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Title: Evaluation of intravenous midazolam limited sampling models to determine area under the concentration time curve during cytochrome P450 3A baseline, inhibition and induction or activation.
Journal: International journal of clinical pharmacology and therapeutics 20120701
Title: Alkaloids from the root of Isatis indigotica.
Journal: Journal of natural products 20120622
Title: In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection.
Journal: Archives of virology 20120401
Title: Daphne Genkwa sieb. Et zucc. Water-soluble extracts act on enterovirus 71 by inhibiting viral entry.
Journal: Viruses 20120401
Title: Combating enterovirus replication: state-of-the-art on antiviral research.
Journal: Biochemical pharmacology 20120115
Title: Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility.
Journal: Antiviral therapy 20120101
Title: Oncolytic virotherapy for hematological malignancies.
Journal: Advances in virology 20120101
Title: In-Silico screening of Pleconaril and its novel substituted derivatives with Neuraminidase of H1N1 Influenza strain.
Journal: BMC research notes 20120101
Title: Inhibition of enterovirus 71 (EV-71) infections by a novel antiviral peptide derived from EV-71 capsid protein VP1.
Journal: PloS one 20120101
Title: Pharmacological and biological antiviral therapeutics for cardiac coxsackievirus infections.
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Title: Towards the design of combination therapy for the treatment of enterovirus infections.
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Title: Neonatal myocardial infarction or myocarditis?
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Title: Pharmacophore-based design, synthesis, and biological evaluation of novel chloro-pyridazine piperazines as human rhinovirus (HRV-3) inhibitors.
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Title: Complete coding sequence characterization and comparative analysis of the putative novel human rhinovirus (HRV) species C and B.
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Title: Curing the common cold.
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Title: Genetic diversity of a Korean echovirus 5 isolate and response of the strain to five antiviral drugs.
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Title: Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia.
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Title: Antiviral activity of 3(2H)- and 6-chloro-3(2H)-isoflavenes against highly diverged, neurovirulent vaccine-derived, type2 poliovirus sewage isolates.
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Title: Cytolytic replication of echoviruses in colon cancer cell lines.
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Title: Oncolytic virotherapy for multiple myeloma: past, present, and future.
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Title: Assessment of oral midazolam limited sampling strategies to predict area under the concentration time curve (AUC) during cytochrome P450 (CYP) 3A baseline, inhibition and induction or activation.
Journal: International journal of clinical pharmacology and therapeutics 20101201
Title: The need for treatment against human parechoviruses: how, why and when?
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Title: Clinical features, diagnosis, and management of enterovirus 71.
Journal: The Lancet. Neurology 20101101
Title: Viral meningoencephalitis: a review of diagnostic methods and guidelines for management.
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Title: Enterovirus genotype EV-104 in humans, Italy, 2008-2009.
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Title: An RNA replication-center assay for high content image-based quantifications of human rhinovirus and coxsackievirus infections.
Journal: Virology journal 20100101
Title: Human rhinovirus C: a newly discovered human rhinovirus species.
Journal: Emerging health threats journal 20100101
Title: Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats.
Journal: Microbiology and immunology 20091001
Title: Role of rhinovirus C in apparently life-threatening events in infants, Spain.
Journal: Emerging infectious diseases 20090901
Title: New perspectives of infections in cardiovascular disease.
Journal: Current cardiology reviews 20090501
Title: New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.
Journal: Antiviral research 20090101
Title: Frequency and clinical relevance of human bocavirus infection in acute exacerbations of chronic obstructive pulmonary disease.
Journal: International journal of chronic obstructive pulmonary disease 20090101
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Journal: BMC infectious diseases 20090101
Title: Selective inhibitors of picornavirus replication.
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Title: Novel human rhinoviruses and exacerbation of asthma in children.
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Title: Potential use of antiviral agents in polio eradication.
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Title: Treatment of viral myocarditis caused by coxsackievirus B.
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Title: Enterovirus-associated hemophagocytic syndrome in children with malignancy: report of three cases and review of the literature.
Journal: European journal of pediatrics 20080101
Title: Distinguishing molecular features and clinical characteristics of a putative new rhinovirus species, human rhinovirus C (HRV C).
Journal: PloS one 20080101
Title: Iota-Carrageenan is a potent inhibitor of rhinovirus infection.
Journal: Virology journal 20080101
Title: A case report of a premature infant with coxsackie B1 meningitis.
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Title: Quantitative structure-activity relationship studies of [(biphenyloxy)propyl]isoxazole derivatives. Inhibitors of human rhinovirus 2 replication.
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Title: WITHDRAWN: Antivirals for the common cold.
Journal: The Cochrane database of systematic reviews 20070718
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Journal: Emerging infectious diseases 20070701
Title: Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis.
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Title: Gateways to clinical trials.
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Title: Duration of pleconaril effect on cytochrome P450 3A activity in healthy adults using the oral biomarker midazolam.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20060501
Title: Investigation of treatment failure in neonatal echovirus 7 infection.
Journal: The Pediatric infectious disease journal 20060301
Title: The effect of oral pleconaril on hepatic cytochrome P450 3A activity in healthy adults using intravenous midazolam as a probe.
