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148016-81-3,MFCD02092739
Catalog No.:AA006UL2

148016-81-3 | Doripenem

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5mg
95%
in stock  
$48.00   $34.00
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10mg
95%
in stock  
$81.00   $57.00
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25mg
95%
in stock  
$191.00   $134.00
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50mg
95
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$343.00   $240.00
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100mg
95
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$504.00   $353.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA006UL2
Chemical Name:
Doripenem
CAS Number:
148016-81-3
Molecular Formula:
C15H24N4O6S2
Molecular Weight:
420.5043
MDL Number:
MFCD02092739
SMILES:
C[C@H]([C@H]1C(=O)N2[C@@H]1[C@@H](C)C(=C2C(=O)O)S[C@@H]1CN[C@@H](C1)CNS(=O)(=O)N)O
Properties
Properties
 
Form:
Solid  
MP:
>186˚C (dec.)  
Storage:
Keep in dry area;-20 ℃;  

Computed Properties
 
Complexity:
780  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
6  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
5  
Rotatable Bond Count:
7  
XLogP3:
-3.4  

Downstream Synthesis Route

[1]Iso,Yasuyoshi;Irie,Tadashi;Nishino,Yutaka;Motokawa,Kiyoshi;Nishitani,Yasuhiro[JournalofAntibiotics,1996,vol.49,#2,p.199-209]

[1]Iso;Irie;Iwaki;Kii;Sendo;Motokawa;Nishitani[JournalofAntibiotics,1996,vol.49,#5,p.478-484]

[2]Nishino,Yutaka;Kobayashi,Makoto;Shinno,Taneyoshi;Izumi,Kenji;Yonezawa,Hiroshi;Masui,Yoshiyuki;Takahira,Masayuki[OrganicProcessResearchandDevelopment,2003,vol.7,#6,p.846-850]

[1]CurrentPatentAssignee:SHIONOGI&CO.,LTD.-EP1852436,2007,A1Locationinpatent:Page/Pagecolumn13

[2]CurrentPatentAssignee:SHIONOGI&CO.,LTD.-EP1852436,2007,A1Locationinpatent:Page/Pagecolumn14

[3]CurrentPatentAssignee:SHIONOGI&CO.,LTD.-EP1852436,2007,A1Locationinpatent:Page/Pagecolumn14

[4]CurrentPatentAssignee:SHIONOGI&CO.,LTD.-EP1852436,2007,A1Locationinpatent:Page/Pagecolumn14

[1]Iso;Irie;Iwaki;Kii;Sendo;Motokawa;Nishitani[JournalofAntibiotics,1996,vol.49,#5,p.478-484]

[2]CurrentPatentAssignee:JOINCAREPHARMACEUTICALGROUPINDUSTRYCO.,LTD.-US2015/38700,2015,A1

[1]Iso;Irie;Iwaki;Kii;Sendo;Motokawa;Nishitani[JournalofAntibiotics,1996,vol.49,#5,p.478-484]

[2]Raju,K.Rajasekhara;Mahesh;Reddy,B.Shankar;Raju,K.Mohana[OrganicPreparationsandProceduresInternational,2016,vol.48,#4,p.342-349]

Literature

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Journal: Chemical research in toxicology 20150518

Title: Pharmacokinetics of single-dose doripenem in adults with cystic fibrosis.

Journal: Journal of clinical pharmacology 20121101

Title: Pharmacodynamics of doripenem in critically ill patients with ventilator-associated Gram-negative bacilli pneumonia.

Journal: International journal of antimicrobial agents 20121101

Title: Two cases of peritonsillar abscess complicated by von Willebrand disease.

Journal: Auris, nasus, larynx 20121001

Title: Pharmacokinetics and monte carlo simulations of doripenem in patients with febrile neutropenia.

Journal: The Annals of pharmacotherapy 20121001

Title: Doripenem: excess mortality.

Journal: Prescrire international 20120901

Title: [Septic shock following flexible transurethral lithotripsy showing favourable response after multidisciplinary treatment mainly composed of recombinant thrombomodulin : a case report].

Journal: Hinyokika kiyo. Acta urologica Japonica 20120901

Title: In vitro antimicrobial activity of 'last-resort' antibiotics against unusual nonfermenting Gram-negative bacilli clinical isolates.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20120801

Title: Pharmacokinetics of doripenem in CSF of patients with non-inflamed meninges.

Journal: The Journal of antimicrobial chemotherapy 20120701

Title: Antimicrobial susceptibility patterns of multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii against carbapenems, colistin, and tigecycline.

Journal: Saudi medical journal 20120701

Title: What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance.

Journal: International journal of antimicrobial agents 20120601

Title: Current epidemiology and growing resistance of gram-negative pathogens.

Journal: The Korean journal of internal medicine 20120601

Title: Synergy of fosfomycin with carbapenems, colistin, netilmicin, and tigecycline against multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa clinical isolates.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20120501

Title: Penetration of doripenem in human brain: an observational microdialysis study in patients with acute brain injury.

Journal: International journal of antimicrobial agents 20120401

Title: Comparative in vitro activity of carbapenems against major Gram-negative pathogens: results of Asia-Pacific surveillance from the COMPACT II study.

Journal: International journal of antimicrobial agents 20120401

Title: Pseudomonas aeruginosa is not just in the intensive care unit any more: implications for empirical therapy.

Journal: Critical care medicine 20120401

Title: Essentials for selecting antimicrobial therapy for intra-abdominal infections.

Journal: Drugs 20120401

Title: Comparison of the next-generation aminoglycoside plazomicin to gentamicin, tobramycin and amikacin.

Journal: Expert review of anti-infective therapy 20120401

Title: Efficacy of doripenem against Escherichia coli and Klebsiella pneumoniae in experimental meningitis.

