533-45-9,MFCD00868012
Catalog No.:AA00DDYE

533-45-9 | Clomethiazole

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
98%(HPLC)
in stock  
$81.00   $57.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00DDYE
Chemical Name:
Clomethiazole
CAS Number:
533-45-9
Molecular Formula:
C6H8ClNS
Molecular Weight:
161.6524
MDL Number:
MFCD00868012
SMILES:
Cc1ncsc1CCCl
Properties
Computed Properties
 
Complexity:
89.1  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.1  

Literature

Title: Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.

Journal: Toxicology letters 20160122

Title: Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver.

Journal: Chemico-biological interactions 20141005

Title: CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway.

Journal: PloS one 20140101

Title: Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

Journal: Journal of medicinal chemistry 20120809

Title: Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20120801

Title: Heart rate turbulence during acute alcohol withdrawal syndrome.

Journal: Drug and alcohol dependence 20120501

Title: Substitution therapy for alcoholism: time for a reappraisal?

Journal: Journal of psychopharmacology (Oxford, England) 20120201

Title: Association between leptin levels and doses of clomethiazole during alcohol withdrawal: a pilot study.

Journal: European addiction research 20120101

Title: Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73.

Journal: Frontiers in psychiatry 20120101

Title: Dihydrocodeine/Agonists for alcohol dependents.

Journal: Frontiers in psychiatry 20120101

Title: Antidopaminergic drugs and acute pancreatitis: a population-based study.

Journal: BMJ open 20120101

Title: Endothelial dysfunction during acute alcohol withdrawal syndrome.

Journal: Drug and alcohol dependence 20111201

Title: Gender and use of hypnotics or sedatives in old age: a nationwide register-based study.

Journal: International journal of clinical pharmacy 20111001

Title: Therapeutic drug monitoring for drugs used in the treatment of substance-related disorders: literature review using a therapeutic drug monitoring appropriateness rating scale.

Journal: Therapeutic drug monitoring 20111001

Title: Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.

Journal: Toxicology and applied pharmacology 20110815

Title: Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity.

Journal: Digestive diseases (Basel, Switzerland) 20110401

Title: S100B and homocysteine in the acute alcohol withdrawal syndrome.

Journal: European archives of psychiatry and clinical neuroscience 20110301

Title: Effects of AMPA and clomethiazole on spreading depression cycles in the rat neocortex in vivo.

Journal: European journal of pharmacology 20110225

Title: Comparison of two oral symptom-triggered pharmacological inpatient treatments of acute alcohol withdrawal: clomethiazole vs. clonazepam.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20110101

Title: Carbamazepine and valproate as adjuncts in the treatment of alcohol withdrawal syndrome: a retrospective cohort study.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20110101

Title: [Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure].

Journal: Psychiatrische Praxis 20100901

Title: Impaired cerebral autoregulation during acute alcohol withdrawal.

Journal: Drug and alcohol dependence 20100801

Title: DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20100401

Title: An open trial of gabapentin in acute alcohol withdrawal using an oral loading protocol.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20100101

Title: Medications acting on the GABA system in the treatment of alcoholic patients.

Journal: Current pharmaceutical design 20100101

Title: Oxazepam versus clomethiazol in alcohol withdrawal treatment.

Journal: European addiction research 20100101

Title: Low effective organizational strategies in visual memory performance of unmedicated alcoholics during early abstinence.

Journal: Psycho-social medicine 20100101

Title: Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry.

Journal: Acta pharmacologica Sinica 20091001

Title: Oxcarbazepine in combination with Tiaprid in inpatient alcohol-withdrawal--a RCT.

Journal: Pharmacopsychiatry 20090901

Title: Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines.

Journal: Dialogues in clinical neuroscience 20090901

Title: [Pharmacotherapy of substance dependence and withdrawal syndromes].

Journal: Therapeutische Umschau. Revue therapeutique 20090601

Title: Gamma hydroxybutyric acid (GHB) for the treatment of alcohol dependence: a review.

Journal: International journal of environmental research and public health 20090601

Title: [Anticonvulsants in the treatment of alcoholism].

Journal: Fortschritte der Neurologie-Psychiatrie 20090401

Title: Modeling subpopulations with the $MIXTURE subroutine in NONMEM: finding the individual probability of belonging to a subpopulation for the use in model analysis and improved decision making.

Journal: The AAPS journal 20090301

Title: Severe protracted alcohol withdrawal syndrome: prevalence and pharmacological treatment at an inpatient detoxification unit--a naturalistic study.

