Home Deuterated Building Blocks 154235-83-3
154235-83-3,MFCD00943201
Catalog No.:AA007G8K

154235-83-3 | Piperidin-1-yl(quinoxalin-6-yl)methanone

Pack Size
Purity
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Price(USD)
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1mg
97%
in stock  
$6.00   $4.00
- +
5mg
97%
in stock  
$14.00   $10.00
- +
10mg
97%
in stock  
$21.00   $15.00
- +
50mg
97%
in stock  
$57.00   $40.00
- +
100mg
97%
in stock  
$96.00   $68.00
- +
250mg
98%
in stock  
$162.00   $113.00
- +
1g
98%
in stock  
$386.00   $270.00
- +
5g
98%
in stock  
$1,258.00   $881.00
- +
10g
98%
in stock  
$2,007.00   $1,405.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007G8K
Chemical Name:
Piperidin-1-yl(quinoxalin-6-yl)methanone
CAS Number:
154235-83-3
Molecular Formula:
C14H15N3O
Molecular Weight:
241.2884
MDL Number:
MFCD00943201
SMILES:
O=C(c1ccc2c(c1)nccn2)N1CCCCC1
Properties
Computed Properties
 
Complexity:
301  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
3  
Rotatable Bond Count:
1  
XLogP3:
1.8  

Downstream Synthesis Route

[1]Hu,Bin;Toda,Kosuke;Wang,Xiaoyu;Antczak,MonikaI.;Smith,Julianne;Geboers,Sophie;Nishikawa,Gen;Li,Hongyun;Dawson,Dawn;Fink,Stephen;Desai,AmarB.;Williams,NoelleS.;Markowitz,SanfordD.;Ready,JosephM.[JournalofMedicinalChemistry,2022,vol.65,#22,p.15327-15343]

CASUnavailable 
  154235-83-3 

[1]Hu,Bin;Toda,Kosuke;Wang,Xiaoyu;Antczak,MonikaI.;Smith,Julianne;Geboers,Sophie;Nishikawa,Gen;Li,Hongyun;Dawson,Dawn;Fink,Stephen;Desai,AmarB.;Williams,NoelleS.;Markowitz,SanfordD.;Ready,JosephM.[JournalofMedicinalChemistry,2022,vol.65,#22,p.15327-15343]

[1]Hu,Bin;Toda,Kosuke;Wang,Xiaoyu;Antczak,MonikaI.;Smith,Julianne;Geboers,Sophie;Nishikawa,Gen;Li,Hongyun;Dawson,Dawn;Fink,Stephen;Desai,AmarB.;Williams,NoelleS.;Markowitz,SanfordD.;Ready,JosephM.[JournalofMedicinalChemistry,2022,vol.65,#22,p.15327-15343]

[1]Hu,Bin;Toda,Kosuke;Wang,Xiaoyu;Antczak,MonikaI.;Smith,Julianne;Geboers,Sophie;Nishikawa,Gen;Li,Hongyun;Dawson,Dawn;Fink,Stephen;Desai,AmarB.;Williams,NoelleS.;Markowitz,SanfordD.;Ready,JosephM.[JournalofMedicinalChemistry,2022,vol.65,#22,p.15327-15343]

[1]Hu,Bin;Toda,Kosuke;Wang,Xiaoyu;Antczak,MonikaI.;Smith,Julianne;Geboers,Sophie;Nishikawa,Gen;Li,Hongyun;Dawson,Dawn;Fink,Stephen;Desai,AmarB.;Williams,NoelleS.;Markowitz,SanfordD.;Ready,JosephM.[JournalofMedicinalChemistry,2022,vol.65,#22,p.15327-15343]

Literature

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Journal: Current neuropharmacology 20101201

Title: Positive allosteric modulators of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor.

Journal: Journal of medicinal chemistry 20101028

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Journal: Behavioural brain research 20100211

Title: Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting.

Journal: Psychopharmacology 20091101

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Title: Effect of CX516, an AMPA-modulating compound, on cognition and behavior in fragile X syndrome: a controlled trial.

Journal: Journal of child and adolescent psychopharmacology 20061001

Title: Positive modulation of glutamatergic receptors potentiates the suppressive effects of antipsychotics on conditioned avoidance responding in rats.

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Journal: Journal of neurochemistry 20041001

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Journal: Neuroscience 20040101

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Journal: Chemistry & biology 20031101

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Title: Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.

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Journal: Toxicology and applied pharmacology 20021201

Title: Preliminary experience with an ampakine (CX516) as a single agent for the treatment of schizophrenia: a case series.

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Journal: European journal of pharmacology 20020405

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Journal: Experimental neurology 20020301

Title: Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report.

Journal: Journal of molecular neuroscience : MN 20020101

Title: Mechanism and impact of allosteric AMPA receptor modulation by the ampakine CX546.

Journal: Neuropharmacology 20011101

Title: A placebo-controlled pilot study of the ampakine CX516 added to clozapine in schizophrenia.

Journal: Journal of clinical psychopharmacology 20011001

Title: Therapeutic approaches to age-associated neurocognitive disorders.

Journal: Dialogues in clinical neuroscience 20010901

Title: Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator.

Journal: The Journal of pharmacology and experimental therapeutics 20010701

Title: Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro.

Journal: Neuropharmacology 20010601

Title: Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo.

Journal: Neuropharmacology 20010601

Title: AMPA receptor blockade improves levodopa-induced dyskinesia in MPTP monkeys.

Journal: Neurology 20000425

Title: Synergistic interactions between ampakines and antipsychotic drugs.

Journal: The Journal of pharmacology and experimental therapeutics 19990401

Title: Effects of AMPA receptor positive modulators on amphetamine- and dizocilpine-induced locomotion.

Journal: European journal of pharmacology 19970806

Title: Broberg BV, Glenth?j BY, Dias R, et al. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl). 2009 Nov;206(4):631-40.

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Tags:154235-83-3 Molecular Formula|154235-83-3 MDL|154235-83-3 SMILES|154235-83-3 Piperidin-1-yl(quinoxalin-6-yl)methanone