Journal: The Journal of antimicrobial chemotherapy 20120301

Title: Evaluation of doripenem in an experimental model of resistant Pseudomonas aeruginosa pneumonia.

Journal: The Journal of antimicrobial chemotherapy 20120301

Title: Predicting doripenem susceptibility based on meropenem and imipenem interpretation for Pseudomonas aeruginosa.

Journal: Diagnostic microbiology and infectious disease 20120301

Title: Comparative Activity of Carbapenem Testing (COMPACT) study in Germany.

Journal: International journal of antimicrobial agents 20120301

Title: Carbapenem-resistant Pseudomonas aeruginosa pneumonia with intermediate minimum inhibitory concentrations to doripenem: combination therapy with high-dose, 4-h infusion of doripenem plus fosfomycin versus intravenous colistin plus fosfomycin.

Journal: International journal of antimicrobial agents 20120301

Title: Determination of doripenem penetration into human prostate tissue and assessment of dosing regimens for prostatitis based on site-specific pharmacokinetic-pharmacodynamic evaluation.

Journal: Journal of chemotherapy (Florence, Italy) 20120201

Title: [Sensitivity surveillance of Pseudomonas aeruginosa isolates for several antibacterial agents in Gifu and Aichi prefecture (2008)].

Journal: The Japanese journal of antibiotics 20120201

Title: [Antimicrobial susceptibilityof clinical isolates of aerobic gram-negative bacteria in 2008].

Journal: The Japanese journal of antibiotics 20120201

Title: ESBLs: A Clear and Present Danger?

Journal: Critical care research and practice 20120101

Title: Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation.

Journal: European journal of clinical pharmacology 20120101

Title: Carbapenem stewardship: does ertapenem affect Pseudomonas susceptibility to other carbapenems? A review of the evidence.

Journal: International journal of antimicrobial agents 20120101

Title: Clostridia in premature neonates' gut: incidence, antibiotic susceptibility, and perinatal determinants influencing colonization.

Journal: PloS one 20120101

Title: Comparative activity of carbapenem testing (the COMPACT study) in Turkey.

Journal: BMC infectious diseases 20120101

Title: CTX-M Enzymes: Origin and Diffusion.

Journal: Frontiers in microbiology 20120101

Title: A comparative analysis of meropenem and doripenem in febrile patients with hematologic malignancies: a single-center retrospective study.

Journal: Japanese journal of infectious diseases 20120101

Title: Correlation between the consumption of meropenem or doripenem and meropenem susceptibility of Pseudomonas aeruginosa in a university hospital in Japan.

Journal: Biological & pharmaceutical bulletin 20120101

Title: A case of Lemierre's syndrome in association with liver abscess without any other metastatic lesions.

Journal: Internal medicine (Tokyo, Japan) 20120101

Title: Doripenem vs meropenem against Pseudomonas and Acinetobacter.

Journal: Indian journal of medical microbiology 20120101

Title: Doripenem dosing recommendations for critically ill patients receiving continuous renal replacement therapy.

Journal: ISRN pharmacology 20120101

Title: Evaluation of doripenem utilization and susceptibilities at a large urban hospital.

Journal: International journal of clinical pharmacy 20111201

Title: In vitro activity studies of doripenem and two other carbapenems tested against Pseudomonas aeruginosa and other non-fermentative bacilli.

Journal: Journal of chemotherapy (Florence, Italy) 20111201

Title: [Surveillance of antimicrobial activity of Pseudomonas aeruginosa isolated in the Kinki district].

Journal: The Japanese journal of antibiotics 20111201

Title: In vitro antibacterial activities of doripenem, imipenem, and meropenem against recent Streptococcus pneumoniae isolates.

Journal: Diagnostic microbiology and infectious disease 20111101

Title: Validation of doripenem dosing in patients with end-stage renal disease receiving hemodialysis.

Journal: The Annals of pharmacotherapy 20111101

Title: Continuous-infusion antipseudomonal Beta-lactam therapy in patients with cystic fibrosis.

Journal: P & T : a peer-reviewed journal for formulary management 20111101

Title: Bacteremia caused by Brevundimonas species at a tertiary care hospital in Taiwan, 2000-2010.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20111001

Title: Longitudinal survey of carbapenem resistance and resistance mechanisms in Enterobacteriaceae and non-fermenters from the USA in 2007-09.

Journal: The Journal of antimicrobial chemotherapy 20111001

Title: Pseudomonas aeruginosa carbapenem resistance mechanisms in Spain: impact on the activity of imipenem, meropenem and doripenem.

Journal: The Journal of antimicrobial chemotherapy 20110901

Title: Pharmacodynamic evaluation of i.v. antimicrobials against Pseudomonas aeruginosa samples collected from U.S. hospitals.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20110901

Title: Bacteraemia caused by Weissella confusa at a university hospital in Taiwan, 1997-2007.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20110801

Title: The laboratory diagnosis of Pseudomonas aeruginosa that produce metallo-β-lactamases in a Dutch tertiary care centre.

Journal: Scandinavian journal of infectious diseases 20110801

Title: Update on resistance of Bacteroides fragilis group and related species with special attention to carbapenems 2006-2009.

Journal: Anaerobe 20110801

Title: Consensus review of the epidemiology and appropriate antimicrobial therapy of complicated urinary tract infections in Asia-Pacific region.

Journal: The Journal of infection 20110801

Title: The Retrospective Cohort of Extended-Infusion Piperacillin-Tazobactam (RECEIPT) study: a multicenter study.

Journal: Pharmacotherapy 20110801

Title: [In vitro combination effects of doripenem with aminoglycoside or ciprofloxacin against Pseudomonas aeruginosa].