Journal: Pharmacopsychiatry 20090301

Title: Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061.

Journal: Pharmacology, biochemistry, and behavior 20090201

Title: Gamma-hydroxybutyric acid versus clomethiazole for the treatment of alcohol withdrawal syndrome in a medical intensive care unit: an open, single-center randomized study.

Journal: The American journal of drug and alcohol abuse 20090101

Title: [Use of combined treatment with melatonin and clomethiazole in circadian rhythm sleep disorder in the elderly with dementia].

Journal: Revista espanola de geriatria y gerontologia 20090101

Title: Reduced cardio-respiratory coupling in acute alcohol withdrawal.

Journal: Drug and alcohol dependence 20081201

Title: [Emergency checklist: delirium tremens].

Journal: MMW Fortschritte der Medizin 20081009

Title: Treatment with clomethiazole is associated with lower rates of premature discharge during alcohol withdrawal.

Journal: Pharmacopsychiatry 20080701

Title: [Pharmacotherapy of alcohol dependence].

Journal: MMW Fortschritte der Medizin 20080519

Title: The effectiveness of anticonvulsants in psychiatric disorders.

Journal: Dialogues in clinical neuroscience 20080301

Title: Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury.

Journal: Critical care (London, England) 20080101

Title: A comprehensive functional analysis of tissue specificity of human gene expression.

Journal: BMC biology 20080101

Title: Pharmacologic neuroprotection: the search continues.

Journal: The journal of extra-corporeal technology 20071201

Title: Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes.

Journal: Archives of biochemistry and biophysics 20071015

Title: Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia.

Journal: Brain research 20070926

Title: Clinical studies with oral lipid based formulations of poorly soluble compounds.

Journal: Therapeutics and clinical risk management 20070801

Title: AMPA receptor activation reduces epileptiform activity in the rat neocortex.

Journal: Brain research 20070716

Title: Oxcarbazepine--efficacy and tolerability during treatment of alcohol withdrawal: a double-blind, randomized, placebo-controlled multicenter pilot study.

Journal: Alcoholism, clinical and experimental research 20070701

Title: Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage.

Journal: The Journal of nutritional biochemistry 20070501

Title: Altered benzodiazepine receptor sensitivity in alcoholism: a study with fMRI and acute lorazepam challenge.

Journal: Psychiatry research 20070415

Title: [Choice of sleeping pills to patients with Parkinson disease].

Journal: Lakartidningen 20070401

Title: Measurement properties of the National Institutes of Health Stroke Scale for people with right- and left-hemisphere lesions: further analysis of the clomethiazole for acute stroke study-ischemic (class-I) trial.

Journal: Archives of physical medicine and rehabilitation 20070301

Title: Alcohol withdrawal syndrome: how to predict, prevent, diagnose and treat it.

Journal: Prescrire international 20070201

Title: Mitochondrial involvement in transhemispheric diaschisis following hypoxia-ischemia: Clomethiazole-mediated amelioration.

Journal: Neuroscience 20070119

Title: [Carbamazepine intoxication. Complication of alcohol detoxification with combined carbamazepine and tiapride].

Journal: Der Nervenarzt 20070101

Title: Reduced baroreflex sensitivity in acute alcohol withdrawal syndrome and in abstained alcoholics.

Journal: Drug and alcohol dependence 20061015

Title: NXY-059: a hopeful sign in the treatment of stroke.

Journal: Stroke 20061001

Title: Heart rate variability and sympathetic skin response in male patients suffering from acute alcohol withdrawal syndrome.

Journal: Alcoholism, clinical and experimental research 20060901

Title: Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen.

Journal: The Journal of pharmacology and experimental therapeutics 20060401

Title: Modeling drug- and system-related changes in body temperature: application to clomethiazole-induced hypothermia, long-lasting tolerance development, and circadian rhythm in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20060401

Title: Mallory body forming cells express the preneoplastic hepatocyte phenotype.

Journal: Experimental and molecular pathology 20060401

Title: Chorea induced by low-dose trazodone.

Journal: European neurology 20060101

Title: Driving under the influence of chlormethiazole.

Journal: Forensic science international 20051029

Title: Oxcarbazepine versus carbamazepine in the treatment of alcohol withdrawal.

Journal: Addiction biology 20050901

Title: Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia.

Journal: Journal of neurology 20050901

Title: Effects of anticonvulsants on soman-induced epileptiform activity in the guinea-pig in vitro hippocampus.

Journal: European journal of pharmacology 20050822

Title: The effects of clomethiazole on polysomnographically recorded sleep in healthy subjects.

