Home Other Building Blocks 149184-22-5
149184-22-5,MFCD09266221
Catalog No.:AA00AOIU

149184-22-5 | CGP 55845

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$155.00   $108.00
- +
10mg
≥98%
in stock  
$292.00   $204.00
- +
25mg
≥98%
in stock  
$690.00   $483.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00AOIU
Chemical Name:
CGP 55845
CAS Number:
149184-22-5
Molecular Formula:
C18H23Cl3NO3P
Molecular Weight:
438.7129
MDL Number:
MFCD09266221
SMILES:
O[C@H](CP(=O)(Cc1ccccc1)O)CN[C@H](c1ccc(c(c1)Cl)Cl)C.Cl
Properties
Computed Properties
 
Complexity:
448  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  

Literature

Title: Presynaptic but not postsynaptic GABA signaling at unitary mossy fiber synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822

Title: GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus.

Journal: The European journal of neuroscience 20120801

Title: M2 muscarinic acetylcholine receptors regulate long-term potentiation at hippocampal CA3 pyramidal cell synapses in an input-specific fashion.

Journal: Journal of neurophysiology 20120701

Title: Glissandi: transient fast electrocorticographic oscillations of steadily increasing frequency, explained by temporally increasing gap junction conductance.

Journal: Epilepsia 20120701

Title: Traumatic alterations in GABA signaling disrupt hippocampal network activity in the developing brain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321

Title: Interneurons provide circuit-specific depolarization and hyperpolarization.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321

Title: Sound-driven synaptic inhibition in primary visual cortex.

Journal: Neuron 20120223

Title: On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice.

Journal: Neuropharmacology 20120101

Title: Effects of GABAB ligands alone and in combination with paroxetine on hippocampal BDNF gene expression.

Journal: European journal of pharmacology 20111205

Title: Visual-induced excitation leads to firing pauses in striatal cholinergic interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803

Title: Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110727

Title: The role of interneurons in shaping Purkinje cell responses in the cerebellar cortex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720

Title: Calcium microdomains near R-type calcium channels control the induction of presynaptic long-term potentiation at parallel fiber to purkinje cell synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110406

Title: Astrocytes control GABAergic inhibition of neurons in the mouse barrel cortex.

Journal: The Journal of physiology 20110301

Title: Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110216

Title: Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20110201

Title: Aberrant GABA(A) receptor-mediated inhibition in cortico-thalamic networks of succinic semialdehyde dehydrogenase deficient mice.

Journal: PloS one 20110101

Title: GABA(B) receptor feedback regulation of bipolar cell transmitter release.

Journal: The Journal of physiology 20101215

Title: Control of extracellular dopamine at dendrite and axon terminals.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100519

Title: Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence.

Journal: Biological psychiatry 20100501

Title: Increased insertion of glutamate receptor 2-lacking alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors at hippocampal synapses upon repeated morphine administration.

Journal: Molecular pharmacology 20100501

Title: Differential role of GABAA and GABAB receptors in two distinct output stations of the rat striatum: studies on the substantia nigra pars reticulata and the globus pallidus.

Journal: Neuroscience 20100428

Title: Calcium and cAMP signaling induced by gamma-hydroxybutyrate receptor(s) stimulation in NCB-20 neurons.

Journal: Neuroscience 20100428

Title: Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100113

Title: Activity-mediated plasticity of GABA equilibrium potential in rat hippocampal CA1 neurons.

Journal: Experimental neurology 20100101

Title: Analgesic α-conotoxins Vc1.1 and RgIA inhibit N-type calcium channels in sensory neurons of α9 nicotinic receptor knockout mice.

Journal: Channels (Austin, Tex.) 20100101

Title: The time course of dopamine transmission in the ventral tegmental area.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20091021

Title: The timing of external input controls the sign of plasticity at local synapses.

Journal: Nature neuroscience 20091001

Title: Dynamics of fast and slow inhibition from cerebellar golgi cells allow flexible control of synaptic integration.

Journal: Neuron 20090924

Title: GABA(B) receptor activation triggers BDNF release and promotes the maturation of GABAergic synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090916

Title: Linking genetically defined neurons to behavior through a broadly applicable silencing allele.

Journal: Neuron 20090813

Title: Impaired function of GABA(B) receptors in tissues from pharmacoresistant epilepsy patients.

Journal: Epilepsia 20090701

Title: The functional equivalence of ascending and parallel fiber inputs in cerebellar computation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090701

Title: Dysfunction of the dentate basket cell circuit in a rat model of temporal lobe epilepsy.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090617

Title: Tonic activation of GABAB receptors reduces release probability at inhibitory connections in the cerebellar glomerulus.

Journal: Journal of neurophysiology 20090601

Title: Noradrenergic control of associative synaptic plasticity by selective modulation of instructive signals.

