title: Efficacy and safety of a once-daily fixed-dose combination of abacavir/lamivudine compared with abacavir twice daily and lamivudine once daily as separate entities in antiretroviral-experienced HIV-1-infected patients (CAL30001 Study).

Journal: Journal of acquired immune deficiency syndromes (1999) 20060415

Title: Neuropsychiatric reaction induced by abacavir in a pediatric human immunodeficiency virus-infected patient.

Journal: The Pediatric infectious disease journal 20060401

Title: Genetic factors in the predisposition to drug-induced hypersensitivity reactions.

Journal: The AAPS journal 20060301

Title: Impact of pregnancy on abacavir pharmacokinetics.

Journal: AIDS (London, England) 20060227

Title: Effectiveness and safety of abacavir, lamivudine, and zidovudine in antiretroviral therapy-naive HIV-infected patients: results from a large multicenter observational cohort.

Journal: Journal of acquired immune deficiency syndromes (1999) 20060201

Title: Acute respiratory manifestations of the abacavir hypersensitivity reaction.

Journal: AIDS (London, England) 20060109

Title: Predicting and diagnosing abacavir and nevirapine drug hypersensitivity: from bedside to bench and back again.

Journal: Pharmacogenomics 20060101

Title: An open-label, randomized comparative pilot study of a single-class quadruple therapy regimen versus a 2-class triple therapy regimen for individuals initiating antiretroviral therapy.

Journal: Antiviral therapy 20060101

Title: Long-term safety and tolerability of the lamivudine/abacavir combination as components of highly active antiretroviral therapy.

Journal: Drug safety 20060101

Title: Genetic testing may avoid abacavir hypersensitivity reaction.

Journal: AIDS treatment news 20060101

Title: Abacavir-induced reversible Fanconi syndrome with nephrogenic diabetes insipidus in a patient with acquired immunodeficiency syndrome.

Journal: Journal of postgraduate medicine 20060101

Title: An immunological comparison of third companion in advanced drug-naive HIV-infected patients.

Journal: HIV clinical trials 20060101

Title: Pilot study of once-daily simplification therapy with abacavir/lamivudine/zidovudine and efavirenz for treatment of HIV-1 infection.

Journal: HIV clinical trials 20060101

Title: Once-daily abacavir/lamivudine/zidovudine plus tenofovir for the treatment of HIV-1 infection in antiretroviral-naïve subjects: a 48-week pilot study.

Journal: HIV clinical trials 20060101

Title: [Development and validation of laboratory methods for antiretroviral quantitation using HPLC].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20060101

Title: Rare selection of the K65R mutation in antiretroviral-naive patients failing a first-line abacavir/ lamivudine-containing HAART regimen.

Journal: Antiviral therapy 20060101

Title: Less than the sum of its parts: failure of a tenofovir-abacavir-Lamivudine triple-nucleoside regimen.

Journal: The Journal of infectious diseases 20051201

Title: Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects.

Journal: The Journal of infectious diseases 20051201

Title: Abacavir and lamivudine fixed-dose combination tablet once daily compared with abacavir and lamivudine twice daily in HIV-infected patients over 48 weeks (ESS30008, SEAL).

Journal: Journal of acquired immune deficiency syndromes (1999) 20051201

Title: Fixed dose combination abacavir/lamivudine in the treatment of HIV-1 infection.

Journal: Expert review of anti-infective therapy 20051201

Title: Severe rhabdomyolysis during a hypersensitivity reaction to abacavir in a patient treated with ciprofibrate.

Journal: AIDS (London, England) 20051104

Title: Triple nucleoside reverse transcriptase inhibitor- vs. nonnucleoside reverse transcriptase inhibitor-containing regimens as first-line therapy: efficacy and durability in a prospective cohort of French HIV-infected patients.

Journal: HIV medicine 20051101

Title: Genotypic and phenotypic resistance patterns at virological failure in a simplification trial with nevirapine, efavirenz or abacavir.

Journal: AIDS (London, England) 20050902

Title: Lack of antagonism between abacavir, lamivudine, and tenofovir against wild-type and drug-resistant HIV-1.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050815

Title: Fatal lactic acidosis associated with tenofovir and abacavir.

Journal: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 20050701

Title: Induction with abacavir/lamivudine/zidovudine plus efavirenz for 48 weeks followed by 48-week maintenance with abacavir/lamivudine/zidovudine alone in antiretroviral-naive HIV-1-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050701

Title: Antiretroviral treatment simplification with 3 NRTIs or 2 NRTIs plus nevirapine in HIV-1-infected patients treated with successful first-line HAART.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050701

Title: Abacavir dosing with hepatic dysfunction.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050615

Title: Metabolic benefits 24 months after replacing a protease inhibitor with abacavir, efavirenz or nevirapine.

Journal: AIDS (London, England) 20050610

Title: Clinical and immunogenetic correlates of abacavir hypersensitivity.

Journal: AIDS (London, England) 20050610

Title: [Consequences of replacing abacavir for indinavir in successful antiretroviral treatment of a patient with HIV infection].

Journal: Presse medicale (Paris, France : 1983) 20050604

Title: Pharmacogenetic testing: proofs of principle and pharmacoeconomic implications.

Journal: Mutation research 20050603

Title: HLA-B*5701 typing by sequence-specific amplification: validation and comparison with sequence-based typing.

Journal: Tissue antigens 20050601

Title: A long-term survival case of small cell lung cancer in an HIV-infected patient.

Journal: Japanese journal of clinical oncology 20050601

Title: Switching from protease inhibitors to a single-class regimen of abacavir/lamivudine/zidovudine plus tenofovir in patients with HIV load suppression.

Journal: AIDS (London, England) 20050520

Title: Application of phosphoramidate pronucleotide technology to abacavir leads to a significant enhancement of antiviral potency.

Journal: Journal of medicinal chemistry 20050519

Title: Intracellular cytokines may model immunoregulation of abacavir hypersensitivity in HIV-infected subjects.

