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156161-89-6,MFCD00797882
Catalog No.:AA001OHP

156161-89-6 | BQ-788 Sodium

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1mg
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$322.00   $225.00
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5mg
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$642.00   $449.00
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10mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA001OHP
Chemical Name:
BQ-788 Sodium
CAS Number:
156161-89-6
Molecular Formula:
C34H50N5NaO7
Molecular Weight:
663.7799
MDL Number:
MFCD00797882
SMILES:
CCCC[C@H](C(=O)[O-])NC(=O)[C@@H](Cc1cn(c2c1cccc2)C(=O)OC)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@H](C)CCC[C@@H]1C.[Na+]
Properties
Properties
 
Form:
Solid  
MP:
>144°C (dec.)  
Storage:
-20 ℃;Inert atmosphere;  

Computed Properties
 
Complexity:
1080  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
47  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
14  

Literature

Title: Activation of the endothelin system mediates pathological angiogenesis during ischemic retinopathy.

Journal: The American journal of pathology 20141101

Title: Endothelins reciprocally regulate VEGF-A and angiopoietin-1 production in cultured rat astrocytes: implications on astrocytic proliferation.

Journal: Glia 20121201

Title: Endothelin-1 increases superoxide production in human coronary artery bypass grafts.

Journal: Life sciences 20121015

Title: The influence of ETA and ETB receptor blockers on LPS-induced oxidative stress and NF-κB signaling pathway in heart.

Journal: General physiology and biophysics 20120901

Title: Blocking endothelin-B receptors rescues retinal ganglion cells from optic nerve injury through suppression of neuroinflammation.

Journal: Investigative ophthalmology & visual science 20120608

Title: EndothelinA-endothelinB receptor cross-talk in rat basilar artery in situ.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20120401

Title: BMP-9 induced endothelial cell tubule formation and inhibition of migration involves Smad1 driven endothelin-1 production.

Journal: PloS one 20120101

Title: Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase.

Journal: Journal of vascular research 20120101

Title: Pharmacological differences of endothelin receptors-mediated modulation in cultured interstitial cells of Cajal from the murine small and large intestine.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101

Title: Age-associated alterations in retinal arteriole reactivity to endothelin-1 differ between the sexes.

Journal: Mechanisms of ageing and development 20120101

Title: ETA and ETB receptors are expressed in vascular adventitial fibroblasts.

Journal: American journal of physiology. Heart and circulatory physiology 20111201

Title: Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats.

Journal: Brain research 20111028

Title: Tobacco-associated pulmonary vascular dysfunction in smokers: role of the ET-1 pathway.

Journal: American journal of physiology. Lung cellular and molecular physiology 20110601

Title: Endothelin receptor A-specific stimulation of glomerular inflammation and injury in a streptozotocin-induced rat model of diabetes.

Journal: Diabetologia 20110401

Title: 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1.

Journal: American journal of physiology. Heart and circulatory physiology 20110401

Title: Effect of avosentan (SPP-301) in porcine ciliary arteries.

Journal: Current eye research 20110201

Title: Endothelin modulates the cardiovascular effects of clonidine in the rat.

Journal: Pharmacological research 20101201

Title: Acid regulation of NaDC-1 requires a functional endothelin B receptor.

Journal: Kidney international 20101101

Title: Molecular signaling of pruritus induced by endothelin-1 in mice.

Journal: Experimental biology and medicine (Maywood, N.J.) 20101101

Title: Endothelin-1 and -3 modulate the neuronal norepinephrine transporter through multiple signalling pathways in the rat posterior hypothalamus.

Journal: Neurochemistry international 20101001

Title: Effects of cardiopulmonary bypass on endothelin-1-induced contraction and signaling in human skeletal muscle microcirculation.

Journal: Circulation 20100914

Title: Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats.

Journal: Canadian journal of physiology and pharmacology 20100601

Title: Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice.

Journal: Pain 20100501

Title: Regulation of glucose uptake by endothelin-1 in human skeletal muscle in vivo and in vitro.

Journal: The Journal of clinical endocrinology and metabolism 20100501

Title: Sex differences in endothelin-1-mediated vasoconstrictor tone in middle-aged and older adults.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20100201

Title: Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.