Journal: Neuron 20090416

Title: Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals.

Journal: Journal of neurophysiology 20090401

Title: Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels.

Journal: Neuroscience 20090218

Title: Chronic CXCL10 alters neuronal properties in rat hippocampal culture.

Journal: Journal of neuroimmunology 20090215

Title: Role of ionotropic glutamate receptors in long-term potentiation in rat hippocampal CA1 oriens-lacunosum moleculare interneurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090128

Title: Noradrenergic excitation of a subpopulation of GABAergic cells in the basolateral amygdala via both activation of nonselective cationic conductance and suppression of resting K+ conductance: a study using glutamate decarboxylase 67-green fluorescent protein knock-in mice.

Journal: Neuroscience 20081210

Title: Behavioral and electrophysiological effects of pallidal GABAB receptor activation and blockade on haloperidol-induced akinesia in rats.

Journal: Brain research 20081209

Title: GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum.

Journal: The Journal of physiology 20081201

Title: Autonomous initiation and propagation of action potentials in neurons of the subthalamic nucleus.

Journal: The Journal of physiology 20081201

Title: Tonic GABAergic inhibition of sympathetic preganglionic neurons: a novel substrate for sympathetic control.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081119

Title: Conductances mediating intrinsic theta-frequency membrane potential oscillations in layer II parasubicular neurons.

Journal: Journal of neurophysiology 20081101

Title: Analgesic alpha-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081022

Title: Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats.

Journal: American journal of physiology. Heart and circulatory physiology 20080801

Title: GABA(B) receptor modulation of feedforward inhibition through hippocampal neurogliaform cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080702

Title: Effects of subtype-selective group I mGluR antagonists on synchronous activity induced by 4-aminopyridine/CGP 55845 in adult guinea pig hippocampal slices.

Journal: Neuropharmacology 20080701

Title: Cellular and behavioral interactions of gabapentin with alcohol dependence.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080528

Title: Influence of positive allosteric modulators on GABA(B) receptor coupling in rat brain: a scintillation proximity assay characterisation of G protein subtypes.

Journal: Journal of neurochemistry 20080401

Title: Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens.

Journal: Neuropharmacology 20080401

Title: Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive.

Journal: Journal of neurophysiology 20080201

Title: SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses.

Journal: Nature neuroscience 20080201

Title: Dual GABAergic synaptic response of fast excitation and slow inhibition in the medial habenula of rat epithalamus.

Journal: Journal of neurophysiology 20070901

Title: Dendritic spikes in apical dendrites of neocortical layer 2/3 pyramidal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070822

Title: Activation of presynaptic GABA(A) receptors induces glutamate release from parallel fiber synapses.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20070822

Title: Effects of mu-opioid receptor modulation on GABAB receptor synaptic function in hippocampal CA1.

Journal: Journal of neurophysiology 20070301

Title: Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice.

Journal: The European journal of neuroscience 20070201

Title: Nucleus-specific abnormalities of GABAergic synaptic transmission in a genetic model of absence seizures.

Journal: Journal of neurophysiology 20061201

Title: Enaminones and norepinephrine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro.

Journal: The European journal of neuroscience 20061101

Title: Hippocampal partial kindling decreased hippocampal GABAB receptor efficacy and wet dog shakes in rats.

Journal: Behavioural brain research 20061016

Title: Functional alignment of feedback effects from visual cortex to thalamus.

Journal: Nature neuroscience 20061001

Title: Concentration-dependent effects of anticonvulsant enaminone methyl 4-(4'-bromophenyl)aminocyclohex-3-en-6-methyl-2-oxo-1-oate on neuronal excitability in vitro.

Journal: Neuroscience 20060811

Title: Specific subtypes of GABAA receptors mediate phasic and tonic forms of inhibition in hippocampal pyramidal neurons.

Journal: Journal of neurophysiology 20060801

Title: Origins of GABA(A) and GABA(B) receptor-mediated responses of globus pallidus induced after stimulation of the putamen in the monkey.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060614

Title: GABA(B) receptor-activation inhibits GABAergic synaptic transmission in parvocellular neurones of rat hypothalamic paraventricular nucleus.

Journal: Journal of neuroendocrinology 20060301

Title: NMDA receptor-mediated transmission contributes to network 'hyperexcitability' in the rat insular cortex.

Journal: The European journal of neuroscience 20060201

Title: Simultaneous NMDA-dependent long-term potentiation of EPSCs and long-term depression of IPSCs in cultured rat hippocampal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125

Title: GABAergic signaling at mossy fiber synapses in neonatal rat hippocampus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111

Title: An NMDA receptor/nitric oxide cascade is involved in cerebellar LTD but is not localized to the parallel fiber terminal.

