Name: Name:Boc-7-hydroxy-(s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Brand: AABLOCKS
SKU: AA007JUJ
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA007JUJ

Chemical Name: Boc-7-hydroxy-(s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

CAS Number: 142335-42-0

Molecular Formula: C15H19NO5

Molecular Weight: 293.3151

MDL Number: MFCD00671683

SMILES: O=C(N1Cc2cc(O)ccc2C[C@H]1C(=O)O)OC(C)(C)C

NSC Number: 667003

Properties

Complexity: 417

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 21

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 1.9

Downstream Synthesis Route

142335-41-9

142335-42-0

[1]CurrentPatentAssignee:CANCERTHERAPEUTICSCRCPTYLTD-WO2017/153513,2017,A1Locationinpatent:Page/Pagecolumn81;94

[2]Locationinpatent:experimentalpartZhang,Yingjie;Feng,Jinhong;Jia,Yuping;Wang,Xuejian;Zhang,Lei;Liu,Chunxi;Fang,Hao;Xu,Wenfang[JournalofMedicinalChemistry,2011,vol.54,#8,p.2823-2838]

[3]Locationinpatent:schemeortableZhang,Yingjie;Fang,Hao;Feng,Jinhong;Jia,Yuping;Wang,Xuejian;Xu,Wenfang[JournalofMedicinalChemistry,2011,vol.54,#15,p.5532-5539]

[4]CurrentPatentAssignee:KYMERATHERAPEUTICSINC-WO2021/188948,2021,A1Locationinpatent:Paragraph001111;001116-001117

[5]CurrentPatentAssignee:KYMERATHERAPEUTICSINC-WO2021/188948,2021,A1Locationinpatent:Paragraph001111;001116-001117

[6]CurrentPatentAssignee:KYMERATHERAPEUTICSINC-US2019/192668,2019,A1Locationinpatent:Paragraph3284;3287

[7]CurrentPatentAssignee:KYMERATHERAPEUTICSINC-WO2020/113233,2020,A1Locationinpatent:Paragraph001115;001120;001121

[8]CurrentPatentAssignee:KYMERATHERAPEUTICSINC-WO2020/264499,2020,A1Locationinpatent:Paragraph002286;002291-00292

[9]Verschueren;Toth;Tourwe;Lebl;VanBinst;Hruby[Synthesis,1992,#5,p.458-460]

[10]Vendeville,Sandrine;Goossens,Filip;Debreu-Fontaine,Marie-Ange;Landry,Valérie;Davioud-Charvet,Elisabeth;Grellier,Philippe;Scharpe,Simon;Sergheraert,Christian[BioorganicandMedicinalChemistry,2002,vol.10,#6,p.1719-1729]

[11]Locationinpatent:experimentalpartZhang,Yingjie;Feng,Jinhong;Liu,Chunxi;Zhang,Lei;Jiao,Jie;Fang,Hao;Su,Li;Zhang,Xiaopan;Zhang,Jian;Li,Minyong;Wang,Binghe;Xu,Wenfang[BioorganicandMedicinalChemistry,2010,vol.18,#5,p.1761-1772]

24424-99-5

128502-56-7

142335-42-0

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[2]Patent:WO2018/183171,2018,A1.Locationinpatent:Page/Pagecolumn37;38

[3]JournaloftheAmericanChemicalSociety,1996,vol.118,p.8300-8307

[4]Patent:WO2009/34388,2009,A1.Locationinpatent:Page/Pagecolumn42

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[6]JournalofMedicinalChemistry,2015,vol.58,p.1556-1562

142335-42-0

598-41-4

(S)-3-(Carbamoylmethyl-carbamoyl)-7-hydroxy-3,4-dihydro-1H-isoquinoline-2-carboxylicacidtert-butylester

[1]Wiczk,Wiesław;Stachowiak,Krystyna;Skurski,Piotr;ŁAnkiewicz,Leszek;Michniewicz,Alicja;Rój,Anna[JournaloftheAmericanChemicalSociety,1996,vol.118,#35,p.8300-8307]

142335-42-0

74-89-5

(S)-7-Hydroxy-3-methylcarbamoyl-3,4-dihydro-1H-isoquinoline-2-carboxylicacidtert-butylester

[1]Wiczk,Wiesław;Stachowiak,Krystyna;Skurski,Piotr;ŁAnkiewicz,Leszek;Michniewicz,Alicja;Rój,Anna[JournaloftheAmericanChemicalSociety,1996,vol.118,#35,p.8300-8307]

142335-42-0

18107-18-1

262616-16-0

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[2]CurrentPatentAssignee:ASTELLASPHARMAINC.-WO2009/34388,2009,A1Locationinpatent:Page/Pagecolumn42-43

142335-42-0 | Boc-7-hydroxy-(s)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid