Title: miR-122 Release in Exosomes Precedes Overt Tolvaptan-Induced Necrosis in a Primary Human Hepatocyte Micropatterned Coculture Model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20180101
Title: Editor's Highlight: Candidate Risk Factors and Mechanisms for Tolvaptan-Induced Liver Injury Are Identified Using a Collaborative Cross Approach.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20170401
Title: Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160301
Title: Inhibition of Human Hepatic Bile Acid Transporters by Tolvaptan and Metabolites: Contributing Factors to Drug-Induced Liver Injury?
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20160101
Title: A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131101
Title: Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD.
Journal: Journal of the American Society of Nephrology : JASN 20120928
Title: Antidiuretic hormone antagonist to reduce cystine stone formation.
Journal: Annals of internal medicine 20120918
Title: [Hyponatremia : The water-intolerant patient].
Journal: Medizinische Klinik, Intensivmedizin und Notfallmedizin 20120901
Title: Update on tolvaptan for the treatment of hyponatremia.
Journal: Expert review of pharmacoeconomics & outcomes research 20120801
Title: Chronic administration of oral vasopressin type 2 receptor antagonist tolvaptan exerts both myocardial and renal protective effects in rats with hypertensive heart failure.
Journal: Circulation. Heart failure 20120701
Title: Efficacy of oral tolvaptan in acute heart failure patients with hypotension and renal impairment.
Journal: Journal of cardiovascular medicine (Hagerstown, Md.) 20120701
Title: Serum and urine responses to the aquaretic agent tolvaptan in hospitalized hyponatremic patients.
Journal: International urology and nephrology 20120601
Title: Diagnosis and management of hyponatremia in cancer patients.
Journal: The oncologist 20120601
Title: A comprehensive, longitudinal description of the in-hospital and post-discharge clinical, laboratory, and neurohormonal course of patients with heart failure who die or are re-hospitalized within 90 days: analysis from the EVEREST trial.
Journal: Heart failure reviews 20120501
Title: Syndrome of inappropriate secretion of antidiuretic hormone in traumatic brain injury: when tolvaptan becomes a life saving drug.
Journal: Journal of neurology, neurosurgery, and psychiatry 20120501
Title: Efficacy and tolerance of urea compared with vaptans for long-term treatment of patients with SIADH.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20120501
Title: [A case of venlafaxine-induced syndrome of inappropriate ADH secretion (SIADH) - treatment with tolvaptan].
Journal: Deutsche medizinische Wochenschrift (1946) 20120501
Title: [Diagnostics and new treatment methods of syndrome of inappropriate antidiuretic hormone secretion (SIADH)].
Journal: Ugeskrift for laeger 20120409
Title: [SIADH - a 'shambles'].
Journal: Ugeskrift for laeger 20120409
Title: Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan, a non-peptide AVP antagonist in healthy subjects.
Journal: British journal of clinical pharmacology 20120401
Title: Pharmacokinetics and pharmacodynamics of oral tolvaptan administered in 15- to 60-mg single doses to healthy Korean men.
Journal: Journal of cardiovascular pharmacology 20120401
Title: Oxytocin and vasopressin agonists and antagonists as research tools and potential therapeutics.
Journal: Journal of neuroendocrinology 20120401
Title: Vaptans: a potential new approach for treating chronic hyponatremia in psychotic patients.
Journal: Clinical schizophrenia & related psychoses 20120401
Title: [SIADH and vaptans].
Journal: Annales d'endocrinologie 20120401
Title: Medical therapy for acute decompensated heart failure: what recent clinical trials have taught us about diuretics and vasodilators.
Journal: Current heart failure reports 20120301
Title: Tolvaptan, an oral vasopressin antagonist, in the treatment of hyponatremia in cirrhosis.
Journal: Journal of hepatology 20120301
Title: Polycystic kidney disease: a 2011 update.
Journal: Current opinion in nephrology and hypertension 20120301
Title: Clinical course and predictive value of liver function tests in patients hospitalized for worsening heart failure with reduced ejection fraction: an analysis of the EVEREST trial.
Journal: European journal of heart failure 20120301
Title: Hyponatremia, heart failure, and the role of tolvaptan.
Journal: Postgraduate medicine 20120301
Title: Considerations regarding the management of hyponatraemia secondary to SIADH.