Journal: Journal of neurophysiology 20051201

Title: Inhibition [corrected] of olfactory receptor neuron input to olfactory bulb glomeruli mediated by suppression of presynaptic calcium influx.

Journal: Journal of neurophysiology 20051001

Title: Independent roles of calcium and voltage-dependent potassium currents in controlling spike frequency adaptation in lateral amygdala pyramidal neurons.

Journal: The European journal of neuroscience 20051001

Title: Recruitment of local excitatory circuits in the superior colliculus following deafferentation and the regeneration of retinocollicular inputs.

Journal: The European journal of neuroscience 20051001

Title: Distinct mechanisms of presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta.

Journal: Journal of neurophysiology 20050901

Title: GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters.

Journal: Journal of neurophysiology 20050801

Title: Anticonvulsant enaminones depress excitatory synaptic transmission in the rat brain by enhancing extracellular GABA levels.

Journal: British journal of pharmacology 20050801

Title: Nicotine-induced switch in the nicotinic cholinergic mechanisms of facilitation of long-term potentiation induction.

Journal: The European journal of neuroscience 20050801

Title: Chronic intermittent ethanol exposure enhances NMDA-receptor-mediated synaptic responses and NMDA receptor expression in hippocampal CA1 region.

Journal: Brain research 20050628

Title: Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices expressing a C-terminal truncated GABA(B2) receptor subunit.

Journal: Epilepsy research 20050601

Title: Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.

Journal: Journal of neurophysiology 20050501

Title: Intraglomerular inhibition: signaling mechanisms of an olfactory microcircuit.

Journal: Nature neuroscience 20050301

Title: Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

Title: Kv1 K+ channels control Purkinje cell output to facilitate postsynaptic rebound discharge in deep cerebellar neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209

Title: Distinct properties of functional KCC2 expression in immature mouse hippocampal neurons in culture and in acute slices.

Journal: The European journal of neuroscience 20050201

Title: GABAB receptor antagonist-mediated antidepressant-like behavior is serotonin-dependent.

Journal: The Journal of pharmacology and experimental therapeutics 20050101

Title: Cortical injury affects short-term plasticity of evoked excitatory synaptic currents.

Journal: Journal of neurophysiology 20050101

Title: Presynaptic NMDA autoreceptors facilitate axon excitability: a new molecular target for the anticonvulsant gabapentin.

Journal: The European journal of neuroscience 20050101

Title: Tonic activation of presynaptic GABA(B) receptors on rat pallidosubthalamic terminals.

Journal: Acta pharmacologica Sinica 20050101

Title: GABAB receptors in the medial septum/diagonal band slice from 16-25 day rat.

Journal: Neuroscience 20050101

Title: Adrenergic receptor modulation of hippocampal CA3 network activity.

Journal: Epilepsy research 20050101

Title: The spinal GABAergic system is a strong modulator of burst frequency in the lamprey locomotor network.

Journal: Journal of neurophysiology 20041001

Title: Mechanism of GABA receptor-mediated inhibition of spontaneous GABA release onto cerebellar Purkinje cells.

Journal: The European journal of neuroscience 20040801

Title: Distinct properties of presynaptic group II and III metabotropic glutamate receptor-mediated inhibition of perforant pathway-CA1 EPSCs.

Journal: The European journal of neuroscience 20040501

Title: 5-Hydroxytryptamine 1B receptors mediate presynaptic inhibition of monosynaptic IPSC in the rat dorsolateral septal nucleus.

Journal: Neuroscience research 20040301

Title: Lamina-specific differences in GABA(B) autoreceptor-mediated regulation of spontaneous GABA release in rat entorhinal cortex.

Journal: Neuropharmacology 20040101

Title: Does gabapentin act as an agonist at native GABA(B) receptors?

Journal: Journal of biomedical science 20040101

Title: GABA(B) receptor activation augments TASK-1 in MAH cells and mediates autoreceptor feedback during hypoxia.

Journal: Biochemical and biophysical research communications 20031212

Title: Mechanisms contributing to the exacerbated epileptiform activity in hippocampal slices of GABAB1 receptor subunit knockout mice.

Journal: Epilepsy research 20031201

Title: Synaptic and non-synaptic mechanisms of amygdala recruitment into temporolimbic epileptiform activities.

Journal: The European journal of neuroscience 20031101

Title: Effects of the GABA-uptake inhibitor tiagabine in rat globus pallidus.

Journal: Experimental brain research 20030901

Title: GABAC receptors in the rat superior colliculus and pretectum participate in synaptic neurotransmission.

Journal: Journal of neurophysiology 20030401

Title: Presynaptic and postsynaptic GABAA receptors in rat suprachiasmatic nucleus.

Journal: Neuroscience 20030101

Title: Excitatory GABA input directly drives seizure-like rhythmic synchronization in mature hippocampal CA1 pyramidal cells.