Journal: The Japanese journal of antibiotics 20110801

Title: Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.

Journal: The Medical clinics of North America 20110701

Title: In vivo efficacy of doripenem (DRPM) against Pseudomonas aeruginosa in murine chronic respiratory tract infection model.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110601

Title: Phenotypic and genotypic screening and clonal analysis of carbapenem-resistant Klebsiella pneumoniae at a single hospital.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20110601

Title: Comparative in vitro susceptibility of Burkholderia pseudomallei to doripenem, ertapenem, tigecycline and moxifloxacin.

Journal: International journal of antimicrobial agents 20110601

Title: Removal of doripenem during hemodialysis and the optimum dosing regimen for patients undergoing hemodialysis.

Journal: Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 20110601

Title: Diagnosis and management of community-acquired pneumonia in adults.

Journal: American family physician 20110601

Title: Comparative activity of carbapenem testing: the COMPACT study.

Journal: The Journal of antimicrobial chemotherapy 20110501

Title: Simultaneous determination of eight β-lactam antibiotics in human serum by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501

Title: A liquid chromatography assay for a quantification of doripenem, ertapenem, imipenem, meropenem concentrations in human plasma: application to a clinical pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110501

Title: Bacteremia caused by Laribacter hongkongensis misidentified as Acinetobacter lwoffii: report of the first case in Korea.

Journal: Journal of Korean medical science 20110501

Title: [Activity of doripenem against anaerobic bacteria].

Journal: Pathologie-biologie 20110401

Title: In vitro antibacterial activity of doripenem against clinical isolates from French teaching hospitals: proposition of zone diameter breakpoints.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20110401

Title: Fluoroquinolone use is not associated with the change in imipenem susceptibility of Pseudomonas aeruginosa in 25 hospitals.

Journal: Advances in therapy 20110401

Title: Epileptogenic potential of carbapenem agents: mechanism of action, seizure rates, and clinical considerations.

Journal: Pharmacotherapy 20110401

Title: Gastrointestinal selective capacity of doripenem, meropenem, and imipenem for carbapenem-resistant gram-negative bacilli in treated patients with pneumonia.

Journal: Infection control and hospital epidemiology 20110401

Title: Efficacy of combination use of Beta-lactamase inhibitor with penicillin and fluoroquinolones for antibiotic prophylaxis in transrectal prostate biopsy.

Journal: Korean journal of urology 20110401

Title: [Comparative evaluation of in vitro activities of carbapenems against gram-negative pathogens: Turkish data of COMPACT study].

Journal: Mikrobiyoloji bulteni 20110401

Title: Structures of the class D carbapenemase OXA-24 from Acinetobacter baumannii in complex with doripenem.

Journal: Journal of molecular biology 20110304

Title: Antimicrobial activity of doripenem and other carbapenems against gram-negative pathogens from Korea.

Journal: Microbial drug resistance (Larchmont, N.Y.) 20110301

Title: Pharmacodynamic profiling of intravenous antibiotics against prevalent Gram-negative organisms across the globe: the PASSPORT Program-Asia-Pacific Region.

Journal: International journal of antimicrobial agents 20110301

Title: Antimicrobial susceptibility of 15,644 pathogens from Canadian hospitals: results of the CANWARD 2007-2009 study.

Journal: Diagnostic microbiology and infectious disease 20110301

Title: Pretracheal abscess following two weeks of endotracheal intubation.

Journal: The Yale journal of biology and medicine 20110301

Title: Stability of doripenem, imipenem and meropenem at elevated room temperatures.

Journal: International journal of antimicrobial agents 20110201

Title: Potential interaction between valproic acid and doripenem.

Journal: Current drug safety 20110201

Title: Determination of doripenem and related substances in medicinal product using capillary electrophoresis.

Journal: Journal of separation science 20110201

Title: [Validity of using imipenem as a representative carbapenems and levofloxacin as a representative fluoroquinolones in antibiotics susceptibility test for enterobacteriaceae].

Journal: The Japanese journal of antibiotics 20110201

Title: Crystal structures of penicillin-binding protein 3 from Pseudomonas aeruginosa: comparison of native and antibiotic-bound forms.

Journal: Journal of molecular biology 20110107

Title: Clostridium sphenoides bloodstream infection in man.

Journal: Emerging infectious diseases 20110101

Title: WSES consensus conference: Guidelines for first-line management of intra-abdominal infections.

Journal: World journal of emergency surgery : WJES 20110101

Title: Antimicrobial resistance surveillance in the AFHSC-GEIS network.

Journal: BMC public health 20110101

Title: [Antibiotic susceptibility to parental antibiotics and penicillin-binding-protein genotype in Haemophilus influenzae isolated from children with invasive infection].

Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20110101

Title: Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong.

Journal: PloS one 20110101

Title: New treatment options against gram-negative organisms.

Journal: Critical care (London, England) 20110101

Title: Antimicrobial treatment of 'complicated' intra-abdominal infections and the new IDSA guidelines ? a commentary and an alternative European approach according to clinical definitions.

Journal: European journal of medical research 20110101

Title: Impact of a Multimodal Antimicrobial Stewardship Program on Pseudomonas aeruginosa Susceptibility and Antimicrobial Use in the Intensive Care Unit Setting.

Journal: Critical care research and practice 20110101

Title: Management of refractory Pseudomonas aeruginosa infection in cystic fibrosis.

Journal: Infection and drug resistance 20110101

Title: Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials.

Journal: BMC infectious diseases 20110101

Title: Effect of hemopurification rate on doripenem pharmacokinetics in critically ill patients receiving high-flow continuous hemodiafiltration.

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101

Title: Molecular basis of NDM-1, a new antibiotic resistance determinant.