Journal: Best practice & research. Clinical endocrinology & metabolism 20120301
Title: Perspectives on the management of hyponatraemia secondary to SIADH across Europe.
Journal: Best practice & research. Clinical endocrinology & metabolism 20120301
Title: Revision and update on clinical practice guideline for liver cirrhosis.
Journal: The Korean journal of hepatology 20120301
Title: Effect of grapefruit juice on the pharmacokinetics of tolvaptan, a non-peptide arginine vasopressin antagonist, in healthy subjects.
Journal: European journal of clinical pharmacology 20120201
Title: Absolute bioavailability of tolvaptan and determination of minimally effective concentrations in healthy subjects.
Journal: International journal of clinical pharmacology and therapeutics 20120201
Title: Evaluation of costs associated with tolvaptan-mediated hospital length of stay reduction among US patients with the syndrome of inappropriate antidiuretic hormone secretion, based on SALT-1 and SALT-2 trials.
Journal: Hospital practice (1995) 20120201
Title: V2 vasopressin receptor (V2R) mutations in partial nephrogenic diabetes insipidus highlight protean agonism of V2R antagonists.
Journal: The Journal of biological chemistry 20120113
Title: Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients.
Journal: Journal of intensive care medicine 20120101
Title: Tolvaptan.
Journal: British journal of clinical pharmacology 20120101
Title: Massive aquaresis after tolvaptan administration and albumin infusion in a patient with alcoholic cirrhosis.
Journal: The American journal of medicine 20120101
Title: Evaluation of costs associated with tolvaptan-mediated length-of-stay reduction among heart failure patients with hyponatremia in the US, based on the EVEREST trial.
Journal: Journal of medical economics 20120101
Title: Mechanism-based therapeutics for autosomal dominant polycystic kidney disease: recent progress and future prospects.
Journal: Nephron. Clinical practice 20120101
Title: The role of copeptin as a diagnostic and prognostic biomarker for risk stratification in the emergency department.
Journal: BMC medicine 20120101
Title: [Hyponatremic syndrome].
Journal: La Clinica terapeutica 20120101
Title: Preliminary report of tolvaptan treatment in Japanese patients with heart failure.
Journal: International heart journal 20120101
Title: Vasopressin receptor antagonists and their role in clinical medicine.
Journal: Indian journal of endocrinology and metabolism 20120101
Title: [Tolvaptan and CKD, a balance is needed: promises and problems of new drugs in a moment of crisis].
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20120101
Title: Long-term treatment of hyponatremic patients with nephrogenic syndrome of inappropriate antidiuresis: personal experience and review of published case reports.
Journal: Nephron. Clinical practice 20120101
Title: Hyponatremia in cirrhosis and end-stage liver disease: treatment with the vasopressin V₂-receptor antagonist tolvaptan.
Journal: Digestive diseases and sciences 20120101
Title: Vasopressin receptor antagonist in the treatment of the syndrome of inappropriate antidiuretic hormone in general hospital practice.
Journal: Endocrine journal 20120101
Title: [Hyponatremic hypervolemia in heart failure--the hot spot for vasopressin receptor antagonists?].
Journal: Wiadomosci lekarskie (Warsaw, Poland : 1960) 20120101
Title: Tolvaptan for heart failure patients with volume overload.
Journal: Cardiovascular drugs and therapy 20111201
Title: High sensitivity to tolvaptan in paraneoplastic syndrome of inappropriate ADH secretion (SIADH).
Journal: Annals of oncology : official journal of the European Society for Medical Oncology 20111201
Title: Vasopressin V1 receptor-mediated aldosterone production as a result of selective V2 receptor antagonism: a potential explanation for the failure of tolvaptan to reduce cardiovascular outcomes in the EVEREST trial.
Journal: European journal of heart failure 20111201
Title: Tolvaptan for the treatment of hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion.
Journal: Expert review of cardiovascular therapy 20111201
Title: [Disorders of fluid and electrolyte balance].
Journal: Deutsche medizinische Wochenschrift (1946) 20111201
Title: Pharmacokinetics, pharmacodynamics and safety of tolvaptan, a novel, oral, selective nonpeptide AVP V2-receptor antagonist: results of single- and multiple-dose studies in healthy Japanese male volunteers.
Journal: Cardiovascular drugs and therapy 20111201
Title: Effects of tolvaptan on volume overload in Japanese patients with heart failure: results of a phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study.
Journal: Cardiovascular drugs and therapy 20111201
Title: Efficacy and safety of tolvaptan in heart failure patients with volume overload despite the standard treatment with conventional diuretics: a phase III, randomized, double-blind, placebo-controlled study (QUEST study).
Journal: Cardiovascular drugs and therapy 20111201
Title: Efficacy and safety of tolvaptan in heart failure patients with sustained volume overload despite the use of conventional diuretics: a phase III open-label study.
Journal: Cardiovascular drugs and therapy 20111201
Title: Phase III clinical pharmacology study of tolvaptan.
Journal: Cardiovascular drugs and therapy 20111201
Title: Effects of tolvaptan on systemic and renal hemodynamic function in dogs with congestive heart failure.
Journal: Cardiovascular drugs and therapy 20111201
Title: Anti-edematous effects of tolvaptan in experimental rodent models.
Journal: Cardiovascular drugs and therapy 20111201
Title: Nonclinical safety profile of tolvaptan.
Journal: Cardiovascular drugs and therapy 20111201
Title: Nonclinical pharmacokinetics of a new nonpeptide V2 receptor antagonist, tolvaptan.
Journal: Cardiovascular drugs and therapy 20111201
Title: A multicenter, randomized, double-blind, placebo-controlled study of tolvaptan monotherapy compared to furosemide and the combination of tolvaptan and furosemide in patients with heart failure and systolic dysfunction.
Journal: Journal of cardiac failure 20111201
Title: Controlling the flood gates: vaptans, furosemide and the quest for a renal protective diuresis.
Journal: Journal of cardiac failure 20111201
Title: Methyl 5-chloro-2-nitro-benzoate.
Journal: Acta crystallographica. Section E, Structure reports online 20111201
Title: V2 receptor antagonist; tolvaptan.
Journal: Electrolyte & blood pressure : E & BP 20111201
Title: Tolvaptan inhibits ERK-dependent cell proliferation, Cl⁻ secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin.
Journal: American journal of physiology. Renal physiology 20111101
Title: [Slow the pace of renal failure in autosomal dominant polycystic kidney disease: hopes and disappointments].
Journal: Presse medicale (Paris, France : 1983) 20111101
Title: [Tolvaptan (vasopressin receptor antagonist)].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20111101
Title: [Tolvaptan in antidiuretic hormone secretion syndrome secondary to treatment with citalopram].
Journal: Revista clinica espanola 20111001
Title: Changes in renal function during hospitalization and soon after discharge in patients admitted for worsening heart failure in the placebo group of the EVEREST trial.
Journal: European heart journal 20111001
Title: Worsening kidney function in decompensated heart failure: treat the heart, don't mind the kidney.
Journal: European heart journal 20111001
Title: Tolvaptan in autosomal dominant polycystic kidney disease: three years' experience.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20111001
Title: Renal dysfunction in acute heart failure.
Journal: Korean circulation journal 20111001
Title: Neuro-endocrine regulation of blood pressure.
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Title: [The efficacy and safety of tolvaptan on treating heart failure patients with hyponatremia].
Journal: Zhonghua xin xue guan bing za zhi 20111001
Title: Targeting hyponatremia and hemodynamics in acute decompensated heart failure: is there a role for vasopressin antagonists?
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Title: Vaptans are not the mainstay of treatment in hyponatremia: perhaps not yet.
Journal: Kidney international 20110901
Title: Short-term effects of tolvaptan on renal function and volume in patients with autosomal dominant polycystic kidney disease.
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Title: The therapeutic use of vaptans for the treatment of dilutional hyponatremia.
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Title: [Practical approach to hyponatremia].
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Title: Hyponatremia in hospitalized patients: the potential role of tolvaptan.
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Title: Tolvaptan inhibition of desmopressin effects on coagulation factors in a patient with decreased von Willebrand factor and polycystic kidney disease.
Journal: Blood 20110714
Title: Identifying patients hospitalized with heart failure at risk for unfavorable future quality of life.