Journal: European archives of psychiatry and clinical neuroscience 20050801

Title: The role of laminin-integrin signaling in triggering MB formation. An in vivo and in vitro study.

Journal: Experimental and molecular pathology 20050801

Title: Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice.

Journal: Hepatology (Baltimore, Md.) 20050801

Title: Clomethiazole: mechanisms underlying lasting neuroprotection following hypoxia-ischemia.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050601

Title: The p105/50 NF-kappaB pathway is essential for Mallory body formation.

Journal: Experimental and molecular pathology 20050601

Title: CYP2E1 inhibition enhances mallory body formation.

Journal: Experimental and molecular pathology 20050601

Title: Effect of intravenous magnesium sulphate in reducing irritability and restlessness in pure and polysubstance opiate detoxification.

Journal: Psychiatry research 20050515

Title: Rapid and long-lasting tolerance to clomethiazole-induced hypothermia in the rat.

Journal: European journal of pharmacology 20050411

Title: Alcohol, vitamin A, and cancer.

Journal: Alcohol (Fayetteville, N.Y.) 20050401

Title: Treatment of alcohol withdrawal syndrome with combined carbamazepine and tiapride in a patient with probable sleep apnoe syndrome.

Journal: Pharmacopsychiatry 20050301

Title: Generic three-column parallel LC-MS/MS system for high-throughput in vitro screens.

Journal: Journal of chromatography. A 20041126

Title: Factor analysis of the National Institutes of Health Stroke Scale in patients with large strokes.

Journal: Archives of neurology 20041101

Title: Polysomnography during withdrawal with clomethiazole or placebo in alcohol dependent patients--a double-blind and randomized study.

Journal: Pharmacopsychiatry 20040901

Title: Chlormethiazole potentiates the discriminative stimulus effects of methamphetamine in rats.

Journal: European journal of pharmacology 20040628

Title: Clomethiazole alters immune function within an isolated cardiopulmonary bypass circuit.

Journal: Anesthesia and analgesia 20040401

Title: Treatment of alcohol withdrawal: chlormethiazole vs. carbamazepine and the effect on memory performance--a pilot study.

Journal: Addiction biology 20040301

Title: The proteasome inhibitor, PS-341, causes cytokeratin aggresome formation.

Journal: Experimental and molecular pathology 20040201

Title: Early impairment in consciousness predicts mortality after hemispheric ischemic stroke.

Journal: Critical care medicine 20040101

Title: Changes in fatalities due to overdose of anxiolytic and sedative drugs in the UK (1983-1999).

Journal: Drug safety 20040101

Title: The pharmacology of chlormethiazole: a potential neuroprotective agent?

Journal: CNS drug reviews 20040101

Title: Activity of chlormethiazole at human recombinant GABA(A) and NMDA receptors.

Journal: British journal of pharmacology 20031101

Title: Treatment of acute alcohol withdrawal with gabapentin: results from a controlled two-center trial.

Journal: Journal of clinical psychopharmacology 20031001

Title: Population pharmacokinetics of clomethiazole and its effect on the natural course of sedation in acute stroke patients.

Journal: British journal of clinical pharmacology 20030801

Title: Long-term effects of clomethiazole in a model of global ischemia.

Journal: Experimental neurology 20030801

Title: Diazepam and chlormethiazole attenuate the development of hyperthermia in an animal model of the serotonin syndrome.

Journal: Neurochemistry international 20030701

Title: The effect of clomethiazole on plasma concentrations of interleukin-6, -8, -1beta, tumor necrosis factor-alpha, and neutrophil adhesion molecule expression during experimental extracorporeal circulation.

Journal: Anesthesia and analgesia 20030701

Title: Pharmacokinetics and sedative effects in healthy subjects and subjects with impaired liver function after continuous infusion of clomethiazole.

Journal: European journal of clinical pharmacology 20030601

Title: Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures.

Journal: Brain research 20030516

Title: Symptom-triggered versus standard chlormethiazole treatment of inpatient alcohol withdrawal: clinical implications from a chart analysis.

Journal: European addiction research 20030101

Title: Alcohol withdrawal treatment in intoxicated vs non-intoxicated patients: a controlled open-label study with tiapride/carbamazepine, clomethiazole and diazepam.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20030101

Title: Assessment of cognitive and motor deficits in a marmoset model of stroke.

Journal: ILAR journal 20030101

Title: The vitamin-E analog trolox and the NMDA antagonist MK-801 protect pyramidal neurons in hippocampal slice cultures from IL-1beta-induced neurodegeneration.