Journal: PloS one 20110101

Title: Structure of apo- and monometalated forms of NDM-1--a highly potent carbapenem-hydrolyzing metallo-β-lactamase.

Journal: PloS one 20110101

Title: Meropenem vs standard of care for treatment of late onset sepsis in children of less than 90 days of age: study protocol for a randomised controlled trial.

Journal: Trials 20110101

Title: [Review of the effectiveness of an empirical antibiotic therapy in suspected ventilator-associated pneumonia].

Journal: Anestezjologia intensywna terapia 20110101

Title: Diuretics induced uremia and nonrecovery of renal function in a patient with acute renal failure caused by sepsis.

Journal: Indian journal of pharmacology 20110101

Title: Polymyxin Combination Therapy and the Use of Serum Bactericidal Titers in the Management of KPC-Producing Klebsiella pneumoniae Infections: A Report of 3 Cases.

Journal: Case reports in medicine 20110101

Title: Effective antibiotics in combination against extreme drug-resistant Pseudomonas aeruginosa with decreased susceptibility to polymyxin B.

Journal: PloS one 20110101

Title: Surveillance of broad-spectrum antibiotic prescription in Singaporean hospitals: a 5-year longitudinal study.

Journal: PloS one 20110101

Title: [Antimicrobial sensitive of Morganella morganii].

Journal: Medycyna doswiadczalna i mikrobiologia 20110101

Title: [Susceptibility to antibiotics of Enterobacter spp. rods isolated from urine].

Journal: Medycyna doswiadczalna i mikrobiologia 20110101

Title: Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

Title: Assessing the pharmacodynamic profile of intravenous antibiotics against prevalent Gram-negative organisms collected in Colombia.

Journal: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20110101

Title: A novel combination regimen for the treatment of refractory bacteremia due to multidrug-resistant Pseudomonas aeruginosa in a liver transplant recipient.

Journal: Transplant infectious disease : an official journal of the Transplantation Society 20101201

Title: In vitro activity of doripenem and other carbapenems against contemporary Gram-negative pathogens isolated from hospitalised patients in the Asia-Pacific region: results of the COMPACT Asia-Pacific Study.

Journal: International journal of antimicrobial agents 20101201

Title: Use of high-dose 4-hour infusion of doripenem, in combination with fosfomycin, for treatment of carbapenem-resistant Pseudomonas aeruginosa pneumonia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20101201

Title: Doripenem: a new carbapenem antibiotic.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20101201

Title: Safety and efficacy of intravenous doripenem for the treatment of complicated urinary tract infections and pyelonephritis.

Journal: Journal of chemotherapy (Florence, Italy) 20101201

Title: Efficacy of doripenem in the treatment of Pseudomonas aeruginosa experimental pneumonia versus imipenem and meropenem.

Journal: The Journal of antimicrobial chemotherapy 20101101

Title: Nosocomial infections: new therapeutic alternatives.

Journal: Expert review of anti-infective therapy 20101101

Title: The UV-derivative spectrophotometry for the determination of doripenem in the presence of its degradation products.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20101001

Title: Cost-effectiveness model of empiric doripenem compared with imipenem-cilastatin in ventilator-associated pneumonia.

Journal: Surgical infections 20101001

Title: Antimicrobial activity of doripenem against bacterial isolates from humans and animals.

Journal: The Journal of antibiotics 20101001

Title: Stability of doripenem in polyvinyl chloride bags and elastomeric pumps.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100915

Title: Activity of doripenem against extended-spectrum beta-lactamase-producing Enterobacteriaceae and Pseudomonas aeruginosa isolates.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20100901

Title: Newer antibacterial agents and their potential role in cystic fibrosis pulmonary exacerbation management.

Journal: The Journal of antimicrobial chemotherapy 20100901

Title: [Comparative activity of doripenem, meropenem, and imipenem in recent clinical isolates obtained during the COMPACT-Spain epidemiological surveillance study].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20100901

Title: [Available carbapenems: Properties and differences].

Journal: Enfermedades infecciosas y microbiologia clinica 20100901

Title: [Role of new carbapenems in nosocomial intraabdominal infection].

Journal: Enfermedades infecciosas y microbiologia clinica 20100901

Title: Clostridium difficile bacteremia, Taiwan.

Journal: Emerging infectious diseases 20100801

Title: The pharmacokinetics and pharmacodynamics of the carbapanemes: focus on doripenem.

Journal: Journal of chemotherapy (Florence, Italy) 20100801

Title: Proposed disc zone breakpoints for doripenem for use with the BSAC disc susceptibility testing method.

Journal: The Journal of antimicrobial chemotherapy 20100701

Title: Activity of doripenem with and without levofloxacin, amikacin, and colistin against Pseudomonas aeruginosa and Acinetobacter baumannii.

Journal: Diagnostic microbiology and infectious disease 20100601

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100601

Title: Biochemical and structural characterization of Mycobacterium tuberculosis beta-lactamase with the carbapenems ertapenem and doripenem.

Journal: Biochemistry 20100504

Title: Pharmacokinetic/pharmacodynamic modeling and simulation to determine effective dosage regimens for doripenem.

Journal: Journal of pharmaceutical sciences 20100501

Title: Stability of meropenem and doripenem solutions for administration by continuous infusion.

Journal: The Journal of antimicrobial chemotherapy 20100501

Title: Penetration of doripenem into prostatic tissue following intravenous administration in prostatectomy patients.

Journal: International journal of antimicrobial agents 20100501

Title: Potential of doripenem for the treatment of infections with multidrug-resistant Pseudomonas spp.

Journal: International journal of antimicrobial agents 20100501

Title: In vitro activities of doripenem and other carbapenems against clinically important bacteria isolated in intensive care units: nationwide data from the SMART Programme.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20100401

Title: Treatment of Acinetobacter infections.

