+1 858-523-8231
Login | Register
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
Home Fluorides 1393465-84-3
1393465-84-3,MFCD29472265
Catalog No.:AA001AQ0

1393465-84-3 | Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$55.00   $38.00
- +
5mg
97%
in stock  
$163.00   $114.00
- +
10mg
97%
in stock  
$234.00   $164.00
- +
25mg
97%
in stock  
$456.00   $319.00
- +
50mg
97%
in stock  
$499.00   $349.00
- +
100mg
97%
in stock  
$852.00   $597.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001AQ0
Chemical Name:
Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-
CAS Number:
1393465-84-3
Molecular Formula:
C24H22F2N6O3S
Molecular Weight:
512.5317
MDL Number:
MFCD29472265
SMILES:
CCN(S(=O)(=O)Nc1ccc(c(c1F)C(=O)c1c[nH]c2c1cc(cn2)c1cnc(nc1)C1CC1)F)C
Properties
Computed Properties
 
Complexity:
895  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  
XLogP3:
2.6  

Literature

Title: RAF inhibitors that evade paradoxical MAPK pathway activation.

Journal: Nature 20151022

Title: Boar seminal zinc-precipitable protein and the haemagglutinin.

Journal: Journal of reproduction and fertility 19751201

Title: Zhang C, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-586.

Title: Basile KJ, et al. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res. 2014 May;27(3):479-84

Title: Le K, et al. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells. Pigment Cell Melanoma Res. 2013 Jul;26(4):509-17

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1393465-84-3
1393466-87-9

1393466-87-9

 1859158-65-8

1859158-65-8
Building Blocks
More >
Tags:1393465-84-3 Molecular Formula|1393465-84-3 MDL|1393465-84-3 SMILES|1393465-84-3 Sulfamide, N'-[3-[[5-(2-cyclopropyl-5-pyrimidinyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-N-ethyl-N-methyl-