Catalog No.:AA01DQ15

141758-74-9 | Exendin 4 (Heloderma suspectum)

Name: Name:Exendin 4 (Heloderma suspectum)
Brand: AABLOCKS
SKU: AA01DQ15
Availability: InStock
Rating: 90 (10 reviews)

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1mg

97%,Contains acetic acid:0-15%

in stock

$184.00 $129.00

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5mg

97%,Contains acetic acid:0-15%

in stock

$354.00 $248.00

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Technical Information
Properties
Literature
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Technical Information
Properties
Literature

Technical Information

Catalog Number:

AA01DQ15

Chemical Name:

Exendin 4 (Heloderma suspectum)

CAS Number:

141758-74-9

Molecular Formula:

C184H282N50O60S

Molecular Weight:

4186.5719

MDL Number:

MFCD08704781

SMILES:

NCCCCC(C(=O)NC(C(=O)NCC(=O)NCC(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)N1CCCC1C(=O)N1CCCC1C(=O)N1CCCC1C(=O)NC(C(=O)N)CO)C)CO)CO)CC(=O)N)NC(=O)C(NC(=O)C(Cc1c[nH]c2c1cccc2)NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(O)C)NC(=O)C(NC(=O)C(C(O)C)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(Cc1nc[nH]c1)N)CCC(=O)O)Cc1ccccc1)CO)CC(=O)O)CC(C)C)CO)CCCCN)CCC(=O)N)CCSC)CCC(=O)O)CCC(=O)O)CCC(=O)O)C)CCCNC(=N)N)CC(C)C)Cc1ccccc1)CCC(=O)O)CC(C)C

Properties

Computed Properties

Complexity:

10300

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Heavy Atom Count:

295

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Rotatable Bond Count:

135

XLogP3:

-21

Literature

Title: Brain GLP-1/IGF-1 Signaling and Autophagy Mediate Exendin-4 Protection Against Apoptosis in Type 2 Diabetic Rats.

Journal: Molecular neurobiology 20180501

Title: Teneligliptin, a dipeptidyl peptidase-4 inhibitor, attenuated pro-inflammatory phenotype of perivascular adipose tissue and inhibited atherogenesis in normoglycemic apolipoprotein-E-deficient mice.

Journal: Vascular pharmacology 20170901

Title: Prediction of thyroid C-cell carcinogenicity after chronic administration of GLP1-R agonists in rodents.

Journal: Toxicology and applied pharmacology 20170401

Title: EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage.

Journal: Toxicology and applied pharmacology 20170115

Title: Fingerprinting of neurotoxic compounds using a mouse embryonic stem cell dual luminescence reporter assay.

Journal: Archives of toxicology 20170101

Title: High fat diet and GLP-1 drugs induce pancreatic injury in mice.

Journal: Toxicology and applied pharmacology 20140415

Title: Pulmonary GLP-1 receptor increases at birth and exogenous GLP-1 receptor agonists augmented surfactant-protein levels in litters from normal and nitrofen-treated pregnant rats.

Journal: Endocrinology 20130301

Title: On-target effects of GLP-1 receptor agonists on thyroid C-cells in rats and mice.

Journal: Toxicologic pathology 20130201

Title: Glucagon-like peptide-1 receptor agonist protects against hyperglycemia-induced cardiocytes injury by inhibiting high mobility group box 1 expression.

Journal: Molecular biology reports 20121201

Title: Effect of exenatide on cholecystokinin-induced gallbladder emptying in fasting healthy subjects.

Journal: Regulatory peptides 20121110

Title: [D-Leu-4]-OB3, a synthetic peptide amide with leptin-like activity, augments the effects of orally delivered exenatide and pramlintide acetate on energy balance and glycemic control in insulin-resistant male C57BLK/6-m db/db mice.

Journal: Regulatory peptides 20121110

Title: Glucagon-like peptide-1 (GLP-1) receptor agonism or DPP-4 inhibition does not accelerate neoplasia in carcinogen treated mice.

Journal: Regulatory peptides 20121110

Title: Protective effects of GLP-1 on glomerular endothelium and its inhibition by PKCβ activation in diabetes.

Journal: Diabetes 20121101

Title: Human embryonic stem cell differentiation into insulin secreting β-cells for diabetes.

Journal: Cell biology international 20121101

Title: Exenatide once weekly for the treatment of type 2 diabetes: effectiveness and tolerability in patient subpopulations.

Journal: International journal of clinical practice 20121101

Title: Structural stability-chromatographic retention relationship on exenatide diastereomer separation.

Journal: Analytical and bioanalytical chemistry 20121101

Title: Repression of sterol regulatory element-binding protein 1-c is involved in the protective effects of exendin-4 in pancreatic β-cell line.

Journal: Molecular and cellular endocrinology 20121015

Title: Oleic acid and glucose regulate glucagon-like peptide 1 receptor expression in a rat pancreatic ductal cell line.

Journal: Toxicology and applied pharmacology 20121015

Title: Amelioration of neurodegenerative changes in cellular and rat models of diabetes-related Alzheimer's disease by exendin-4.

Journal: Age (Dordrecht, Netherlands) 20121001

Title: Patient-reported outcomes in trials of incretin-based therapies in patients with type 2 diabetes mellitus.

Journal: Diabetes, obesity & metabolism 20121001

Title: Harnessing the incretin system beyond glucose control: potential cardiovascular benefits of GLP-1 receptor agonists in type 2 diabetes.

Journal: Diabetes & metabolism 20121001

Title: Impaired MEK signaling and SERCA expression promote ER stress and apoptosis in insulin-resistant macrophages and are reversed by exenatide treatment.

Journal: Diabetes 20121001

Title: Recent advances in incretin-based therapies.

Journal: Clinical endocrinology 20121001

Title: DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice.

Journal: Journal of molecular endocrinology 20121001

Title: Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice.

Journal: American journal of physiology. Renal physiology 20121001

Title: An update in incretin-based therapy: a focus on glucagon-like peptide-1 receptor agonists.

Journal: Diabetes technology & therapeutics 20121001

Title: Exendin-4 reverses biochemical and behavioral deficits in a pre-motor rodent model of Parkinson's disease with combined noradrenergic and serotonergic lesions.