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Title: [Heart and kidney failure combined. Trouble seldom comes alone].
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Title: Effects of tolvaptan on physician-assessed symptoms and signs in patients hospitalized with acute heart failure syndromes: analysis from the efficacy of vasopressin antagonism in heart failure outcome study with tolvaptan (EVEREST) trials.
Journal: American heart journal 20110601
Title: In vitro P-glycoprotein interactions and steady-state pharmacokinetic interactions between tolvaptan and digoxin in healthy subjects.
Journal: Journal of clinical pharmacology 20110501
Title: Tolvaptan: a new therapeutic agent.
Journal: Reviews on recent clinical trials 20110501
Title: Efficacy and safety of oral tolvaptan therapy in patients with the syndrome of inappropriate antidiuretic hormone secretion.
Journal: European journal of endocrinology 20110501
Title: Rationale and design of the TEMPO (Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and its Outcomes) 3-4 Study.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20110501
Title: Arginine vasopressin (AVP) and treatment with arginine vasopressin receptor antagonists (vaptans) in congestive heart failure, liver cirrhosis and syndrome of inappropriate antidiuretic hormone secretion (SIADH).
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Title: Tolvaptan for the treatment of heart failure: a review of the literature.
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Title: [Treatment of hyponatremia: new developments and controversies].
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Title: New drugs for hyponatraemia. Cost effectiveness of tolvaptan.
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Title: Hyponatremia: vasopressin antagonists in hyponatremia: more data needed.
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Title: Hyponatremia: diagnosis, complications, and management including V2 receptor antagonists.
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Title: Vaptans for the treatment of hyponatremia.
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Title: Effect of serum sodium concentration and tolvaptan treatment on length of hospitalization in patients with heart failure.
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Title: Hepatic alteration after treatment using tolvaptan.
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Title: The cardiorenal syndrome: making the connection.
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Title: Differentiation of arginine vasopressin antagonistic effects by selective V2 versus dual V2/V1a receptor blockade in a preclinical heart failure model.
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Title: Therapeutic options for the management of the cardiorenal syndrome.
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Title: The cardiorenal syndrome: a review.
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Title: Aortocaval fistula in rat: a unique model of volume-overload congestive heart failure and cardiac hypertrophy.
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Title: Cardiorenal syndrome in acute heart failure syndromes.
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Title: Hyponatremia and congestive heart failure: a marker of increased mortality and a target for therapy.
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Title: Tolvaptan for the management of syndrome of inappropriate antidiuretic hormone secretion: lessons learned in titration of dose.
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Title: Cause of seizures: Lungs, not the brain.
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Title: Pharmacological management of cardiorenal syndromes.
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Title: Tolvaptan, hyponatremia, and heart failure.
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Title: Management of renal failure and ascites in patients with cirrhosis.
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Title: Cardiovascular agents affect the tone of pulmonary arteries and veins in precision-cut lung slices.
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Title: [Treatment of hyponatremia: role of vaptans].
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Title: New drugs for hyponatraemia.
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Title: Targeting B-Raf as a treatment strategy for polycystic kidney disease.
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Title: Hyponatremia in acute decompensated heart failure: mechanisms, prognosis, and treatment options.
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Title: Arginine vasopressin receptor antagonists (vaptans): pharmacological tools and potential therapeutic agents.
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Title: Dyspnoea and worsening heart failure in patients with acute heart failure: results from the Pre-RELAX-AHF study.
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Title: A multicenter, open-label, dose-ranging study to exploratively evaluate the efficacy, safety, and dose-response of tolvaptan in patients with decompensated liver cirrhosis.
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Title: Tolvaptan: a vasopressin antagonist for the management of euvolemic and hypervolemic hyponatremia.
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Title: Vasopressin receptor antagonists for the treatment of hyponatremia: systematic review and meta-analysis.
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Title: Chronic hyponatremia impairs memory in rats: effects of vasopressin antagonist tolvaptan.
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Title: Vasopressin-receptor antagonists.
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Title: The assessment and treatment of water imbalance in patients with psychosis.
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Title: Treatment options for hyponatremia in heart failure.
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Title: The syndrome of inappropriate antidiuretic hormone: current and future management options.
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Title: Hyponatraemia: new associations and new treatments.
