Title: The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.
Journal: ACS chemical biology 20140221
Title: Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27.
Journal: Cell death & disease 20131001
Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Journal: The Biochemical journal 20130415
Title: Reactive oxygen species (ROS) and sensitization to TRAIL-induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511.
Journal: Biochemical pharmacology 20121115
Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Journal: Nature biotechnology 20111101
Title: Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.
Journal: Cancer research 20101201
Title: Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.
Journal: Toxicology and applied pharmacology 20091201
Title: Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate.
Journal: American journal of physiology. Cell physiology 20091001
Title: Intracellular signal transduction pathways in the regulation of fowl sperm motility: evidence for the involvement of phosphatidylinositol 3-kinase (PI3-K) cascade.
Journal: Molecular reproduction and development 20090701
Title: LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway.
Journal: Biochemical and biophysical research communications 20081205
Title: LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism.
Journal: Toxicology and applied pharmacology 20081001
Title: Detailed molecular analysis of the induction of the L-PK gene by glucose.
Journal: Biochemical and biophysical research communications 20080718
Title: LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization.
Journal: Cell death and differentiation 20071001
Title: PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.
Journal: The European journal of neuroscience 20070801
Title: Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.
Journal: Biochemical and biophysical research communications 20070504
Title: Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20070215
Title: GM3 signals regulating TNF-alpha expression are mediated by Rictor and Arhgdib in mouse melanoma B16 cells.
Journal: Oncology 20070101
Title: Enhancement of cytokine-mediated NF-kappaB activation by phosphatidylinositol 3-kinase inhibitors in monocytic cells.
Journal: International immunopharmacology 20060601
Title: LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms.
Journal: The Journal of pharmacology and experimental therapeutics 20050901
Title: LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway.
Journal: Cancer research 20050715
Title: LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism.
Journal: FEBS letters 20040213
Title: Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes.
Journal: American journal of physiology. Heart and circulatory physiology 20040201
Title: The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401
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Title: Kristof AS, et al. LY303511 (2-piperazinyl-8-phenyl-4H-1-benzopyran-4-one) acts via phosphatidylinositol 3-kinase-independent pathways to inhibit cell proliferation via mammalian target of rapamycin (mTOR)- and non-mTOR-dependent mechanisms. J Pharmacol Exp Ther. 2005 Sep;314(3):1134-43.
