Home Other Building Blocks 1476-53-5
1476-53-5,MFCD30207859
Catalog No.:AA00AOQB

1476-53-5 | Novobiocin sodium salt

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$8.00   $6.00
- +
5mg
98%
in stock  
$11.00   $8.00
- +
25mg
98%
in stock  
$19.00   $14.00
- +
100mg
98%
in stock  
$37.00   $26.00
- +
1g
≥95%
in stock  
$63.00   $44.00
- +
5g
≥95%
in stock  
$205.00   $143.00
- +
10g
in stock  
$324.00   $227.00
- +
25g
in stock  
$591.00   $414.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00AOQB
Chemical Name:
Novobiocin sodium salt
CAS Number:
1476-53-5
Molecular Formula:
C31H35N2NaO11
Molecular Weight:
634.6062
MDL Number:
MFCD30207859
SMILES:
COC1C(OC(=O)N)C(O)C(OC1(C)C)Oc1ccc2c(c1C)oc(=O)c(c2O)NC(=O)c1ccc(c(c1)CC=C(C)C)[O-].[Na+]
Properties
Computed Properties
 
Complexity:
1160  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
9  
Undefined Atom Stereocenter Count:
4  

Downstream Synthesis Route
1476-53-5   
4-hydroxy-3-(3-methylbut-2-enyl)benzamide 

[1]JournalofPharmaceuticalSciences,1983,vol.72,p.23-26

[1]JournalofMedicinalChemistry,2007,vol.50,p.6189-6200

[2]EuropeanJournalofMedicinalChemistry,2014,vol.83,p.498-507

[1]JournaloftheAmericanChemicalSociety,2018,vol.140,p.6749-6753

[2]JournalofMedicinalChemistry,2019,vol.62,p.9103-9115

[3]JournalofMedicinalChemistry,2007,vol.50,p.6189-6200

[1]Tetrahedron,2012,vol.68,p.2306-2312

[1]Tetrahedron,2012,vol.68,p.2306-2312

Literature

Title: Heat shock protein 70 is necessary to improve mitochondrial bioenergetics and reverse diabetic sensory neuropathy following KU-32 therapy.

Journal: The Journal of pharmacology and experimental therapeutics 20140201

Title: Isolation and characterization of new p-Terphenyls with antifungal, antibacterial, and antioxidant activities from halophilic actinomycete Nocardiopsis gilva YIM 90087.

Journal: Journal of agricultural and food chemistry 20130327

Title: Hsp90 stabilizes Cdc25A and counteracts heat shock-mediated Cdc25A degradation and cell-cycle attenuation in pancreatic carcinoma cells.

Journal: Human molecular genetics 20121101

Title: A forward chemical screen identifies antibiotic adjuvants in Escherichia coli.

Journal: ACS chemical biology 20120921

Title: Structure-based discovery of substituted 4,5'-bithiazoles as novel DNA gyrase inhibitors.

Journal: Journal of medicinal chemistry 20120726

Title: Structural and functional dissection of aminocoumarin antibiotic biosynthesis: a review.

Journal: Journal of structural and functional genomics 20120601

Title: Geldanamycin and its derivatives as Hsp90 inhibitors.

Journal: Frontiers in bioscience (Landmark edition) 20120601

Title: Functional study of the novel multidrug efflux pump KexD from Klebsiella pneumoniae.

Journal: Gene 20120501

Title: C-terminal heat shock protein 90 inhibitor decreases hyperglycemia-induced oxidative stress and improves mitochondrial bioenergetics in sensory neurons.

Journal: Journal of proteome research 20120406

Title: A combination of direct viable count and fluorescence in situ hybridization for specific enumeration of viable Lactobacillus delbrueckii subsp.bulgaricus and Streptococcus thermophilus.

Journal: Letters in applied microbiology 20120301

Title: Evaluation of gyrase B as a drug target in Mycobacterium tuberculosis.

Journal: The Journal of antimicrobial chemotherapy 20120201

Title: Thai ethnomedicinal plants as resistant modifying agents for combating Acinetobacter baumannii infections.

Journal: BMC complementary and alternative medicine 20120101

Title: Rhomboids of Mycobacteria: characterization using an aarA mutant of Providencia stuartii and gene deletion in Mycobacterium smegmatis.

Journal: PloS one 20120101

Title: A high-throughput screen for directed evolution of aminocoumarin amide synthetases.