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Title: Hyponatremia: Prolonged use of the vasopressin antagonist tolvaptan is a safe and effective treatment for hyponatremia.
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Title: Treatment of hypervolemic or euvolemic hyponatremia associated with heart failure, cirrhosis, or the syndrome of inappropriate antidiuretic hormone with tolvaptan: a clinical review.
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Title: Renal and anti-aldosterone actions of vasopressin-2 receptor antagonism and B-type natriuretic peptide in experimental heart failure.
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Title: Causes of death and rehospitalization in patients hospitalized with worsening heart failure and reduced left ventricular ejection fraction: results from Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan (EVEREST) program.
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Title: Renal dysfunction in patients with chronic liver disease.
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Title: Pharmacokinetics, pharmacodynamics, and safety of tolvaptan, a nonpeptide AVP antagonist, during ascending single-dose studies in healthy subjects.
Journal: Journal of clinical pharmacology 20071201
Title: Aminocarbonylation route to tolvaptan.
Journal: Bioorganic & medicinal chemistry letters 20071201
Title: Clinical trials update from the European Society of Cardiology Congress in Vienna, 2007: PROSPECT, EVEREST, ARISE, ALOFT, FINESSE, Prague-8, CARESS in MI and ACUITY.
Journal: Cardiovascular drugs and therapy 20071201
Title: Tolvaptan, an oral vasopressin V2 receptor antagonist for heart failure?
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20071201
Title: Effects of nonpeptide vasopressin V2 antagonist tolvaptan in rats with heart failure.
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Title: Hyponatremia and vasopressin antagonism in congestive heart failure.
Journal: Clinical cardiology 20071101
Title: Current issues for nurse practitioners: Hyponatremia.
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Title: V2 receptor antagonism with tolvaptan in heart failure.
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Title: Water in health and disease: new aspects of disturbances in water metabolism.
Journal: The Netherlands journal of medicine 20071001
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Journal: Methods and findings in experimental and clinical pharmacology 20071001
Title: Effects of tolvaptan, an oral vasopressin V2 receptor antagonist, in hyponatremia.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20070801
Title: Pharmacokinetic and pharmacodynamic interaction between tolvaptan, a non-peptide AVP antagonist, and furosemide or hydrochlorothiazide.
Journal: Journal of cardiovascular pharmacology 20070801
Title: [Vasopressin antagonists in treatment of hyponatremia].
Journal: Polskie Archiwum Medycyny Wewnetrznej 20070801
Title: Multicenter, randomized, double-blind, placebo-controlled study on the effect of oral tolvaptan on left ventricular dilation and function in patients with heart failure and systolic dysfunction.
Journal: Journal of the American College of Cardiology 20070605
Title: Arginine vasopressin receptor antagonists for heart failure: a winter climbing to the Everest's tip?
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Title: Vaptans: a promising therapy in the management of advanced cirrhosis.
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Journal: Rinsho byori. The Japanese journal of clinical pathology 20070601
Title: [Vasopressin V2-receptor antagonist, tolvaptan, for treatment of heart failure].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528
Title: Hyponatremia: current treatment strategies and the role of vasopressin antagonists.
Journal: The Annals of pharmacotherapy 20070501
Title: What new drugs can nephrologists look forward to in the next year or two?
Journal: Nature clinical practice. Nephrology 20070501
Title: Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial.
Journal: JAMA 20070328
Title: Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials.
Journal: JAMA 20070328
Title: Climbing the mountain of acute decompensated heart failure: the EVEREST Trials.
Journal: JAMA 20070328
Title: Tolvaptan for hyponatremia.
Journal: The New England journal of medicine 20070301
Title: Tolvaptan for hyponatremia.
Journal: The New England journal of medicine 20070301
Title: Tolvaptan for hyponatremia.
Journal: The New England journal of medicine 20070301
Title: Tolvaptan for hyponatremia.
Journal: The New England journal of medicine 20070301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070301
Title: Nephrogenic syndrome of inappropriate antidiuresis in adults: high phenotypic variability in men and women from a large pedigree.
Journal: Journal of the American Society of Nephrology : JASN 20070201
Title: New agents for managing hyponatremia in hospitalized patients.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20070201
Title: Evaluation and management of hyponatremia: an emerging role for vasopressin receptor antagonists.