Journal: Neuropeptides 20121001

Title: Safety of exenatide once weekly in patients with type 2 diabetes mellitus treated with a thiazolidinedione alone or in combination with metformin for 2 years.

Journal: Clinical therapeutics 20121001

Title: Role of ERp46 in β-cell lipoapoptosis through endoplasmic reticulum stress pathway as well as the protective effect of exendin-4.

Journal: Biochemical and biophysical research communications 20120928

Title: Euglycemic agent-mediated hypothalamic transcriptomic manipulation in the N171-82Q model of Huntington disease is related to their physiological efficacy.

Journal: The Journal of biological chemistry 20120914

Title: Investigation of the haemodynamic effects of exenatide in healthy male subjects.

Journal: British journal of clinical pharmacology 20120901

Title: Exendin-4 directly improves endothelial dysfunction in isolated aortas from obese rats through the cAMP or AMPK-eNOS pathways.

Journal: Diabetes research and clinical practice 20120901

Title: Protection of exenatide for retinal ganglion cells with different glucose concentrations.

Journal: Peptides 20120901

Title: Human β-cell proliferation and intracellular signaling: driving in the dark without a road map.

Journal: Diabetes 20120901

Title: Exendin-4, a glucagon-like peptide-1 receptor agonist, inhibits cell apoptosis induced by lipotoxicity in pancreatic β-cell line.

Journal: Peptides 20120901

Title: Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism.

Journal: Hypertension (Dallas, Tex. : 1979) 20120901

Title: Expenditures for medicaid patients treated with exenatide compared with other diabetes management regimens.

Journal: The American journal of managed care 20120901

Title: Glucagon-like peptide-1 (GLP-1) induces M2 polarization of human macrophages via STAT3 activation.

Journal: Biochemical and biophysical research communications 20120824

Title: Pulmonary administered palmitic-acid modified exendin-4 peptide prolongs hypoglycemia in type 2 diabetic db/db mice.

Journal: Regulatory peptides 20120820

Title: Delivery of two-step transcription amplification exendin-4 plasmid system with arginine-grafted bioreducible polymer in type 2 diabetes animal model.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20120820

Title: Exenatide extended-release: a review of its use in type 2 diabetes mellitus.

Journal: Drugs 20120820

Title: Self-assembled glycol chitosan nanogels containing palmityl-acylated exendin-4 peptide as a long-acting anti-diabetic inhalation system.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20120810

Title: GLP-1 based therapies: differential effects on fasting and postprandial glucose.

Journal: Diabetes, obesity & metabolism 20120801

Title: GLP-1 agonists exenatide and liraglutide: a review about their safety and efficacy.

Journal: Current clinical pharmacology 20120801

Title: Glycaemic efficacy of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors as add-on therapy to metformin in subjects with type 2 diabetes-a review and meta analysis.

Journal: Diabetes, obesity & metabolism 20120801

Title: Pancreatic insulin and exocrine secretion are under the modulatory control of distinct subpopulations of vagal motoneurones in the rat.

Journal: The Journal of physiology 20120801

Title: [Exendin-4 ameliorates high glucose- and TNF-α-induced vascular endothelial cell damage by inhibiting p38 MAPK and NF-κB p65 translocation].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120801

Title: Efficacy and tolerability of exenatide monotherapy in obese patients with newly diagnosed type 2 diabetes: a randomized, 26 weeks metformin-controlled, parallel-group study.

Journal: Chinese medical journal 20120801

Title: The effects of 13 wk of liraglutide treatment on endocrine and exocrine pancreas in male and female ZDF rats: a quantitative and qualitative analysis revealing no evidence of drug-induced pancreatitis.

Journal: American journal of physiology. Endocrinology and metabolism 20120715

Title: Exenatide and sitagliptin are not associated with increased risk of acute renal failure: a retrospective claims analysis.

Journal: Diabetes, obesity & metabolism 20120701

Title: Metabolic outcomes of matched patient populations initiating exenatide BID vs. insulin glargine in an ambulatory care setting.

Journal: Diabetes, obesity & metabolism 20120701

Title: Remission of insulin resistance in type 2 diabetic patients after gastric bypass surgery or exenatide therapy.

Journal: Obesity surgery 20120701

Title: Exenatide prevents high-glucose-induced damage of retinal ganglion cells through a mitochondrial mechanism.

Journal: Neurochemistry international 20120701

Title: Exenatide alters myocardial glucose transport and uptake depending on insulin resistance and increases myocardial blood flow in patients with type 2 diabetes.

Journal: The Journal of clinical endocrinology and metabolism 20120701

Title: Drug-induced hypoglycaemia in type 2 diabetes.

Journal: Expert opinion on drug safety 20120701

Title: A comparison of currently available GLP-1 receptor agonists for the treatment of type 2 diabetes.

Journal: Expert opinion on pharmacotherapy 20120701

Title: Exenatide for once-weekly administration.

Journal: Drug and therapeutics bulletin 20120701

Title: Exenatide twice daily: analysis of effectiveness and safety data stratified by age, sex, race, duration of diabetes, and body mass index.

Journal: Postgraduate medicine 20120701

Title: Exenatide once weekly for the treatment of type 2 diabetes mellitus: clinical results in subgroups of patients using different concomitant medications.

Journal: Postgraduate medicine 20120701

Title: Exendin-4 decreases amphetamine-induced locomotor activity.

Journal: Physiology & behavior 20120625

Title: Type 2 diabetes: which drug as add-on to metformin?

Journal: Lancet (London, England) 20120616

Title: Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial.

Journal: Lancet (London, England) 20120616

Title: Combination exenatide-sitagliptin therapy used with glipizide in a patient with type 2 diabetes mellitus.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120615

Title: Liraglutide: short-lived effect on gastric emptying -- long lasting effects on body weight.

Journal: Diabetes, obesity & metabolism 20120601

Title: Clinical relevance of anti-exenatide antibodies: safety, efficacy and cross-reactivity with long-term treatment.

Journal: Diabetes, obesity & metabolism 20120601

Title: Exenatide, a glucagon-like peptide-1 receptor agonist, acutely inhibits intestinal lipoprotein production in healthy humans.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20120601

Title: The role of combination therapy in type 2 diabetes in the post-ACCORD era.