Journal: Analytical biochemistry 20111201

Title: Multiplexing interactions to control antibiotic release from cyclodextrin hydrogels.

Journal: Macromolecular bioscience 20111110

Title: Theiler's murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin.

Journal: Cell stress & chaperones 20110901

Title: Engineering an antibiotic to fight cancer: optimization of the novobiocin scaffold to produce anti-proliferative agents.

Journal: Journal of medicinal chemistry 20110609

Title: An artificial pathway to 3,4-dihydroxybenzoic acid allows generation of new aminocoumarin antibiotic recognized by catechol transporters of E. coli.

Journal: Chemistry & biology 20110325

Title: Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin.

Journal: Plant signaling & behavior 20110301

Title: In vitro susceptibility testing of meticillin-resistant and meticillin-susceptible staphylococci to mupirocin and novobiocin.

Journal: Veterinary dermatology 20110201

Title: A high-throughput fluorescence polarization assay for inhibitors of gyrase B.

Journal: Journal of biomolecular screening 20110201

Title: Leishmania amazonensis META2 protein confers protection against heat shock and oxidative stress.

Journal: Experimental parasitology 20110101

Title: A systematic protocol for the characterization of Hsp90 modulators.

Journal: Bioorganic & medicinal chemistry 20110101

Title: Insulin suppresses the expression and function of breast cancer resistance protein in primary cultures of rat brain microvessel endothelial cells.

Journal: Pharmacological reports : PR 20110101

Title: Hsp90β inhibition modulates nitric oxide production and nitric oxide-induced apoptosis in human chondrocytes.

Journal: BMC musculoskeletal disorders 20110101

Title: Development and characterization of a novel C-terminal inhibitor of Hsp90 in androgen dependent and independent prostate cancer cells.

Journal: BMC cancer 20110101

Title: Structure and mechanism of the magnesium-independent aromatic prenyltransferase CloQ from the clorobiocin biosynthetic pathway.

Journal: Journal of molecular biology 20101210

Title: [Comparasion of two methods for recovery of Aeromonas spp. in feces from agar CIN (Cefsulodin-Irgasan-Novobiocin)].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20101201

Title: Activation of heat shock factor 1 plays a role in pyrrolidine dithiocarbamate-mediated expression of the co-chaperone BAG3.

Journal: The international journal of biochemistry & cell biology 20101101

Title: Specific inhibitors of the breast cancer resistance protein (BCRP).

Journal: ChemMedChem 20100903

Title: Activation of the plasma kallikrein-kinin system on human lung epithelial cells.

Journal: Biological chemistry 20100901

Title: Heterologous expression of the biosynthetic gene clusters of coumermycin A(1), clorobiocin and caprazamycins in genetically modified Streptomyces coelicolor strains.

Journal: Biopolymers 20100901

Title: Surveillance study of novobiocin and phenylbutazone residues in raw bovine milk using liquid chromatography-tandem mass spectrometry.

Journal: Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20100801

Title: Effect of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) micelles on pharmacokinetics and intestinal toxicity of irinotecan hydrochloride: potential involvement of breast cancer resistance protein (ABCG2).

Journal: The Journal of pharmacy and pharmacology 20100801

Title: Click chemistry to probe Hsp90: Synthesis and evaluation of a series of triazole-containing novobiocin analogues.

Journal: Bioorganic & medicinal chemistry letters 20100701

Title: Use of an inducible promoter for antibiotic production in a heterologous host.

Journal: Applied microbiology and biotechnology 20100601

Title: Comparative efficacy of novobiocin and amoxicillin in experimental sepsis caused by beta-lactam-susceptible and highly resistant pneumococci.

Journal: International journal of antimicrobial agents 20100601

Title: Biological activities of pargamicin A, a novel cyclic peptide antibiotic from Amycolatopsis sp.

Journal: The Journal of antibiotics 20100601

Title: LVIS553 transcriptional regulator specifically recognizes novobiocin as an effector molecule.

Journal: The Journal of biological chemistry 20100528

Title: Coumabiocins A-F, aminocoumarins from an organic extract of Streptomyces sp. L-4-4.

Journal: Journal of natural products 20100528

Title: Hsp90 directly modulates the spatial distribution of AF9/MLLT3 and affects target gene expression.

Journal: The Journal of biological chemistry 20100416

Title: S-Adenosylmethionine (SAM) and antibiotic biosynthesis: effect of external addition of SAM and of overexpression of SAM biosynthesis genes on novobiocin production in Streptomyces.

