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151720-43-3,MFCD00949087
Catalog No.:AA007E2G

151720-43-3 | Oxamflatin

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1mg
≥95%
in stock  
$110.00   $77.00
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5mg
≥95%
in stock  
$486.00   $340.00
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10mg
≥95%
in stock  
$860.00   $602.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007E2G
Chemical Name:
Oxamflatin
CAS Number:
151720-43-3
Molecular Formula:
C17H14N2O4S
Molecular Weight:
342.3691
MDL Number:
MFCD00949087
SMILES:
ONC(=O)/C=C/C#Cc1cccc(c1)NS(=O)(=O)c1ccccc1
NSC Number:
729360
Properties
Computed Properties
 
Complexity:
618  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
2.1  

Literature

Title: Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells.

Journal: Molecular biology reports 20111101

Title: Histone deacetylase inhibition improves activation of ribosomal RNA genes and embryonic nucleolar reprogramming in cloned mouse embryos.

Journal: Biology of reproduction 20111101

Title: Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells.

Journal: The Journal of biological chemistry 20110624

Title: Oxamflatin significantly improves nuclear reprogramming, blastocyst quality, and in vitro development of bovine SCNT embryos.

Journal: PloS one 20110101

Title: Inhibition of class IIb histone deacetylase significantly improves cloning efficiency in mice.

Journal: Biology of reproduction 20101201

Title: A sensitive and specific liquid chromatography-tandem mass spectrometric method for determination of belinostat in plasma from liver cancer patients.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100915

Title: Characterisation of the novel apoptotic and therapeutic activities of the histone deacetylase inhibitor romidepsin.

Journal: Molecular cancer therapeutics 20080501

Title: Histone deacetylase inhibitor enhances 5-fluorouracil cytotoxicity by down-regulating thymidylate synthase in human cancer cells.

Journal: Molecular cancer therapeutics 20061201

Title: Conformational analogues of Oxamflatin as histone deacetylase inhibitors.

Journal: Organic & biomolecular chemistry 20061021

Title: Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.

Journal: Cell death and differentiation 20040901

Title: Novel mechanisms of apoptosis induced by histone deacetylase inhibitors.

Journal: Cancer research 20030801

Title: Kim YB, et al. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 1999 Apr 15;18(15):2461-70.

Title: Wang YL, et al. HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. Curr Mol Med. 2016;16(3):232-42.

Title: Faghihloo E, et al. The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. Cancer Gene Ther. 2016 Nov;23(11):396-399.

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