Journal: The Journal of allergy and clinical immunology 20050501

Title: The Protease Inhibitor Transfer Study (PROTRA 1): abacavir and efavirenz in combination as a substitute for a protease inhibitor in heavily pretreated HIV-1-infected patients with undetectable plasma viral load.

Journal: HIV medicine 20050501

Title: Efficacy of tenofovir as intensification of zidovudine/lamivudine/abacavir fixed-dose combination in the treatment of HIV-positive patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050415

Title: Abacavir once or twice daily combined with once-daily lamivudine and efavirenz for the treatment of antiretroviral-naive HIV-infected adults: results of the Ziagen Once Daily in Antiretroviral Combination Study.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050401

Title: [Toxic epidermal necrolysis associated with abacavir].

Journal: Enfermedades infecciosas y microbiologia clinica 20050401

Title: Long term probability of detection of HIV-1 drug resistance after starting antiretroviral therapy in routine clinical practice.

Journal: AIDS (London, England) 20050325

Title: Abacavir pharmacokinetics in hepatic dysfunction.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050315

Title: Abacavir pharmacokinetics in human immunodeficiency virus-infected children ranging in age from 1 month to 16 years: a population analysis.

Journal: Journal of clinical pharmacology 20050301

Title: Selection of a rare resistance profile in an HIV-1-infected patient exhibiting a failure to an antiretroviral regimen including tenofovir DF.

Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20050301

Title: Increased adipocyte apoptosis in lipoatrophy improves within 48 weeks of switching patient therapy from Stavudine to abacavir or zidovudine.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050301

Title: Interruption and discontinuation of highly active antiretroviral therapy in the multicenter AIDS cohort study.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050301

Title: Early virologic failure in a pilot study evaluating the efficacy of therapy containing once-daily abacavir, lamivudine, and tenofovir DF in treatment-naive HIV-infected patients.

Journal: AIDS patient care and STDs 20050301

Title: Factors associated with virological response in HIV-infected patients failing antiretroviral therapy: a prospective cohort study.

Journal: HIV medicine 20050301

Title: Simultaneous determination of the HIV nucleoside analogue reverse transcriptase inhibitors lamivudine, didanosine, stavudine, zidovudine and abacavir in human plasma by reversed phase high performance liquid chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050225

Title: A randomized study comparing a three- and four-drug HAART regimen in first-line therapy (QUAD study).

Journal: The Journal of antimicrobial chemotherapy 20050201

Title: Body composition and metabolic changes in antiretroviral-naive patients randomized to didanosine and stavudine vs. abacavir and lamivudine.

Journal: Journal of acquired immune deficiency syndromes (1999) 20050201

Title: Weight related differences in the pharmacokinetics of abacavir in HIV-infected patients.

Journal: British journal of clinical pharmacology 20050201

Title: The impact of abacavir on lipids and lipodystrophy.

Journal: The AIDS reader 20050201

Title: GlaxoSmithKline receives European approval for Kivexa.

Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20050201

Title: Improvements in lipoatrophy, mitochondrial DNA levels and fat apoptosis after replacing stavudine with abacavir or zidovudine.

Journal: AIDS (London, England) 20050103

Title: Lipoatrophy and mitochondrial DNA assays: see all, know all?

Journal: AIDS (London, England) 20050103

Title: Antiretroviral drug pharmacokinetics in hepatitis with hepatic dysfunction.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050101

Title: Abacavir plus lamivudine: a review of their combined use in the management of HIV infection.

Journal: Drugs 20050101

Title: Substituting abacavir for hyperlipidemia-associated protease inhibitors in HAART regimens improves fasting lipid profiles, maintains virologic suppression, and simplifies treatment.

Journal: BMC infectious diseases 20050101

Title: Abacavir compared to protease inhibitors as part of HAART regimens for treatment of HIV infection: patient satisfaction and implications for adherence.

Journal: AIDS patient care and STDs 20050101

Title: Top stories of 2004. ACTG 5095: efavirenz beats AZT + 3TC + abacavir.

Journal: AIDS clinical care 20050101

Title: Quadruple-drug induction HAART in advanced HIV infection.

Journal: HIV clinical trials 20050101

Title: Abacavir, efavirenz, didanosine, with or without hydroxyurea, in HIV-infected adults failing initial nucleoside/protease inhibitor-containing regimens.

Journal: BMC infectious diseases 20050101

Title: Plasma pharmacokinetics of once- versus twice-daily lamivudine and abacavir: simplification of combination treatment in HIV-1-infected children (PENTA-13).

Journal: Antiviral therapy 20050101

Title: In vitro combination studies of tenofovir and other nucleoside analogues with ribavirin against HIV-1.

Journal: Antiviral therapy 20050101

Title: Pharmacokinetics and pharmacodynamics of low dose mycophenolate mofetil in HIV-infected patients treated with abacavir, efavirenz and nelfinavir.

Journal: Clinical pharmacokinetics 20050101

Title: Lack of a metabolic and antiviral drug interaction between tenofovir, abacavir and lamivudine.

Journal: Antiviral therapy 20050101

Title: Once-daily abacavir in place of twice-daily administration.

Journal: The Annals of pharmacotherapy 20050101

Title: [An analisys fo causes for the discontinuation of a simplified antiretroviral regimen with abacavir, lamivudine and zidovudine].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20050101

Title: Will pharmacogenomic discoveries improve HIV therapeutics?

Journal: Topics in HIV medicine : a publication of the International AIDS Society, USA 20050101

Title: The antiviral activity, mechanism of action, clinical significance and resistance of abacavir in the treatment of pediatric AIDS.

Journal: Current pharmaceutical design 20050101

Title: Failure of tenofovir + abacavir + 3TC combination; full report published, more insight.

Journal: AIDS treatment news 20050101

Title: Early virologic failure and rescue therapy of tenofovir, abacavir, and lamivudine for initial treatment of HIV-1 infection: TONUS study.

Journal: HIV clinical trials 20050101

Title: Higher virological effectiveness of NNRTI-based antiretroviral regimens containing nevirapine or efavirenz compared to a triple NRTI regimen as initial therapy in HIV-1-infected adults.