Journal: Archives of microbiology 20100401

Title: Evaluation of indomethacin and dexamethasone effects on BCRP-mediated drug resistance in MCF-7 parental and resistant cell lines.

Journal: Drug and chemical toxicology 20100401

Title: Reducing the variability of antibiotic production in Streptomyces by cultivation in 24-square deepwell plates.

Journal: Journal of bioscience and bioengineering 20100301

Title: The crystal structure of the novobiocin biosynthetic enzyme NovP: the first representative structure for the TylF O-methyltransferase superfamily.

Journal: Journal of molecular biology 20100115

Title: The synthesis and evaluation of flavone and isoflavone chimeras of novobiocin and derrubone.

Journal: Bioorganic & medicinal chemistry 20100101

Title: Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in diabetic mice.

Journal: ASN neuro 20100101

Title: Molecular mechanisms of biliary excretion of cefditoren and the effects of cefditoren on the expression levels of hepatic transporters.

Journal: Drug metabolism and pharmacokinetics 20100101

Title: Transcriptional regulation of the novobiocin biosynthetic gene cluster.

Journal: Microbiology (Reading, England) 20091201

Title: Enhancing antibiotic activity: a strategy to control Acinetobacter infections.

Journal: The Journal of antimicrobial chemotherapy 20091201

Title: Modulation of Hsf1 activity by novobiocin and geldanamycin.

Journal: Biochemistry and cell biology = Biochimie et biologie cellulaire 20091201

Title: Gene cloning and characteristics of the RND-type multidrug efflux pump MuxABC-OpmB possessing two RND components in Pseudomonas aeruginosa.

Journal: Microbiology (Reading, England) 20091101

Title: The aminocoumarins: biosynthesis and biology.

Journal: Natural product reports 20091001

Title: Influence of efflux transporters on liver, bile and brain disposition of amitriptyline in mice.

Journal: International journal of pharmaceutics 20090813

Title: Free energies and entropies of water molecules at the inhibitor-protein interface of DNA gyrase.

Journal: Journal of the American Chemical Society 20090513

Title: The basal flux of Akt in the mitochondria is mediated by heat shock protein 90.

Journal: Journal of neurochemistry 20090301

Title: Neuroprotective activity and evaluation of Hsp90 inhibitors in an immortalized neuronal cell line.

Journal: Bioorganic & medicinal chemistry 20090215

Title: Antiproliferative and apoptotic activities of tosylcyclonovobiocic acids as potent heat shock protein 90 inhibitors in human cancer cells.

Journal: Cancer letters 20090208

Title: Tosylcyclonovobiocic acids promote cleavage of the hsp90-associated cochaperone p23.

Journal: Biochemical and biophysical research communications 20090206

Title: Transcriptional responses of Bacillus subtillis and thuringiensis to antibiotics and anti-tumour drugs.

Journal: International journal of molecular medicine 20090101

Title: Aminocoumarins mutasynthesis, chemoenzymatic synthesis, and metabolic engineering.

Journal: Methods in enzymology 20090101

Title: The design, synthesis, and evaluation of coumarin ring derivatives of the novobiocin scaffold that exhibit antiproliferative activity.

Journal: The Journal of organic chemistry 20081121

Title: novE and novG act as positive regulators of novobiocin biosynthesis.

Journal: Archives of microbiology 20081101

Title: Growth of pure cultures of Verocytotoxin-producing Escherichia coli in a range of enrichment media.

Journal: Journal of applied microbiology 20081101

Title: Synthesis of 4-amino-5-cyano-2, 6-disubstituted pyrimidines as a potential antifilarial DNA topoisomerase II inhibitors.

Journal: Medicinal chemistry (Shariqah (United Arab Emirates)) 20081101

Title: Crystallization and preliminary X-ray analysis of the O-carbamoyltransferase NovN from the novobiocin-biosynthetic cluster of Streptomyces spheroides.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20081101

Title: Drug-sensing hydrogels for the inducible release of biopharmaceuticals.

Journal: Nature materials 20081001

Title: Ligand and protein fishing with heat shock protein 90 coated magnetic beads.

Journal: Analytical chemistry 20081001

Title: Use of a halogenase of hormaomycin biosynthesis for formation of new clorobiocin analogues with 5-chloropyrrole moieties.

Journal: Chembiochem : a European journal of chemical biology 20080811

Title: Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin.