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Journal: Current pharmaceutical design 20060101
Title: An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study.
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Title: Insights into the genetic basis for natural phenotypic resistance of human rhinoviruses to pleconaril.
Journal: Antiviral research 20051201
Title: Pharmacophore modeling, docking, and principal component analysis based clustering: combined computer-assisted approaches to identify new inhibitors of the human rhinovirus coat protein.
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Title: Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment.
Journal: The Journal of antimicrobial chemotherapy 20051001
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Title: 2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder.
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Title: Pleconaril--an advance in the treatment of enteroviral infection in immuno-compromised patients.
Journal: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology 20050101
Title: Using benefit harm tradeoffs to estimate sufficiently important difference: the case of the common cold.
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Title: Failure to clear persistent vaccine-derived neurovirulent poliovirus infection in an immunodeficient man.
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Title: Neonatal coxsackie B virus infection-a treatable disease?
Journal: European journal of pediatrics 20040401
Title: Presentation, diagnosis, and management of enterovirus infections in neonates.
Journal: Paediatric drugs 20040101
Title: Safety and efficacy evaluation of pleconaril for treatment of the common cold.
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Title: Pleconaril for infantile enterovirus meningitis.
Journal: Current neurology and neuroscience reports 20031101
Title: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.
Journal: Journal of medicinal chemistry 20031009
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031001
Title: Human rhinovirus capsid dynamics is controlled by canyon flexibility.
Journal: Virology 20030915
Title: An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus.
Journal: Journal of medicinal chemistry 20030717
Title: Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors.
Journal: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20030701
Title: Antiviral activity of betulin, betulinic and betulonic acids against some enveloped and non-enveloped viruses.
Journal: Fitoterapia 20030701
Title: Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20030615
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030601
Title: Survival after pulmonary edema due to enterovirus 71 encephalitis.
Journal: Neurology 20030527
Title: Nucleotide variation in Sabin type 2 poliovirus from an immunodeficient patient with poliomyelitis.
Journal: The Journal of general virology 20030501
Title: Diagnosis and treatment of rhinovirus respiratory infections.
Journal: Chest 20030501
Title: Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis.
Journal: The Pediatric infectious disease journal 20030401
Title: Pleconaril, a novel antipicornaviral agent.
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Title: SPECT scans for monitoring response to pleconaril therapy in chronic enteroviral meningoencephalitis.
Journal: The Journal of infection 20030201
Title: Enteroviral infections in primary immunodeficiency (PID): a survey of morbidity and mortality.
Journal: The Journal of infection 20030101
Title: A fatal case of coxsackievirus B4 meningoencephalitis.
Journal: Archives of neurology 20030101
Title: Viral respiratory infections due to rhinoviruses: current knowledge, new developments.
Journal: American journal of therapeutics 20030101
Title: [Polio-like myelitis due to Coxsackie-Virus B 3: Course under treatment with pleconaril].
Journal: Klinische Padiatrie 20030101
Title: Severe Coxsackie virus B infection in preterm newborns treated with pleconaril.
Journal: European journal of pediatrics 20020901
Title: Management of viral infections in immunocompromised cancer patients.
Journal: Swiss medical weekly 20020713
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Title: FDA panel rejects common cold treatment.
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Title: Gateways to clinical trials.
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Title: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.
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Title: Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors.
Journal: Journal of medicinal chemistry 20020411
Title: Challenges and options in the management of viral infections after stem cell transplantation.
Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20020401
Title: Gateways to Clinical Trials.
Journal: Methods and findings in experimental and clinical pharmacology 20020401
Title: Highlights in the development of new antiviral agents.
Journal: Mini reviews in medicinal chemistry 20020401
Title: Oral pleconaril treatment of picornavirus-associated viral respiratory illness in adults: efficacy and tolerability in phase II clinical trials.
Journal: Antiviral therapy 20020301
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Journal: Lancet (London, England) 20020209
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Journal: Seminars in pediatric infectious diseases 20020101
Title: Recent advances in the treatment of rhinovirus infections.
Journal: Current opinion in pharmacology 20011001
Title: Acute flaccid paralysis syndrome associated with echovirus 19, managed with pleconaril and intravenous immunoglobulin.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010901
Title: Antiviral agents for influenza, hepatitis C and herpesvirus, enterovirus and rhinovirus infections.
Journal: The Medical journal of Australia 20010716
Title: Severe neonatal enteroviral hepatitis treated with pleconaril.
Journal: The Pediatric infectious disease journal 20010401
Title: Treatment of ALS with pleconaril.
Journal: Neurology 20010313
Title: Enterovirus infections: diagnosis and treatment.
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Title: What's new with enteroviral infections?
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Title: Treatment of potentially life-threatening enterovirus infections with pleconaril.
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Title: Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency.
Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010101
Title: The treatment of rhinovirus infections: progress and potential.
Journal: Antiviral research 20010101
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Journal: The Cochrane database of systematic reviews 20010101
Title: In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses.
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Title: In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.
Journal: Antimicrobial agents and chemotherapy 19991001
Title: Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
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