Journal: HIV clinical trials 20050101

Title: Anti-HIV agents. Abacavir once or twice daily.

Journal: TreatmentUpdate 20050101

Title: Fatal inflammatory AIDS-associated PML with high CD4 counts on HAART: a new clinical entity?

Journal: Neurology 20041228

Title: More on abacavir-induced neuropsychiatric reactions.

Journal: AIDS (London, England) 20041203

Title: Determination of abacavir in human plasma by high-performance liquid chromatography with ultraviolet detection and the analytical error function.

Journal: Biomedical chromatography : BMC 20041201

Title: Updated clinical risk factor analysis of suspected hypersensitivity reactions to abacavir.

Journal: The Annals of pharmacotherapy 20041201

Title: Short communication: benefits in the lipid profile after substitution of abacavir for Stavudine: a 48-week prospective study.

Journal: AIDS research and human retroviruses 20041201

Title: No rechallenge for abacavir.

Journal: AIDS patient care and STDs 20041201

Title: The HIV-1 nucleoside reverse transcriptase inhibitors stavudine and zidovudine alter adipocyte functions in vitro.

Journal: AIDS (London, England) 20041105

Title: Long-term efficacy after switch from protease inhibitor-containing highly active antiretroviral therapy to abacavir, lamivudine, and zidovudine.

Journal: AIDS (London, England) 20041105

Title: Membrane permeation characteristics of abacavir in human erythrocytes and human T-lymphoblastoid CD4+ CEM cells: comparison with (-)-carbovir.

Journal: Biochemical pharmacology 20041101

Title: [Risk factors for Abacavir-induced hypersensibility syndrome in the 'real world'].

Journal: Pathologie-biologie 20041101

Title: Effect of concurrent zidovudine use on the resistance pathway selected by abacavir-containing regimens.

Journal: HIV medicine 20041101

Title: Tenofovir use in a patient with a severe renal impairment.

Journal: HIV medicine 20041101

Title: HLA-B*5701 and abacavir hypersensitivity.

Journal: Pharmacogenetics 20041101

Title: Correlation between rules-based interpretation and virtual phenotype interpretation of HIV-1 genotypes for predicting drug resistance in HIV-infected individuals.

Journal: Journal of virological methods 20041001

Title: Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20041001

Title: Baseline resistance and virological outcome in patients with virological failure who start a regimen containing abacavir: EuroSIDA study.

Journal: Antiviral therapy 20041001

Title: Rate of viral rebound according to specific drugs in the regimen in 2120 patients with HIV suppression.

Journal: AIDS (London, England) 20040903

Title: Sweet's syndrome following abacavir therapy.

Journal: Journal of the American Academy of Dermatology 20040901

Title: Improved antiviral activity of the aryloxymethoxyalaninyl phosphoramidate (APA) prodrug of abacavir (ABC) is due to the formation of markedly increased carbovir 5'-triphosphate metabolite levels.

Journal: FEBS letters 20040827

Title: Phenotypic impact of HIV reverse transcriptase M184I/V mutations in combination with single thymidine analog mutations on nucleoside reverse transcriptase inhibitor resistance.

Journal: AIDS (London, England) 20040820

Title: Changes in mitochondrial DNA in peripheral blood mononuclear cells from HIV-infected patients with lipoatrophy randomized to receive abacavir.

Journal: The Journal of infectious diseases 20040815

Title: Triple-nucleoside regimens versus efavirenz.

Journal: The New England journal of medicine 20040812

Title: Triple-nucleoside regimens versus efavirenz.

Journal: The New England journal of medicine 20040812

Title: Lack of recurrence of hyperlactatemia in HIV-infected patients switched from stavudine to abacavir or zidovudine.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040801

Title: The pharmacogenetics of antiretroviral therapy: a review of studies to date.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040701

Title: Markedly diminished lipolysis and partial restoration of glucose metabolism, without changes in fat distribution after extended discontinuation of protease inhibitors in severe lipodystrophic human immunodeficient virus-1-infected patients.

Journal: The Journal of clinical endocrinology and metabolism 20040701

Title: Triple nucleoside treatment with abacavir plus the lamivudine/zidovudine combination tablet (COM) compared to indinavir/COM in antiretroviral therapy-naïve adults: results of a 48-week open-label, equivalence trial (CNA3014).

Journal: Current medical research and opinion 20040701

Title: Predictors of adherence and virologic outcome in HIV-infected patients treated with abacavir- or indinavir-based triple combination HAART also containing lamivudine/zidovudine.

Journal: Current medical research and opinion 20040701

Title: In vivo examination of hydroxyurea and the novel ribonucleotide reductase inhibitors trimidox and didox in combination with the reverse transcriptase inhibitor abacavir: suppression of retrovirus-induced immunodeficiency disease.

Journal: Antiviral research 20040601

Title: Three-year durability of dual-nucleoside versus triple-nucleoside therapy in a Thai population with HIV infection.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040601

Title: Bringing genomics to the bedside: a cost-effective pharmacogenomic test?

Journal: Pharmacogenetics 20040601

Title: Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity.

Journal: Pharmacogenetics 20040601

Title: Reversibility of lipoatrophy in HIV-infected patients 2 years after switching from a thymidine analogue to abacavir: the MITOX Extension Study.

Journal: AIDS (London, England) 20040430

Title: Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection.

Journal: The New England journal of medicine 20040429

Title: [Valuable combination partner. Great benefit for therapy naive patients].

Journal: MMW Fortschritte der Medizin 20040426

Title: Which nucleoside and nucleotide backbone combinations select for the K65R mutation in HIV-1 reverse transcriptase.

Journal: AIDS (London, England) 20040409

Title: Suppression of human immunodeficiency virus replication in human brain tissue by nucleoside reverse transcriptase inhibitors.

Journal: Journal of neurovirology 20040401

Title: Abacavir hypersensitivity reaction predicted by genetic test.

Journal: AIDS treatment news 20040326

Title: Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20040323

Title: [Pharmacogenetics. Tailored therapy in medicine -- opportunities and challenges].

Journal: Praxis 20040303

Title: Comment: Reasons for early abacavir discontinuation in HIV-infected patients.