Journal: Peptides 20100201

Title: Production and binding of endothelin-2 (EDN2) in the rat ovary: endothelin receptor subtype A (EDNRA)-mediated contraction.

Journal: Reproduction, fertility, and development 20100101

Title: Intracerebroventricular administration of an endothelin ET(B)-receptor agonist increases expression of matrix metalloproteinase-2 and -9 in rat brain.

Journal: Journal of pharmacological sciences 20100101

Title: Ablation of transient receptor potential vanilloid 1 abolishes endothelin-induced increases in afferent renal nerve activity: mechanisms and functional significance.

Journal: Hypertension (Dallas, Tex. : 1979) 20091201

Title: Impairment of coronary endothelial cell ET(B) receptor function after short-term inhalation exposure to whole diesel emissions.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090901

Title: Dietary sodium modulates the interaction between efferent renal sympathetic nerve activity and afferent renal nerve activity: role of endothelin.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090801

Title: Two distinct types of mouse melanocyte: differential signaling requirement for the maintenance of non-cutaneous and dermal versus epidermal melanocytes.

Journal: Development (Cambridge, England) 20090801

Title: Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.

Journal: Neuroscience letters 20090703

Title: Endothelin ET(B) receptors in arteries and veins: multiple actions in the vein.

Journal: The Journal of pharmacology and experimental therapeutics 20090601

Title: Involvement of NO and MEK/ERK pathway in enhancement of endothelin-1-induced mesenteric artery contraction in later-stage type 2 diabetic Goto-Kakizaki rat.

Journal: American journal of physiology. Heart and circulatory physiology 20090501

Title: Fibrinogen-induced endothelin-1 production from endothelial cells.

Journal: American journal of physiology. Cell physiology 20090401

Title: ETB2 receptor subtype stimulation relaxes the iris sphincter muscle.

Journal: Physiological research 20090101

Title: The effect of endothelin-1 on alveolar fluid clearance and pulmonary edema formation in the rat.

Journal: Anesthesia and analgesia 20090101

Title: Normothermic perfusion of ischaemic porcine kidneys: an evaluation of ex vivo function and endothelin receptor antagonism.

Journal: Journal of nephrology 20090101

Title: Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity.

Journal: Cellular signalling 20081201

Title: Regulation of glial inflammatory mediators synthesis: possible role of endothelins.

Journal: Peptides 20081201

Title: Role of nitric oxide in regulation of retinal blood flow in response to hyperoxia in cats.

Journal: Investigative ophthalmology & visual science 20081001

Title: Endothelins modulate inflammatory reaction in zymosan-induced arthritis: participation of LTB4, TNF-alpha, and CXCL-1.

Journal: Journal of leukocyte biology 20080901

Title: Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes.

Journal: American journal of physiology. Heart and circulatory physiology 20080901

Title: The role of endothelin pathway in modulation of airway reactivity to methacholine in C57Bl/6 and BALB/c mice.

Journal: European journal of pharmacology 20080820

Title: Antagonism of endothelin-1 inhibits hypoxia-induced apoptosis in cardiomyocytes.

Journal: Canadian journal of physiology and pharmacology 20080801

Title: Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.

Journal: American journal of physiology. Heart and circulatory physiology 20080701

Title: Chronic ethanol intake modulates vascular levels of endothelin-1 receptor and enhances the pressor response to endothelin-1 in anaesthetized rats.

Journal: British journal of pharmacology 20080701

Title: Endothelin receptor blockers protect against ischemia/reperfusion impairment of gastrointestinal motility in rats.

Journal: Pharmacological research 20080601

Title: Role of endothelin receptors on basal and endothelin-1-stimulated lung myofibroblast proliferation.

Journal: Canadian journal of physiology and pharmacology 20080601

Title: Contractile changes of the clitoral cavernous smooth muscle in female rabbits with experimentally induced overactive bladder.

Journal: The journal of sexual medicine 20080501

Title: Effects of endothelin receptor type-A and type-B antagonists on prostaglandin F2alpha-induced luteolysis of the sheep corpus luteum.