Journal: Current diabetes reports 20120601

Title: Current treatments and strategies for type 2 diabetes: can we do better with GLP-1 receptor agonists?

Journal: Annals of medicine 20120601

Title: Regulation of microRNA-375 by cAMP in pancreatic β-cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20120601

Title: Restoration of leptin responsiveness in diet-induced obese mice using an optimized leptin analog in combination with exendin-4 or FGF21.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20120601

Title: Glucagon-like peptide 1, insulin, sensory neurons, and diabetic neuropathy.

Journal: Journal of neuropathology and experimental neurology 20120601

Title: Long-term effects of adding exenatide to a regimen of metformin and/or sulfonylurea in type 2 diabetes: an uncontrolled, open-label trial in Hungary.

Journal: Clinical therapeutics 20120601

Title: Non-insulin injectable treatments (glucagon-like peptide-1 and its analogs) and cardiovascular disease.

Journal: Diabetes technology & therapeutics 20120601

Title: Review of the safety and efficacy of exenatide once weekly for the treatment of type 2 diabetes mellitus.

Journal: The Annals of pharmacotherapy 20120601

Title: Hormone copycats.

Journal: Diabetes forecast 20120601

Title: Effect of PANDER in βTC6-cell lipoapoptosis and the protective role of exendin-4.

Journal: Biochemical and biophysical research communications 20120518

Title: Functional enhancement of beta cells in transplanted pancreatic islets by secretion signal peptide-linked exendin-4 gene transduction.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20120510

Title: Insulin avoidance and treatment outcomes among patients with a professional driving licence starting glucagon-like peptide 1 (GLP-1) agonists in the Association of British Clinical Diabetologists (ABCD) nationwide exenatide and liraglutide audits.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20120501

Title: The effects of exenatide bid on metabolic control, medication use and hospitalization in patients with type 2 diabetes mellitus in clinical practice: a systematic review.

Journal: Diabetes, obesity & metabolism 20120501

Title: Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats.

Journal: Clinical science (London, England : 1979) 20120501

Title: 3-Iodothyronamine: a modulator of the hypothalamus-pancreas-thyroid axes in mice.

Journal: British journal of pharmacology 20120501

Title: Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the Kras(G12D) mouse model.

Journal: Diabetes 20120501

Title: Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro.

Journal: Endocrinology 20120501

Title: Target-mediated pharmacokinetic and pharmacodynamic model of exendin-4 in rats, monkeys, and humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20120501

Title: GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic β-cells from glucolipotoxicity.

Journal: The Journal of endocrinology 20120501

Title: Baseline factors associated with glycemic control and weight loss when exenatide twice daily is added to optimized insulin glargine in patients with type 2 diabetes.

Journal: Diabetes care 20120501

Title: The novel use of GLP-1 analogue and insulin combination in type 2 diabetes mellitus.

Journal: Recent patents on endocrine, metabolic & immune drug discovery 20120501

Title: Exendin-4 treatment enhances L-DOPA evoked release of striatal dopamine and decreases dyskinetic movements in the 6-hydoxydopamine lesioned rat.

Journal: The Journal of pharmacy and pharmacology 20120501

Title: GLP-1-based therapies and the exocrine pancreas: more light, or just more heat?

Journal: Diabetes 20120501

Title: GLP-1 receptor agonist effects on normal and neoplastic pancreata.

Journal: Diabetes 20120501

Title: Ramadan fasting: a study of changes in glucose profiles among patients with diabetes using continuous glucose monitoring.

Journal: Diabetes care 20120501

Title: Extending the reach of Exendin-4: new pathways in the control of body weight and glucose homeostasis.

Journal: Endocrinology 20120501

Title: Immunotherapies in diabetes mellitus type 1.

Journal: The Medical clinics of North America 20120501

Title: Validation studies on blood collection from the jugular vein of conscious mice.

Journal: Journal of the American Association for Laboratory Animal Science : JAALAS 20120501

Title: The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120404

Title: An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Journal: The Journal of clinical investigation 20120402

Title: The peptide-hormone glucagon-like peptide-1 activates cAMP and inhibits growth of breast cancer cells.

Journal: Breast cancer research and treatment 20120401

Title: The role of GLP-1 mimetics and basal insulin analogues in type 2 diabetes mellitus: guidance from studies of liraglutide.

Journal: Diabetes, obesity & metabolism 20120401

Title: GLP-1, exendin-4 and C-peptide regulate pancreatic islet microcirculation, insulin secretion and glucose tolerance in rats.

Journal: Clinical science (London, England : 1979) 20120401

Title: The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide.

Journal: Neuropharmacology 20120401

Title: The ghrelin gene products and exendin-4 promote survival of human pancreatic islet endothelial cells in hyperglycaemic conditions, through phosphoinositide 3-kinase/Akt, extracellular signal-related kinase (ERK)1/2 and cAMP/protein kinase A (PKA) signalling pathways.

Journal: Diabetologia 20120401

Title: Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks.

Journal: Diabetes care 20120401

Title: The design of the liraglutide clinical trial programme.

Journal: Diabetes, obesity & metabolism 20120401

Title: Liraglutide in oral antidiabetic drug combination therapy.

Journal: Diabetes, obesity & metabolism 20120401

Title: Comparison of liraglutide versus other incretin-related anti-hyperglycaemic agents.

Journal: Diabetes, obesity & metabolism 20120401

Title: GLP-1 receptor agonists: a clinical perspective on cardiovascular effects.

Journal: Diabetes & vascular disease research 20120401

Title: Injectable hydrogel for sustained protein release by salt-induced association of hyaluronic acid nanogel.

Journal: Macromolecular bioscience 20120401

Title: Exendin-4 restores glucolipotoxicity-induced gene expression in human coronary artery endothelial cells.

Journal: Biochemical and biophysical research communications 20120323

Title: Roux-en-Y gastric bypass in rats increases sucrose taste-related motivated behavior independent of pharmacological GLP-1-receptor modulation.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20120315

Title: Preparation and evaluation of palmitic acid-conjugated exendin-4 with delayed absorption and prolonged circulation for longer hypoglycemia.

