Title: Metformin and epothilone A treatment up regulate pro-apoptotic PARP-1, Casp-3 and H2AX genes and decrease of AKT kinase level to control cell death of human hepatocellular carcinoma and ovary adenocarcinoma cells.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20180301
Title: Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B.
Journal: Toxicology in vitro : an international journal published in association with BIBRA 20130201
Title: Overexpression of mitotic centromere-associated Kinesin stimulates microtubule detachment and confers resistance to paclitaxel.
Journal: Molecular cancer therapeutics 20110601
Title: Extended and clustered conformers of epothilone A.
Journal: The journal of physical chemistry. B 20110407
Title: Synthesis and SAR of C12-C13-oxazoline derivatives of epothilone A.
Journal: Bioorganic & medicinal chemistry letters 20090715
Title: Differential responses of mitotic spindle pole formation to microtubule-stabilizing agents epothilones A and B at low concentrations.
Journal: Cell cycle (Georgetown, Tex.) 20080215
Title: Cyclostreptin binds covalently to microtubule pores and lumenal taxoid binding sites.
Journal: Nature chemical biology 20070201
Title: Prostaglandins from a zoanthid: paclitaxel-like neurite-degenerating and microtubule-stabilizating activities.
Journal: Bioscience, biotechnology, and biochemistry 20060301
Title: Total synthesis and biological assessment of benzimidazole-based analogues of epothilone A: ambivalent effects on cancer cell growth inhibition.
Journal: Chembiochem : a European journal of chemical biology 20060101
Title: beta-Amyloid and endoplasmic reticulum stress responses in primary neurons: effects of drugs that interact with the cytoskeleton.
Journal: Journal of molecular neuroscience : MN 20060101
Title: Studies towards the synthesis of epothilone A via organoboranes.
Journal: Organic & biomolecular chemistry 20051021
Title: Much anticipated--the bioactive conformation of epothilone and its binding to tubulin.
Journal: Angewandte Chemie (International ed. in English) 20050218
Title: EpoK, a cytochrome P450 involved in biosynthesis of the anticancer agents epothilones A and B. Substrate-mediated rescue of a P450 enzyme.
Journal: Biochemistry 20041123
Title: The binding mode of epothilone A on alpha,beta-tubulin by electron crystallography.
Journal: Science (New York, N.Y.) 20040806
Title: What makes epothilones stick?
Journal: Chemistry & biology 20040201
Title: Polyketide-nonribosomal peptide epothilone antitumor agents: the EpoA, B, C subunits.
Journal: Journal of industrial microbiology & biotechnology 20030801
Title: Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.
Journal: Cancer research 20030101
Title: Total synthesis of epothilone a through stereospecific epoxidation of the p-methoxybenzyl ether of epothilone C.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20020816
Title: Studies on the biosynthesis of epothilones: hydroxylation of Epo A and B to epothilones E and F.
Journal: The Journal of antibiotics 20020101
Title: Gene expression profiling of epothilone A-resistant cells.
Journal: Novartis Foundation symposium 20020101
Title: Anticancer therapy with novel tubulin-interacting drugs.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy 20011201
Title: Stereoselective syntheses of epothilones A and B via nitrile oxide cycloadditions and related studies.
Journal: The Journal of organic chemistry 20010921
Title: The epothilones, eleutherobins, and related types of molecules.
Journal: Current pharmaceutical design 20010901
Title: Epothilone biosynthesis: assembly of the methylthiazolylcarboxy starter unit on the EpoB subunit.
Journal: Chemistry & biology 20010901
Title: New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies.
Journal: Journal of natural products 20010701
Title: Stereoselective syntheses of epothilones A and B via directed nitrile oxide cycloaddition.
Journal: Journal of the American Chemical Society 20010418
Title: Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F.
Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20010417
Title: Studies on the biosynthesis of epothilones: the PKS and Epothilone C/D monooxygenase.
Journal: The Journal of antibiotics 20010201
Title: Solid phase synthesis of complex natural products and libraries thereof.
Journal: Biopolymers 20010101
Title: Kowalski RJ, et al. Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R)). J Biol Chem. 1997 Jan 24;272(4):2534-41.
Title: Cheng KL, et al. Novel microtubule-targeting agents - the epothilones. Biologics. 2008 Dec;2(4):789-811.