Journal: Biology of reproduction 20080401

Title: Endothelin-1 mediates hypoxia-induced inhibition of voltage-gated K+ channel expression in pulmonary arterial myocytes.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080201

Title: Intracellular mechanisms and receptor types for endothelin-1-induced positive and negative inotropy in mouse ventricular myocardium.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20080201

Title: The endothelin-1 pathway and the development of cardiovascular defects in the haemodynamically challenged chicken embryo.

Journal: Journal of vascular research 20080101

Title: Endothelin-1 potentiation of coronary artery contraction after ischemia-reperfusion.

Journal: Vascular pharmacology 20080101

Title: Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes.

Journal: American journal of physiology. Heart and circulatory physiology 20071001

Title: NADPH oxidase mediates angiotensin II-induced endothelin-1 expression in vascular adventitial fibroblasts.

Journal: Cardiovascular research 20070901

Title: Short-term regulation of tyrosine hydroxylase activity and expression by endothelin-1 and endothelin-3 in the rat posterior hypothalamus.

Journal: Regulatory peptides 20070816

Title: Endothelin-1 and pancreatic islet vasculature: studies in vivo and on isolated, vascularly perfused pancreatic islets.

Journal: American journal of physiology. Endocrinology and metabolism 20070601

Title: Multiple signaling pathways involved in the effect of endothelin type B receptor in rat median eminence.

Journal: Acta biologica Hungarica 20070601

Title: Endothelin-B receptors on suprachoroidal melanocytes mediate an endothelin-1-induced increase in the intracellular calcium concentration of rabbit ocular suprachoroidal tissue.

Journal: Current eye research 20070601

Title: Endothelin-1 activates ETA receptors to cause reflex scratching in BALB/c mice.

Journal: British journal of pharmacology 20070501

Title: Endogenous endothelin in human coronary vascular function: differential contribution of endothelin receptor types A and B.

Journal: Hypertension (Dallas, Tex. : 1979) 20070501

Title: Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice.

Journal: Prostaglandins, leukotrienes, and essential fatty acids 20070501

Title: Dual endothelin receptor blockade acutely improves insulin sensitivity in obese patients with insulin resistance and coronary artery disease.

Journal: Diabetes care 20070301

Title: Intraindividual comparison of human radial and internal thoracic arteries in vitro and the effect of preoperative calcium blocker therapy.

Journal: Fundamental & clinical pharmacology 20070201

Title: Endothelin-A and -B receptors, superoxide, and Ca2+ signaling in afferent arterioles.

Journal: American journal of physiology. Renal physiology 20070101

Title: Endothelin-1-mediated wave-like [Ca2+]i oscillations in intact rabbit inferior vena cava.

Journal: Journal of vascular research 20070101

Title: Pathophysiological role of endothelin in ectopic ossification of human spinal ligaments induced by mechanical stress.

Journal: Calcified tissue international 20061201

Title: Paradoxical coronary microcirculatory constriction during ischemia: a synergic function for nitric oxide and endothelin.

Journal: American journal of physiology. Heart and circulatory physiology 20061001

Title: Endothelin and nitric oxide mediate adaptation of the cortical collecting duct to metabolic acidosis.

Journal: American journal of physiology. Renal physiology 20061001

Title: Synergistic activation of salmon cardiac function by endothelin and beta-adrenergic stimulation.

Journal: American journal of physiology. Heart and circulatory physiology 20060901

Title: Activation of p38 MAPK is involved in endothelin-1-stimulated COX-2 expression in cultured Feline esophageal smooth muscle cells.

Journal: Molecules and cells 20060831

Title: Ethanol consumption enhances endothelin-1-induced contraction in the isolated rat carotid.

Journal: The Journal of pharmacology and experimental therapeutics 20060801

Title: Vagally mediated cholestatic and choleretic effects of centrally applied Endothelin-1 through ETA receptors.

Journal: Regulatory peptides 20060715

Title: Orofacial cold hyperalgesia due to infraorbital nerve constriction injury in rats: reversal by endothelin receptor antagonists but not non-steroidal anti-inflammatory drugs.

Journal: Pain 20060701

Title: Autocrine effects of endothelin on in vitro proliferation of vascular smooth muscle cells from spontaneously hypertensive and normotensive rats.

Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20060701

Title: Enzymatic pathways involved in the generation of endothelin-1(1-31) from exogenous big endothelin-1 in the rabbit aorta.