Journal: International journal of pharmaceutics 20120315

Title: Exogenous peptide YY3-36 and Exendin-4 further decrease food intake, whereas octreotide increases food intake in rats after Roux-en-Y gastric bypass.

Journal: International journal of obesity (2005) 20120301

Title: 18F-radiolabeled analogs of exendin-4 for PET imaging of GLP-1 in insulinoma.

Journal: European journal of nuclear medicine and molecular imaging 20120301

Title: 18F-Labelled exendin to image GLP-1 receptor-expressing tissues: from niche to blockbuster?

Journal: European journal of nuclear medicine and molecular imaging 20120301

Title: Incretin-based therapies in clinical practice: from efficacy to effectiveness. Focus on liraglutide.

Journal: Minerva endocrinologica 20120301

Title: Comparison of triple quadrupole and high-resolution TOF-MS for quantification of peptides.

Journal: Bioanalysis 20120301

Title: Self-inducible secretion of glucagon-like peptide-1 (GLP-1) that allows MIN6 cells to maintain insulin secretion and insure cell survival.

Journal: Molecular and cellular endocrinology 20120226

Title: Normalizing action of exendin-4 and GLP-1 in the glucose metabolism of extrapancreatic tissues in insulin-resistant and type 2 diabetic states.

Journal: Journal of molecular endocrinology 20120201

Title: Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study.

Journal: Obesity (Silver Spring, Md.) 20120201

Title: Glucagon-like peptide-1 regulation of carbohydrate intake is differentially affected by obesogenic diets.

Journal: Obesity (Silver Spring, Md.) 20120201

Title: Preventive effects of exenatide on endothelial dysfunction induced by ischemia-reperfusion injury via KATP channels.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20120201

Title: Novel biological action of the dipeptidylpeptidase-IV inhibitor, sitagliptin, as a glucagon-like peptide-1 secretagogue.

Journal: Endocrinology 20120201

Title: Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study.

Journal: Diabetes care 20120201

Title: Improvement of psoriasis during exenatide treatment in a patient with diabetes.

Journal: Diabetes & metabolism 20120201

Title: Pharmacokinetics, pharmacodynamics, and tolerability of a generic formulation of exenatide: a randomized, open-label, single- and multiple-dose study in healthy Chinese volunteers.

Journal: Arzneimittel-Forschung 20120201

Title: Glucagon-like peptide-1 agonists.

Journal: BMJ (Clinical research ed.) 20120110

Title: Repeated administration of exendin-4 reduces focal cerebral ischemia-induced infarction in rats.

Journal: Brain research 20120103

Title: Clinical outcomes using long-term combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Title: Glucokinase activation repairs defective bioenergetics of islets of Langerhans isolated from type 2 diabetics.

Journal: American journal of physiology. Endocrinology and metabolism 20120101

Title: Exenatide exerts a potent antiinflammatory effect.

Journal: The Journal of clinical endocrinology and metabolism 20120101

Title: Successful treatment of prediabetes in clinical practice: targeting insulin resistance and β-cell dysfunction.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Title: Case report of acute necrotizing pancreatitis associated with combination treatment of sitagliptin and exenatide.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Title: Exendin-4 protects against sulfonylurea-induced β-cell apoptosis.

Journal: Journal of pharmacological sciences 20120101

Title: Clinical efficacy and safety of once-weekly glucagon-like peptide-1 agonists in development for treatment of type 2 diabetes mellitus in adults.

Journal: The Annals of pharmacotherapy 20120101

Title: Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials.

Journal: BMJ (Clinical research ed.) 20120101

Title: Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice.

Journal: PloS one 20120101

Title: The efficacy and tolerability of exenatide in comparison to placebo; a systematic review and meta-analysis of randomized clinical trials.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20120101

Title: Long-term cost-consequence analysis of exenatide once weekly vs sitagliptin or pioglitazone for the treatment of type 2 diabetes patients in the United States.

Journal: Journal of medical economics 20120101

Title: Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis.

Journal: PloS one 20120101

Title: Effect of exenatide on the pharmacokinetics of a combination oral contraceptive in healthy women: an open-label, randomised, crossover trial.

Journal: BMC clinical pharmacology 20120101

Title: Exenatide BID and liraglutide QD treatment patterns among type 2 diabetes patients in Germany.

Journal: Journal of medical economics 20120101

Title: Use of concomitant glucose-lowering therapies and associated treatment results observed in clinical trials of twice-daily exenatide.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20120101

Title: [Natriuretic effect of exenatide: high efficacy and site of action].

Journal: Eksperimental'naia i klinicheskaia farmakologiia 20120101

Title: Hypoglycemics for the treatment of type 2 diabetes in patients with chronic kidney disease: a focus on new agents.

Journal: CANNT journal = Journal ACITN 20120101

Title: Health and economic outcomes for exenatide once weekly, insulin, and pioglitazone therapies in the treatment of type 2 diabetes: a simulation analysis.

Journal: Vascular health and risk management 20120101

Title: Exendin-4 reduces glycemia by increasing liver glucokinase activity: an insulin independent effect.

Journal: Pharmacological reports : PR 20120101

Title: Molecularly engineered islet cell clusters for diabetes mellitus treatment.

Journal: Cell transplantation 20120101

Title: Suppression of the nuclear factor Eny2 increases insulin secretion in poorly functioning INS-1E insulinoma cells.

Journal: Experimental diabetes research 20120101

Title: Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor.

Journal: Experimental diabetes research 20120101

Title: Effects of glucagon-like peptide-1 receptor agonists on body weight: a meta-analysis.

Journal: Experimental diabetes research 20120101

Title: Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial.

Journal: Cardiovascular diabetology 20120101

Title: Investigation of transport mechanism of exendin-4 across Madin Darby canine kidney cell monolayers.

Journal: Biological & pharmaceutical bulletin 20120101

Title: A review on the association between glucagon-like peptide-1 receptor agonists and thyroid cancer.

Journal: Experimental diabetes research 20120101

Title: Long-term cost-utility analysis of exenatide once weekly versus insulin glargine for the treatment of type 2 diabetes patients in the US.

Journal: Journal of medical economics 20120101

Title: Sustained exendin-4 secretion through gene therapy targeting salivary glands in two different rodent models of obesity/type 2 diabetes.

