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1443246-62-5,MFCD27977571
Catalog No.:AA01ENJ9

1443246-62-5 | N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea

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1mg
97%
in stock  
$18.00   $13.00
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5mg
97%
in stock  
$41.00   $29.00
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10mg
97%
in stock  
$60.00   $42.00
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25mg
97%
in stock  
$101.00   $71.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01ENJ9
Chemical Name:
N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
CAS Number:
1443246-62-5
Molecular Formula:
C17H14F2N4O
Molecular Weight:
328.3161
MDL Number:
MFCD27977571
SMILES:
O=C(Nc1cc(nn1c1ccccc1)C)Nc1ccc(c(c1)F)F
Properties
Computed Properties
 
Complexity:
433  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
3.4  

Downstream Synthesis Route

[1]Kaufmann,Kristian;Romaine,Ian;Days,Emily;Pascual,Conrado;Malik,Adam;Yang,Liya;Zou,Bende;Du,Yu;Sliwoski,Greg;Morrison,RyanD.;Denton,Jerod;Niswender,ColleenM.;Daniels,J.Scott;Sulikowski,GaryA.;Xie,Xinmin;Lindsley,CraigW.;Weaver,C.David[ACSChemicalNeuroscience,2013,vol.4,#9,p.1278-1286]

[2]CurrentPatentAssignee:VANDERBILTUNIVERSITY-US9067894,2015,B1Locationinpatent:Page/Pagecolumn23

1131-18-6   
CASUnavailable 
  1443246-62-5 

[1]Kulkarni,AbhijitR.;Garai,Sumanta;Thakur,GaneshA.[JournalofOrganicChemistry,2017,vol.82,#2,p.992-999]

Literature

Title: ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.

Journal: ACS chemical neuroscience 20130918

Title: Wen W, et al. Discovery of 'molecular switches' within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorg Med Chem Lett. 2013 Aug 15;23(16):4562-6.

Title: Kaufmann K, et al. ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86.

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Tags:1443246-62-5 Molecular Formula|1443246-62-5 MDL|1443246-62-5 SMILES|1443246-62-5 N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea