Home Indole and Oxindoles 140896-21-5
140896-21-5,MFCD00214306
Catalog No.:AA01CP7N

140896-21-5 | Indolicidin

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
100%
1 week  
$351.00   $246.00
- +
2mg
100%
1 week  
$511.00   $358.00
- +
5mg
100%
1 week  
$842.00   $589.00
- +
10mg
100%
1 week  
$1,198.00   $839.00
- +
25mg
100%
1 week  
$1,749.00   $1,224.00
- +
50mg
100%
1 week  
$2,332.00   $1,632.00
- +
100mg
100%
1 week  
$3,132.00   $2,192.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01CP7N
Chemical Name:
Indolicidin
CAS Number:
140896-21-5
Molecular Formula:
C100H132N26O13
Molecular Weight:
1906.2845
MDL Number:
MFCD00214306
SMILES:
NCCCCC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N)CCCNC(=N)N)CCCNC(=N)N)Cc1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2)NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C1CCCN1C(=O)C(NC(=O)C(C(CC)C)N)CC(C)C
Properties
Computed Properties
 
Complexity:
4190  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
14  
Heavy Atom Count:
139  
Hydrogen Bond Acceptor Count:
17  
Hydrogen Bond Donor Count:
23  
Rotatable Bond Count:
50  
XLogP3:
5.8  

Literature

Title: In vitro activity of several antimicrobial peptides against colistin-susceptible and colistin-resistant Acinetobacter baumannii.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20120401

Title: Antibacterial and anti-biofilm effects of cathelicidin peptides against pathogens isolated from cystic fibrosis patients.

Journal: Peptides 20110901

Title: Isopeptide ligation catalyzed by quintessential sortase A: mechanistic cues from cyclic and branched oligomers of indolicidin.

Journal: The Journal of biological chemistry 20110708

Title: Indolicidin action on membrane permeability: carrier mechanism versus pore formation.

Journal: Biochimica et biophysica acta 20110101

Title: Effect of antimicrobial peptide-amide: indolicidin on biological membranes.

Journal: Journal of biomedicine & biotechnology 20110101

Title: Interaction studies of novel cell selective antimicrobial peptides with model membranes and E. coli ATCC 11775.

Journal: Biochimica et biophysica acta 20101001

Title: The effects of tryptophan and hydrophobicity on the structure and bioactivity of novel indolicidin derivatives with promising pharmaceutical potential.

Journal: Organic & biomolecular chemistry 20100407

Title: Structure-activity relationship of indolicidin, a Trp-rich antibacterial peptide.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20100401

Title: High potency and broad-spectrum antimicrobial peptides synthesized via ring-opening polymerization of alpha-aminoacid-N-carboxyanhydrides.

Journal: Biomacromolecules 20100111

Title: Differential activity of innate defense antimicrobial peptides against Nocardia species.

Journal: BMC microbiology 20100101

Title: Combinatorial microscopy for the study of protein-membrane interactions in supported lipid bilayers: Order parameter measurements by combined polarized TIRFM/AFM.

Journal: Journal of structural biology 20091001

Title: Coupling molecular dynamics simulations with experiments for the rational design of indolicidin-analogous antimicrobial peptides.

Journal: Journal of molecular biology 20090925

Title: Design of novel indolicidin-derived antimicrobial peptides with enhanced cell specificity and potent anti-inflammatory activity.

Journal: Peptides 20090501

Title: The novel adjuvant combination of CpG ODN, indolicidin and polyphosphazene induces potent antibody- and cell-mediated immune responses in mice.

Journal: Vaccine 20090323

Title: Study of the antimicrobial peptide indolicidin and a mutant in micelle medium by molecular dynamics simulation.

Journal: Genetics and molecular research : GMR 20081007

Title: Oxidized phospholipids as potential molecular targets for antimicrobial peptides.

Journal: Biochimica et biophysica acta 20081001

Title: An atomic force microscopy study of the interactions between indolicidin and supported planar bilayers.

Journal: Journal of nanoscience and nanotechnology 20080901

Title: Cationic peptide-induced remodelling of model membranes: direct visualization by in situ atomic force microscopy.

Journal: Journal of structural biology 20080401

Title: Thermodynamics of the interactions of tryptophan-rich cathelicidin antimicrobial peptides with model and natural membranes.

Journal: Biochimica et biophysica acta 20080401

Title: Efficacy of the bovine antimicrobial peptide indolicidin combined with piperacillin/tazobactam in experimental rat models of polymicrobial peritonitis.

Journal: Critical care medicine 20080101

Title: [Activity of indolicidin, alone or together with oxacillin, against Staphylococcus aureus and S. epidermidis].

Journal: Medycyna doswiadczalna i mikrobiologia 20080101

Title: Molecular dynamics simulations of indolicidin association with model lipid bilayers.

Journal: Biophysical journal 20070615

Title: Cation-pi interactions stabilize the structure of the antimicrobial peptide indolicidin near membranes: molecular dynamics simulations.

