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Home Amines 145783-15-9
145783-15-9,MFCD16875503
Catalog No.:AA001DBL

145783-15-9 | 4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001DBL
Chemical Name:
4,6-Dichloro-2-(propylthio)pyrimidin-5-amine
CAS Number:
145783-15-9
Molecular Formula:
C7H9Cl2N3S
Molecular Weight:
238.1375
MDL Number:
MFCD16875503
SMILES:
CCCSc1nc(Cl)c(c(n1)Cl)N
Properties
Properties
 
BP:
334°C at 760 mmHg  
Form:
Solid  
Storage:
Keep in dry area;Room Temperature;  

Computed Properties
 
Complexity:
149  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.2  

Upstream Synthesis Route

[1]Patent:US2011/71290,2011,A1,.Locationinpatent:Page/Pagecolumn3

[2]Patent:WO2012/138981,2012,A2,.Locationinpatent:Page/Pagecolumn49

[3]Patent:EP2586773,2013,A1,.Locationinpatent:Paragraph0059-0060

[4]Patent:WO2013/60837,2013,A1,.Locationinpatent:Page/Pagecolumn26

[5]Patent:WO2005/95358,2005,A2,.Locationinpatent:Page/Pagecolumn5

[6]Patent:WO2010/30224,2010,A1,.Locationinpatent:Page/Pagecolumn7

[7]JournalofHeterocyclicChemistry,2017,vol.54,#1,p.436-449

[8]Patent:CN106432248,2017,A,.Locationinpatent:Paragraph0086;0087

[9]EuropeanJournalofMedicinalChemistry,2017,vol.138,p.1034-1041

[10]MedChemComm,2017,vol.8,#8,p.1655-1658

[11]Patent:CN106928235,2017,A,.Locationinpatent:Paragraph0058;0059

[12]Patent:CN107033148,2017,A,.Locationinpatent:Paragraph0060;0061

[13]EuropeanJournalofMedicinalChemistry,2018,vol.146,p.147-156

[1]Patent:WO2005/95358,2005,A2,.Locationinpatent:Page/Pagecolumn5-6

[2]BioorganicandMedicinalChemistryLetters,2012,vol.22,#11,p.3598-3602

[1]Patent:WO2014/23681,2014,A1,.Locationinpatent:Page/Pagecolumn30;31

[2]Patent:US2015/152114,2015,A1,.Locationinpatent:Paragraph0143-0148;0152-0153

[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,#11,p.3598-3602

[2]JournalofHeterocyclicChemistry,2017,vol.54,#1,p.436-449

[3]Patent:CN106432248,2017,A,

[4]EuropeanJournalofMedicinalChemistry,2017,vol.138,p.1034-1041

[5]MedChemComm,2017,vol.8,#8,p.1655-1658

[6]Patent:CN106928235,2017,A,

[7]Patent:CN107033148,2017,A,

[8]EuropeanJournalofMedicinalChemistry,2018,vol.146,p.147-156

[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,#11,p.3598-3602

Downstream Synthesis Route
145783-15-9    274693-55-9   
2-((3aR,4S,6R,6aS)-6-5-amino-6-chloro-2-(mercaptopropyl)pyrimidin-4-ylamino}-2,2-dimethyltetrahydro-3aH-cyclopentad1,3dioxolan-4-yl)oxyethanol 

[1]Patent:CN105503876,2016,A.Locationinpatent:Paragraph0015

[2]Patent:CN105198864,2018,B.Locationinpatent:Paragraph0022-0031

[3]Patent:CN105669681,2016,A.Locationinpatent:Paragraph0028

[4]Patent:CN103626745,2016,B.Locationinpatent:Paragraph0080;0081;0082

[5]Patent:CN107033146,2017,A.Locationinpatent:Paragraph0070-0074

[6]StructuralChemistry,2018,vol.29,p.1663-1670

[7]BioorganicandMedicinalChemistryLetters,2007,vol.17,p.6013-6018

[8]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.3598-3602

[9]Patent:WO2012/142983,2012,A1.Locationinpatent:Page/Pagecolumn5-7

[10]Patent:CN107089984,2017,A.Locationinpatent:Paragraph0041;0051;0060;0069

[11]StructuralChemistry,2018,vol.29,p.871-879

145783-15-9    330681-18-0   
(3R,4R)-3-5-Amino-6-chloro-2-(propylthio)pyrimidin-4-ylamino-4-hydroxy-1-pyrrolidinecarboxylate,1,1-dimethylethylester 

