Title: Differential Regulation of Gene Expression by Cholesterol Biosynthesis Inhibitors That Reduce (Pravastatin) or Enhance (Squalestatin 1) Nonsterol Isoprenoid Levels in Primary Cultured Mouse and Rat Hepatocytes.
Journal: The Journal of pharmacology and experimental therapeutics 20160801
Title: Critical time window of neuronal cholesterol synthesis during neurite outgrowth.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120530
Title: Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase.
Journal: The Journal of biological chemistry 20120525
Title: Effects of farnesyl pyrophosphate accumulation on calvarial osteoblast differentiation.
Journal: Endocrinology 20110801
Title: Prevention of transplant coronary artery disease by prenylation inhibitors.
Journal: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20110701
Title: Inhibition of the isoprenoid biosynthesis pathway; detection of intermediates by UPLC-MS/MS.
Journal: Biochimica et biophysica acta 20110401
Title: A general access to zaragozic acids: total synthesis and structure elucidation of zaragozic acid D and formal syntheses of zaragozic acids A and C.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20110314
Title: Improvement of dolichol-linked oligosaccharide biosynthesis by the squalene synthase inhibitor zaragozic acid.
Journal: The Journal of biological chemistry 20110225
Title: Activation of PPAR-γ and PTEN cascade participates in lovastatin-mediated accelerated differentiation of oligodendrocyte progenitor cells.
Journal: Glia 20101101
Title: Molecular docking studies to map the binding site of squalene synthase inhibitors on dehydrosqualene synthase of Staphylococcus aureus.
Journal: Journal of biomolecular structure & dynamics 20101001
Title: 4-Nitrobenzoate inhibits coenzyme Q biosynthesis in mammalian cell cultures.
Journal: Nature chemical biology 20100701
Title: Cholesterol reduction impairs exocytosis of synaptic vesicles.
Journal: Journal of cell science 20100215
Title: Farnesyl pyrophosphate inhibits epithelialization and wound healing through the glucocorticoid receptor.
Journal: The Journal of biological chemistry 20100115
Title: Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis.
Journal: Journal of Alzheimer's disease : JAD 20100101
Title: Cholesterol biosynthesis modulation regulates dengue viral replication.
Journal: Virology 20090620
Title: Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation.
Journal: Nature chemical biology 20080901
Title: Inhibition of squalene synthase upregulates PCSK9 expression in rat liver.
Journal: Archives of biochemistry and biophysics 20080215
Title: The ergosterol biosynthesis inhibitor zaragozic acid promotes vacuolar degradation of the tryptophan permease Tat2p in yeast.
Journal: Biochimica et biophysica acta 20070701
Title: Squalene synthase, a determinant of Raft-associated cholesterol and modulator of cancer cell proliferation.
Journal: The Journal of biological chemistry 20070629
Title: The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus.
Journal: Journal of hepatology 20070301
Title: Squalestatin alters the intracellular trafficking of a neurotoxic prion peptide.
Journal: BMC neuroscience 20070101
Title: Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20061204
Title: Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate kinase deficiency.
Journal: Arthritis and rheumatism 20060701
Title: INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins.
Journal: The EMBO journal 20051116
Title: Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids.
Journal: Archives of biochemistry and biophysics 20050201
Title: Simultaneous determination of farnesyl and geranylgeranyl pyrophosphate levels in cultured cells.
Journal: Analytical biochemistry 20050101
Title: Statin inhibition of Fc receptor-mediated phagocytosis by macrophages is modulated by cell activation and cholesterol.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20041101
Title: Squalestatin cures prion-infected neurons and protects against prion neurotoxicity.
Journal: The Journal of biological chemistry 20040409
Title: Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses.
Journal: Blood 20030501
Title: Squalestatin 1-inducible expression of rat CYP2B: evidence that an endogenous isoprenoid is an activator of the constitutive androstane receptor.
Journal: Molecular pharmacology 20021101
Title: Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase.
Journal: Plant physiology 20020901
Title: Novel approach to the zaragozic acids. Enantioselective total synthesis of 6,7-dideoxysqualestatin H5.
Journal: The Journal of organic chemistry 20020614
Title: Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes.
Journal: Hepatology (Baltimore, Md.) 20020601
Title: Modeling of binding modes and inhibition mechanism of some natural ligands of farnesyl transferase using molecular docking.
Journal: Journal of medicinal chemistry 20020328
Title: A Link between cholesterol levels and phenobarbital induction of cytochromes P450.
Journal: Biochemical and biophysical research communications 20020222
Title: Rapid synthesis of the 7-deoxy zaragozic acid core.
Journal: Organic letters 20020124
Title: Inhibitors of sterol biosynthesis and amphotericin B reduce the viability of pneumocystis carinii f. sp. carinii.
Journal: Antimicrobial agents and chemotherapy 20000601
Title: Truncation of human squalene synthase yields active, crystallizable protein.
Journal: Archives of biochemistry and biophysics 19980215
Title: Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems.
Journal: Archives of biochemistry and biophysics 19950201
Title: Structure-activity relationships of C1 and C6 side chains of zaragozic acid A derivatives.
Journal: Journal of medicinal chemistry 19941111
Title: Zaragozic acids: a family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase.
Journal: Proceedings of the National Academy of Sciences of the United States of America 19930101