Journal: Expert opinion on pharmacotherapy 20100401

Title: Predictability of doripenem susceptibility in Acinetobacter baumannii isolates based on other carbapenem susceptibilities and bla OXA gene status.

Journal: Pharmacotherapy 20100401

Title: Pharmacodynamic modeling of intravenous antibiotics against gram-negative bacteria collected in the United States.

Journal: Clinical therapeutics 20100401

Title: [Update on antimicrobial chemotherapy].

Journal: Medecine et maladies infectieuses 20100301

Title: Economic assessment of doripenem versus imipenem in the treatment of ventilator-associated pneumonia.

Journal: Journal of medical economics 20100301

Title: Enhancing resistance to cephalosporins in class C beta-lactamases: impact of Gly214Glu in CMY-2.

Journal: Biochemistry 20100209

Title: Doripenem: an early look at a carbapenem not yet approved for pediatrics.

Journal: The Pediatric infectious disease journal 20100201

Title: Economic evaluation of doripenem for the treatment of nosocomial pneumonia in the US: discrete event simulation.

Journal: Current medical research and opinion 20100101

Title: Doripenem pharmacokinetics in critically ill patients receiving continuous hemodiafiltration (CHDF).

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100101

Title: Lessons learned from the anaerobe survey: historical perspective and review of the most recent data (2005-2007).

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100101

Title: Infected foot ulcers in male and female diabetic patients: a clinico-bioinformative study.

Journal: Annals of clinical microbiology and antimicrobials 20100101

Title: Complete genome sequence and lifestyle of black-pigmented Corynebacterium aurimucosum ATCC 700975 (formerly C. nigricans CN-1) isolated from a vaginal swab of a woman with spontaneous abortion.

Journal: BMC genomics 20100101

Title: Novel treatment approach to combat an infection with Acinetobacter.

Journal: Proceedings (Baylor University. Medical Center) 20100101

Title: A focus on intra-abdominal infections.

Journal: World journal of emergency surgery : WJES 20100101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20100101

Title: Medical resource utilization among patients with ventilator-associated pneumonia: pooled analysis of randomized studies of doripenem versus comparators.

Journal: Critical care (London, England) 20100101

Title: Pharmacokinetic-pharmacodynamic profiling of four antimicrobials against gram-negative bacteria collected from Shenyang, China.

Journal: BMC infectious diseases 20100101

Title: Bench-to-bedside review: The role of beta-lactamases in antibiotic-resistant Gram-negative infections.

Journal: Critical care (London, England) 20100101

Title: Current status of carbapenem antibiotics.

Journal: Current topics in medicinal chemistry 20100101

Title: [Nonfermentative gram-negative bacteria: isolation rates and antibiotic sensitivity].

Journal: Anesteziologiia i reanimatologiia 20100101

Title: Imipenem resistance of Pseudomonas in pneumonia: a systematic literature review.

Journal: BMC pulmonary medicine 20100101

Title: Molecular and therapeutic potential and toxicity of valproic acid.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Multidrug resistant acinetobacter.

Journal: Journal of global infectious diseases 20100101

Title: Interaction of CTX-M-15 enzyme with cefotaxime: a molecular modelling and docking study.

Journal: Bioinformation 20100101

Title: [PCR-RAPD typing of carbapenem-resistant Pseudomonas aeruginosa strains].

Journal: Medycyna doswiadczalna i mikrobiologia 20100101

Title: Multiresistant bacteria and current therapy - the economical side of the story.

Journal: European journal of medical research 20100101

Title: [In vitro activity of doripenem and other carbapenems against Pseudomonas aeruginosa].

Journal: Revista Argentina de microbiologia 20100101

Title: Comparison of the in vitro activity of meropenem and doripenem against Pseudomonas aeruginosa and multidrug-resistant Enterobacteriaceae.

Journal: Acta clinica Belgica 20100101

Title: Current strategies for the prevention and management of central line-associated bloodstream infections.

Journal: Infection and drug resistance 20100101

Title: The 1.4 A crystal structure of the class D beta-lactamase OXA-1 complexed with doripenem.

Journal: Biochemistry 20091222

Title: Correlation between meropenem and doripenem use density and the incidence of carbapenem-resistant Pseudomonas aeruginosa.

Journal: International journal of antimicrobial agents 20091201

Title: Susceptibility of Pseudomonas aeruginosa clinical isolates in Japan to doripenem and other antipseudomonal agents.

Journal: International journal of antimicrobial agents 20091201

Title: Meta-analysis of doripenem vs comparators in patients with pseudomonas infections enrolled in four phase III efficacy and safety clinical trials.

Journal: Current medical research and opinion 20091201

Title: [Doripenem: need for a new carbapenem].

Journal: Medecine et maladies infectieuses 20091201

Title: Newer beta-lactam antibiotics: doripenem, ceftobiprole, ceftaroline, and cefepime.

Journal: Infectious disease clinics of North America 20091201

Title: [A case of pulmonary infection caused by Pseudomonas aeruginosa with anorexia nervosa].

Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20091201

Title: Doripenem versus bacteria: an emerging battleground.

Journal: Journal of chemotherapy (Florence, Italy) 20091101

Title: The role of sulfamide derivatives in medicinal chemistry: a patent review (2006-2008).

Journal: Expert opinion on therapeutic patents 20091001

Title: [New antibiotics: small or big advances?].

Journal: Der Internist 20091001

Title: Multidrug-resistant Gram-negative infections: what are the treatment options?

Journal: Drugs 20091001

Title: The changing face of antibiotic therapy.