Journal: PloS one 20120101

Title: Determining predictors of response to exenatide in type 2 diabetes.

Journal: Journal of the American Pharmacists Association : JAPhA 20120101

Title: Exendin-4 protected against cognitive dysfunction in hyperglycemic mice receiving an intrahippocampal lipopolysaccharide injection.

Journal: PloS one 20120101

Title: Willingness to pay for diabetes drug therapy in type 2 diabetes patients: based on LEAD clinical programme results.

Journal: Journal of medical economics 20120101

Title: Inhibition of the expression of TGF-β1 and CTGF in human mesangial cells by exendin-4, a glucagon-like peptide-1 receptor agonist.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Glycemic control and weight changes in patients with type 2 diabetes intensified to three insulin regimens after therapeutic failure to exenatide.

Journal: Acta clinica Belgica 20120101

Title: Effects of combined exenatide and pioglitazone therapy on hepatic fat content in type 2 diabetes.

Journal: Obesity (Silver Spring, Md.) 20111201

Title: Exenatide improves glycemic variability assessed by continuous glucose monitoring in subjects with type 2 diabetes.

Journal: Diabetes technology & therapeutics 20111201

Title: Beyond glucose lowering: glucagon-like peptide-1 receptor agonists, body weight and the cardiovascular system.

Journal: Diabetes & metabolism 20111201

Title: Emerging GLP-1 receptor agonists.

Journal: Expert opinion on emerging drugs 20111201

Title: Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial.

Journal: Diabetologia 20111201

Title: Glucagon-like peptide-1 receptor agonists suppress water intake independent of effects on food intake.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111201

Title: Drug treatment of obesity.

Journal: The Psychiatric clinics of North America 20111201

Title: [Protective effects of glucagon-like peptide-1 on beta-cells: preclinical and clinical data].

Journal: Giornale italiano di cardiologia (2006) 20111201

Title: [Effects of glucagon-like peptide-1 on appetite and body weight: preclinical and clinical data].

Journal: Giornale italiano di cardiologia (2006) 20111201

Title: Exenatide enhances kaliuresis under conditions of hyperkalemia.

Journal: Bulletin of experimental biology and medicine 20111201

Title: [Incretin-based therapy for treating patients with type 2 diabetes].

Journal: Orvosi hetilap 20111127

Title: Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats.

Journal: British journal of pharmacology 20111101

Title: Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: a randomized, double-blind, crossover study.

Journal: Diabetes, obesity & metabolism 20111101

Title: Encapsulation of exenatide in poly-(D,L-lactide-co-glycolide) microspheres produced an investigational long-acting once-weekly formulation for type 2 diabetes.

Journal: Diabetes technology & therapeutics 20111101

Title: Exendin-4 upregulates the expression of Wnt-4, a novel regulator of pancreatic β-cell proliferation.

Journal: American journal of physiology. Endocrinology and metabolism 20111101

Title: Umami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats.

Journal: The Journal of pharmacology and experimental therapeutics 20111101

Title: Evaluating the long-term cost-effectiveness of liraglutide versus exenatide BID in patients with type 2 diabetes who fail to improve with oral antidiabetic agents.

Journal: Clinical therapeutics 20111101

Title: Exenatide and sitagliptin: pancreatitis and pancreatic cancer. Harms on the rise.

Journal: Prescrire international 20111101

Title: Effect of exenatide on gastric emptying and graft survival in islet allograft recipients.

Journal: Transplantation proceedings 20111101

Title: The pharmacologic basis for clinical differences among GLP-1 receptor agonists and DPP-4 inhibitors.

Journal: Postgraduate medicine 20111101

Title: An update on exenatide, a novel therapeutic option for patients with type 2 diabetes.

Journal: Drugs of today (Barcelona, Spain : 1998) 20111101

Title: Exendin-4 regulates the expression of the ATP-binding cassette transporter A1 via transcriptional factor PREB in the pancreatic β cell line.

Journal: Journal of endocrinological investigation 20111001

Title: Functional association of the N-terminal residues with the central region in glucagon-related peptides.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20111001

Title: Exenatide once-weekly clinical development: safety and efficacy across a range of background therapies.

Journal: Diabetes technology & therapeutics 20111001

Title: Glucagon-like peptide-1 receptor activation stimulates hepatic lipid oxidation and restores hepatic signalling alteration induced by a high-fat diet in nonalcoholic steatohepatitis.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20111001

Title: A physiological role of glucagon-like peptide-1 receptors in the central nervous system of Suncus murinus (house musk shrew).

Journal: European journal of pharmacology 20111001

Title: Exendin-4 increases histone acetylase activity and reverses epigenetic modifications that silence Pdx1 in the intrauterine growth retarded rat.

Journal: Diabetologia 20111001

Title: A thorough QT study to evaluate the effects of singledose exenatide 10 μg on cardiac repolarization in healthy subjects.

Journal: International journal of clinical pharmacology and therapeutics 20111001

Title: [Rare cause of insufficient metabolic control of diabetes mellitus - Case 10/2011].

Journal: Deutsche medizinische Wochenschrift (1946) 20111001

Title: Peptide ligations accelerated by N-terminal aspartate and glutamate residues.

Journal: Organic letters 20110916

Title: Glucagon-like peptide-1 analogues for Type 2 diabetes mellitus: current and emerging agents.

Journal: Drugs 20110910

Title: Roux-en-Y gastric bypass-induced improvement of glucose tolerance and insulin resistance in type 2 diabetic rats are mediated by glucagon-like peptide-1.

Journal: Obesity surgery 20110901

Title: The safety and tolerability of GLP-1 receptor agonists in the treatment of type 2 diabetes: a review.

Journal: Diabetes/metabolism research and reviews 20110901

Title: Sitagliptin or exenatide once weekly for type 2 diabetes: comparison of the clinical trials.

Journal: Expert opinion on pharmacotherapy 20110901

Title: The metabolic syndrome influences the response to incretin-based therapies.

Journal: Acta diabetologica 20110901

Title: Peptide complex containing GLP-1 exhibited long-acting properties in the treatment of type 2 diabetes.

Journal: Diabetes research and clinical practice 20110901

Title: Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients.

Journal: European journal of pharmacology 20110901

Title: GLP-1 receptor agonists today.