Journal: Neurotoxicity research 20030101

Title: The neuroprotective agents chlomethiazole and SB203580 inhibit IL-1beta signalling but not its biosynthesis in rat cortical glial cells.

Journal: Journal of neurochemistry 20021101

Title: Chlormethiazole treatment prevents reduced hepatic vitamin A levels in ethanol-fed rats.

Journal: Alcoholism, clinical and experimental research 20021101

Title: Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.

Journal: European journal of pharmacology 20021011

Title: The role of the ubiquitin-proteasome pathway in the formation of mallory bodies.

Journal: Experimental and molecular pathology 20021001

Title: Clinical trial of the neuroprotectant clomethiazole in coronary artery bypass graft surgery: a randomized controlled trial.

Journal: Anesthesiology 20020901

Title: Serum concentration of chlormethiazole and therapeutic effect in acute alcohol withdrawal syndrome: an open clinical trial.

Journal: Therapeutic drug monitoring 20020601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: [Delirium in old age can be prevented and treated].

Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20020320

Title: [Diagnosis and treatment of delirium].

Journal: Praxis 20020313

Title: Investigation of the effect of chlormethiazole on cerebral chemistry in neurosurgical patients: a combined study of microdialysis and a neuroprotective agent.

Journal: British journal of clinical pharmacology 20020301

Title: The Mallory body as an aggresome: in vitro studies.

Journal: Experimental and molecular pathology 20020201

Title: Neuroprotective agents in acute ischemic stroke.

Journal: The Journal of the Association of Physicians of India 20020201

Title: Clomethiazole Acute Stroke Study in ischemic stroke (CLASS-I): final results.

Journal: Stroke 20020101

Title: Clomethiazole: an unsuccessful bachelor, but perhaps a prosperous married man?

Journal: Stroke 20020101

Title: Double-blind controlled trial of gamma-hydroxybutyrate and clomethiazole in the treatment of alcohol withdrawal.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire) 20020101

Title: GABA agonist: clomethiazole.

Journal: Current medical research and opinion 20020101

Title: A study of the mechanisms involved in the neurotoxic action of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') on dopamine neurones in mouse brain.

Journal: British journal of pharmacology 20011201

Title: The Clomethiazole Acute Stroke Study in tissue-type plasminogen activator-treated stroke (CLASS-T): final results.

Journal: Neurology 20011009

Title: Neuroprotective efficacy of AR-A008055, a clomethiazole analogue, in a global model of acute ischaemic stroke and its effect on ischaemia-induced glutamate and GABA efflux in vitro.

Journal: Neuropharmacology 20010801

Title: The interaction of AR-A008055 and its enantiomers with the GABA(A) receptor complex and their sedative, muscle relaxant and anticonvulsant activity.

Journal: Neuropharmacology 20010801

Title: Studies on the neuroprotective effect of the enantiomers of AR-A008055, a compound structurally related to clomethiazole, on MDMA ('ecstasy')-induced neurodegeneration in rat brain.

Journal: Psychopharmacology 20010801

Title: Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study.

Journal: European archives of psychiatry and clinical neuroscience 20010801

Title: [Clomethiazole as an adjuvant in the treatment of confusional psychosis].

Journal: Fortschritte der Neurologie-Psychiatrie 20010601

Title: Ethanol enhances retinoic acid metabolism into polar metabolites in rat liver via induction of cytochrome P4502E1.

Journal: Gastroenterology 20010101

Title: Current status and perspectives of neuroprotection in ischemic stroke treatment.

Journal: Cerebrovascular diseases (Basel, Switzerland) 20010101

Title: Chlormethiazole: effectiveness against toxic effects of cocaine in mice.

Journal: The Journal of pharmacology and experimental therapeutics 20001001

Title: Effect of starvation and chlormethiazole on cytochrome P450s of rat nasal mucosa.

Journal: Biochemical pharmacology 20000601

Title: The clomethiazole acute stroke study in ischemic, hemorrhagic, and t-PA treated stroke: Design of a phase III trial in the united states and canada.

Journal: Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 19980101

Title: Inhibition of CYP2E1 activity does not abolish pulsatile urine alcohol concentrations during chronic alcohol infusions.

Journal: European journal of biochemistry 19950615

Title: Sudden death after intravenous application of lorazepam in a patient treated with clozapine.