Journal: Leukemia 20080701

Title: Novobiocin inhibits the self-splicing of the primary transcripts of T4 phage thymidylate synthase gene.

Journal: Molecular and cellular biochemistry 20080701

Title: The Hsp90 inhibitor radicicol interacts with the ATP-binding pocket of bacterial sensor kinase PhoQ.

Journal: Journal of molecular biology 20080523

Title: L347P PINK1 mutant that fails to bind to Hsp90/Cdc37 chaperones is rapidly degraded in a proteasome-dependent manner.

Journal: Neuroscience research 20080501

Title: The biosynthesis and biological role of 6-deoxyheptose in the lipopolysaccharide O-antigen of Yersinia pseudotuberculosis.

Journal: Molecular microbiology 20080401

Title: Synthesis and biological activity of simplified denoviose-coumarins related to novobiocin as potent inhibitors of heat-shock protein 90 (hsp90).

Journal: Bioorganic & medicinal chemistry letters 20080401

Title: Optimizing glycosyltransferase specificity via 'hot spot' saturation mutagenesis presents a catalyst for novobiocin glycorandomization.

Journal: Chemistry & biology 20080401

Title: Development of novobiocin analogues that manifest anti-proliferative activity against several cancer cell lines.

Journal: The Journal of organic chemistry 20080321

Title: The omlA gene is involved in multidrug resistance and its expression is inhibited by coumarins in Xanthomonas campestris pv. phaseoli.

Journal: Archives of microbiology 20080301

Title: Mono ADP-ribosylation inhibitors prevent inflammatory cytokine release in alveolar epithelial cells.

Journal: Molecular and cellular biochemistry 20080301

Title: Effects of dry cow treatment of beef cows on pathogenic organisms, milk somatic cell counts, and calf growth during the subsequent lactation.

Journal: Journal of animal science 20080301

Title: Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants.

Journal: The Journal of biological chemistry 20080201

Title: Transferred NOE and saturation transfer difference NMR studies of novobiocin binding to EnvZ suggest binding mode similar to DNA gyrase.

Journal: Chemical biology & drug design 20080101

Title: Components of SurA required for outer membrane biogenesis in uropathogenic Escherichia coli.

Journal: PloS one 20080101

Title: Novobiocin and additional inhibitors of the Hsp90 C-terminal nucleotide-binding pocket.

Journal: Current medicinal chemistry 20080101

Title: Intrinsic novobiocin resistance in Staphylococcus saprophyticus.

Journal: Antimicrobial agents and chemotherapy 20071201

Title: In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs.

Journal: Drug metabolism and pharmacokinetics 20071201

Title: New novobiocin analogues as antiproliferative agents in breast cancer cells and potential inhibitors of heat shock protein 90.

Journal: Journal of medicinal chemistry 20071129

Title: Persistence of rRNA operon mutated copies and rapid re-emergence of linezolid resistance in Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20070901

Title: Growth inhibitory factors in bovine faeces impairs detection of Salmonella Dublin by conventional culture procedure.

Journal: Journal of applied microbiology 20070901

Title: New aminocoumarin antibiotics derived from 4-hydroxycinnamic acid are formed after heterologous expression of a modified clorobiocin biosynthetic gene cluster.

Journal: The Journal of antibiotics 20070801

Title: Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7.

Journal: Biochemistry 20070717

Title: Staphylococcus pettenkoferi sp. nov., a novel coagulase-negative staphylococcal species isolated from human clinical specimens.

Journal: International journal of systematic and evolutionary microbiology 20070701

Title: Streptococcus pneumononiae gyrase ATPase: development and validation of an assay for inhibitor discovery and characterization.

Journal: Analytical biochemistry 20070601

Title: A library of noviosylated coumarin analogues.

Journal: The Journal of organic chemistry 20070511

Title: Intramammary infections in heifers during early lactation following intramammary infusion of pirlimycin hydrochloride or penicillin-novobiocin at the first milking after parturition.

Journal: The Journal of dairy research 20070501

Title: Effects of deletions of mbtH-like genes on clorobiocin biosynthesis in Streptomyces coelicolor.

Journal: Microbiology (Reading, England) 20070501

Title: Biosynthesis of clorobiocin: investigation of the transfer and methylation of the pyrrolyl-2-carboxyl moiety.