Journal: British journal of hospital medicine (London, England : 2005) 20091001

Title: BSAC standardized disc susceptibility testing method (version 8).

Journal: The Journal of antimicrobial chemotherapy 20090901

Title: Doripenem: a new carbapenem in the treatment of nosocomial infection.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

Title: In vitro activity of doripenem.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

Title: Efficacy of intravenous infusion of doripenem.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

Title: Safety of intravenous infusion of doripenem.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

Title: Clinical and economic consequences of ventilator-associated pneumonia.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

Title: Antimicrobial resistance among and therapeutic options against gram-negative pathogens.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090815

Title: Impact of dissimilar susceptibility breakpoints for doripenem on susceptibility and carbapenem discordance for Pseudomonas aeruginosa.

Journal: Diagnostic microbiology and infectious disease 20090801

Title: Doripenem-induced intertriginous drug eruption as a mild form of AGEP.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20090801

Title: Update on the treatment of Pseudomonas aeruginosa pneumonia.

Journal: The Journal of antimicrobial chemotherapy 20090801

Title: Doripenem.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090715

Title: An analysis of current pharmaceutical industry practices for making clinical trial results publicly accessible.

Journal: Contemporary clinical trials 20090701

Title: Comparative in vitro activities of nemonoxacin, doripenem, tigecycline and 16 other antimicrobials against Nocardia brasiliensis, Nocardia asteroides and unusual Nocardia species.

Journal: The Journal of antimicrobial chemotherapy 20090701

Title: Pharmacokinetics, safety, and tolerability of doripenem after 0.5-, 1-, and 4-hour infusions in healthy volunteers.

Journal: Journal of clinical pharmacology 20090701

Title: Lost in translation: differences in antimicrobial indication approval policies between the United States and Europe.

Journal: Clinical therapeutics 20090701

Title: Successful treatment with doripenem and tobramycin of ventriculitis due to imipenem- and meropenem-resistant Pseudomonas aeruginosa.

Journal: The Journal of antimicrobial chemotherapy 20090601

Title: Doripenem: position in clinical practice.

Journal: Expert review of anti-infective therapy 20090601

Title: [Analysis on the sensitivity to beta-lactam antibiotics of respiratory-infectious isolates on the second survey on the sensitivity of isolates conducted by the Japanese Society of Chemotherapy in 2007--concerning the aspect of PK/PD break points].

Journal: The Japanese journal of antibiotics 20090601

Title: Doripenem activity tested against a global collection of Enterobacteriaceae, including isolates resistant to other extended-spectrum agents.

Journal: Diagnostic microbiology and infectious disease 20090401

Title: Activity of a novel carbapenem, doripenem, against anaerobic pathogens.

Journal: Diagnostic microbiology and infectious disease 20090401

Title: Antimicrobial activities of doripenem and other carbapenems against Pseudomonas aeruginosa, other nonfermentative bacilli, and Aeromonas spp.

Journal: Diagnostic microbiology and infectious disease 20090401

Title: Pharmacokinetic-pharmacodynamic modeling to support doripenem dose regimen optimization for critically ill patients.

Journal: Diagnostic microbiology and infectious disease 20090401

Title: In vitro potency of doripenem tested against an international collection of rarely isolated bacterial pathogens.

Journal: Diagnostic microbiology and infectious disease 20090401

Title: Antimicrobial activity of doripenem tested against prevalent Gram-positive pathogens: results from a global surveillance study (2003-2007).

Journal: Diagnostic microbiology and infectious disease 20090401

Title: Doripenem: antimicrobial profile and clinical potential.

Journal: Diagnostic microbiology and infectious disease 20090401

Title: Pharmacokinetic-pharmacodynamic target attainment analysis of doripenem in infected patients.

Journal: International journal of antimicrobial agents 20090301

Title: Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA.

Journal: The Journal of antimicrobial chemotherapy 20090301

Title: In vitro activity of doripenem against Acinetobacter baumannii clinical isolates.

Journal: International journal of antimicrobial agents 20090201

Title: New antibiotics for healthcare-associated pneumonia.

Journal: Seminars in respiratory and critical care medicine 20090201

Title: Monte Carlo simulation for evaluation of the efficacy of carbapenems and new quinolones against ESBL-producing Escherichia coli.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20090201

Title: Doripenem: a new addition to the carbapenem class of antimicrobials.

Journal: Recent patents on anti-infective drug discovery 20090101

Title: Management of severe abdominal infections.

Journal: Recent patents on anti-infective drug discovery 20090101

Title: Current status of newer carbapenems.

Journal: Current medicinal chemistry 20090101

Title: Doripenem monohydrate, a broad-spectrum carbapenem antibiotic.

Journal: Clinical therapeutics 20090101

Title: Current treatment of pseudomonal infections in the elderly.

Journal: Drugs & aging 20090101

Title: The use of carbapenems in the treatment of serious infections.

Journal: Journal of intensive care medicine 20090101

Title: Overview of seizure-inducing potential of doripenem.

Journal: Drug safety 20090101

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20090101

Title: Characteristics of doripenem: a new broad-spectrum antibiotic.

Journal: Drug design, development and therapy 20090101

Title: New antibiotics: optimal use in current clinical practice.

Journal: International journal of antimicrobial agents 20090101

Title: [Activity of doripenem against Pseudomonas spp. and Acinetobacter spp. rods].

Journal: Medycyna doswiadczalna i mikrobiologia 20090101

Title: New antibiotics for antibiotic-resistant bacteria.

Journal: F1000 biology reports 20090101

Title: Recent changes in the epidemiology and management of extended-spectrum β-lactamase-producing Enterobacteriaceae.

Journal: F1000 medicine reports 20090101

Title: Management of infections due to KPC-producing Klebsiella pneumoniae.

