Home Thiazoles 137-00-8
137-00-8,MFCD18207669
Catalog No.:AA0012LV

137-00-8 | 4-Methyl-5-thiazoleethanol

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5g
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in stock  
$5.00   $3.00
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10g
95%
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$6.00   $4.00
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25g
95%
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$13.00   $9.00
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100g
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0012LV
Chemical Name:
4-Methyl-5-thiazoleethanol
CAS Number:
137-00-8
Molecular Formula:
C6H9NOS
Molecular Weight:
143.2068
MDL Number:
MFCD18207669
SMILES:
Cc1ncsc1CCO
FEMA Number:
3204
Properties
Properties
 
BP:
135°C at 760 mmHg  
Form:
Liquid  
Refractive Index:
n20/D 1.550(lit.)  
Solubility:
alcohol: soluble(lit.)  
Stability:
Stench  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
89.1  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
0.8  

Upstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,2015,vol.137,#30,p.9571-9574

[1]JournaloftheAmericanChemicalSociety,1949,vol.71,p.1985,1986

[2]YakugakuZasshi,1959,vol.79,p.143,149

[3]Chem.Abstr.,1959,p.13168

[4]OrganicProcessResearchandDevelopment,2008,vol.12,#4,p.736-739

[1]JournaloftheAmericanChemicalSociety,1982,vol.104,#18,p.4934-4943

[2]Patent:WO2011/132048,2011,A1,.Locationinpatent:Page/Pagecolumn39

[3]Patent:EP1186604,2002,A1,.Locationinpatent:Page114

[4]OrganicProcessResearchandDevelopment,2008,vol.12,#4,p.736-739

[1]Patent:US2017/158680,2017,A1,.Locationinpatent:Paragraph0385

[2]JournaloftheAmericanChemicalSociety,2001,vol.123,#6,p.1017-1022

[3]PharmaceuticalChemistryJournal,1999,vol.33,#12,p.658-660

[4]JournaloftheAmericanChemicalSociety,1982,vol.104,#18,p.4934-4943

[5]BioorganicandMedicinalChemistry,2016,vol.24,#22,p.5988-6003

[6]BioorganicandMedicinalChemistryLetters,2008,vol.18,#6,p.2206-2210

[7]ZhurnalObshcheiKhimii,1956,vol.26,p.3445,3448;engl.Ausg.S.3835,3837

[8]YakugakuZasshi,1956,vol.76,p.337

[9]Chem.Abstr.,1956,p.13875

[10]JournaloftheAmericanChemicalSociety,1936,vol.58,p.1803

[11]BulletinoftheAgriculturalChemicalSocietyofJapan,1937,vol.13,p.47

[12]Chem.Abstr.,1937,p.7435

[13]ChemicalandPharmaceuticalBulletin,1971,vol.19,p.2229-2234

[14]JournalofMedicinalChemistry,2012,vol.55,#15,p.6784-6801

[1]JournaloftheAmericanChemicalSociety,1935,vol.57,p.1849

[2]BulletinoftheAgriculturalChemicalSocietyofJapan,1937,vol.13,p.47

[3]Chem.Abstr.,1937,p.7435

Downstream Synthesis Route

[1]ZhurnalObshcheiKhimii,1941,vol.11,p.1019,1021    Chem.Abstr.,1942,p.6542

137-00-8   
3-(chloromethyl)-6-methylpyridin-2-ylaminehydrochloride 
  13860-66-7 

[1]BioorganicandMedicinalChemistryLetters,2008,vol.18,p.2206-2210

[2]Patent:WO2005/95344,2005,A1.Locationinpatent:Page/Pagecolumn37

[3]ChemischeBerichte,1953,vol.86,p.461,464

[1]Hoppe-Seyler'sZeitschriftfurPhysiologischeChemie,1939,vol.259,p.48,50

[2]YakugakuZasshi/JournalofthePharmaceuticalSocietyofJapan,1951,vol.71,p.69,70,71    Chem.Abstr.,1951,p.8537

[3]JournaloftheAmericanChemicalSociety,2008,vol.130,p.3276-3277

[1]OrganicSyntheses,1984,vol.62,p.170-170

[2]JournalofBiologicalChemistry,1947,vol.167,p.699,701,703

[3]Patent:US4894483,1990,A

[1]Theranostics,2019,vol.9,p.6532-6549

[2]EuropeanJournalofMedicinalChemistry,2011,vol.46,p.3651-3661

[3]Molecules,2016,vol.21

[4]Patent:CN106543194,2017,A.Locationinpatent:Paragraph0079;0080;0081

[5]Tetrahedron,2008,vol.64,p.8797-8800

[6]JournaloftheAmericanChemicalSociety,1935,vol.57,p.1849

[7]Patent:CN107286114,2017,A.Locationinpatent:Paragraph0103;0108;0109

Literature

Title: Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

Journal: Journal of medicinal chemistry 20120809

Title: Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).