Journal: British journal of pharmacology 20060601

Title: Targeting the endothelin axis in human melanoma: combination of endothelin receptor antagonism and alkylating agents.

Journal: Experimental biology and medicine (Maywood, N.J.) 20060601

Title: Effects of antagonists for endothelin ET(A) and ET(B) receptors on coronary endothelial and myocardial function after ischemia-reperfusion in anesthetized goats.

Journal: Vascular pharmacology 20060501

Title: Endothelin B receptor antagonist increases preproendothelin-1 transcription in bovine aortic endothelial cells and in vivo.

Journal: Journal of cardiovascular pharmacology 20060501

Title: Effect of age on insulin-induced endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats.

Journal: Experimental gerontology 20060301

Title: Selective endothelin B receptor blockade does not influence BNP-induced natriuresis in man.

Journal: Kidney international 20060301

Title: Enhanced endothelium-dependent vasodilatation by dual endothelin receptor blockade in individuals with insulin resistance.

Journal: Journal of cardiovascular pharmacology 20060301

Title: Difference in the characteristics of ETA-receptor-stimulated response between rat small pulmonary and renal arteries.

Journal: Journal of cardiovascular pharmacology 20060301

Title: Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway.

Journal: Hypertension (Dallas, Tex. : 1979) 20060201

Title: Pharmacological properties of endothelin-1 in the rabbit corpus cavernosum.

Journal: In vivo (Athens, Greece) 20060101

Title: Endothelin-1 enhances glutamate-induced retinal cell death, possibly through ETA receptors.

Journal: Investigative ophthalmology & visual science 20051201

Title: Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201

Title: Pathways of glomerular toxicity of cyclosporine-A: an 'in vitro' study.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201

Title: Enhanced response of pig coronary arteries to endothelin-1 after ischemia-reperfusion. Role of endothelin receptors, nitric oxide and prostanoids.

Journal: European journal of pharmacology 20051107

Title: Endothelin-1-dependent leptin induction in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide.

Journal: Biochemical and biophysical research communications 20051104

Title: Functional characterization and expression of endothelin receptors in rat carotid artery: involvement of nitric oxide, a vasodilator prostanoid and the opening of K+ channels in ETB-induced relaxation.

Journal: British journal of pharmacology 20051101

Title: Glibenclamide reveals role for endothelin in hypoxia-induced vasoconstriction in rat intrapulmonary arteries.

Journal: Journal of cardiovascular pharmacology 20051001

Title: Endothelin-1 causes systemic vasodilatation in anaesthetised turtles (Trachemys scripta) through activation of ETB-receptors.

Journal: The Journal of experimental biology 20051001

Title: Involvement of nitric oxide pathways in short term modulation of tyrosine hydroxylase activity by endothelins 1 and 3 in the rat anterior hypothalamus.

Journal: Biochemical and biophysical research communications 20050902

Title: Development of an efficient strategy for the synthesis of the ETB receptor antagonist BQ-788 and some related analogues.

Journal: Peptides 20050801

Title: Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle.

Journal: European journal of pharmacology 20050711

Title: Endothelin-3 applied to the brain evokes opposite effects on bile secretion mediated by a central nitric oxide pathway.

Journal: Peptides 20050701

Title: Endothelin-1 induces lipolysis in 3T3-L1 adipocytes.

Journal: American journal of physiology. Endocrinology and metabolism 20050601

Title: Characterization of endothelin-converting enzyme activities in ARPE-19 cells, a human retinal pigmented epithelial cell line.

Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050601

Title: Vascular reactivity of mesenteric arteries and veins to endothelin-1 in a murine model of high blood pressure.

Journal: Vascular pharmacology 20050601

Title: NO and NO-independent mechanisms mediate ETB receptor buffering of ET-1-induced renal vasoconstriction in the rat.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050501

Title: Exaggerated coronary vasoreactivity to endothelin-1 in aged rats: role of protein kinase C.

Journal: Cardiovascular research 20050501

Title: Endothelin receptor blockade improves endothelial function in atherosclerotic patients on angiotensin converting enzyme inhibition.

Journal: Journal of internal medicine 20050301

Title: Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway.

Journal: Experimental eye research 20050301

Title: Receptor subtypes mediating the inotropic effects and Ca(2+) signaling induced by endothelin-1 through crosstalk with norepinephrine in canine ventricular myocardium.

Journal: Journal of pharmacological sciences 20050301

Title: Endothelin-1-induced proliferation of human endothelial cells depends on activation of K+ channels and Ca+ influx.

Journal: Acta physiologica Scandinavica 20050201

Title: Narrow-band ultraviolet-B stimulates proliferation and migration of cultured melanocytes.

Journal: Experimental dermatology 20041201

Title: Significance of the endothelin ETA receptor in the haemodynamic and inotropic effects of endothelin-1 in rats.

Journal: Clinical science (London, England : 1979) 20041101

Title: Mechanisms underlying enhanced contractile response to endothelin-1 in diabetic rat basilar artery.

Journal: Peptides 20041101

Title: The impact of respiratory syncytial virus infection on endothelin receptor function and release in sheep bronchial explants.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Inhibitory actions of endothelin-1 on pain processing.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Pharmacological characterization of YM598, a selective endothelin-A receptor antagonist.

Journal: Journal of cardiovascular pharmacology 20041101

Title: The effect of cerivastatin therapy on vascular responses to endothelin antagonists in humans.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Endothelin-1-induced vasodilatation in rat breast tumor is mediated through endothelin-B receptors.

Journal: Journal of cardiovascular pharmacology 20041101

Title: The endothelin/sarafotoxin-induced increase of the proliferation of undifferentiated and DMSO-differentiated GEM-81 goldfish erythrophoroma cells is mediated by ETB receptors.

Journal: Pigment cell research 20041001

Title: Endothelin-B-receptor-selective antagonist inhibits endothelin-1 induced potentiation on the vasoconstriction to noradrenaline and angiotensin II.

Journal: Journal of hypertension 20041001

Title: Endothelin A receptor antagonism and angiotensin-converting enzyme inhibition are synergistic via an endothelin B receptor-mediated and nitric oxide-dependent mechanism.

Journal: Journal of the American Society of Nephrology : JASN 20041001

Title: Association of endothelin with lung hemorrhage induced by immune complexes in rats.

Journal: Inflammation 20041001

Title: Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonist.

Journal: European journal of pharmacology 20040913

Title: Endothelin-3 induced mesenteric vasoconstriction and PMN infiltration in the rat small intestine: role of endothelin receptors.

Journal: Regulatory peptides 20040615

Title: Endothelins and their inhibition in the human skin microcirculation: ET[1-31], a new vasoconstrictor peptide.

Journal: British journal of clinical pharmacology 20040601

Title: Analysis of ET-A and ET-B receptors using an isolated perfused rat lung preparation.

Journal: Acta physiologica Scandinavica 20040601

Title: Increased O2*- production and upregulation of ETB receptors by sympathetic neurons in DOCA-salt hypertensive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20040501

Title: Modulatory effect of endothelin-1 and -3 on neuronal norepinephrine release in the rat posterior hypothalamus.

Journal: Regulatory peptides 20040415

Title: ET-1 induces cortical spreading depression via activation of the ETA receptor/phospholipase C pathway in vivo.

Journal: American journal of physiology. Heart and circulatory physiology 20040401

Title: Intraportal nicotine infusion in rats decreases hepatic blood flow through endothelin-1 and both endothelin A and endothelin B receptors.

Journal: Toxicology and applied pharmacology 20040401

Title: Effects of endothelin-1 on portal-systemic collaterals of common bile duct-ligated cirrhotic rats.

Journal: European journal of clinical investigation 20040401

Title: Implantation of tumoral XC cells induces chronic, endothelin-dependent, thermal hyperalgesia in mice.

Journal: Cellular and molecular neurobiology 20040401

Title: Endothelin causes contraction of human esophageal muscularis mucosae through interaction with both ETA and ETB receptors.

Journal: Regulatory peptides 20040315

Title: Alteration in endothelin receptor sub-type responsiveness and in the endothelin-TXA(2) mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats.

Journal: Diabetes research and clinical practice 20040301

Title: Mechanisms underlying diabetes enhancement of endothelin-1-induced contraction in rabbit basilar artery.

Journal: European journal of pharmacology 20040223

Title: Endothelins contribute towards nociception induced by antigen in ovalbumin-sensitised mice.

Journal: British journal of pharmacology 20040201

Title: Role of oxidative stress and nitric oxide in regulation of spontaneous tone in aorta of DOCA-salt hypertensive rats.

Journal: British journal of pharmacology 20040201

Title: Inward current oscillation underlying tonic contraction caused via ETA receptors in pig detrusor smooth muscle.

Journal: American journal of physiology. Renal physiology 20040101

Title: Stimulation of NHE3 in OKP cells by an autocrine mechanism.

Journal: Nephron. Experimental nephrology 20040101

Title: In-vivo interaction of nitric oxide and endothelin.

Journal: Journal of hypertension 20040101

Title: Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts.

Journal: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20040101

Title: Angiotensin II signaling pathways mediate expression of cardiac T-type calcium channels.

Journal: Circulation research 20031212

Title: Endothelin-like action of Pausinystalia yohimbe aqueous extract on vascular and renal regional hemodynamics in Sprague Dawley rats.

Journal: Methods and findings in experimental and clinical pharmacology 20031201

Title: Glucose-dependent insulinotropic peptide stimulates thymidine incorporation in endothelial cells: role of endothelin-1.

Journal: American journal of physiology. Endocrinology and metabolism 20030801

Title: Dual role of endothelin-1 via ETA and ETB receptors in regulation of cardiac contractile function in mice.

Journal: American journal of physiology. Heart and circulatory physiology 20030701

Title: Thrombin inhibits NMDA-mediated nociceptive activity in the mouse: possible mediation by endothelin.

Journal: The Journal of physiology 20030615

Title: Endothelin ET(A) but not ET(B) receptors mediate contraction of common bile duct.

Journal: Regulatory peptides 20030515

Title: Endothelin-1 directly modulates its own secretion: studies utilising the cell immunoblot technique.

Journal: Regulatory peptides 20030515

Title: Antiapoptotic effect of endothelin-1 in rat cardiomyocytes in vitro.

Journal: Hypertension (Dallas, Tex. : 1979) 20030501

Title: Cyclooxygenase is regulated by ET-1 and MAPKs in peripheral lung microvascular smooth muscle cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20030401

Title: Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs.

Journal: European journal of pharmacology 20030328

Title: Will endothelin receptor antagonists have a role in heart failure?

Journal: The Medical clinics of North America 20030301

Title: Effect of endothelin-1 (1-31) on the renal resistance vessels.

Journal: The journal of medical investigation : JMI 20030201

Title: Evidence for the involvement of ET(B) receptors in ET-1-induced changes in blood flow to the rat breast tumor.

Journal: Cancer chemotherapy and pharmacology 20030101

Title: ETA, mixed ETA/ETB receptor antagonists, and protein kinase C inhibitor prevent acute hypoxic pulmonary vasoconstriction: influence of potassium channels.

Journal: Journal of cardiovascular pharmacology 20030101

Title: Endothelin receptor blockade lowers plasma aldosterone levels via different mechanisms in primary aldosteronism and high-to-normal renin hypertension.

Journal: Cardiovascular research 20030101

Title: Et-A receptor antagonist BQ123 prevents radiocontrast media-induced renal medullary hypoxia.

Journal: Acta radiologica (Stockholm, Sweden : 1987) 20030101

Title: Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach.

Journal: Journal of pharmacological sciences 20030101

Title: Selective blockade of endothelin-B receptors exacerbates ischemic brain damage in the rat.

Journal: Stroke 20021201

Title: Role of endothelin type B receptor in NO/cGMP signaling pathway in rat median eminence.

Journal: Cellular and molecular neurobiology 20021201

Title: Mechanism of endothelin-1-induced cytosolic Ca(2+) mobility in cultured H9c2 myocardiac ventricular cells.

Journal: Cellular signalling 20021001

Title: Increased activity of endogenous endothelin in patients with type II diabetes mellitus.

Journal: Circulation 20021001

Title: Different contractile effects of alpha1- and alpha2-adrenergic agonists on horse isolated common digital artery smooth muscle ring preparations in vitro.

Journal: Pharmacological research 20021001

Title: Effects of endothelin-1 on release of adrenomedullin and C-type natriuretic peptide from individual human vascular endothelial cells.

