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1570-64-5,MFCD00002321
Catalog No.:AA00HYCN

1570-64-5 | 4-Chloro-2-methylphenol

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10g
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$7.00   $5.00
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25g
97%
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$12.00   $8.00
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100g
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$42.00   $29.00
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500g
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00HYCN
Chemical Name:
4-Chloro-2-methylphenol
CAS Number:
1570-64-5
Molecular Formula:
C7H7ClO
Molecular Weight:
142.5829
MDL Number:
MFCD00002321
SMILES:
Clc1ccc(c(c1)C)O
NSC Number:
2851
UN Number:
2669
Properties
Properties
 
BP:
225.3°C at 760 mmHg  
Form:
Solid  
MP:
43-46 °C(lit.)  
Refractive Index:
1.5449 (estimate)  
Storage:
Inert atmosphere;Room Temperature;  

Computed Properties
 
Complexity:
94.9  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
9  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
XLogP3:
2.8  

Upstream Synthesis Route

[1]SyntheticCommunications,2002,vol.32,#2,p.279-286

[2]Synlett,2011,#11,p.1537-1542

[3]JournaloftheChemicalSociety,ChemicalCommunications,1980,#1,p.8-9

[4]JournaloftheChemicalSociety,ChemicalCommunications,1980,#1,p.8-9

[5]ZhurnalRusskagoFiziko-KhimicheskagoObshchestva,1928,vol.60,p.161

[6]Chem.Zentralbl.,1928,vol.99,#II,p.767

[7]TetrahedronLetters,1988,vol.29,#11,p.1319-1322

[8]Tetrahedron,1982,vol.38,#15,p.2339-2346

[9]ZhurnalRusskagoFiziko-KhimicheskagoObshchestva,1928,vol.60,p.161

[10]Chem.Zentralbl.,1928,vol.99,#II,p.767

[11]JournaloftheChemicalSociety,1928,p.3269

[12]TetrahedronLetters,1983,vol.24,#30,p.3117-3120

[13]Tetrahedron,1982,vol.38,#15,p.2339-2346

[14]JournaloftheChemicalSociety,PerkinTransactions2:PhysicalOrganicChemistry(1972-1999),1988,p.385-392

[15]SyntheticCommunications,2002,vol.32,#5,p.735-740

[16]TetrahedronLetters,2003,vol.44,#29,p.5491-5494

[17]JournalofOrganicChemistry,2012,vol.77,#13,p.5823-5828

[18]JournalofSulfurChemistry,2015,vol.36,#1,p.74-85

[19]JournalofSulfurChemistry,2018,vol.39,#6,p.607-621

[1]JournalofPhotochemistryandPhotobiologyA:Chemistry,2012,vol.228,#1,p.8-14

[1]JournalofPhysicalChemistry,1994,vol.98,#37,p.9158-9164

[1]IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,2004,vol.43,#6,p.1335-1338

[1]RussianJournalofAppliedChemistry,2009,vol.82,#3,p.396-401

Downstream Synthesis Route

[1]EuropeanJournalofMedicinalChemistry,2008,vol.43,p.1570-1574

[2]JustusLiebigsAnnalenderChemie,1918,vol.417,p.231

[3]Tetrahedron,1989,vol.45,p.1299-1310

[4]Patent:US2007/197512,2007,A1.Locationinpatent:Page/Pagecolumn78

[1]Patent:CN106365975,2017,A.Locationinpatent:Paragraph0027;0028;0029

[2]Patent:CN107488108,2017,A.Locationinpatent:Paragraph0034;0035

[3]InorganicChemistry,2019,vol.58,p.12933-12942

[4]JournalofOrganicChemistry,2012,vol.77,p.5823-5828

[5]JournalofOrganicChemistry,2017,vol.82,p.7529-7537

[6]Synthesis,1986,p.868-870

[7]AsianJournalofChemistry,2018,vol.30,p.167-170

[8]JournalfurPraktischeChemie(Weinheim),1999,vol.341,p.59-61

[9]GazzettaChimicaItaliana,1898,vol.28I,p.211

[10]JournalfurpraktischeChemie(Leipzig1954),1888,vol.<2>38,p.328

[11]JournaloftheChemicalSociety.PerkintransactionsII,1989,p.1529-1536

[12]Tetrahedron,2002,vol.58,p.8059-8065

[13]IndianJournalofChemistry,SectionA:Inorganic,Physical,TheoreticalandAnalytical,2001,vol.40,p.1196-1202