Journal: Archives of microbiology 20070301

Title: Crystallization and preliminary X-ray analysis of the O-methyltransferase NovP from the novobiocin-biosynthetic cluster of Streptomyces spheroides.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20070301

Title: Using novobiocin as a specific inhibitor of breast cancer resistant protein to assess the role of transporter in the absorption and disposition of topotecan.

Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101

Title: Novobiocin: redesigning a DNA gyrase inhibitor for selective inhibition of hsp90.

Journal: Journal of the American Chemical Society 20061206

Title: Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import.

Journal: The Journal of biological chemistry 20061103

Title: Metabolic engineering of the heterologous production of clorobiocin derivatives and elloramycin in Streptomyces coelicolor M512.

Journal: Metabolic engineering 20061101

Title: Crystallization and preliminary X-ray analysis of the aromatic prenyltransferase CloQ from the clorobiocin biosynthetic cluster of Streptomyces roseochromogenes.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20061101

Title: Can individual repair kinetics of UVC-induced DNA damage in human lymphocytes be assessed through the comet assay?

Journal: Mutation research 20061010

Title: The biosynthetic gene clusters of aminocoumarin antibiotics.

Journal: Planta medica 20061001

Title: Characterization of the Vibrio cholerae vexAB and vexCD efflux systems.

Journal: Archives of microbiology 20060901

Title: Effects of pharmaceutical products and municipal wastewaters on temperature-dependent mitochondrial electron transport activity in Elliptio complanata mussels.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060801

Title: Biosynthesis of the unusual 5,5-gem-dimethyl-deoxysugar noviose: investigation of the C-methyltransferase gene cloU.

Journal: Microbiology (Reading, England) 20060801

Title: Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1.

Journal: Biochemistry 20060718

Title: Requirements for Bacillus subtilis bacteriophage phi29 DNA ejection.

Journal: Gene 20060607

Title: Effects of selected pharmaceutical products on phagocytic activity in Elliptio complanata mussels.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20060601

Title: Growth studies of plasmid bearing and plasmid cured Yersinia enterocolitica GER O:3 in the presence of cefsulodin, irgasan and novobiocin at 25 and 37 degrees C.

Journal: Journal of applied microbiology 20060601

Title: Modulation of chaperone function and cochaperone interaction by novobiocin in the C-terminal domain of Hsp90: evidence that coumarin antibiotics disrupt Hsp90 dimerization.

Journal: The Journal of biological chemistry 20060317

Title: Activity screening of carrier domains within nonribosomal peptide synthetases using complex substrate mixtures and large molecule mass spectrometry.

Journal: Biochemistry 20060214

Title: Transport of glyburide by placental ABC transporters: implications in fetal drug exposure.

Journal: Placenta 20060101

Title: Using natural product inhibitors to validate Hsp90 as a molecular target in cancer.

Journal: Current topics in medicinal chemistry 20060101

Title: Inhibitors of the HSP90 molecular chaperone: current status.

Journal: Advances in cancer research 20060101

Title: Hsp90 functions to balance the phosphorylation state of Akt during C2C12 myoblast differentiation.

Journal: Cellular signalling 20051201

Title: Acyl transfer in clorobiocin biosynthesis: involvement of several proteins in the transfer of the pyrrole-2-carboxyl moiety to the deoxysugar.

Journal: Chembiochem : a European journal of chemical biology 20051201

Title: An atypical type II topoisomerase from Mycobacterium smegmatis with positive supercoiling activity.

Journal: Molecular microbiology 20051201

Title: CouO and NovO: C-methyltransferases for tailoring the aminocoumarin scaffold in coumermycin and novobiocin antibiotic biosynthesis.

Journal: Biochemistry 20051115

Title: Genetic polymorphisms of ATP-binding cassette transporters ABCB1 and ABCG2: therapeutic implications.

Journal: Expert opinion on pharmacotherapy 20051101

Title: Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss.

Journal: Journal of ethnopharmacology 20051003

Title: NovJ/NovK catalyze benzylic oxidation of a beta-hydroxyl tyrosyl-S-pantetheinyl enzyme during aminocoumarin ring formation in novobiocin biosynthesis.

Journal: Biochemistry 20050927

Title: Metabolic engineering of aminocoumarins: inactivation of the methyltransferase gene cloP and generation of new clorobiocin derivatives in a heterologous host.

Journal: Chembiochem : a European journal of chemical biology 20050801

Title: Breast cancer resistance protein-mediated efflux of androgen in putative benign and malignant prostate stem cells.

Journal: Cancer research 20050801

Title: NovG, a DNA-binding protein acting as a positive regulator of novobiocin biosynthesis.