Journal: The Annals of pharmacotherapy 20040301

Title: Severe anemia secondary to a probable drug interaction between zidovudine and valproic acid.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040301

Title: Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations.

Journal: Pharmacogenomics 20040301

Title: Life-threatening reaction after first ever dose of abacavir in an HIV-1-infected patient.

Journal: AIDS (London, England) 20040220

Title: Managing HIV lipoatrophy.

Journal: Lancet (London, England) 20040207

Title: Genotypic resistance profile in treatment-experienced HIV-infected individuals after abacavir and efavirenz salvage regimen.

Journal: Antiviral research 20040201

Title: Antiviral efficacy of abacavir in antiretroviral therapy-experienced adults harbouring HIV-1 with specific patterns of resistance to nucleoside reverse transcriptase inhibitors.

Journal: Antiviral therapy 20040201

Title: Development of abacavir hypersensitivity reaction after rechallenge in a previously asymptomatic patient.

Journal: AIDS (London, England) 20040123

Title: Improvement in lipoatrophy associated with highly active antiretroviral therapy in human immunodeficiency virus-infected patients switched from stavudine to abacavir or zidovudine: the results of the TARHEEL study.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20040115

Title: Six-week randomized controlled trial to compare the tolerabilities, pharmacokinetics, and antiviral activities of GW433908 and amprenavir in human immunodeficiency virus type 1-infected patients.

Journal: Antimicrobial agents and chemotherapy 20040101

Title: The NEAT study: a 48-week open-label study to compare the antiviral efficacy and safety of GW433908 versus nelfinavir in antiretroviral therapy-naive HIV-1-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040101

Title: Intensification of antiretroviral therapy accelerates the decay of the HIV-1 latent reservoir and decreases, but does not eliminate, ongoing virus replication.

Journal: Journal of acquired immune deficiency syndromes (1999) 20040101

Title: Determination of Abacavir in maternal plasma, amniotic fluid, fetal and placental tissues by a polarity switching liquid chromatography/tandem mass spectrometry method.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Can the peripheral blood monocyte count be used as a marker of CSF resistance to antiretroviral drugs?

Journal: Journal of neurovirology 20040101

Title: The reverse transcriptase (RT) mutation V118I is associated with virologic failure on abacavir-based antiretroviral treatment (ART) in HIV-1 infection.

Journal: Scandinavian journal of infectious diseases 20040101

Title: Adherence, quality of life, and general satisfaction with co-formulated zidovudine, lamivudine, and abacavir on antiretroviral-experienced patients.

Journal: HIV clinical trials 20040101

Title: Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex.

Journal: AIDS (London, England) 20040101

Title: EU issues warning about HAART regimen.

Journal: AIDS patient care and STDs 20040101

Title: Simplified therapy with zidovudine, lamivudine, and abacavir for very nonadherent, treatment-failing patients.

Journal: HIV clinical trials 20040101

Title: Abacavir/lamivudine/zidovudine continues to be a valid and useful antiretroviral regimen.

Journal: The Annals of pharmacotherapy 20040101

Title: Pharmacogenetics to predict drug-related adverse events.

Journal: Toxicologic pathology 20040101

Title: K65R-associated virologic failure in HIV-infected patients receiving tenofovir-containing triple nucleoside/nucleotide reverse transcriptase inhibitor regimens.

Journal: MedGenMed : Medscape general medicine 20040101

Title: Antiretrovirals, Part II: focus on non-protease inhibitor antiretrovirals (NRTIs, NNRTIs, and fusion inhibitors).

Journal: Psychosomatics 20040101

Title: [Simplification to lamivudine, zidovudine, and abacavir therapy: impact on adherence, clinical outcome, and economic issues].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20040101

Title: Efficacy and safety of abacavir plus lamivudine versus didanosine plus stavudine when combined with a protease inhibitor, a nonnucleoside reverse transcriptase inhibitor, or both in HIV-1 positive antiretroviral-naive persons.

Journal: HIV clinical trials 20040101

Title: Change to abacavir-lamivudine-tenofovir combination treatment in patients with HIV-1 who had complete virological suppression.

Journal: Lancet (London, England) 20031213

Title: TMC125 exerts similar initial antiviral potency as a five-drug, triple class antiretroviral regimen.

Journal: AIDS (London, England) 20031205

Title: [Delayed drug sensitivity].

Journal: Revista clinica espanola 20031201

Title: A randomized trial of nelfinavir and abacavir in combination with efavirenz and adefovir dipivoxil in HIV-1-infected persons with virological failure receiving indinavir.

Journal: Antiviral therapy 20031201

Title: The continuing evolution of HIV therapy.

Journal: The AIDS reader 20031201

Title: Meta-analysis of randomized controlled trials of simplified versus continued protease inhibitor-based antiretroviral therapy in HIV-1-infected patients.

Journal: AIDS (London, England) 20031121

Title: Safety and efficacy of switching to alternative nucleoside analogues following symptomatic hyperlactatemia and lactic acidosis.

Journal: AIDS (London, England) 20031121

Title: Unusual clinical presentation of hypersensitivity reaction to abacavir.

Journal: AIDS (London, England) 20031107

Title: Triple combinations regimens for HIV.

Journal: The Lancet. Infectious diseases 20031101

Title: Twice-daily Trizivir versus Combivir-abacavir in antiretroviral-experienced adults with human immunodeficiency virus-1 infection: a formulation-switch trial.

Journal: Pharmacotherapy 20031101

Title: Abacavir plus lamivudine: a thymidine analogue-sparing NRTI backbone.

Journal: The AIDS reader 20031101

Title: Meeting notes from the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Abacavir as initial therapy and as a once-daily drug.

Journal: AIDS clinical care 20031101

Title: Meeting notes from the 43rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Suboptimal response to once-daily abacavir + 3TC + tenofovir.

Journal: AIDS clinical care 20031101

Title: Early nonresponse for tenofovir regimen.

Journal: AIDS patient care and STDs 20031101

Title: [Hypersensitive reaction to abacavir or syphilitic hepatitis?].