Journal: Nature clinical practice. Nephrology 20070201
Title: Recognition and treatment of hyponatremia in acutely ill hospitalized patients.
Journal: Clinical therapeutics 20070201
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Journal: Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20070118
Title: Role of vasopressin in rat distal colon function.
Journal: The Journal of physiology 20070115
Title: Clinical trials update from the American Heart Association 2006: OAT, SALT 1 and 2, MAGIC, ABCD, PABA-CHF, IMPROVE-CHF, and percutaneous mitral annuloplasty.
Journal: European journal of heart failure 20070101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070101
Title: Cerebral correlates of hyponatremia.
Journal: Neurocritical care 20070101
Title: Therapeutic potential of vasopressin receptor antagonists.
Journal: Drugs 20070101
Title: Aquaretic agents: what's beyond the treatment of hyponatremia?
Journal: Current pharmaceutical design 20070101
Title: Tolvaptan, an orally active vasopressin V(2)-receptor antagonist - pharmacology and clinical trials.
Journal: Cardiovascular drug reviews 20070101
Title: Clinical trials update from the American College of Cardiology 2007: ALPHA, EVEREST, FUSION II, VALIDD, PARR-2, REMODEL, SPICE, COURAGE, COACH, REMADHE, pro-BNP for the evaluation of dyspnoea and THIS-diet.
Journal: European journal of heart failure 20070101
Title: Improvement in hyponatremia during hospitalization for worsening heart failure is associated with improved outcomes: insights from the Acute and Chronic Therapeutic Impact of a Vasopressin Antagonist in Chronic Heart Failure (ACTIV in CHF) trial.
Journal: Acute cardiac care 20070101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070101
Title: Comparison of 60-day mortality in hospitalized heart failure patients with versus without hypothermia.
Journal: The American journal of cardiology 20061201
Title: Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia.
Journal: The New England journal of medicine 20061116
Title: Vasopressin antagonists--progress and promise.
Journal: The New England journal of medicine 20061116
Title: Tolvaptan for the treatment of hyponatremia and congestive heart failure.
Journal: Future cardiology 20061101
Title: A flexible approach for the preparation of substituted benzazepines: application to the synthesis of tolvaptan.
Journal: Bioorganic & medicinal chemistry 20060915
Title: AVP receptor antagonists as aquaretics: review and assessment of clinical data.
Journal: Cleveland Clinic journal of medicine 20060901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060901
Title: Vasopressin antagonists.
Journal: Cellular and molecular life sciences : CMLS 20060801
Title: Vasopressin antagonists as aquaretic agents for the treatment of hyponatremia.
Journal: The American journal of medicine 20060701
Title: Vasopressin receptor antagonists.
Journal: Kidney international 20060601
Title: The clinical effects of vasopressin receptor antagonists in heart failure.
Journal: Cleveland Clinic journal of medicine 20060601
Title: Vasopressin receptor antagonists in heart failure.
Journal: Recent patents on cardiovascular drug discovery 20060601
Title: Vasopressin excess and hyponatremia.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20060501
Title: Tolvaptan: a selective vasopressin type 2 receptor antagonist in congestive heart failure.
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Title: [Diuretics].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060501
Title: Vaptans and the treatment of water-retaining disorders.
Journal: Seminars in nephrology 20060501
Title: Vasopressin receptor antagonists: pharmacological tools and potential therapeutic agents.
Journal: Autonomic & autacoid pharmacology 20060401
Title: Vasopressin v(2) receptor blockade with tolvaptan versus fluid restriction in the treatment of hyponatremia.
Journal: The American journal of cardiology 20060401
Title: Vasopressin-2-receptor antagonism augments water excretion without changes in renal hemodynamics or sodium and potassium excretion in human heart failure.
Journal: American journal of physiology. Renal physiology 20060201
Title: Hyponatremia and heart failure--treatment considerations.
Journal: Congestive heart failure (Greenwich, Conn.) 20060101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060101
Title: Comparison of two doses and dosing regimens of tolvaptan in congestive heart failure.
Journal: Journal of cardiovascular pharmacology 20051101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20051001
Title: New drugs for prevention, relief. How you might benefit if 3 medications win FDA approval.