Journal: PloS one 20120101

Title: Purification, crystallization and preliminary X-ray diffraction analysis of ThiM from Staphylococcus aureus.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20110401

Title: Purification, crystallization and preliminary X-ray diffraction analysis of the thiaminase type II from Staphylococcus aureus.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20110101

Title: Thiamin (vitamin B1) biosynthesis and regulation: a rich source of antimicrobial drug targets?

Journal: International journal of biological sciences 20110101

Title: Exploring metabolic pathway reconstruction and genome-wide expression profiling in Lactobacillus reuteri to define functional probiotic features.

Journal: PloS one 20110101

Title: Global transcriptome response in Lactobacillus sakei during growth on ribose.

Journal: BMC microbiology 20110101

Title: Identification of inhibitors against Mycobacterium tuberculosis thiamin phosphate synthase, an important target for the development of anti-TB drugs.

Journal: PloS one 20110101

Title: Domain organization in Candida glabrata THI6, a bifunctional enzyme required for thiamin biosynthesis in eukaryotes.

Journal: Biochemistry 20101116

Title: Variation of some fermentative sulfur compounds in Italian 'millesime' classic sparkling wines during aging and storage on lees.

Journal: Journal of agricultural and food chemistry 20100908

Title: Synthesis and odor evaluation of five new sulfur-containing ester flavor compounds from 4-ethyloctanoic acid.

Journal: Molecules (Basel, Switzerland) 20100729

Title: New structural insights and molecular-modelling studies of 4-methyl-5-beta-hydroxyethylthiazole kinase from Pyrococcus horikoshii OT3 (PhThiK).

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20091001

Title: The ADP-dependent sugar kinase family: kinetic and evolutionary aspects.

Journal: IUBMB life 20090701

Title: Combining specificity determining and conserved residues improves functional site prediction.

Journal: BMC bioinformatics 20090101

Title: The vitamin B1 metabolism of Staphylococcus aureus is controlled at enzymatic and transcriptional levels.

Journal: PloS one 20090101

Title: The genes and enzymes involved in the biosynthesis of thiamin and thiamin diphosphate in yeasts.

Journal: Cellular & molecular biology letters 20080101

Title: A new thiamin salvage pathway.

Journal: Nature chemical biology 20070801

Title: Non-empirical study of the phosphorylation reaction catalyzed by 4-methyl-5-beta-hydroxyethylthiazole kinase: relevance of the theory of intermolecular interactions.

Journal: Journal of molecular modeling 20070701

Title: Thiazole synthase from Escherichia coli: an investigation of the substrates and purified proteins required for activity in vitro.

Journal: The Journal of biological chemistry 20070615

Title: Effect of pH on the Maillard reaction of [13C5]xylose, cysteine, and thiamin.

Journal: Journal of agricultural and food chemistry 20070221

Title: Structure of the thiazole biosynthetic enzyme THI1 from Arabidopsis thaliana.

Journal: The Journal of biological chemistry 20061013

Title: Recent progress in understanding thiamin biosynthesis and its genetic regulation in Saccharomyces cerevisiae.

Journal: Applied microbiology and biotechnology 20060801

Title: Biosynthesis of thiamin thiazole: determination of the regiochemistry of the S/O acyl shift by using 1,4-dideoxy-D-xylulose-5-phosphate.

Journal: Angewandte Chemie (International ed. in English) 20060519

Title: Vitamin B1 de novo synthesis in the human malaria parasite Plasmodium falciparum depends on external provision of 4-amino-5-hydroxymethyl-2-methylpyrimidine.

Journal: Biological chemistry 20060101

Title: Chromatographic study of photolysis of aqueous cyanocobalamin solution in presence of vitamins B and C.

Journal: Pakistan journal of pharmaceutical sciences 20040101

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