Journal: Diabetes research and clinical practice 20110901

Title: Glucagon-like peptide-1 receptor activation inhibits growth and augments apoptosis in murine CT26 colon cancer cells.

Journal: Endocrinology 20110901

Title: Brain GLP-1 signaling regulates femoral artery blood flow and insulin sensitivity through hypothalamic PKC-δ.

Journal: Diabetes 20110901

Title: Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice.

Journal: Diabetes 20110901

Title: Effects of exenatide on measures of β-cell function after 3 years in metformin-treated patients with type 2 diabetes.

Journal: Diabetes care 20110901

Title: Incretin-based therapy and the quest for sustained improvements in β-cell health.

Journal: Diabetes care 20110901

Title: Clinical implications of exenatide as a twice-daily or once-weekly therapy for type 2 diabetes.

Journal: Postgraduate medicine 20110901

Title: In vivo imaging of transplanted islets with 64Cu-DO3A-VS-Cys40-Exendin-4 by targeting GLP-1 receptor.

Journal: Bioconjugate chemistry 20110817

Title: Cardiovascular effects of glucagonlike peptide-1 agonists.

Journal: The American journal of cardiology 20110802

Title: Safety, efficacy and tolerability of exenatide in combination with insulin in the Association of British Clinical Diabetologists nationwide exenatide audit*.

Journal: Diabetes, obesity & metabolism 20110801

Title: Albumin-coated porous hollow poly(lactic-co-glycolic acid) microparticles bound with palmityl-acylated exendin-4 as a long-acting inhalation delivery system for the treatment of diabetes.

Journal: Pharmaceutical research 20110801

Title: Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110801

Title: Mechanisms mediating the diuretic and natriuretic actions of the incretin hormone glucagon-like peptide-1.

Journal: American journal of physiology. Renal physiology 20110801

Title: Comparison of exendin-4 on beta-cell replication in mouse and human islet grafts.

Journal: Transplant international : official journal of the European Society for Organ Transplantation 20110801

Title: Effects of a single dose of exenatide on appetite, gut hormones, and glucose homeostasis in adults with Prader-Willi syndrome.

Journal: The Journal of clinical endocrinology and metabolism 20110801

Title: Response at 3 months to insulin dose decisions made at exenatide initiation in the Association of British Clinical Diabetologists (ABCD) nationwide exenatide audit.

Journal: Diabetes research and clinical practice 20110801

Title: GLP-1 receptor agonists and HBA1c target of <7% in type 2 diabetes: meta-analysis of randomized controlled trials.

Journal: Current medical research and opinion 20110801

Title: Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4.

Journal: Endocrinology 20110801

Title: Incretin effect: GLP-1, GIP, DPP4.

Journal: Diabetes research and clinical practice 20110801

Title: Management of type 2 diabetes: new and future developments in treatment.

Journal: Lancet (London, England) 20110709

Title: Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies.

Journal: Gastroenterology 20110701

Title: Comparative effects of the long-acting GLP-1 receptor ligands, liraglutide and exendin-4, on food intake and body weight suppression in rats.

Journal: Obesity (Silver Spring, Md.) 20110701

Title: Exendin-4 increases islet amyloid deposition but offsets the resultant beta cell toxicity in human islet amyloid polypeptide transgenic mouse islets.

Journal: Diabetologia 20110701

Title: The GLP-1 mimetic exenatide potentiates insulin secretion in healthy cats.

Journal: Domestic animal endocrinology 20110701

Title: GLP-1-based therapies: the dilemma of uncertainty.

Journal: Gastroenterology 20110701

Title: Efficacy and safety of long-acting glucagon-like peptide-1 receptor agonists compared with exenatide twice daily and sitagliptin in type 2 diabetes mellitus: a systematic review and meta-analysis.

Journal: The Annals of pharmacotherapy 20110701

Title: Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: DURATION-2: efficacy and safety of switching from maximum daily sitagliptin or pioglitazone to once-weekly exenatide.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20110601

Title: Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: results from the Liraglutide Effect and Action in Diabetes (LEAD) trials.

Journal: The Journal of clinical endocrinology and metabolism 20110601

Title: Divergent effects of GLP-1 analogs exendin-4 and exendin-9 on the expression of myosin heavy chain isoforms in C2C12 myotubes.

Journal: Peptides 20110601

Title: GLP-1 analogs containing disulfide bond exhibited prolonged half-life in vivo than GLP-1.

Journal: Peptides 20110601

Title: Exenatide improves weight loss insulin sensitivity and β-cell function following administration to a type 2 diabetic HIV patient on antiretroviral therapy.

Journal: Annales d'endocrinologie 20110601

Title: An overview of once-weekly glucagon-like peptide-1 receptor agonists--available efficacy and safety data and perspectives for the future.

Journal: Diabetes, obesity & metabolism 20110501

Title: Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity.

Journal: British journal of pharmacology 20110501

Title: An analysis of the impact of FDA's guidelines for addressing cardiovascular risk of drugs for type 2 diabetes on clinical development.

Journal: Contemporary clinical trials 20110501

Title: DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes.

Journal: The Journal of clinical endocrinology and metabolism 20110501

Title: Application of novel peptide (Pp1) improving the half-life of exendin-4 in vivo.

Journal: Peptides 20110501

Title: GLP-1 and exendin-4 can reverse hyperlipidic-related osteopenia.

Journal: The Journal of endocrinology 20110501

Title: Incretin effects on β-cell function, replication, and mass: the human perspective.

Journal: Diabetes care 20110501

Title: Long-acting glucagon-like peptide 1 receptor agonists: a review of their efficacy and tolerability.

Journal: Diabetes care 20110501

Title: [Clinical application of exenatide in Japanese patients with type 2 diabetes mellitus].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20110501

Title: Mono-PEGylated dimeric exendin-4 as high receptor binding and long-acting conjugates for type 2 anti-diabetes therapeutics.

Journal: Bioconjugate chemistry 20110420

Title: A 4-arm polyethylene glycol derivative conjugated with exendin-4 peptide and palmitylamine having dual-function of size-increase and albumin-binding for long hypoglycemic action.

Journal: Regulatory peptides 20110411

Title: Journal withdraws article after complaints from drug manufacturers.

