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147780-50-5,MFCD18252387
Catalog No.:AA001F4H

147780-50-5 | 10H-Phenothiazine, 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-

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100mg
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2 weeks  
$543.00   $380.00
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  • Technical Information
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Technical Information
Catalog Number:
AA001F4H
Chemical Name:
10H-Phenothiazine, 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-
CAS Number:
147780-50-5
Molecular Formula:
C20H22N2S
Molecular Weight:
322.4671
MDL Number:
MFCD18252387
SMILES:
c1ccc2c(c1)N(C[C@H]1CN3CCC1CC3)c1c(S2)cccc1
NSC Number:
303612
Properties
Computed Properties
 
Complexity:
398  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
1  
XLogP3:
4.6  

Literature

Title: [Egg allergy: with or without cake?].

Journal: Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20110701

Title: Asymmetric synthesis of (+)-mequitazine from quinine.

Journal: Organic letters 20110701

Title: Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate.

Journal: Chemical & pharmaceutical bulletin 20091101

Title: Photodegradation and photostability-indication of mequitazine.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20091015

Title: Effects of pranlukast hydrate on airway hyperresponsiveness in non-asthmatic patients with Japanese cedar pollinosis.

Journal: Allergology international : official journal of the Japanese Society of Allergology 20090601

Title: The relationship between drug treatment and the clinical characteristics of febrile seizures.

Journal: World journal of pediatrics : WJP 20080801

Title: [Efficiency of mequitazine in the treatment of allergic rhinitis and chronic urticaria in children. A bibliographic systematic review].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20080101

Title: [Allergies in ENT].

Journal: Dakar medical 20070101

Title: Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.

Journal: European journal of clinical pharmacology 20061201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Repeated-dose effects of mequitazine, cetirizine and dexchlorpheniramine on driving and psychomotor performance.

Journal: British journal of clinical pharmacology 20060101

Title: Spectrophotometric determination of some antihistaminic drugs using 7,7,8,8-tetracyanoquinodimethane (TCNQ).

Journal: Journal of AOAC International 20060101

Title: [Symptomatic treatment of allergic rhinitis with mequitazine (Primalan)].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20060101

Title: Determination of mequitazine in human plasma by gas-chromatography/mass spectrometry with ion-trap detector and its pharmacokinetics after oral administration to volunteers.

Journal: Archives of pharmacal research 20051001

Title: Effect of titanium dioxide on photostability of solid-state mequitazine.

Journal: Chemical & pharmaceutical bulletin 20050901

Title: Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes.

Journal: Biological & pharmaceutical bulletin 20050501

Title: [Comparison of three antiallergic eyedrops in a specific conjunctival provocation test: mequitazine, levocabastine and dexamethasone].

Journal: Journal francais d'ophtalmologie 20050301

Title: [Efficacy of mequitazine (Primalan) on the relief of symptoms of allergic rhinoconjunctivitis in children. Documented clinical experience].

Journal: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) 20050101

Title: Randomised double masked trial comparing the efficacy and tolerance of 0.05% mequitazine eye drops versus 0.05% levocabastine and placebo in allergic conjunctivitis induced by a conjunctival provocation test with Dermatophagoides pteronyssinus.

Journal: The British journal of ophthalmology 20040301

Title: A dose-ranging study of the effects of mequitazine on actual driving, memory and psychomotor performance as compared to dexchlorpheniramine, cetirizine and placebo.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040201

Title: [Experience in clinical use of primalan (mequitazine) in allergology].

Journal: Terapevticheskii arkhiv 20030101

Title: Stability indicating methods for assay of mequitazine in presence of its degradate.

Journal: Journal of pharmaceutical and biomedical analysis 20020620

Title: E. coli MEP synthase: steady-state kinetic analysis and substrate binding.

Journal: Biochemistry 20020108

Title: Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity.

Journal: Journal of cellular biochemistry 20020101

Title: Localized heat urticaria: a clinical study using laser Doppler flowmetry.

Journal: Journal of dermatological science 20010601

Title: Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes.

Journal: The Journal of pharmacology and experimental therapeutics 19980201

Title: Efficacy of mequitazine in comparison with placebo assessed by ocular challenge with allergen in allergic conjunctivitis.

Journal: Allergy 19970401

Title: The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor.

Journal: Journal of medicinal chemistry 19950818

Title: 'In vivo' and 'in vitro' evaluation of four antihistamines (astemizole, azatadine, mequitazine, terfenadine).

Journal: Allergologia et immunopathologia 19890101

Title: Evaluation of the antimuscarinic activity of atropine, terfenadine and mequitazine in healthy volunteers.

Journal: British journal of clinical pharmacology 19880101

Title: [Comparative study of a new antihistamine, mequitazine, and placebos].

Journal: Acta allergologica 19751101

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SDS
Tags:147780-50-5 Molecular Formula|147780-50-5 MDL|147780-50-5 SMILES|147780-50-5 10H-Phenothiazine, 10-[(3R)-1-azabicyclo[2.2.2]oct-3-ylmethyl]-