Journal: The journal of physical chemistry. B 20070111

Title: Fungicidal activity of five cathelicidin peptides against clinically isolated yeasts.

Journal: The Journal of antimicrobial chemotherapy 20061101

Title: Solvent-dependent structure of two tryptophan-rich antimicrobial peptides and their analogs studied by FTIR and CD spectroscopy.

Journal: Biochimica et biophysica acta 20061001

Title: Recombinant expression of indolicidin concatamers in Escherichia coli.

Journal: Applied microbiology and biotechnology 20060501

Title: Mechanisms of antimicrobial peptide action: studies of indolicidin assembly at model membrane interfaces by in situ atomic force microscopy.

Journal: Journal of structural biology 20060401

Title: Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin.

Journal: Bioorganic & medicinal chemistry letters 20041115

Title: New indolicidin analogues with potent antibacterial activity.

Journal: The journal of peptide research : official journal of the American Peptide Society 20041101

Title: Membrane-mediated capillary electrophoresis: interaction of cationic peptides with bicelles.

Journal: Electrophoresis 20040501

Title: Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus.

Journal: International journal of antimicrobial agents 20040401

Title: [Structure-function relationship between analogues of the antibacterial peptide indolicidin. I. Synthesis and biological activity of analogues with increased amphipathicity and elevated net positive charge of the molecule].

Journal: Bioorganicheskaia khimiia 20040101

Title: Structure-based design of an indolicidin peptide analogue with increased protease stability.

Journal: Biochemistry 20031209

Title: Membrane binding and permeation by indolicidin analogs studied by a biomimetic lipid/polydiacetylene vesicle assay.

Journal: Peptides 20031101

Title: Indolicidin, a 13-residue basic antimicrobial peptide rich in tryptophan and proline, interacts with Ca(2+)-calmodulin.

Journal: Biochemical and biophysical research communications 20031003

Title: Fungicidal effect of indolicidin and its interaction with phospholipid membranes.

Journal: Biochemical and biophysical research communications 20030530

Title: Induction of autophagic cell death in Leishmania donovani by antimicrobial peptides.

Journal: Molecular and biochemical parasitology 20030301

Title: Cathelicidin peptides as candidates for a novel class of antimicrobials.

Journal: Current pharmaceutical design 20020101

Title: Tryptophan-rich antimicrobial peptides: comparative properties and membrane interactions.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20020101

Title: Comparison of the membrane association of two antimicrobial peptides, magainin 2 and indolicidin.

Journal: Biophysical journal 20011101

Title: Structure-function relationships in the tryptophan-rich, antimicrobial peptide indolicidin.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20011001

Title: Morphology of fast-tumbling bicelles: a small angle neutron scattering and NMR study.

Journal: Biochimica et biophysica acta 20010806

Title: Protein chemistry at membrane interfaces: non-additivity of electrostatic and hydrophobic interactions.

Journal: Journal of molecular biology 20010608

Title: Determination of membrane immersion depth with O(2): a high-pressure (19)F NMR study.

Journal: Biophysical journal 20010301

Title: Formation and characterization of a single Trp-Trp cross-link in indolicidin that confers protease stability without altering antimicrobial activity.

Journal: The Journal of biological chemistry 20000421

Title: Activity of nitazoxanide alone and in combination with azithromycin and rifabutin against Cryptosporidium parvum in cell culture.

Journal: The Journal of antimicrobial chemotherapy 20000401

Title: Structural features and biological activities of the cathelicidin-derived antimicrobial peptides.

Journal: Biopolymers 20000101

Title: Antimicrobial activity of polycationic peptides.

Journal: Peptides 19991101

Title: In vitro anticryptosporidial activity of ranalexin alone and in combination with other peptides and with hydrophobic antibiotics.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 19991101

Title: In-vitro activity of polycationic peptides against Cryptosporidium parvum, Pneumocystis carinii and yeast clinical isolates.

Journal: The Journal of antimicrobial chemotherapy 19990901

Title: In-vitro activity of lytic peptides alone and in combination with macrolides and inhibitors of dihydrofolate reductase against Pneumocystis carinii.

Journal: The Journal of antimicrobial chemotherapy 19981001

Title: Anti-HIV-1 activity of indolicidin, an antimicrobial peptide from neutrophils.

Journal: Journal of leukocyte biology 19980101

Title: Liposomal entrapment of the neutrophil-derived peptide indolicidin endows it with in vivo antifungal activity.

Journal: Biochimica et biophysica acta 19950726

Title: Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils.

Journal: The Journal of biological chemistry 19920305

Title: Selsted ME, et al. Indolicidin, a novel bactericidal tridecapeptide amide from neutrophils. J Biol Chem. 1992 Mar 5;267(7):4292-5.

Title: Falla TJ, et al. Mode of action of the antimicrobial peptide indolicidin. J Biol Chem. 1996 Aug 9;271(32):19298-303.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:140896-21-5 Molecular Formula|140896-21-5 MDL|140896-21-5 SMILES|140896-21-5 Indolicidin