Journal: Heart advisor 20051001
Title: Overview of randomized clinical trials in acute heart failure syndromes.
Journal: The American journal of cardiology 20050919
Title: Pharmacology of new agents for acute heart failure syndromes.
Journal: The American journal of cardiology 20050919
Title: Role of vasopressin antagonists in the management of acute decompensated heart failure.
Journal: Current heart failure reports 20050901
Title: Tolvaptan administration does not affect steady state amiodarone concentrations in patients with cardiac arrhythmias.
Journal: Journal of cardiovascular pharmacology and therapeutics 20050901
Title: Combination pharmacologic therapies for heart failure: what next after angiotensin-converting enzyme inhibitors and beta-blockers?
Journal: Current heart failure reports 20050801
Title: Therapeutic effects of tolvaptan, a potent, selective nonpeptide vasopressin V2 receptor antagonist, in rats with acute and chronic severe hyponatremia.
Journal: Endocrinology 20050701
Title: Current treatments and novel pharmacologic treatments for hyponatremia in congestive heart failure.
Journal: The American journal of cardiology 20050502
Title: Rationale and design of the multicenter, randomized, double-blind, placebo-controlled study to evaluate the Efficacy of Vasopressin antagonism in Heart Failure: Outcome Study with Tolvaptan (EVEREST).
Journal: Journal of cardiac failure 20050501
Title: Vasopressin receptor antagonists in the management of acute heart failure.
Journal: Expert opinion on investigational drugs 20050501
Title: The therapeutic potential of vasopressin receptor antagonists in congestive heart failure.
Journal: Expert opinion on investigational drugs 20050501
Title: V2 receptor antagonists in cystic kidney diseases: an exciting step towards a practical treatment.
Journal: Journal of the American Society of Nephrology : JASN 20050401
Title: Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat.
Journal: Journal of the American Society of Nephrology : JASN 20050401
Title: Vasopressin antagonism: a future treatment option in heart failure.
Journal: European heart journal 20050301
Title: Vasopressin antagonists in heart failure.
Journal: Current heart failure reports 20041201
Title: Trial finds tolvaptan may help manage congestion in people with heart failure, but did not reduce death or hospitalisation.
Journal: Evidence-based cardiovascular medicine 20041201
Title: Is vasopressin-receptor antagonism an advancement in the treatment of heart failure?
Journal: Expert opinion on pharmacotherapy 20041001
Title: Tolvaptan (Otsuka).
Journal: Current opinion in investigational drugs (London, England : 2000) 20040901
Title: A new class of heart failure drugs? Tolvaptan could be a welcome helper for 'water pills' and their potentially serious side effects.
Journal: Health news (Waltham, Mass.) 20040901
Title: New heart failure drug shows promise.
Journal: Health news (Waltham, Mass.) 20040601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040601
Title: Rofecoxib use increases acute myocardial infarction risk.
Journal: Circulation 20040504
Title: Effects of tolvaptan, a vasopressin antagonist, in patients hospitalized with worsening heart failure: a randomized controlled trial.
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Title: Vasopressin receptor antagonists: will the 'vaptans' fulfill their promise?
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Title: American Heart Association scientific sessions.
Journal: Expert opinion on investigational drugs 20040401
Title: New drug fights fluid build-up. Medication may relieve a common heart failure symptom.
Journal: Heart advisor 20040401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040101
Title: Vasopressin receptor antagonists in heart failure.
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Title: [Heart failure. Can vasopressin antagonists improve the prognosis?].
Journal: MMW Fortschritte der Medizin 20031127
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030901
Title: Vasopressin: a new target for the treatment of heart failure.
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Title: Vasopressin V2-receptor blockade with tolvaptan in patients with chronic heart failure: results from a double-blind, randomized trial.
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Title: Rationale and study design for a multicenter, randomized, double-blind, placebo-controlled study of the effects of tolvaptan on the acute and chronic outcomes of patients hospitalized with worsening congestive heart failure.
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Title: Gateways to Clinical Trials. June 2002.
Journal: Methods and findings in experimental and clinical pharmacology 20020601
Title: Effects of the V(2)-receptor antagonist OPC-41061 and the loop diuretic furosemide alone and in combination in rats.
Journal: The Journal of pharmacology and experimental therapeutics 20000101