Journal: Presse medicale (Paris, France : 1983) 20031011

Title: Reasons for early abacavir discontinuation in HIV-infected patients.

Journal: The Annals of pharmacotherapy 20031001

Title: Epidemiological risk factors for hypersensitivity reactions to abacavir.

Journal: HIV medicine 20031001

Title: Impact of an educational program on efficacy and adherence with a twice-daily lamivudine/zidovudine/abacavir regimen in underrepresented HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20031001

Title: Warning issued on non-response rates.

Journal: AIDS patient care and STDs 20031001

Title: Anti-HIV agents. Trying times for tenofovir and abacavir.

Journal: TreatmentUpdate 20031001

Title: Anti-HIV agents. Abacavir--as good as AZT?

Journal: TreatmentUpdate 20031001

Title: Anti-HIV agents. Abacavir only once-daily.

Journal: TreatmentUpdate 20031001

Title: Anti-HIV agents. Who gets abacavir allergies?

Journal: TreatmentUpdate 20031001

Title: Low efficacy and high frequency of adverse events in a randomized trial of the triple nucleoside regimen abacavir, stavudine and didanosine.

Journal: AIDS (London, England) 20030926

Title: Substitution of nevirapine, efavirenz, or abacavir for protease inhibitors in patients with human immunodeficiency virus infection.

Journal: The New England journal of medicine 20030911

Title: [Antiretroviral-induced toxiderma in HIV-infected patients].

Journal: Presse medicale (Paris, France : 1983) 20030906

Title: Factors associated with maintenance of long-term plasma human immunodeficiency virus RNA suppression.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030901

Title: GlaxoSmithKline halts AIDS study.

Journal: The Lancet. Infectious diseases 20030901

Title: Perspectives on HAART: switch maintenance therapy.

Journal: International journal of STD & AIDS 20030901

Title: Capillary electrophoresis-ion trap mass spectrometry analysis of Ziagen and its phosphorylated metabolites.

Journal: Electrophoresis 20030901

Title: Meeting notes from the 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment. Exploring once-daily tenofovir + 3TC + abacavir: an argument for clinical-trials-based data.

Journal: AIDS clinical care 20030901

Title: Clinically relevant interpretation of genotype for resistance to abacavir.

Journal: AIDS (London, England) 20030815

Title: Viral dynamics and their relations to baseline factors and longer term virologic responses in treatment-naive HIV-1-infected patients receiving abacavir in combination with HIV-1 protease inhibitors.

Journal: Journal of acquired immune deficiency syndromes (1999) 20030815

Title: [Opiates withdrawal syndrome after treatment with zidovudine + lamivudine + abcavir in patients with positivity for HIV and treated with methadone].

Journal: Revista clinica espanola 20030801

Title: Susceptibility of human T cell leukemia virus type I to nucleoside reverse transcriptase inhibitors.

Journal: The Journal of infectious diseases 20030801

Title: A controlled Phase II trial assessing three doses of enfuvirtide (T-20) in combination with abacavir, amprenavir, ritonavir and efavirenz in non-nucleoside reverse transcriptase inhibitor-naive HIV-infected adults.

Journal: Antiviral therapy 20030801

Title: Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients.

Journal: Antiviral therapy 20030801

Title: Early intensification with abacavir in subjects at high risk for incomplete viral suppression.

Journal: Antiviral therapy 20030801

Title: Failure of combination abacavir + tenofovir + lamivudine (3TC).

Journal: AIDS treatment news 20030725

Title: Comparison of symptoms of influenza A with abacavir-associated hypersensitivity reaction.

Journal: International journal of STD & AIDS 20030701

Title: AACTG A5095, Trizivir, and the role of all-nucleoside regimens: an editorial.

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20030701

Title: Abandon Trizivir when it's working well? A rebuttal.

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20030701

Title: Generation of stable cell lines expressing Lamivudine-resistant hepatitis B virus for antiviral-compound screening.

Journal: Antimicrobial agents and chemotherapy 20030601

Title: Management of severely immunocompromised human immunodeficiency virus type 1-infected African orphans with structured treatment interruption: another kind of salvage therapy.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030601

Title: Cutaneous manifestations of antiviral therapy.

Journal: Journal of the American Academy of Dermatology 20030601

Title: A 48-week, randomized, open-label comparison of three abacavir-based substitution approaches in the management of dyslipidemia and peripheral lipoatrophy.

Journal: Journal of acquired immune deficiency syndromes (1999) 20030501

Title: Randomized, controlled, 48-week study of switching stavudine and/or protease inhibitors to combivir/abacavir to prevent or reverse lipoatrophy in HIV-infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20030501

Title: Pharmacogenetics: a practical role in predicting antiretroviral drug toxicity?

Journal: Journal of HIV therapy 20030501

Title: Mechanisms of drug hypersensitivity in HIV-infected patients: the role of the immune system.

Journal: Journal of HIV therapy 20030501

Title: Replacing stavudine by abacavir reduces lactate levels and may improve lipoatrophy.

Journal: AIDS (London, England) 20030411

Title: Abacavir arm stopped in clinical trial.

Journal: AIDS treatment news 20030404

Title: Antiretroviral therapy-induced psychosis: case report and brief review of the literature.

Journal: HIV medicine 20030401

Title: HIV-1 reverse transcriptase and protease resistance mutations selected during 16-72 weeks of therapy in isolates from antiretroviral therapy-experienced patients receiving abacavir/efavirenz/amprenavir in the CNA2007 study.

Journal: Antiviral therapy 20030401

Title: Salvage therapy with abacavir in HIV-1-infected patients with previously documented M184V mutation: a possibility of NRTI recycling.

Journal: Antiviral therapy 20030401

Title: Triple nucleoside combination zidovudine/lamivudine/abacavir versus zidovudine/lamivudine/nelfinavir as first-line therapy in HIV-1-infected adults: a randomized trial.

Journal: Antiviral therapy 20030401

Title: K65R with and without S68: a new resistance profile in vivo detected in most patients failing abacavir, didanosine and stavudine.