Journal: F1000 medicine reports 20090101

Title: Doripenem in hospital infections: a focus on nosocomial pneumonia, complicated intra-abdominal infections, and complicated urinary tract infections.

Journal: Infection and drug resistance 20090101

Title: What's new and not so new on the antimicrobial horizon?

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20081201

Title: New developments in carbapenems.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20081201

Title: Gateways to clinical trials. December 2008.

Journal: Methods and findings in experimental and clinical pharmacology 20081201

Title: Effects of treatment with antimicrobial agents on the human colonic microflora.

Journal: Therapeutics and clinical risk management 20081201

Title: Pharmacodynamic assessment of doripenem in peritoneal fluid against Gram-negative organisms: use of population pharmacokinetic modeling and Monte Carlo simulation.

Journal: Diagnostic microbiology and infectious disease 20081101

Title: New antibiotic agents for bloodstream infections.

Journal: International journal of antimicrobial agents 20081101

Title: Non-susceptibility trends among Enterobacteriaceae from bacteraemias in the UK and Ireland, 2001-06.

Journal: The Journal of antimicrobial chemotherapy 20081101

Title: Current status of newer antiinfectives.

Journal: Recent patents on anti-infective drug discovery 20081101

Title: Stability of doripenem in vitro in representative infusion solutions and infusion bags.

Journal: Clinical therapeutics 20081101

Title: Lucasti et al in the May 2008 issue of Clinical Therapeutics.

Journal: Clinical therapeutics 20081001

Title: Pharmacokinetic-pharmacodynamic modeling and simulation for bactericidal effect in an in vitro dynamic model.

Journal: Journal of pharmaceutical sciences 20080901

Title: Development of breakpoints of carbapenems for intraabdominal infections based on pharmacokinetics and pharmacodynamics in peritoneal fluid.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080801

Title: Efficacy and safety of doripenem versus piperacillin/tazobactam in nosocomial pneumonia: a randomized, open-label, multicenter study.

Journal: Current medical research and opinion 20080701

Title: Compatibility of doripenem with other drugs during simulated Y-site administration.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080701

Title: New drugs08, part 2.

Journal: Nursing 20080701

Title: Doripenem (Doribax): the newest addition to the carbapenems.

Journal: Proceedings (Baylor University. Medical Center) 20080701

Title: Doripenem: a new carbapenem.

Journal: South Dakota medicine : the journal of the South Dakota State Medical Association 20080701

Title: Susceptibility of clinical isolates of Pseudomonas aeruginosa in the Northern Kyushu district of Japan to carbapenem antibiotics, determined by an integrated concentration method: evaluation of the method based on Monte Carlo simulation.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20080601

Title: Quantification of doripenem in human plasma and peritoneal fluid by high-performance liquid chromatography with ultraviolet detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080501

Title: Doripenem: an expected arrival in the treatment of infections caused by multidrug-resistant Gram-negative pathogens.

Journal: Expert opinion on investigational drugs 20080501

Title: Doripenem (doribax)--a new parenteral carbapenem.

Journal: Obstetrics and gynecology 20080501

Title: Efficacy and tolerability of IV doripenem versus meropenem in adults with complicated intra-abdominal infection: a phase III, prospective, multicenter, randomized, double-blind, noninferiority study.

Journal: Clinical therapeutics 20080501

Title: Pharmacokinetic-pharmacodynamic modeling and simulation for in vivo bactericidal effect in murine infection model.

Journal: Journal of pharmaceutical sciences 20080401

Title: Current therapies for pseudomonas aeruginosa.

Journal: Critical care clinics 20080401

Title: Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: a multicenter, randomized study.

Journal: Critical care medicine 20080401

Title: 'The truth, if it exists, is in the details'.

Journal: Critical care medicine 20080401

Title: Hospital resource utilization with doripenem versus imipenem in the treatment of ventilator-associated pneumonia.

Journal: Clinical therapeutics 20080401

Title: [Clinical examination of doripenem for infectious diseases in gynecological and associated fields].

Journal: The Japanese journal of antibiotics 20080401

Title: Activity of doripenem and comparator beta-lactams against US clinical isolates of Streptococcus pneumoniae with defined mutations in the penicillin-binding domains of pbp1a, pbp2b and pbp2x.

Journal: The Journal of antimicrobial chemotherapy 20080301

Title: The role of carbapenems in the treatment of severe nosocomial respiratory tract infections.

Journal: Expert opinion on pharmacotherapy 20080301

Title: Doripenem (doribax), a new carbapenem antibacterial agent.

Journal: P & T : a peer-reviewed journal for formulary management 20080301

Title: Multidrug-resistant Gram-negative bacterial infections: the emerging threat and potential novel treatment options.

Journal: Current opinion in investigational drugs (London, England : 2000) 20080201

Title: [In-vitro activity of panipenem against clinical isolates in 2006].

Journal: The Japanese journal of antibiotics 20080201

Title: Doripenem (Doribax)--a new parenteral carbapenem.

Journal: The Medical letter on drugs and therapeutics 20080128

Title: Carbapenems: a potent class of antibiotics.

Journal: Expert opinion on pharmacotherapy 20080101

Title: New drugs: doripenem, raltegravir, and ixabepilone.

Journal: Journal of the American Pharmacists Association : JAPhA 20080101

Title: Pharmacodynamic optimization of beta-lactams in the patient care setting.

Journal: Critical care (London, England) 20080101

Title: An overview of harms associated with beta-lactam antimicrobials: where do the carbapenems fit in?

Journal: Critical care (London, England) 20080101

Title: Doripenem: a review of its use in the treatment of bacterial infections.

Journal: Drugs 20080101

Title: Clinical review: balancing the therapeutic, safety, and economic issues underlying effective antipseudomonal carbapenem use.

