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149709-62-6,MFCD00920862
Catalog No.:AA001LVO

149709-62-6 | 3-{[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]carbamoyl}propanoic acid

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100mg
98%
in stock  
$41.00   $29.00
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1g
98%
in stock  
$181.00   $127.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001LVO
Chemical Name:
3-{[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]carbamoyl}propanoic acid
CAS Number:
149709-62-6
Molecular Formula:
C24H29NO5
Molecular Weight:
411.4908
MDL Number:
MFCD00920862
SMILES:
CCOC(=O)[C@@H](C[C@@H](Cc1ccc(cc1)c1ccccc1)NC(=O)CCC(=O)O)C
Properties
Computed Properties
 
Complexity:
550  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
12  
XLogP3:
3.7  

Literature

Title: The effect of angiotensin receptor neprilysin inhibitor, sacubitril/valsartan, on central nervous system amyloid-β concentrations and clearance in the cynomolgus monkey.

Journal: Toxicology and applied pharmacology 20170515

Title: The Role of Neprilysin Inhibitors in Cardiovascular Disease.

Journal: Current heart failure reports 20151201

Title: Neprilysin Inhibition in Heart Failure with Reduced Ejection Fraction: A Clinical Review.

Journal: Pharmacotherapy 20150901

Title: Angiotensin-neprilysin inhibition versus enalapril in heart failure.

Journal: The New England journal of medicine 20140911

Title: The angiotensin receptor neprilysin inhibitor LCZ696 in heart failure with preserved ejection fraction: a phase 2 double-blind randomised controlled trial.

Journal: Lancet (London, England) 20121020

Title: [2 promising substances for diastolic heart failure].

Journal: MMW Fortschritte der Medizin 20120910

Title: Metabolic actions could confound advantageous effects of combined angiotensin II receptor and neprilysin inhibition.

Journal: Hypertension (Dallas, Tex. : 1979) 20110201

Title: Blood-pressure reduction with LCZ696.

Journal: Lancet (London, England) 20100410

Title: Blood-pressure reduction with LCZ696, a novel dual-acting inhibitor of the angiotensin II receptor and neprilysin: a randomised, double-blind, placebo-controlled, active comparator study.

Journal: Lancet (London, England) 20100410

Title: Pharmacokinetics and pharmacodynamics of LCZ696, a novel dual-acting angiotensin receptor-neprilysin inhibitor (ARNi).

Journal: Journal of clinical pharmacology 20100401

Title: Ksander GM, et al. Dicarboxylic acid dipeptide neutral endopeptidase inhibitors. J Med Chem. 1995 May 12;38(10):1689-700.

Title: Voors AA, et al. The potential role of valsartan + AHU377 ( LCZ696 ) in the treatment of heart failure. Expert Opin Investig Drugs. 2013 Aug;22(8):1041-7.

Title: von Lueder TG, et al. Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. Circ Heart Fail. 2015 Jan;8(1):71-8.

Title: Hegde, L.G., et al. Comparative efficacy of AHU-377, a potent neprilysin inhibitor, in two rat models of volume-dependent hypertension. BMC Pharmacol 11, P33 (2011).

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SDS
Tags:149709-62-6 Molecular Formula|149709-62-6 MDL|149709-62-6 SMILES|149709-62-6 3-{[(2S,4R)-5-Ethoxy-4-methyl-5-oxo-1-(4-phenylphenyl)pentan-2-yl]carbamoyl}propanoic acid