Journal: Antiviral therapy 20030401

Title: Enanthema as the first clinical manifestation of abacavir hypersensitivity reaction: a case report.

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20030301

Title: Effect of co-formulated zidovudine, lamivudine and abacavir (Trizivir) on antiretroviral-naive patients presenting with advanced HIV-1 infection.

Journal: AIDS (London, England) 20030214

Title: Simplification of protease inhibitor-containing regimens with efavirenz, nevirapine or abacavir: safety and efficacy outcomes.

Journal: Antiviral therapy 20030201

Title: Thymidine analogue-sparing highly active antiretroviral therapy (HAART).

Journal: Journal of HIV therapy 20030201

Title: Predictive value of provirus load and DNA human immunodeficiency virus genotype for successful abacavir-based simplified therapy.

Journal: The Journal of infectious diseases 20030101

Title: Lamivudine/zidovudine/abacavir: triple combination tablet.

Journal: Drugs 20030101

Title: Compact quadruple therapy with the lamivudine/zidovudine combination tablet plus abacavir and efavirenz, followed by the lamivudine/zidovudine/abacavir triple nucleoside tablet plus efavirenz in treatment-naïve HIV-infected adults.

Journal: HIV clinical trials 20030101

Title: Clinical vignette in antiretroviral therapy: rash illness.

Journal: Journal of the International Association of Physicians in AIDS Care (Chicago, Ill. : 2002) 20030101

Title: Viread, Epivir and Ziagen combination: failure in naïve patients with a once-daily regimen.

Journal: Positively aware : the monthly journal of the Test Positive Aware Network 20030101

Title: Thrombotic thrombocytopenic purpura associated with abacavir in a patient with HIV infection.

Journal: Journal of intensive care medicine 20030101

Title: Time-dependent changes in HIV nucleoside analogue phosphorylation and the effect of hydroxyurea.

Journal: AIDS (London, England) 20021206

Title: Evolution of antiretroviral phenotypic and genotypic drug resistance in antiretroviral-naive HIV-1-infected children treated with abacavir/lamivudine, zidovudine/lamivudine or abacavir/zidovudine, with or without nelfinavir (the PENTA 5 trial).

Journal: Antiviral therapy 20021201

Title: Chronic cough induced by abacavir apart from a context of hypersensitivity.

Journal: Allergie et immunologie 20021201

Title: The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes.

Journal: Chemico-biological interactions 20021110

Title: Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir.

Journal: AIDS (London, England) 20021108

Title: The importance of being modest--reflections on the pharmacogenetics of abacavir.

Journal: Pharmacogenomics 20021101

Title: Neuropsychiatric reaction induced by abacavir.

Journal: The American journal of medicine 20021101

Title: Mechanistic studies to understand the progressive development of resistance in human immunodeficiency virus type 1 reverse transcriptase to abacavir.

Journal: The Journal of biological chemistry 20021025

Title: The prevalence and determinants of the K65R mutation in HIV-1 reverse transcriptase in tenofovir-naive patients.

Journal: AIDS (London, England) 20021018

Title: Stevens-Johnson syndrome associated with abacavir therapy.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021001

Title: Phenotypic and genotypic HIV-1 drug resistance assays provide complementary information.

Journal: Journal of acquired immune deficiency syndromes (1999) 20021001

Title: Efficacy and safety of a quadruple combination Combivir + abacavir + efavirenz regimen in antiretroviral treatment-naive HIV-1-infected adults: La Francilienne.

Journal: Journal of acquired immune deficiency syndromes (1999) 20021001

Title: The abacavir hypersensitivity reaction: a review.

Journal: Clinical therapeutics 20021001

Title: The addition of mycophenolate mofetil to antiretroviral therapy including abacavir is associated with depletion of intracellular deoxyguanosine triphosphate and a decrease in plasma HIV-1 RNA.

Journal: Journal of acquired immune deficiency syndromes (1999) 20020901

Title: Disseminated intravascular coagulation as a manifestation of abacavir hypersensitivity reaction.

Journal: AIDS (London, England) 20020816

Title: FDA notifications. Product tampering labels Ziagen as Combivir.

Journal: AIDS alert 20020801

Title: Dual vs single protease inhibitor therapy following antiretroviral treatment failure: a randomized trial.

Journal: JAMA 20020710

Title: Abacavir substitution for nucleoside analogs in patients with HIV lipoatrophy: a randomized trial.

Journal: JAMA 20020710

Title: Hyperlactataemia and lactic acidosis during antiretroviral therapy: relevance, reproducibility and possible risk factors.

Journal: AIDS (London, England) 20020705

Title: Dose proportional inhibition of HIV-1 replication by mycophenolic acid and synergistic inhibition in combination with abacavir, didanosine, and tenofovir.

Journal: Antiviral research 20020701

Title: Effect of combination antiretroviral therapy on cerebrospinal fluid HIV RNA, HIV resistance, and clinical manifestations of encephalopathy.

Journal: The Journal of pediatrics 20020701

Title: Genome-based pharmacogenetics and the pharmaceutical industry.

Journal: Nature reviews. Drug discovery 20020701

Title: Safety of abacavir therapy after temporary interruptions in patients without hypersensitivity reactions to the drug.

Journal: AIDS (London, England) 20020614

Title: Intracellular carbovir triphosphate levels in patients taking abacavir once a day.

Journal: AIDS (London, England) 20020524

Title: Therapeutic vaccination in primary HIV infection, the Quest trial.

Journal: Vaccine 20020506

Title: Efficacy and safety of abacavir plus efavirenz as a salvage regimen in HIV-infected individuals after 48 weeks.

Journal: AIDS (London, England) 20020503

Title: Switching to zidovudine plus lamivudine plus abacavir maintains viral suppression in patients with high viral load before antiretroviral therapy: a retrospective clinical cohort analysis.

Journal: AIDS (London, England) 20020503

Title: A randomized trial of simplified maintenance therapy with abacavir, lamivudine, and zidovudine in human immunodeficiency virus infection.

Journal: The Journal of infectious diseases 20020501

Title: Abacavir hypersensitivity reaction.