Journal: Neuroscience 20030101

Title: Spontaneous epileptiform activity mediated by GABA(A) receptors and gap junctions in the rat hippocampal slice following long-term exposure to GABA(B) antagonists.

Journal: Neuropharmacology 20020901

Title: GABAergic modulation of primary gustatory afferent synaptic efficacy.

Journal: Journal of neurobiology 20020801

Title: Comparison of receptive field expansion produced by GABA(B) and GABA(A) receptor antagonists in raccoon primary somatosensory cortex.

Journal: Experimental brain research 20020501

Title: Differential ontogeny of GABA(B)-receptor-mediated pre- and postsynaptic modulation of GABA and glycine transmission in respiratory rhythm-generating network in mouse.

Journal: The Journal of physiology 20020415

Title: Recombinant GABA(B) receptors formed from GABA(B1) and GABA(B2) subunits selectively inhibit N-type Ca(2+) channels in NG108-15 cells.

Journal: European journal of pharmacology 20020405

Title: GABA(B) presynaptic inhibition has an in vivo time constant sufficiently rapid to allow modulation at theta frequency.

Journal: Journal of neurophysiology 20020301

Title: Fast network oscillations in the rat dentate gyrus in vitro.

Journal: Journal of neurophysiology 20020201

Title: Pre- and postsynaptic inhibition mediated by GABA(B) receptors in cerebellar inhibitory interneurons.

Journal: Journal of neurophysiology 20020101

Title: In vivo modulation of ventral tegmental area dopamine and glutamate efflux by local GABA(B) receptors is altered after repeated amphetamine treatment.

Journal: Neuroscience 20020101

Title: Modulation of synaptic transmission in hippocampal CA1 neurons by a novel neurotoxin (beta-pompilidotoxin) derived from wasp venom.

Journal: Neuroscience research 20011201

Title: Regulation of muscarinic acetylcholine receptor-mediated synaptic responses by GABA(B) receptors in the rat hippocampus.

Journal: The Journal of physiology 20010915

Title: Paradoxical reduction of synaptic inhibition by vigabatrin.

Journal: Journal of neurophysiology 20010801

Title: Effects of high-affinity GABAB receptor antagonists on active and passive avoidance responding in rodents with gamma-hydroxybutyrolactone-induced absence syndrome.

Journal: Psychopharmacology 20010801

Title: Beta gamma-mediated enhancement of corticotropin-releasing hormone-stimulated adenylyl cyclase activity by activation of gamma-aminobutyric acid(B) receptors in membranes of rat frontal cortex.

Journal: Biochemical pharmacology 20010715

Title: 5-Hydroxytryptamine facilitates spatiotemporal propagation of optical signals in the hippocampal-septal pathway.

Journal: Neuroscience research 20010701

Title: Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.

Journal: Brain research bulletin 20010701

Title: Dynamic modulation of excitation and inhibition during stimulation at gamma and beta frequencies in the CA1 hippocampal region.

Journal: Journal of neurophysiology 20010601

Title: Electrophysiological characterization of 'giant' cells in stratum radiatum of the CA3 hippocampal region.

Journal: Journal of neurophysiology 20010501

Title: Enhanced temporal stability of cholinergic hippocampal gamma oscillations following respiratory alkalosis in vitro.

Journal: Journal of neurophysiology 20010501

Title: Kindling induces transient NMDA receptor-mediated facilitation of high-frequency input in the rat dentate gyrus.

Journal: Journal of neurophysiology 20010501

Title: Developmental regulation of GABA(B) receptor function in rat spinal cord.

Journal: Life sciences 20010406

Title: Contribution of GABA(A) and GABA(B) receptors to thalamic neuronal activity during spontaneous absence seizures in rats.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010215

Title: Cloning and functional expression of GABA(B) receptors from Drosophila.

Journal: The European journal of neuroscience 20010201

Title: Multireceptor GABAergic regulation of synaptic communication in amphibian retina.

Journal: The Journal of physiology 20010101

Title: Reorganisation of respiratory network activity after loss of glycinergic inhibition.

Journal: Pflugers Archiv : European journal of physiology 20010101

Title: Cocaine and kindling alter the sensitivity of group II and III metabotropic glutamate receptors in the central amygdala.

Journal: Journal of neurophysiology 20000801

Title: CGP 35348 and CGP 55845A block the baclofen-induced depression of dorsal root evoked potentials in lumbar motoneurons of the neonatal rat.

Journal: Neuroscience letters 19960823

Title: Antagonism of baclofen-induced depression of whole-cell synaptic currents in spinal dorsal horn neurones by the potent GABAB antagonist CGP55845.

Journal: Neuropharmacology 19931201

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 149184-22-5
Tags:149184-22-5 Molecular Formula|149184-22-5 MDL|149184-22-5 SMILES|149184-22-5 CGP 55845