Home Other Building Blocks 14984-68-0
14984-68-0,MFCD00079012
Catalog No.:AA001LZB

14984-68-0 | Cloperastine hydrochloride

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
95%
in stock  
$6.00   $4.00
- +
1g
98%(HPLC)
in stock  
$48.00   $34.00
- +
5g
>97.0%(T)(HPLC)
in stock  
$79.00   $56.00
- +
25g
>97.0%(T)(HPLC)
in stock  
$258.00   $180.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001LZB
Chemical Name:
Cloperastine hydrochloride
CAS Number:
14984-68-0
Molecular Formula:
C20H25Cl2NO
Molecular Weight:
366.3246
MDL Number:
MFCD00079012
SMILES:
Clc1ccc(cc1)C(c1ccccc1)OCCN1CCCCC1.Cl
NSC Number:
758635
Properties
Properties
 
Form:
Solid  
MP:
147.9°  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
318  
Covalently-Bonded Unit Count:
2  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  

Downstream Synthesis Route
14984-68-0   
1-2-(4-chlorophenyl)phenylmethoxyethylpiperidinone 

[1]AngewandteChemie-InternationalEdition,2016,vol.55,p.7212-7217    Angew.Chem.,2016,vol.128,p.7328-7333,6

[1]CurrentPatentAssignee:CHONGQINGSANSHENGIND-CN113651772,2021,ALocationinpatent:Paragraph0038-0040;0044-0046

[1]CurrentPatentAssignee:CHONGQINGSANSHENGIND-CN113651772,2021,ALocationinpatent:Paragraph0041-0046

[1]Li,Qiaoli;Xu,Lanting;Ma,Dawei[AngewandteChemie-InternationalEdition,2022,vol.61,#43][Angew.Chem.,2022,vol.134,#43]

Literature

Title: Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol.

Journal: Environmental toxicology 20140201

Title: Development of chromatographic methods for the determination of genotoxic impurities in cloperastine fendizoate.

Journal: Journal of pharmaceutical and biomedical analysis 20120305

Title: Cloperastine-based cough syrup and acute dystonic reactions.

Journal: Developmental medicine and child neurology 20120301

Title: [Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance?].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Discovery of potent small-molecule inhibitors of multidrug-resistant Plasmodium falciparum using a novel miniaturized high-throughput luciferase-based assay.

Journal: Antimicrobial agents and chemotherapy 20100901

Title: [Novel antidepressant-like action of drugs possessing GIRK channel blocking action in rats].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100501

Title: Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography-tandem mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20100205

Title: Ameliorating effects of cloperastine on dysfunction of the urinary bladder caused by cerebral infarction in conscious rats.

Journal: Canadian journal of physiology and pharmacology 20091101

Title: Effects of solid-state reaction between paracetamol and cloperastine hydrochloride on the pharmaceutical properties of their preparations.

Journal: International journal of pharmaceutics 20070420

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Levocloperastine in the treatment of chronic nonproductive cough: comparative efficacy versus standard antitussive agents.

Journal: Drugs under experimental and clinical research 20040101

Title: Takahara A, et al. Effects of the antitussive drug cloperastine on ventricular repolarization in halothane-anesthetized guinea pigs. J Pharmacol Sci. 2012;120(3):165-75.

Title: Catania MA, et al. Pharmacological and clinical overview of cloperastine in treatment of cough. Ther Clin Risk Manag. 2011;7:83-92.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:14984-68-0 Molecular Formula|14984-68-0 MDL|14984-68-0 SMILES|14984-68-0 Cloperastine hydrochloride