Journal: The American journal of psychiatry 19940501

Title: Striatal dopamine release in vivo following neurotoxic doses of methamphetamine and effect of the neuroprotective drugs, chlormethiazole and dizocilpine.

Journal: British journal of pharmacology 19930301

Title: [Cholestatic hepatitis secondary to clomethiazole].

Journal: Medicina clinica 19920516

Title: The neurotoxic effects of methamphetamine on 5-hydroxytryptamine and dopamine in brain: evidence for the protective effect of chlormethiazole.

Journal: Neuropharmacology 19920401

Title: A single-dose study of the pharmacodynamic effects of chlormethiazole, temazepam and placebo in elderly parkinsonian patients.

Journal: Age and ageing 19911101

Title: Focal dystonic reaction to phenytoin.

Journal: Developmental medicine and child neurology 19841001

Title: Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome.

Journal: Epilepsia 19810201

Title: Alpha and beta coma in drug intoxication uncomplicated by cerebral hypoxia.

Journal: Electroencephalography and clinical neurophysiology 19790101

Title: Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA(A) receptors.Eur J Pharmacol. 2002 Oct 11;452(3):255-62.

Title: Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44(8):1424-30

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Tags:533-45-9 Molecular Formula|533-45-9 MDL|533-45-9 SMILES|533-45-9 Clomethiazole
Catalog No.: AA00DDYE
533-45-9,MFCD00868012
533-45-9 | Clomethiazole
Pack Size: 100mg
Purity: 98%(HPLC)
in stock
$81.00 $57.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA00DDYE
Chemical Name: Clomethiazole
CAS Number: 533-45-9
Molecular Formula: C6H8ClNS
Molecular Weight: 161.6524
MDL Number: MFCD00868012
SMILES: Cc1ncsc1CCCl
Properties
Complexity: 89.1  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 9  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.1  
Literature fold

Title: Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class.

Journal: Toxicology letters20160122

Title: Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver.

Journal: Chemico-biological interactions20141005

Title: CMZ reversed chronic ethanol-induced disturbance of PPAR-α possibly by suppressing oxidative stress and PGC-1α acetylation, and activating the MAPK and GSK3β pathway.

Journal: PloS one20140101

Title: Design and synthesis of neuroprotective methylthiazoles and modification as NO-chimeras for neurodegenerative therapy.

Journal: Journal of medicinal chemistry20120809

Title: Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20120801

Title: Heart rate turbulence during acute alcohol withdrawal syndrome.

Journal: Drug and alcohol dependence20120501

Title: Substitution therapy for alcoholism: time for a reappraisal?

Journal: Journal of psychopharmacology (Oxford, England)20120201

Title: Association between leptin levels and doses of clomethiazole during alcohol withdrawal: a pilot study.

Journal: European addiction research20120101

Title: Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73.

Journal: Frontiers in psychiatry20120101

Title: Dihydrocodeine/Agonists for alcohol dependents.

Journal: Frontiers in psychiatry20120101

Title: Antidopaminergic drugs and acute pancreatitis: a population-based study.

Journal: BMJ open20120101

Title: Endothelial dysfunction during acute alcohol withdrawal syndrome.

Journal: Drug and alcohol dependence20111201

Title: Gender and use of hypnotics or sedatives in old age: a nationwide register-based study.

Journal: International journal of clinical pharmacy20111001

Title: Therapeutic drug monitoring for drugs used in the treatment of substance-related disorders: literature review using a therapeutic drug monitoring appropriateness rating scale.

Journal: Therapeutic drug monitoring20111001

Title: Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice.

Journal: Toxicology and applied pharmacology20110815

Title: Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity.

Journal: Digestive diseases (Basel, Switzerland)20110401

Title: S100B and homocysteine in the acute alcohol withdrawal syndrome.

Journal: European archives of psychiatry and clinical neuroscience20110301

Title: Effects of AMPA and clomethiazole on spreading depression cycles in the rat neocortex in vivo.

Journal: European journal of pharmacology20110225

Title: Comparison of two oral symptom-triggered pharmacological inpatient treatments of acute alcohol withdrawal: clomethiazole vs. clonazepam.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire)20110101

Title: Carbamazepine and valproate as adjuncts in the treatment of alcohol withdrawal syndrome: a retrospective cohort study.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire)20110101

Title: [Diagnostics and therapy of alcohol withdrawal syndrome: focus on delirium tremens and withdrawal seizure].

Journal: Psychiatrische Praxis20100901

Title: Impaired cerebral autoregulation during acute alcohol withdrawal.