Journal: BMJ (Clinical research ed.) 20110411

Title: Exendin-4 regulates GLUT2 expression via the CaMKK/CaMKIV pathway in a pancreatic β-cell line.

Journal: Metabolism: clinical and experimental 20110401

Title: Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes.

Journal: Diabetologia 20110401

Title: The glucose-lowering potential of exendin-4 orally delivered via a pH-sensitive nanoparticle vehicle and effects on subsequent insulin secretion in vivo.

Journal: Biomaterials 20110401

Title: Novel GLP-1 mimetics developed to treat type 2 diabetes promote progenitor cell proliferation in the brain.

Journal: Journal of neuroscience research 20110401

Title: Pharmacotherapy: GLP-1 analogues and insulin: sound the wedding bells?

Journal: Nature reviews. Endocrinology 20110401

Title: Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice.

Journal: Diabetes 20110401

Title: Acute pancreatitis associated with liraglutide.

Journal: The Annals of pharmacotherapy 20110401

Title: [Treatment of type 2 diabetes mellitus with GLP-1 agonists].

Journal: Vnitrni lekarstvi 20110401

Title: Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation.

Journal: Cell metabolism 20110302

Title: Pharmacokinetic and pharmacodynamic modeling of exendin-4 in type 2 diabetic Goto-Kakizaki rats.

Journal: The Journal of pharmacology and experimental therapeutics 20110301

Title: Exenatide bid observational study (ExOS): baseline population characteristics of a prospective research study to evaluate the clinical effectiveness of exenatide bid use in patients with type 2 diabetes in a real-world setting.

Journal: Current medical research and opinion 20110301

Title: Exenatide twice daily versus premixed insulin aspart 70/30 in metformin-treated patients with type 2 diabetes: a randomized 26-week study on glycemic control and hypoglycemia.

Journal: Diabetes care 20110301

Title: Role of glucagon-like peptide-1 and its agonists on early prevention of cardiac remodeling in type 1 diabetic rat hearts.

Journal: General physiology and biophysics 20110301

Title: Glucagon-like peptide-1 analogues for type 2 diabetes.

Journal: BMJ (Clinical research ed.) 20110216

Title: Exendin-4, a glucagon-like peptide-1 receptor agonist, reduces intimal thickening after vascular injury.

Journal: Biochemical and biophysical research communications 20110204

Title: Effect of administration time of exenatide on satiety responses, blood glucose, and adverse events in healthy volunteers.

Journal: Journal of clinical pharmacology 20110201

Title: Effect of exenatide on fat deposition and a metabolic profile in patients with metabolic syndrome.

Journal: Metabolic syndrome and related disorders 20110201

Title: Exendin-4 improves hepatocyte injury by decreasing proliferation through blocking NGF/TrkA in diabetic mice.

Journal: Peptides 20110201

Title: Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes.

Journal: Biomaterials 20110201

Title: The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses.

Journal: Endocrinology 20110201

Title: Glucagon-like peptide-1 receptor agonist treatment prevents glucocorticoid-induced glucose intolerance and islet-cell dysfunction in humans.

Journal: Diabetes care 20110201

Title: Exenatide - pharmacokinetics, pharmacodynamics, safety and tolerability in patients ≥ 75 years of age with Type 2 diabetes.

Journal: International journal of clinical pharmacology and therapeutics 20110201

Title: Weight-related quality of life, health utility, psychological well-being, and satisfaction with exenatide once weekly compared with sitagliptin or pioglitazone after 26 weeks of treatment.

Journal: Diabetes care 20110201

Title: Effect of exenatide on inflammatory and oxidative stress markers in patients with type 2 diabetes mellitus.

Journal: Diabetes technology & therapeutics 20110201

Title: Pharmacology of GLP-1 agonists: describing the therapeutic potential to patients.

Journal: The Journal of the American Osteopathic Association 20110201

Title: Optimizing outcomes for GLP-1 agonists.

Journal: The Journal of the American Osteopathic Association 20110201

Title: Incretin therapies in the management of elderly patients with type 2 diabetes mellitus.

Journal: Hospital practice (1995) 20110201

Title: Summaries for patients: Does adding exenatide to insulin treatment benefit patients with type 2 diabetes?

Journal: Annals of internal medicine 20110118

Title: Use of twice-daily exenatide in Basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial.

Journal: Annals of internal medicine 20110118

Title: The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test.

Journal: European journal of pharmacology 20110110

Title: Intravitreal injection of exendin-4 analogue protects retinal cells in early diabetic rats.

Journal: Investigative ophthalmology & visual science 20110105

Title: Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal rats.

Journal: Clinical science (London, England : 1979) 20110101

Title: Durability of effects of exenatide treatment on glycemic control, body weight, systolic blood pressure, C-reactive protein, and triglyceride concentrations.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Title: Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: a retrospective analysis of the LifeLink database.

Journal: Diabetes care 20110101

Title: Exendin-4 suppresses SRC activation and reactive oxygen species production in diabetic Goto-Kakizaki rat islets in an Epac-dependent manner.

Journal: Diabetes 20110101

Title: Structural study of an active analog of EX-4 in solution and micelle associated states.

Journal: Biopolymers 20110101

Title: Pharmacokinetics and pharmacodynamics of exenatide extended-release after single and multiple dosing.

Journal: Clinical pharmacokinetics 20110101

Title: Focus on incretin-based therapies: targeting the core defects of type 2 diabetes.

Journal: Postgraduate medicine 20110101

Title: Exenatide improves glucose homeostasis and prolongs survival in a murine model of dilated cardiomyopathy.

Journal: PloS one 20110101

Title: Cardiovascular safety of exenatide BID: an integrated analysis from controlled clinical trials in participants with type 2 diabetes.

Journal: Cardiovascular diabetology 20110101

Title: Down-regulation of zinc transporter 8 in the pancreas of db/db mice is rescued by Exendin-4 administration.

Journal: Molecular medicine reports 20110101

Title: Exenatide: excessive weight loss.

Journal: Prescrire international 20110101

Title: Cost-utility of exenatide once weekly compared with insulin glargine in patients with type 2 diabetes in the UK.