Journal: AIDS patient care and STDs 20020501

Title: HLA B57 and abacavir hypersensitivity.

Journal: The Hopkins HIV report : a bimonthly newsletter for healthcare providers 20020501

Title: Abacavir hypersensitivity reaction.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020415

Title: Scientists find some genes a bad omen for anti-HIV drug.

Journal: JAMA 20020403

Title: Tenofovir exhibits low cytotoxicity in various human cell types: comparison with other nucleoside reverse transcriptase inhibitors.

Journal: Antiviral research 20020401

Title: Risk factor analysis of hypersensitivity reactions to abacavir.

Journal: Clinical therapeutics 20020401

Title: Genetic variations in HLA-B region and hypersensitivity reactions to abacavir.

Journal: Lancet (London, England) 20020330

Title: Improved long-term suppression of HIV-1 replication with a triple-class multidrug regimen compared with standard of care antiretroviral therapy.

Journal: AIDS (London, England) 20020329

Title: Parallel decline of CD8+/CD38++ T cells and viraemia in response to quadruple highly active antiretroviral therapy in primary HIV infection.

Journal: AIDS (London, England) 20020308

Title: Individualising HIV treatment--pharmacogenetics and immunogenetics.

Journal: Lancet (London, England) 20020302

Title: Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir.

Journal: Lancet (London, England) 20020302

Title: Comparison of dual nucleoside-analogue reverse-transcriptase inhibitor regimens with and without nelfinavir in children with HIV-1 who have not previously been treated: the PENTA 5 randomised trial.

Journal: Lancet (London, England) 20020302

Title: Mutations in HIV-1 reverse transcriptase during therapy with abacavir, lamivudine and zidovudine in HIV-1-infected adults with no prior antiretroviral therapy.

Journal: Antiviral therapy 20020301

Title: Switching to abacavir to reduce fat wasting.

Journal: TreatmentUpdate 20020301

Title: Using abacavir to avoid lipid problems.

Journal: TreatmentUpdate 20020301

Title: Response to lamivudine-zidovudine plus abacavir twice daily in antiretroviral-naive, incarcerated patients with HIV infection taking directly observed treatment.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020215

Title: Abacavir expanded access program for adult patients infected with human immunodeficiency virus type 1.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020215

Title: HIV-1 genotype and phenotype correlate with virological response to abacavir, amprenavir and efavirenz in treatment-experienced patients.

Journal: AIDS (London, England) 20020215

Title: Efficacy of highly active antiretroviral therapy in HIV-1 infected children.

Journal: The Lancet. Infectious diseases 20020201

Title: Evidence of immune reconstitution in antiretroviral drug-experienced patients with advanced HIV disease.

Journal: AIDS research and human retroviruses 20020120

Title: Combined effect of zidovudine (ZDV), lamivudine (3TC) and abacavir (ABC) antiretroviral therapy in suppressing in vitro FIV replication.

Journal: Antiviral research 20020101

Title: Kawasaki-like syndrome: abacavir hypersensitivity?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020101

Title: Antiretroviral rounds. A very discordant response.

Journal: AIDS clinical care 20020101

Title: Vertigo and abacavir.

Journal: AIDS patient care and STDs 20020101

Title: Easier abacavir regimen has promising results.

Journal: AIDS alert 20020101

Title: 'Fine tuning' HIV therapy. Report on the 9th Conference on Retroviruses and Opportunistic Infections.

Journal: Positive living (Los Angeles, Calif.) 20020101

Title: Selected topics from the 9th Conference on Retroviruses and Opportunistic Infections.

Journal: HIV clinical trials 20020101

Title: Prednisolone does not prevent hypersensitivity reactions in antiretroviral drug regimens containing abacavir with or without nevirapine.

Journal: AIDS (London, England) 20011207

Title: Agranulocytosis and fever seven weeks after starting abacavir.

Journal: AIDS (London, England) 20011207

Title: Understanding drug hypersensitivity: what to look for when prescribing abacavir.

Journal: The AIDS reader 20011201

Title: Editorial comment: the challenge of prescribing abacavir.

Journal: The AIDS reader 20011201

Title: Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20011120

Title: Lipodystrophy in HIV-1-positive patients is associated with insulin resistance in multiple metabolic pathways.

Journal: AIDS (London, England) 20011109

Title: The role of NNRTIs in antiretroviral combination therapy: an introduction.

Journal: International journal of STD & AIDS 20011101

Title: Improvement of HAART-associated insulin resistance and dyslipidemia after replacement of protease inhibitors with abacavir.

Journal: European journal of medical research 20011029

Title: High-performance liquid chromatographic assay for abacavir and its two major metabolites in human urine and cerebrospinal fluid.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011025

Title: Penetration of the nucleoside analogue abacavir into the genital tract of men infected with human immunodeficiency virus type 1.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20011015

Title: Methadone blood concentrations are decreased by the administration of abacavir plus amprenavir.

Journal: Therapeutic drug monitoring 20011001

Title: Hypersensitivity related to abacavir in two members of a family.

Journal: The Annals of pharmacotherapy 20011001

Title: Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir.

Journal: Clinical therapeutics 20011001

Title: HIV protease inhibitor substitution in patients with lipodystrophy: a randomized, controlled, open-label, multicentre study.

Journal: AIDS (London, England) 20010928

Title: Comparison of genotypic and phenotypic resistance patterns of human immunodeficiency virus type 1 isolates from patients treated with stavudine and didanosine or zidovudine and lamivudine.

Journal: The Journal of infectious diseases 20010915

Title: [Acceptance of antiretroviral therapy. HIV-infected patients assess convenient triple combination].

Journal: MMW Fortschritte der Medizin 20010906

Title: Transport characteristics of the anti-human immunodeficiency virus nucleoside analog, abacavir, into brain and cerebrospinal fluid.

Journal: The Journal of pharmacology and experimental therapeutics 20010901

Title: Pharmacokinetics of abacavir in HIV-1-infected patients with impaired renal function.

Journal: Nephron 20010901

Title: Antiviral activity of cyclosaligenyl prodrugs of acyclovir, carbovir and abacavir.