Journal: Drug and alcohol dependence20100801

Title: DNA methylation of the POMC gene promoter is associated with craving in alcohol dependence.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20100401

Title: An open trial of gabapentin in acute alcohol withdrawal using an oral loading protocol.

Journal: Alcohol and alcoholism (Oxford, Oxfordshire)20100101

Title: Medications acting on the GABA system in the treatment of alcoholic patients.

Journal: Current pharmaceutical design20100101

Title: Oxazepam versus clomethiazol in alcohol withdrawal treatment.

Journal: European addiction research20100101

Title: Low effective organizational strategies in visual memory performance of unmedicated alcoholics during early abstinence.

Journal: Psycho-social medicine20100101

Title: Characterization of cardamonin metabolism by P450 in different species via HPLC-ESI-ion trap and UPLC-ESI-quadrupole mass spectrometry.

Journal: Acta pharmacologica Sinica20091001

Title: Oxcarbazepine in combination with Tiaprid in inpatient alcohol-withdrawal--a RCT.

Journal: Pharmacopsychiatry20090901

Title: Neurotoxicity of drugs of abuse--the case of methylenedioxyamphetamines (MDMA, ecstasy), and amphetamines.

Journal: Dialogues in clinical neuroscience20090901

Title: [Pharmacotherapy of substance dependence and withdrawal syndromes].

Journal: Therapeutische Umschau. Revue therapeutique20090601

Title: Gamma hydroxybutyric acid (GHB) for the treatment of alcohol dependence: a review.

Journal: International journal of environmental research and public health20090601

Title: [Anticonvulsants in the treatment of alcoholism].

Journal: Fortschritte der Neurologie-Psychiatrie20090401

Title: Modeling subpopulations with the $MIXTURE subroutine in NONMEM: finding the individual probability of belonging to a subpopulation for the use in model analysis and improved decision making.

Journal: The AAPS journal20090301

Title: Severe protracted alcohol withdrawal syndrome: prevalence and pharmacological treatment at an inpatient detoxification unit--a naturalistic study.

Journal: Pharmacopsychiatry20090301

Title: Subchronic MK-801 behavioural deficits in rats: partial reversal by the novel nitrate GT 1061.

Journal: Pharmacology, biochemistry, and behavior20090201

Title: Gamma-hydroxybutyric acid versus clomethiazole for the treatment of alcohol withdrawal syndrome in a medical intensive care unit: an open, single-center randomized study.

Journal: The American journal of drug and alcohol abuse20090101

Title: [Use of combined treatment with melatonin and clomethiazole in circadian rhythm sleep disorder in the elderly with dementia].

Journal: Revista espanola de geriatria y gerontologia20090101

Title: Reduced cardio-respiratory coupling in acute alcohol withdrawal.

Journal: Drug and alcohol dependence20081201

Title: [Emergency checklist: delirium tremens].

Journal: MMW Fortschritte der Medizin20081009

Title: Treatment with clomethiazole is associated with lower rates of premature discharge during alcohol withdrawal.

Journal: Pharmacopsychiatry20080701

Title: [Pharmacotherapy of alcohol dependence].

Journal: MMW Fortschritte der Medizin20080519

Title: The effectiveness of anticonvulsants in psychiatric disorders.

Journal: Dialogues in clinical neuroscience20080301

Title: Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury.

Journal: Critical care (London, England)20080101

Title: A comprehensive functional analysis of tissue specificity of human gene expression.

Journal: BMC biology20080101

Title: Pharmacologic neuroprotection: the search continues.

Journal: The journal of extra-corporeal technology20071201

Title: Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes.

Journal: Archives of biochemistry and biophysics20071015

Title: Angiogenesis as a predictive marker of neurological outcome following hypoxia-ischemia.

Journal: Brain research20070926

Title: Clinical studies with oral lipid based formulations of poorly soluble compounds.

Journal: Therapeutics and clinical risk management20070801

Title: AMPA receptor activation reduces epileptiform activity in the rat neocortex.

Journal: Brain research20070716

Title: Oxcarbazepine--efficacy and tolerability during treatment of alcohol withdrawal: a double-blind, randomized, placebo-controlled multicenter pilot study.

Journal: Alcoholism, clinical and experimental research20070701

Title: Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage.

Journal: The Journal of nutritional biochemistry20070501

Title: Altered benzodiazepine receptor sensitivity in alcoholism: a study with fMRI and acute lorazepam challenge.

Journal: Psychiatry research20070415

Title: [Choice of sleeping pills to patients with Parkinson disease].

Journal: Lakartidningen20070401

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