Journal: Journal of medical economics 20110101

Title: Glucagon-like peptide-1 receptor agonists and cardiovascular events: a meta-analysis of randomized clinical trials.

Journal: Experimental diabetes research 20110101

Title: Exendin-4 improves blood glucose control in both young and aging normal non-diabetic mice, possible contribution of beta cell independent effects.

Journal: PloS one 20110101

Title: [Cost-effectiveness of exenatide versus insulin glargine in Spanish patients with obesity and type 2 diabetes mellitus].

Journal: Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion 20110101

Title: Assessment of glucagon-like peptide-1 analogue and renin inhibitor on the binding and regulation of GLP-1 receptor in type 1 diabetic rat hearts.

Journal: Experimental diabetes research 20110101

Title: Glucagon-like peptide-1 gene therapy.

Journal: Experimental diabetes research 20110101

Title: Patient factors associated with glucagonlike peptide 1 receptor agonist use with and without insulin.

Journal: Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Title: Discovery of dual-action membrane-anchored modulators of incretin receptors.

Journal: PloS one 20110101

Title: GLP-1 analogs reduce hepatocyte steatosis and improve survival by enhancing the unfolded protein response and promoting macroautophagy.

Journal: PloS one 20110101

Title: Effect of additional treatment with EXenatide in patients with an Acute Myocardial Infarction (EXAMI): study protocol for a randomized controlled trial.

Journal: Trials 20110101

Title: Calcineurin signaling regulates human islet {beta}-cell survival.

Journal: The Journal of biological chemistry 20101217

Title: Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.

Journal: The Journal of physiology 20101215

Title: Chronic treatment of exendin-4 affects cell proliferation and neuroblast differentiation in the adult mouse hippocampal dentate gyrus.

Journal: Neuroscience letters 20101203

Title: Oligoarginine-linked polymers as a new class of penetration enhancers.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20101201

Title: GLP-1 signaling preserves cardiac function in endotoxemic Fischer 344 and DPP4-deficient rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20101201

Title: Exenatide does not evoke pancreatitis and attenuates chemically induced pancreatitis in normal and diabetic rodents.

Journal: American journal of physiology. Endocrinology and metabolism 20101201

Title: A placebo-controlled trial of exenatide twice-daily added to thiazolidinediones alone or in combination with metformin.

Journal: Diabetes, obesity & metabolism 20101201

Title: Changes in body composition after 9 months of treatment with exenatide twice daily versus glimepiride: comment letter on Jendle et al.

Journal: Diabetes, obesity & metabolism 20101201

Title: Remission of diabetes mellitus type 2 with severe hyperglycemia after Exenatide treatment.

Journal: Diabetes research and clinical practice 20101201

Title: [Glucagon-like peptide-1 analogues: effects on body weight and glycemia].

Journal: Giornale italiano di cardiologia (2006) 20101201

Title: Presence of a functional receptor for GLP-1 in osteoblastic cells, independent of the cAMP-linked GLP-1 receptor.

Journal: Journal of cellular physiology 20101101

Title: One-year metabolic outcomes in patients with type 2 diabetes treated with exenatide in routine practice.

Journal: Diabetes & metabolism 20101101

Title: Impact of postprandial and fasting glucose concentrations on HbA1c in patients with type 2 diabetes.

Journal: Diabetes & metabolism 20101101

Title: Anti-inflammatory action of exendin-4 in human islets is enhanced by phosphodiesterase inhibitors: potential therapeutic benefits in diabetic patients.

Journal: Diabetologia 20101101

Title: Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis.

Journal: Diabetes care 20101101

Title: Preparation, characterization, and pharmacodynamics of exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres.

Journal: Chemical & pharmaceutical bulletin 20101101

Title: Exendin-4 protects oxidative stress-induced β-cell apoptosis through reduced JNK and GSK3β activity.

Journal: Journal of Korean medical science 20101101

Title: Novel glucagon-like peptide-1 analog delivered orally reduces postprandial glucose excursions in porcine and canine models.

Journal: Journal of diabetes science and technology 20101101

Title: [Cardiac effects of glucagon-like peptide 1].

Journal: Ugeskrift for laeger 20101011

Title: [Glucagon-like peptide-1: a cardiological perspective].

Journal: Ugeskrift for laeger 20101011

Title: Treatment with omega-3 fatty acids but not exendin-4 improves hepatic steatosis.

Journal: European journal of gastroenterology & hepatology 20101001

Title: Prophylactic use of anti-emetic medications reduced nausea and vomiting associated with exenatide treatment: a retrospective analysis of an open-label, parallel-group, single-dose study in healthy subjects.

Journal: Diabetic medicine : a journal of the British Diabetic Association 20101001

Title: Liraglutide: the therapeutic promise from animal models.

Journal: International journal of clinical practice. Supplement 20101001

Title: Clinical experience with liraglutide.

Journal: International journal of clinical practice. Supplement 20101001

Title: Six-month exenatide improves HOMA hyperbolic product in type 2 diabetic patients mostly by enhancing beta-cell function rather than insulin sensitivity.

Journal: Diabetes & metabolism 20100901

Title: One-year treatment with exenatide vs. insulin glargine: effects on postprandial glycemia, lipid profiles, and oxidative stress.

Journal: Atherosclerosis 20100901

Title: Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

Journal: Molecular pharmacology 20100901

Title: Dose combinations of exendin-4 and salmon calcitonin produce additive and synergistic reductions in food intake in nonhuman primates.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100901

Title: Exenatide suppresses postprandial elevations in lipids and lipoproteins in individuals with impaired glucose tolerance and recent onset type 2 diabetes mellitus.

Journal: Atherosclerosis 20100901

Title: Exenatide therapy in insulin-treated type 2 diabetes and obesity.

Journal: QJM : monthly journal of the Association of Physicians 20100901

Title: Newly appreciated therapeutic effect of GLP-1 receptor agonists: reduction in postprandial lipemia.

Journal: Atherosclerosis 20100901

Title: Exendin-4 protects pancreatic beta cells from human islet amyloid polypeptide-induced cell damage: potential involvement of AKT and mitochondria biogenesis.

Journal: Diabetes, obesity & metabolism 20100901

Title: Distinguishing among incretin-based therapies. Glucose-lowering effects of incretin-based therapies.