Journal: Antiviral chemistry & chemotherapy 20010901

Title: Simplification with abacavir-based triple nucleoside therapy versus continued protease inhibitor-based highly active antiretroviral therapy in HIV-1-infected patients with undetectable plasma HIV-1 RNA.

Journal: AIDS (London, England) 20010817

Title: The abacavir hypersensitivity reaction and interruptions in therapy.

Journal: AIDS (London, England) 20010706

Title: Resistance and cross-resistance to abacavir.

Journal: HIV medicine 20010701

Title: Antiretroviral activity and safety of abacavir in combination with selected HIV-1 protease inhibitors in therapy-naive HIV-1-infected adults.

Journal: Antiviral therapy 20010601

Title: Treatment intensification with abacavir in HIV-infected patients with at least 12 weeks previous lamivudine/zidovudine treatment.

Journal: Antiviral therapy 20010601

Title: A dose-ranging study to evaluate the antiretroviral activity and safety of amprenavir alone and in combination with abacavir in HIV-infected adults with limited antiretroviral experience.

Journal: Antiviral therapy 20010601

Title: Influenza and human immunodeficiency virus infection: absence of HIV progression after acute influenza infection.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010501

Title: Choosing which nuke to use first.

Journal: The AIDS reader 20010501

Title: Drifting agenda for federal treatment research.

Journal: GMHC treatment issues : the Gay Men's Health Crisis newsletter of experimental AIDS therapies 20010501

Title: Resistant to everything.

Journal: AIDS clinical care 20010501

Title: Simultaneous determination of Ziagen and its phosphorylated metabolites by ion-pairing high-performance liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010425

Title: HIV-1 reverse transcriptase sequence in plasma and cerebrospinal fluid of patients with AIDS dementia complex treated with Abacavir.

Journal: AIDS (London, England) 20010413

Title: [Observational study with abacavir. Decreased viral load and quality of life improves].

Journal: MMW Fortschritte der Medizin 20010402

Title: [Determining resistance in HIV therapy. Careful interpretation only].

Journal: MMW Fortschritte der Medizin 20010402

Title: An open-label randomized trial to evaluate different therapeutic strategies of combination therapy in HIV-1 infection: design, rationale, and methods of the initio trial.

Journal: Controlled clinical trials 20010401

Title: A comparison of the steady-state pharmacokinetics and safety of abacavir, lamivudine, and zidovudine taken as a triple combination tablet and as abacavir plus a lamivudine-zidovudine double combination tablet by HIV-1-infected adults.

Journal: Pharmacotherapy 20010401

Title: Open-label phase II trial of amprenavir, abacavir, and fixed-dose zidovudine/lamivudine in newly and chronically HIV-1--infected patients.

Journal: Journal of acquired immune deficiency syndromes (1999) 20010401

Title: A near-fatal hypersensitivity reaction to abacavir: case report and literature review.

Journal: The AIDS reader 20010401

Title: Abacavir-lamivudine-zidovudine vs indinavir-lamivudine-zidovudine in antiretroviral-naive HIV-infected adults: A randomized equivalence trial.

Journal: JAMA 20010307

Title: Increased turnover of CCR5+ and redistribution of CCR5- CD4 T lymphocytes during primary human immunodeficiency virus type 1 infection.

Journal: The Journal of infectious diseases 20010301

Title: International perspectives on antiretroviral resistance. Nucleoside reverse transcriptase inhibitor resistance.

Journal: Journal of acquired immune deficiency syndromes (1999) 20010301

Title: Abacavir/lamivudine/zidovudine as a combined formulation tablet: bioequivalence compared with each component administered concurrently and the effect of food on absorption.

Journal: Journal of clinical pharmacology 20010301

Title: Phase III trials for new PI.

Journal: AIDS patient care and STDs 20010301

Title: Twice-daily triple nucleoside intensification treatment with lamivudine-zidovudine plus abacavir sustains suppression of human immunodeficiency virus type 1: results of the TARGET Study.

Journal: The Journal of infectious diseases 20010215

Title: Severe anaphylactic shock after rechallenge with abacavir without preceding hypersensitivity.

Journal: AIDS (London, England) 20010126

Title: Abacavir and diabetes.

Journal: The New England journal of medicine 20010111

Title: Liquid chromatographic assay for simultaneous determination of abacavir and mycophenolic acid in human plasma using dual spectrophotometric detection.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010105

Title: A randomized, double-blind study of triple nucleoside therapy of abacavir, lamivudine, and zidovudine versus lamivudine and zidovudine in previously treated human immunodeficiency virus type 1-infected children. The CNAA3006 Study Team.

Journal: Pediatrics 20010101

Title: Trizivir on the market.

Journal: Trends in microbiology 20010101

Title: Triple-drug tablet approved for HIV infection.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20010101

Title: Triple nuke therapy--results after one year.

Journal: TreatmentUpdate 20010101

Title: Abacavir sulfate, lamivudine, and zidovudine (Trizivir).

Journal: The Journal of the Association of Nurses in AIDS Care : JANAC 20010101

Title: Intensification of stable background therapy with abacavir in antiretroviral therapy experienced patients: 48-week data from a randomized, double-blind trial.

Journal: HIV medicine 20010101

Title: Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.

Journal: AIDS research and human retroviruses 20000410

Title: Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity.

Journal: Journal of acquired immune deficiency syndromes (1999) 19990815

Title: Four new antiretroviral medications will soon offer more options to HIV patients.

Journal: Faculty notes (New Orleans, La.) 19980101

Title: 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity.

Journal: Antimicrobial agents and chemotherapy 19970501

Title: Combination of mutations in human immunodeficiency virus type 1 reverse transcriptase required for resistance to the carbocyclic nucleoside 1592U89.

Journal: Antimicrobial agents and chemotherapy 19970501

Title: Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89.

Journal: Antimicrobial agents and chemotherapy 19970501

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Tags:216699-07-9 Molecular Formula|216699-07-9 MDL|216699-07-9 SMILES|216699-07-9 4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-(1S,4R)-2-cyclopentene-1-methanolsulfate