[14]JournaloftheIndianChemicalSociety,2002,vol.79,p.420-425

[15]ACSMedicinalChemistryLetters,2014,vol.5,p.1162-1166

[16]JournalofSulfurChemistry,2015,vol.36,p.74-85

[17]JournalofChemistry,2016,vol.2016

[18]Patent:US2494993,1945,

[19]JournalofSulfurChemistry,2018,vol.39,p.607-621

[20]JournalofSulfurChemistry,2019,vol.40,p.529-538

[21]JournalofSulfurChemistry,2020,vol.41,p.345-356

[1]AdvancedSynthesisandCatalysis,2019,vol.361,p.4448-4453

[2]BioorganicandMedicinalChemistryLetters,2016,vol.26,p.999-1004

[3]JournaloftheIndianChemicalSociety,1939,vol.16,p.151,155

[1]Patent:US2009/118312,2009,A1.Locationinpatent:Page/Pagecolumn60

[2]AngewandteChemie,1965,vol.77,p.291-302

[1]Patent:DE2509037,1976,    Chem.Abstr.,1976,vol.85

Literature

Title: Solar photoelectro-Fenton degradation of the herbicide 4-chloro-2-methylphenoxyacetic acid optimized by response surface methodology.

Journal: Journal of hazardous materials 20111030

Title: Functional properties of RYR1 mutations identified in Swedish patients with malignant hyperthermia and central core disease.

Journal: Anesthesia and analgesia 20100701

Title: The effect of structure and a secondary carbon source on the microbial degradation of chlorophenoxy acids.

Journal: Chemosphere 20100501

Title: Liquid chromatography with post-column reagent addition of ammonia in methanol coupled to negative ion electrospray ionization tandem mass spectrometry for determination of phenoxyacid herbicides and their degradation products in surface water.

Journal: Analytical chemistry insights 20100101

Title: Fulvic acid-mediated phototransformation of mecoprop. A pH-dependent reaction.

Journal: Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090701

Title: Pesticide by-products in the Rhône delta (Southern France). The case of 4-chloro-2-methylphenol and of its nitroderivative.

Journal: Chemosphere 20090101

Title: A fatal intoxication from ingestion of 2-methyl-4-chlorophenoxyacetic acid (MCPA).

Journal: Journal of analytical toxicology 20080301

Title: Quantitative determination of chlorophenols in leather by pressurized liquid extraction and liquid chromatography with diode-array detection.

Journal: Journal of chromatography. A 20080104

Title: [Simultaneous determination of nine organochlorine pesticide residues in textile by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20070501

Title: Development of a high analytical performance-tyrosinase biosensor based on a composite graphite-Teflon electrode modified with gold nanoparticles.

Journal: Biosensors & bioelectronics 20061215

Title: Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods.

Journal: Journal of molecular graphics & modelling 20061101

Title: Purification and characterization of two enantioselective alpha-ketoglutarate-dependent dioxygenases, RdpA and SdpA, from Sphingomonas herbicidovorans MH.

Journal: Applied and environmental microbiology 20060701

Title: Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

Journal: Journal of medicinal chemistry 20050908

Title: Photodegradation of chlorinated pesticides dispersed on sand.

Journal: Chemosphere 20050301

Title: Enantioselective biodegradation of mecoprop in aerobic and anaerobic microcosms.

Journal: Chemosphere 20031101

Title: Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptor.

Journal: Chemical research in toxicology 20031001

Title: Changes in enantiomeric fraction as evidence of natural attenuation of mecoprop in a limestone aquifer.

Journal: Journal of contaminant hydrology 20030701

Title: Oxidative transformation of triclosan and chlorophene by manganese oxides.

Journal: Environmental science & technology 20030601

Title: Analysis of acidic pesticides using in situ derivatization with alkylchloroformate and solid-phase microextraction (SPME) for GC-MS.

Journal: Chemosphere 20010901

Title: Determination of the herbicide 4-chloro-2-methylphenoxyacetic acid and its main metabolite, 4-chloro-2-methylphenol in water and soil by liquid chromatography-electrospray tandem mass spectrometry.

Journal: Journal of chromatography. A 20010720

Title: Structural requirements for voltage-dependent block of muscle sodium channels by phenol derivatives.

Journal: British journal of pharmacology 20010401

Title: Phenol derivatives accelerate inactivation kinetics in one inactivation-deficient mutant human skeletal muscle Na(+) channel.

Journal: European journal of pharmacology 20010323

Title: Genotoxicity of ochratoxin A and structurally related compounds in Escherichia coli strains: studies on their mode of action.

Journal: IARC scientific publications 19910101

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