[1]Patent:EP1216248,2004,B1.Locationinpatent:Pagecolumn10-11

[1]Patent:US2011/71290,2011,A1.Locationinpatent:Page/Pagecolumn3

[2]Patent:WO2012/138981,2012,A2.Locationinpatent:Page/Pagecolumn49

[3]Patent:EP2586773,2013,A1.Locationinpatent:Paragraph0059-0060

[4]Patent:WO2013/60837,2013,A1.Locationinpatent:Page/Pagecolumn26

[5]Patent:WO2005/95358,2005,A2.Locationinpatent:Page/Pagecolumn5

[6]Patent:WO2010/30224,2010,A1.Locationinpatent:Page/Pagecolumn7

[7]JournalofHeterocyclicChemistry,2017,vol.54,p.436-449

[8]Patent:CN106432248,2017,A.Locationinpatent:Paragraph0086;0087

[9]EuropeanJournalofMedicinalChemistry,2017,vol.138,p.1034-1041

[10]MedChemComm,2017,vol.8,p.1655-1658

[11]Patent:CN106928235,2017,A.Locationinpatent:Paragraph0058;0059

[12]Patent:CN107033148,2017,A.Locationinpatent:Paragraph0060;0061

[13]EuropeanJournalofMedicinalChemistry,2018,vol.146,p.147-156

[14]Patent:CN111116592,2020,A.Locationinpatent:Paragraph0043;0076-0079

[1]Zhang,Hao;Liu,Jun;Zhang,Luyong;Kong,Lingyi;Yao,Hequan;Sun,Hongbin[BioorganicandMedicinalChemistryLetters,2012,vol.22,#11,p.3598-3602]

[2]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/138981,2012,A2

[3]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/138981,2012,A2

[4]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/138981,2012,A2

[5]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/138981,2012,A2

[6]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/138981,2012,A2

[7]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/138981,2012,A2

[8]CurrentPatentAssignee:TEVAPHARMACEUTICALINDUSTRIESLTD.-WO2012/138981,2012,A2

[9]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-EP2586773,2013,A1

[10]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[11]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[12]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[13]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[14]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[15]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[16]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[17]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[18]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[19]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1

[20]CurrentPatentAssignee:Sandoz(in:Novartis);NOVARTISAG-WO2013/92900,2013,A1

[21]CurrentPatentAssignee:Sandoz(in:Novartis);NOVARTISAG-WO2013/92900,2013,A1

[22]CurrentPatentAssignee:Sandoz(in:Novartis);NOVARTISAG-WO2013/92900,2013,A1

[23]CurrentPatentAssignee:Sandoz(in:Novartis);NOVARTISAG-EP2607355,2013,A1

[24]CurrentPatentAssignee:Sandoz(in:Novartis);NOVARTISAG-EP2607355,2013,A1

[25]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-WO2013/163892,2013,A1

[26]CurrentPatentAssignee:MEGAFINEPHARMA(P)LTD.-WO2014/102830,2014,A1

[27]CurrentPatentAssignee:MEGAFINEPHARMA(P)LTD.-WO2014/102830,2014,A1

[28]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-US2015/73146,2015,A1

[29]CurrentPatentAssignee:CIPLALTD;COTTRILLEMILY-WO2016/30704,2016,A1

[30]CurrentPatentAssignee:CIPLALTD;COTTRILLEMILY-WO2016/30704,2016,A1

[31]CurrentPatentAssignee:CHENGDUHUAYUPHARMACEUTICAL-CN105669681,2016,A

[32]CurrentPatentAssignee:STRIDESPHARMASCIENCELIMITED-WO2016/128996,2016,A2

[33]CurrentPatentAssignee:HAISCOPHARMACEUTICALGROUPCO.,LTD.-CN103664958,2017,B

[34]CurrentPatentAssignee:SHANGHAIHUAYUANMEDICINETECHDEV-CN106866682,2017,A

[35]CurrentPatentAssignee:HUIZHOUXINLITAIPHARMACEUTICAL;SHENZHENSALUBRISPHARMACEUTICALSCO.,LTD.-CN105153167,2017,B

