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1613695-14-9,MFCD26792586
Catalog No.:AA00ABIX

1613695-14-9 | SGC-CBP30

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Purity
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Price(USD)
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5mg
≥98%
in stock  
$158.00   $110.00
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10mg
≥98%
in stock  
$298.00   $208.00
- +
25mg
98%
in stock  
$654.00   $458.00
- +
50mg
98%
in stock  
$852.00   $597.00
- +
100mg
98%
in stock  
$1,400.00   $980.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA00ABIX
Chemical Name:
SGC-CBP30
CAS Number:
1613695-14-9
Molecular Formula:
C28H33ClN4O3
Molecular Weight:
509.0396
MDL Number:
MFCD26792586
SMILES:
COc1ccc(cc1Cl)CCc1nc2c(n1C[C@@H](N1CCOCC1)C)ccc(c2)c1c(C)noc1C
Properties
Computed Properties
 
Complexity:
698  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
6  
Rotatable Bond Count:
8  
XLogP3:
5.2  

Upstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,#26,p.9308-9319

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,#26,p.9308-9319

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,#26,p.9308-9319

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,#26,p.9308-9319

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,#26,p.9308-9319

Downstream Synthesis Route

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,p.9308-9319

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,p.9308-9319

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,p.9308-9319

1857-56-3   
C18H26N4O2 
  1613695-14-9 

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,p.9308-9319

[1]JournaloftheAmericanChemicalSociety,2014,vol.136,p.9308-9319

Literature

Title: CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20150825

Title: Bromodomains and their pharmacological inhibitors.

Journal: ChemMedChem 20140301

Title: Hammitzsch A, et al. CBP30, a selective CBP/p300 bromodomain inhibitor, suppresses human Th17 responses. Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10768-73.

Title: Tao J, Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo. Biomed Pharmacother. 2018 Oct;106:1727-1733.

Title: Hay DA, et al. Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains. J Am Chem Soc. 2014 Jul 2;136(26):9308-19.

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SDS
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