Journal: The Journal of endocrinology 20021001

Title: Effects of endothelin B receptor agonists on amyloid beta protein (25-35)-induced neuronal cell death.

Journal: Brain research 20020906

Title: The vascular endothelin system is not overactive in normotensive hemodialysis patients.

Journal: Kidney international 20020901

Title: Endothelin-1 receptor antagonists reduce cardiac electrical instability induced by high glucose in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020901

Title: Mechanism of RhoA/Rho kinase activation in endothelin-1- induced contraction in rabbit basilar artery.

Journal: American journal of physiology. Heart and circulatory physiology 20020901

Title: Endothelin-1 and -3 diminish neuronal NE release through an NO mechanism in rat anterior hypothalamus.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20020901

Title: Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors.

Journal: European journal of immunology 20020901

Title: Possible mechanism of endothelin-induced Ca2+ mobility in A7r5 cultured vascular smooth muscle cells.

Journal: The Kaohsiung journal of medical sciences 20020901

Title: Local administration of ETA (but not ETB) blockers into the PAG area of the brain decreases blood pressure of DOCA-salt rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20020801

Title: Enhanced vasoconstriction to endothelin-1, angiotensin II and noradrenaline in carriers of the GNB3 825T allele in the skin microcirculation.

Journal: Pharmacogenetics 20020801

Title: Endothelin-1 (1-31) induces a thiorphan-sensitive release of eicosanoids via ET(B) receptors in the guinea pig perfused lung.

Journal: Clinical science (London, England : 1979) 20020801

Title: Role of endothelin receptors in the hypertensive state of kinin B(2) knockout mice subjected to a high-salt diet.

Journal: Clinical science (London, England : 1979) 20020801

Title: Reduction of endothelin-1 binding and inhibition of endothelin-1-mediated detrusor contraction by naftidrofuryl.

Journal: Clinical science (London, England : 1979) 20020801

Title: Two classes of endothelin receptors mediating contraction in esophageal muscularis mucosae.

Journal: Regulatory peptides 20020530

Title: Endothelin B receptor-mediated regulation of endothelin-1 content and release in cultured porcine aorta endothelial cell.

Journal: Journal of cardiovascular pharmacology 20020501

Title: Endothelin receptor function in mesenteric veins from deoxycorticosterone acetate salt-hypertensive rats.

Journal: Journal of hypertension 20020401

Title: A novel bioactive 31-amino acid ET-1 peptide stimulates eosinophil recruitment and increases the levels of eotaxin and IL-5.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020401

Title: Mechanisms transducing the aldosterone secretagogue signal of endothelins in the human adrenal cortex.

Journal: Peptides 20020301

Title: Endothelin-3 induces both human and opossum gallbladder contraction mediated mainly by endothelin-B receptor subtype in vitro.

Journal: Journal of gastroenterology and hepatology 20020301

Title: Role of endothelin ET(A)- and ET(B)-receptors in haemodynamic compensation following haemorrhage in anaesthetized rats.

Journal: British journal of pharmacology 20020201

Title: Improved endothelium-dependent vasodilation after blockade of endothelin receptors in patients with essential hypertension.

Journal: Circulation 20020129

Title: Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth.

Journal: The Journal of clinical endocrinology and metabolism 20020101

Title: Coronary and femoral arterial contraction with high glucose, insulin, and glucose-insulin-potassium solution: effects of hypoxia.

Journal: Heart and vessels 20020101

Title: Functional cross-talk of Ca2+-mobilizing endothelin receptors in C6 glioma cells.

Journal: Physiological research 20020101

Title: Endothelin-1 activates ET(A) receptors to increase intracellular calcium in model sensory neurons.

Journal: Neuroreport 20011204

Title: Endothelin resets renal blood flow autoregulatory efficiency during acute blockade of NO in the rat.

Journal: American journal of physiology. Renal physiology 20011201

Title: Myocardial contractile responsiveness to endothelin-1 in the post-infarction rat model of heart failure: effects of chronic quinapril.

Journal: Journal of molecular and cellular cardiology 20011101

Title: Endothelin-1 induces contraction of human and Australian possum gallbladder in vitro.

Journal: Regulatory peptides 20011015

Title: Endothelin receptor blockade and nitric oxide bioactivity.