Journal: Microbiology (Reading, England) 20050601

Title: Novobiocin induces apoptosis-like cell death in topoisomerase II over-expressing arsenite resistant Leishmania donovani.

Journal: Molecular and biochemical parasitology 20050501

Title: Probing the binding of the coumarin drugs using peptide fragments of DNA gyrase B protein.

Journal: The journal of peptide research : official journal of the American Peptide Society 20050501

Title: Functional characterizations of novWUS involved in novobiocin biosynthesis from Streptomyces spheroides.

Journal: Archives of biochemistry and biophysics 20050401

Title: Assessment of human DNA repair (NER) capacity with DNA repair rate (DRR) by comet assay.

Journal: Biomedical and environmental sciences : BES 20050401

Title: Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway.

Journal: Biochemistry 20050329

Title: Characterization of the formation of the pyrrole moiety during clorobiocin and coumermycin A1 biosynthesis.

Journal: Biochemistry 20050301

Title: Transcriptional regulation through RfaH contributes to intestinal colonization by Escherichia coli.

Journal: FEMS microbiology letters 20050301

Title: The plasmids of Chlamydia trachomatis and Chlamydophila pneumoniae (N16): accurate determination of copy number and the paradoxical effect of plasmid-curing agents.

Journal: Microbiology (Reading, England) 20050301

Title: The effect of topoisomerase II inhibitors on the kinetoplast ultrastructure.

Journal: Parasitology research 20041201

Title: Mass spectrometric pathway monitoring of secondary metabolites: systematic analysis of culture extracts of Streptomyces species.

Journal: Analytical biochemistry 20041201

Title: The integrity of cholesterol-enriched microdomains is essential for the constitutive high activity of protein kinase B in tumour cells.

Journal: Biochemical Society transactions 20041101

Title: Protein A gene expression is regulated by DNA supercoiling which is modified by the ArlS-ArlR two-component system of Staphylococcus aureus.

Journal: Microbiology (Reading, England) 20041101

Title: Production of 8'-halogenated and 8'-unsubstituted novobiocin derivatives in genetically engineered streptomyces coelicolor strains.

Journal: Chemistry & biology 20041101

Title: Synthesis of (-)-noviose from 2,3-O-isopropylidene-D-erythronolactol.

Journal: The Journal of organic chemistry 20041015

Title: A 4.2 kDa synthetic peptide as a potential probe to evaluate the antibacterial activity of coumarin drugs.

Journal: Journal of peptide science : an official publication of the European Peptide Society 20040901

Title: Novobiocin induces a distinct conformation of Hsp90 and alters Hsp90-cochaperone-client interactions.

Journal: Biochemistry 20040629

Title: Evidence that hsp90 is involved in the altered interactions of Acanthamoeba castellanii variants with bacteria.

Journal: Eukaryotic cell 20040601

Title: Destabilization of the non-pathogenic, cellular prion-protein by a small molecular drug.

Journal: Antiviral therapy 20040601

Title: Influence of prepartum pirlimycin hydrochloride or penicillin-novobiocin therapy on mastitis in heifers during early lactation.

Journal: Journal of dairy science 20040601

Title: New aminocoumarin antibiotics formed by a combined mutational and chemoenzymatic approach utilizing the carbamoyltransferase NovN.

Journal: Chemistry & biology 20040501

Title: [Detecting DNA repair capacity of human lymphocytes exposed to ultraviolet C with comet assay].

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20040401

Title: New aminocoumarin antibiotics from a cloQ-defective mutant of the clorobiocin producer Streptomyces roseochromogenes DS12.976.

Journal: The Journal of antibiotics 20040301

Title: In vitro and in vivo production of new aminocoumarins by a combined biochemical, genetic, and synthetic approach.

Journal: Chemistry & biology 20040201

Title: Reversal of breast cancer resistance protein (BCRP/ABCG2)-mediated drug resistance by novobiocin, a coumermycin antibiotic.

Journal: International journal of cancer 20040101

Title: Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring.

Journal: Angewandte Chemie (International ed. in English) 20040101

Title: Resistance to the lactoperoxidase system: role of the lipopolysaccharide layer revisited.

Journal: Communications in agricultural and applied biological sciences 20040101

Title: Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37.

Journal: Oncogene 20031211

Title: An unusual amide synthetase (CouL) from the coumermycin A1 biosynthetic gene cluster from Streptomyces rishiriensis DSM 40489.