Journal: Critical care (London, England) 20080101

Title: Peritoneal penetration of doripenem after intravenous administration in abdominal-surgery patients.

Journal: The Journal of antimicrobial chemotherapy 20071201

Title: Selection of a surrogate beta-lactam testing agent for initial susceptibility testing of doripenem, a new carbapenem.

Journal: Diagnostic microbiology and infectious disease 20071201

Title: [Antimicrobial activity of meropenem against main bacterial species isolated from patient blood in 2006].

Journal: The Japanese journal of antibiotics 20071201

Title: [Analysis on the effective dosage regimens for meropenem, biapenem and doripenem against P. aeruginosa infection based on pharmacokinetics and pharmacodynamics theory].

Journal: The Japanese journal of antibiotics 20071201

Title: Carbapenems in the USA: focus on doripenem.

Journal: Expert review of anti-infective therapy 20071001

Title: Doripenem: A new carbapenem antibiotic a review of comparative antimicrobial and bactericidal activities.

Journal: Therapeutics and clinical risk management 20071001

Title: [Strategies for management of difficult to treat Gram-negative infections: focus on Pseudomonas aeruginosa].

Journal: Le infezioni in medicina : rivista periodica di eziologia, epidemiologia, diagnostica, clinica e terapia delle patologie infettive 20070901

Title: Empiric treatment options in the management of complicated intra-abdominal infections.

Journal: Cleveland Clinic journal of medicine 20070801

Title: Development of an HPLC method for the determination of doripenem in human and mouse serum.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615

Title: Pseudomonas aeruginosa: resistance and therapeutic options at the turn of the new millennium.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20070601

Title: Biochemical characterisation of the CTX-M-14 beta-lactamase.

Journal: International journal of antimicrobial agents 20070201

Title: Investigational treatments for postoperative surgical site infections.

Journal: Expert opinion on investigational drugs 20070201

Title: Comparative review of the carbapenems.

Journal: Drugs 20070101

Title: Occurrence of PER-1 producing clinical isolates of Pseudomonas aeruginosa in Japan and their susceptibility to doripenem.

Journal: The Journal of antibiotics 20061201

Title: Clinical experience with recently approved antibiotics.

Journal: Current opinion in pharmacology 20061001

Title: Challenges in identifying new antimicrobial agents effective for treating infections with Acinetobacter baumannii and Pseudomonas aeruginosa.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20060901

Title: Delayed resistance selection for doripenem when passaging Pseudomonas aeruginosa isolates with doripenem plus an aminoglycoside.

Journal: Diagnostic microbiology and infectious disease 20060701

Title: [New antibiotics for the therapy of respiratory tract infections].

Journal: Pneumologie (Stuttgart, Germany) 20060701

Title: Doripenem.

Journal: Drugs of today (Barcelona, Spain : 1998) 20060601

Title: Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.

Journal: Toxicology 20060501

Title: Potency of carbapenems for the prevention of carbapenem-resistant mutants of Pseudomonas aeruginosa: the high potency of a new carbapenem doripenem.

Journal: The Journal of antibiotics 20060401

Title: Pharmacokinetics and tissue penetration of a new carbapenem, doripenem, intravenously administered to laboratory animals.

Journal: In vivo (Athens, Greece) 20060101

Title: Antimicrobial activity of doripenem (S-4661): a global surveillance report (2003).

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20051201

Title: [A new carbapenem antibiotic for injection: characteristics of doripenem].

Journal: The Japanese journal of antibiotics 20051201

Title: Study of the synergism between carbapenems and vancomycin or teicoplanin against MRSA, focusing on S-4661, a carbapenem newly developed in Japan.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20051001

Title: Acquisitions not a cure for anti-infectives.

Journal: Nature reviews. Drug discovery 20050901

Title: Comparative in vitro antimicrobial activity of a new carbapenem, doripenem: tentative disc diffusion criteria and quality control.

Journal: The Journal of antimicrobial chemotherapy 20050601

Title: Comparative activity of doripenem and three other carbapenems tested against Gram-negative bacilli with various beta-lactamase resistance mechanisms.

Journal: Diagnostic microbiology and infectious disease 20050501

Title: Antibacterial Drug Discovery and Development Summit - Tenth Annual SRI Summit.

Journal: IDrugs : the investigational drugs journal 20050501

Title: Mechanism of the drug interaction between valproic acid and carbapenem antibiotics in monkeys and rats.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20041201

Title: Activities of doripenem (S-4661) against drug-resistant clinical pathogens.

Journal: Antimicrobial agents and chemotherapy 20040801

Title: Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations.

Journal: The Journal of antimicrobial chemotherapy 20040701

Title: Gateways to clinical trials.

Journal: Methods and findings in experimental and clinical pharmacology 20031201

Title: Antimicrobial-induced release of endotoxin from Pseudomonas aeruginosa: comparison of in vitro and animal models.

Journal: The Journal of antimicrobial chemotherapy 20030201

Title: Doripenem: S 4661.

Journal: Drugs in R&D 20030101

Title: In vitro antibacterial activity of S-4661, a new parenteral carbapenem, against urological pathogens isolated from patients with complicated urinary tract infections.

Journal: Journal of chemotherapy (Florence, Italy) 20020401

Title: Anderson DL. Doripenem. Drugs Today (Barc). 2006 Jun;42(6):399-404.

Title: Jones RN, et al. Doripenem (S-4661), a novel carbapenem: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations. J Antimicrob Chemother. 2004 Jul;54(1):144-54. Epub 2004 Jun 9.

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Tags:148016-81-3 Molecular Formula|148016-81-3 MDL|148016-81-3 SMILES|148016-81-3 Doripenem