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Home Amines 1627494-13-6
1627494-13-6,MFCD27987908
Catalog No.:AA001TBB

1627494-13-6 | 8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-6-carboxamide

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Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
250mg
95%
in stock  
$120.00   $84.00
- +
1g
95%
in stock  
$336.00   $235.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA001TBB
Chemical Name:
8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-6-carboxamide
CAS Number:
1627494-13-6
Molecular Formula:
C24H25F2N3O4
Molecular Weight:
457.4698
MDL Number:
MFCD27987908
SMILES:
Fc1cc(cc(c1)F)N[C@@H](c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C)C
Properties
Computed Properties
 
Complexity:
748  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3  

Downstream Synthesis Route

[1]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

CASUnavailable 
  1644433-41-9    1627494-13-6 

[1]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

1627494-13-6    77-78-1   
CASUnavailable 

[1]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

[1]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

CASUnavailable 
  1627494-13-6 

[1]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

[2]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

[3]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

[4]Barlaam,Bernard;Cosulich,Sabina;Degorce,Sébastien;Fitzek,Martina;Green,Stephen;Hancox,Urs;Lambert-VanDerBrempt,Christine;Lohmann,Jean-Jacques;Maudet,Mickaël;Morgentin,Rémy;Pasquet,Marie-Jeanne;Péru,Aurélien;Plé,Patrick;Saleh,Twana;Vautier,Michel;Walker,Mike;Ward,Lara;Warin,Nicolas[JournalofMedicinalChemistry,2015,vol.58,#2,p.943-962]

Literature

Title: Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel.

Journal: Molecular cancer therapeutics 20150101

Title: Hancox U, et al. Inhibition of PI3Kβ signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with RP-56976. Mol Cancer Ther. 2015 Jan;14(1):48-58.

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Tags:1627494-13-6 Molecular Formula|1627494-13-6 MDL|1627494-13-6 SMILES|1627494-13-6 8-[(1R)-1-[(3,5-difluorophenyl)amino]ethyl]-N,N-dimethyl-2-(4-morpholinyl)-4-oxo-4H-1-benzopyran-6-carboxamide