Journal: European journal of biochemistry 20031101

Title: Hsp90 inhibition accelerates cell lysis. Anti-Hsp90 ribozyme reveals a complex mechanism of Hsp90 inhibitors involving both superoxide- and Hsp90-dependent events.

Journal: The Journal of biological chemistry 20030912

Title: CloR, a bifunctional non-heme iron oxygenase involved in clorobiocin biosynthesis.

Journal: The Journal of biological chemistry 20030815

Title: CloN6, a novel methyltransferase catalysing the methylation of the pyrrole-2-carboxyl moiety of clorobiocin.

Journal: Chembiochem : a European journal of chemical biology 20030804

Title: CloN2, a novel acyltransferase involved in the attachment of the pyrrole-2-carboxyl moiety to the deoxysugar of clorobiocin.

Journal: Microbiology (Reading, England) 20030801

Title: Identification of the CysB-regulated gene, hslJ, related to the Escherichia coli novobiocin resistance phenotype.

Journal: FEMS microbiology letters 20030729

Title: D-Gulonolactone as a synthon for L-noviose: first preparation of 4-O-demethyl-L-noviofuranose and related derivatives.

Journal: Organic letters 20030724

Title: Rapid urease screening of Yersinia on CIN agar plates.

Journal: International journal of food microbiology 20030715

Title: Novobiocin biosynthesis: inactivation of the putative regulatory gene novE and heterologous expression of genes involved in aminocoumarin ring formation.

Journal: Archives of microbiology 20030701

Title: Characterization of quercetin binding site on DNA gyrase.

Journal: Biochemical and biophysical research communications 20030627

Title: Development of small molecule Hsp90 inhibitors: utilizing both forward and reverse chemical genomics for drug identification.

Journal: Current medicinal chemistry 20030501

Title: Regulation of cytosolic prostaglandin E2 synthase by 90-kDa heat shock protein.

Journal: Biochemical and biophysical research communications 20030418

Title: Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin.

Journal: Biochemistry 20030415

Title: Clorobiocin biosynthesis in Streptomyces: identification of the halogenase and generation of structural analogs.

Journal: Chemistry & biology 20030301

Title: Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation.

Journal: FEBS letters 20030211

Title: A microarray-based antibiotic screen identifies a regulatory role for supercoiling in the osmotic stress response of Escherichia coli.

Journal: Genome research 20030201

Title: Aromatic residues at the extracellular ends of transmembrane domains 5 and 6 promote ligand activation of the G protein-coupled alpha-factor receptor.

Journal: Biochemistry 20030121

Title: Determination of pharmaceuticals in aqueous samples using positive and negative voltage switching microbore liquid chromatography/electrospray ionization tandem mass spectrometry.

Journal: Journal of mass spectrometry : JMS 20030101

Title: Antimicrobial susceptibilities of Shiga toxin-producing Escherichia coli isolates from pigs with edema disease in Japan.

Journal: Microbiology and immunology 20030101

Title: Novobiocin sensitizes BCRP/MXR/ABCP overexpressing topotecan-resistant human breast carcinoma cells to topotecan and mitoxantrone.

Journal: Anticancer research 20030101

Title: Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics.

Journal: Microbiology (Reading, England) 20021201

Title: The Chlamydomonas reinhardtii organellar genomes respond transcriptionally and post-transcriptionally to abiotic stimuli.

Journal: The Plant cell 20021101

Title: Genetic analysis of the biosynthesis of the pyrrole and carbamoyl moieties of coumermycin A1 and novobiocin.

Journal: Molecular genetics and genomics : MGG 20021101

Title: Nucleotide binding states of hsp70 and hsp90 during sequential steps in the process of glucocorticoid receptor.hsp90 heterocomplex assembly.

Journal: The Journal of biological chemistry 20020913

Title: Expression of foreign LpxA acyltransferases in Neisseria meningitidis results in modified lipid A with reduced toxicity and retained adjuvant activity.

Journal: Cellular microbiology 20020901

Title: Cloning and analysis of the simocyclinone biosynthetic gene cluster of Streptomyces antibioticus Tü 6040.

Journal: Archives of microbiology 20020801

Title: Crystallization of the 43 kDa ATPase domain of Thermus thermophilus gyrase B in complex with novobiocin.

Journal: Acta crystallographica. Section D, Biological crystallography 20020801

Title: Site-directed mutagenesis studies of the amino acid residue at position 412 of Escherichia coli TolC which is required for the activity.