[36]CurrentPatentAssignee:HUNANTIANJICOTTAGEPHARMACEUTICAL-CN107337675,2017,A

[37]CurrentPatentAssignee:JINGCHUUNIVERSITYOFTECHNOLOGY-CN107089984,2017,A

[38]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-CN103626743,2018,B

[39]CurrentPatentAssignee:SHENZHENDONGYANGGUANGINDUSTRIALDEVELOPMENTCOLTD-CN103626743,2018,B

[40]CurrentPatentAssignee:JIANGSUHENGRUIMEDICINECO.,LTD.-US2016/52928,2016,A1

[41]CurrentPatentAssignee:JIANGSUHENGRUIMEDICINECO.,LTD.-US2016/52928,2016,A1

[42]CurrentPatentAssignee:JIANGSUHENGRUIMEDICINECO.,LTD.-US2016/52928,2016,A1

[43]CurrentPatentAssignee:JIANGSUHENGRUIMEDICINECO.,LTD.-US2016/52928,2016,A1

[44]CurrentPatentAssignee:BEIJINGDONGXULIPHARMACEUTICALTECH-CN108329320,2018,A

[45]CurrentPatentAssignee:HEBEIKIVIPHARM-CN108276417,2018,A

[46]CurrentPatentAssignee:TOPFONDPHARMA-CN108690026,2018,A

[47]CurrentPatentAssignee:TOPFONDPHARMA-CN108690026,2018,A

[48]CurrentPatentAssignee:TOPFONDPHARMA-CN108690026,2018,A

[49]CurrentPatentAssignee:TOPFONDPHARMA-CN108690026,2018,A

[50]CurrentPatentAssignee:JIANGXIGUOYAOPHARMACEUTICAL-CN108892670,2018,A

[51]CurrentPatentAssignee:YUTIANRONG;YuTianrong-CN108299441,2018,A

[52]CurrentPatentAssignee:HENANNORMALUNIVERSITY-CN111848632,2020,A

[53]Goffin,Eric;Jacques,Nicolas;Lancellotti,Patrizio;Musumeci,Lucia;Nchimi,Alain;Pirotte,Bernard;Oury,Cécile[EuropeanJournalofMedicinalChemistry,2020,vol.208]

[54]CurrentPatentAssignee:NANJINGYIXINHEPHARMATECH-CN111978326,2020,A

[1]Wang,Yeming;Yan,Hong;Ma,Chao;Lu,Dan[BioorganicandMedicinalChemistryLetters,2015,vol.25,#20,p.4461-4463]

[2]CurrentPatentAssignee:UNIVERSITYOFLIEGE-WO2019/158655,2019,A1Locationinpatent:Page/Pagecolumn66;67

[3]CurrentPatentAssignee:UNIVERSITYOFLIEGE-WO2020/212553,2020,A1Locationinpatent:Page/Pagecolumn78

[4]Goffin,Eric;Jacques,Nicolas;Lancellotti,Patrizio;Musumeci,Lucia;Nchimi,Alain;Pirotte,Bernard;Oury,Cécile[EuropeanJournalofMedicinalChemistry,2020,vol.208]

[5]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-EP2586773,2013,A1Locationinpatent:Paragraph0067-0068

[6]CurrentPatentAssignee:NOVARTISAG;Sandoz(in:Novartis)-WO2013/60837,2013,A1Locationinpatent:Page/Pagecolumn27-28

[7]CurrentPatentAssignee:BEIJINGUNIVERSITYOFTECHNOLOGY-CN107033146,2017,ALocationinpatent:Paragraph0021-0023

[8]Tian,Nana;Wang,Juan;Wang,Yeming;Yan,Hong;Zhao,Zhichang[2021,vol.12,#8,p.1414-1427]

[9]Locationinpatent:schemeortableZhang,Hao;Liu,Jun;Zhang,Luyong;Kong,Lingyi;Yao,Hequan;Sun,Hongbin[BioorganicandMedicinalChemistryLetters,2012,vol.22,#11,p.3598-3602]

[10]Tu,Wangyang;Fan,Jiang;Zhang,Haitang;Xu,Guoji;Liu,Zhiwei;Qu,Jian;Yang,Fanglong;Zhang,Lei;Luan,Tianyu;Yuan,Jijun;Gong,Aishen;Feng,Jun;Sun,Piaoyang;Dong,Qing[BioorganicandMedicinalChemistryLetters,2014,vol.24,#1,p.141-146]

Literature
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