Journal: Cardiovascular research 20011001

Title: The effect of endothelin-1 on nuclear factor kappa B in macrophages.

Journal: Biochemical and biophysical research communications 20010907

Title: High-glucose-induced metallothionein expression in endothelial cells: an endothelin-mediated mechanism.

Journal: American journal of physiology. Cell physiology 20010901

Title: Adrenergic and endothelin B receptor-dependent hypertension in dopamine receptor type-2 knockout mice.

Journal: Hypertension (Dallas, Tex. : 1979) 20010901

Title: Endothelin-A receptor antagonist inhibits angiotensin II and noradrenaline in man.

Journal: British journal of clinical pharmacology 20010801

Title: Differential desensitization of Ca2+ mobilization and vasoconstriction by ET(A) receptors in the gerbil spiral modiolar artery.

Journal: The Journal of membrane biology 20010801

Title: The role of endothelin-B receptors in myocardial and endothelial reperfusion injury after heart transplantation.

Journal: The Thoracic and cardiovascular surgeon 20010601

Title: A novel pharmacological action of ET-1 to prevent the cytotoxicity of doxorubicin in cardiomyocytes.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20010501

Title: Endothelin receptors in human and guinea-pig gallbladder muscle.

Journal: Regulatory peptides 20010420

Title: Intravasal peroxynitrite generation causes dysfunction in the isolated perfused rat lung via endothelin.

Journal: The Journal of pharmacology and experimental therapeutics 20010401

Title: Endothelin-1 induces vasoconstriction on portal-systemic collaterals of portal hypertensive rats.

Journal: Hepatology (Baltimore, Md.) 20010401

Title: Endothelin B receptor-mediated protection against anoxia-reoxygenation injury in perfused rat liver: nitric oxide-dependent and -independent mechanisms.

Journal: Hepatology (Baltimore, Md.) 20010401

Title: Endothelin-1 has a unique oxygen-saving effect by increasing contractile efficiency in the isolated rat heart.

Journal: Circulation 20010320

Title: Potentiation by endothelin-1 of vasoconstrictor response in stroke-prone spontaneously hypertensive rats.

Journal: European journal of pharmacology 20010309

Title: Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex.

Journal: International journal of molecular medicine 20010301

Title: Inhibition of Na(+)/K(+)-atpase by endothelin-1 in human nonpigmented ciliary epithelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20010301

Title: Endothelin receptor blockade inhibits proliferation of Kaposi's sarcoma cells.

Journal: The American journal of pathology 20010301

Title: Endothelin-1-induced potentiation of adrenergic responses in the rabbit pulmonary artery: role of thromboxane A(2).

Journal: European journal of pharmacology 20010216

Title: Endothelins enhance prostaglandin (PGE(2) and PGF(2alpha)) biosynthesis and release by human luteal cells: evidence of a new paracrine/autocrine regulation of luteal function.

Journal: The Journal of clinical endocrinology and metabolism 20010201

Title: Augmentation of endothelial function by endothelin antagonism in human saphenous vein conduits.

Journal: Journal of neurosurgery 20010201

Title: Endothelin receptor blockade improves endothelial function in human internal mammary arteries.

Journal: Cardiovascular research 20010101

Title: Endothelin-1 as a protective factor against beta-adrenergic agonist-induced apoptosis in cardiac myocytes.

Journal: Journal of the American College of Cardiology 20001001

Title: Suc-[Glu9,Ala11,15]-endothelin-1 (8-21), IRL 1620, identifies two populations of ET(B) receptors in guinea-pig bronchus.

Journal: British journal of pharmacology 19990701

Title: Characterization of the binding of endothelin ETB selective ligands in human and rat heart.

Journal: British journal of pharmacology 19961001

Title: Okada M, et al. BQ-788, a selective endothelin ET(B) receptor antagonist. Cardiovasc Drug Rev. 2002 Winter;20(1):53-66.

Title: Sargent CA, et al. Effect of endothelin antagonists with or without BQ 788 on ET-1 responses in pithed rats. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S216-8.

Title: Fattori V, et al. Differential regulation of oxidative stress and cytokine production by endothelin ETA and ETB receptors in superoxide anion-induced inflammation and pain in mice. J Drug Target. 2016 Oct 5:1-27

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