Journal: Microbial pathogenesis 20020801

Title: DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose.

Journal: Biochemistry 20020611

Title: Autoinduction of the ompR response regulator by acid shock and control of the Salmonella enterica acid tolerance response.

Journal: Molecular microbiology 20020601

Title: Novobiocin is a novel inducer of CD38 on cells of the myelomonocytic lineage.

Journal: Biochimica et biophysica acta 20020130

Title: A scintillation proximity assay amenable for screening and characterization of DNA gyrase B subunit inhibitors.

Journal: Analytical biochemistry 20020101

Title: Evidence that the novobiocin-sensitive ATP-binding site of the heat shock protein 90 (hsp90) is necessary for its autophosphorylation.

Journal: Cell biology international 20020101

Title: Long-term experimental evolution in Escherichia coli. X. Quantifying the fundamental and realized niche.

Journal: BMC evolutionary biology 20020101

Title: [Antimicrobial sensitivity of coagulase-positive staphylococcal strains isolated from bovine mastitis in the central dairy catchment area of Argentina ].

Journal: Revista Argentina de microbiologia 20020101

Title: Effect of null mutations in dnaK and dnaJ genes on conjugational DNA transfer, proteolysis and novobiocin susceptibility of Escherichia coli.

Journal: Acta microbiologica Polonica 20020101

Title: Evaluation of culture media for enrichment and isolation of Shigella sonnei and S. flexneri.

Journal: International journal of food microbiology 20011108

Title: A sequence variant of Staphylococcus hominis with a high prevalence of oxacillin and fluoroquinolone resistance.

Journal: Research in microbiology 20011101

Title: Fine Tuning of physico-chemical parameters to optimise a new series of novobiocin analogues.

Journal: Bioorganic & medicinal chemistry letters 20010604

Title: Characterization of a putative RND-type efflux system in Agrobacterium tumefaciens.

Journal: Gene 20010530

Title: Coumarin formation in novobiocin biosynthesis: beta-hydroxylation of the aminoacyl enzyme tyrosyl-S-NovH by a cytochrome P450 NovI.

Journal: Chemistry & biology 20010401

Title: Prevalence of mastitis in dairy heifers and effectiveness of antibiotic therapy.

Journal: Journal of dairy science 20010401

Title: Ups and downs.

Journal: Trends in molecular medicine 20010301

Title: Inhibition of mono-ADP-ribosyltransferase activity during the execution phase of apoptosis prevents apoptotic body formation.

Journal: Archives of biochemistry and biophysics 20010301

Title: Positive effects of some gyrase inhibitors on survival and development of Pimpla turionellae (Hymenoptera: Ichneumonidae) larvae reared on an artificial diet.

Journal: Journal of economic entomology 20010201

Title: Comparison of methods for the determination of antimicrobial resistance in Staphylococcus aureus from bovine mastitis.

Journal: Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20010201

Title: A Mycobacterium smegmatis gyrase B specific monoclonal antibody reveals association of gyrase A and B subunits in the cell.

Journal: FEMS microbiology letters 20010101

Title: Gene expression changes triggered by exposure of Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis.

Journal: Genome research 20010101

Title: The high-resolution crystal structure of a 24-kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin.

Journal: Proteins 19970501

Title: The amphiphilic properties of novenamines determine their activity as inhibitors of HIV-1 RNase H.

Journal: Experientia 19960415

Title: Novobiocin-induced anti-proliferative and differentiating effects in melanoma B16.

Journal: British journal of cancer 19920201

Title: In vitro activity of DNA gyrase inhibitors, singly and in combination, against Mycobacterium avium complex.

Journal: Diagnostic microbiology and infectious disease 19920101

Title: Curing effect of clorobiocin on Escherichia coli plasmids.

Journal: Molecular & general genetics : MGG 19820101

Title: Novobiocin: activity in vitro and in experimental tuberculosis.

Journal: American review of tuberculosis 19570801

Title: Clinical effectiveness and safety of novobiocin.

Journal: Antibiotic medicine & clinical therapy (New York, NY) 19560401

Title: Novobiocin; absorption, diffusion, and excretion studies.

Journal: Antibiotics annual 19560101

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 1476-53-5
Tags:1476-53-5 Molecular Formula|1476-53-5 MDL|1476-53-5 SMILES|1476-53-5 Novobiocin sodium salt